{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:49:42Z","timestamp":1773330582236,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics and Research in Hepatology and Gastroenterology"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.clinre.2011.09.005","type":"journal-article","created":{"date-parts":[[2011,11,9]],"date-time":"2011-11-09T20:28:40Z","timestamp":1320870520000},"page":"845-854","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Effects of testosterone gel treatment in hypogonadal men with liver cirrhosis"],"prefix":"10.1016","volume":"35","author":[{"given":"Alper","family":"Yurci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Yucesoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kursad","family":"Unluhizarci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edip","family":"Torun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebnem","family":"Gursoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mevlut","family":"Baskol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kadri","family":"Guven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Ozbakir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.clinre.2011.09.005_bib0005","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/BF02349641","article-title":"Hypogonadism is not related to the etiology of liver cirrhosis","volume":"30","author":"Kaymako\u011flu","year":"1995","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.clinre.2011.09.005_bib0010","first-page":"145","article-title":"A study of the endocrine manifestations of hepatic cirrhosis","volume":"45","author":"Baker","year":"1976","journal-title":"Q J Med"},{"key":"10.1016\/j.clinre.2011.09.005_bib0015","first-page":"531","article-title":"Gonadal dysfunction and changes in sex hormones in postnecrotic cirrhotic men: a matched study with alcoholic cirrhotic men","volume":"38","author":"Wang","year":"1991","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.clinre.2011.09.005_bib0020","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0168-8278(05)80016-9","article-title":"Changes of sex hormone levels in patients with hepatitis B related postnecrotic cirrhosis: relationship to the severity of portal hypertension","volume":"18","author":"Wang","year":"1993","journal-title":"J Hepatol"},{"key":"10.1016\/j.clinre.2011.09.005_bib0025","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1210\/jcem-40-6-1018","article-title":"Conversion of androgens to estrogen in cirrhosis of the liver","volume":"40","author":"Gordon","year":"1975","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.clinre.2011.09.005_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/jcem-61-1-1","article-title":"Conversion of androgens to estrogens in idiopathic hemochromatosis: comparison with alcoholic liver cirrhosis","volume":"61","author":"Kley","year":"1985","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.clinre.2011.09.005_bib0035","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1439-0272.1985.tb00961.x","article-title":"Hypophyseal-gonadal dysfunction in men with non-alcoholic liver cirrhosis","volume":"17","author":"Moradian","year":"1985","journal-title":"Andrologia"},{"key":"10.1016\/j.clinre.2011.09.005_bib0040","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1002\/hep.510280603","article-title":"Quantitative studies of testicular atrophy following portocaval shunt in rats","volume":"28","author":"Zaitoun","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.clinre.2011.09.005_bib0045","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1136\/gut.17.5.345","article-title":"Hypothalamic-pituitary-gonadal function in men with cirrhosis of the liver","volume":"17","author":"Mowat","year":"1976","journal-title":"Gut"},{"key":"10.1016\/j.clinre.2011.09.005_bib0050","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1093\/ajcp\/20.9.814","article-title":"The testis, breast and prostate of men who die of cirrhosis of the liver","volume":"20","author":"Bennett","year":"1950","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.clinre.2011.09.005_bib0055","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1001\/archinte.1990.00390150061012","article-title":"Gynecomastia and cirrhosis of the liver","volume":"150","author":"Cavanough","year":"1990","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.clinre.2011.09.005_bib0060","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1053\/jhep.2001.20533","article-title":"Hepatic Osteodystrophy","volume":"33","author":"Rouillard","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.clinre.2011.09.005_bib0065","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/S0344-0338(89)80138-4","article-title":"Bone changes in alcoholic cirrhosis of the liver","volume":"184","author":"Chappard","year":"1989","journal-title":"Path Res Pract"},{"key":"10.1016\/j.clinre.2011.09.005_bib0070","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/hep.510280315","article-title":"Bone mineral density, serum insulin-like growth factor I, and bone turnover markers in viral cirrhosis","volume":"28","author":"Gallego-Rojo","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.clinre.2011.09.005_bib0075","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0016-5085(95)90033-0","article-title":"Bone disease in cholestatic liver disease","volume":"108","author":"Hay","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clinre.2011.09.005_bib0080","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0016-5085(88)90438-6","article-title":"Metabolic bone disease in primary biliary cirrhosis at presentation","volume":"94","author":"Mitchison","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clinre.2011.09.005_bib0085","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3109\/07853899708999363","article-title":"Androgen replacement therapy","volume":"29","author":"Wang","year":"1997","journal-title":"Ann Med"},{"key":"10.1016\/j.clinre.2011.09.005_bib0090","first-page":"2839","article-title":"Transdermal testosterone gel improves sexual function, mood, muscle strength and body composition parameters in hypogonadal men","volume":"85","author":"Wang","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.clinre.2011.09.005_bib0095","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1210\/jc.2003-032006","article-title":"Long-term testosterone gel (Androgel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men","volume":"89","author":"Wang","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.clinre.2011.09.005_bib0100","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1023\/B:DDAS.0000037810.59358.d2","article-title":"Beneficial effects of topical testosterone replacement in patients with end-stage liver disease","volume":"49","author":"Neff","year":"2004","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.clinre.2011.09.005_bib0105","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1016\/j.transproceed.2004.11.004","article-title":"Topical testosterone treatment for chronic allograft failure in liver transplant recipients with recurrent hepatitis C virus","volume":"36","author":"Neff","year":"2004","journal-title":"Transplantation Proceedings"},{"key":"10.1016\/j.clinre.2011.09.005_bib0110","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1473-3099(03)00572-3","article-title":"HIV and testosterone therapy [comment]","volume":"3","author":"Hengge U","year":"2003","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.clinre.2011.09.005_bib0115","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1001\/archpsyc.57.2.141","article-title":"A double-blind, placebo controlled trial of testosterone therapy for HIV-positive men with hypogonadal symptoms","volume":"57","author":"Rabkin","year":"2000","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.clinre.2011.09.005_bib0120","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1210\/jcem.84.10.6079","article-title":"A critical evaluation of simple methods for the estimation of free testosterone in serum","volume":"84","author":"Vermeulen","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.clinre.2011.09.005_bib0125","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1055\/s-0028-1093945","article-title":"Effects of testosterone enanthate on plasma concentrations of thyroxine, cortisol, testosterone and hormone binding proteins in patients with hypogonadism","volume":"5","author":"Kley","year":"1973","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.clinre.2011.09.005_bib0130","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1365-2362.1981.tb02016.x","article-title":"Pituitary-testicular function in patients with alcoholic cirrhosis of the liver","volume":"11","author":"Bahnsen","year":"1981","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.clinre.2011.09.005_bib0135","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1373\/clinchem.2007.094870","article-title":"Analog-based free testosterone test results linked to total testosterone concentrations, not free testosterone concentrations","volume":"54","author":"Fritz","year":"2008","journal-title":"Clin Chem"},{"key":"10.1016\/j.clinre.2011.09.005_bib0140","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1373\/clinchem.2007.101303","article-title":"Free testosterone measurement by the analog displacement direct assay: Old concerns and new evidence","volume":"54","author":"Swerdloff","year":"2008","journal-title":"Clin Chem"},{"key":"10.1016\/j.clinre.2011.09.005_bib0145","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1210\/jcem.86.6.7643","article-title":"An extraordinarily inaccurate assay for free testosterone is still with us","volume":"86","author":"Rosner","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.clinre.2011.09.005_bib0150","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/j.1442-2042.2009.02379.x","article-title":"Measurement specific bioavailable testosterone using concanavalin A precipitation: comparison of calculated and assayed bioavailable testosterone","volume":"16","author":"Yamamoto","year":"2009","journal-title":"Int J Urol"},{"key":"10.1016\/j.clinre.2011.09.005_bib0155","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1373\/clinchem.2006.077362","article-title":"Age-associated discrepancy between measured and calculated bioavailable testosterone in men","volume":"53","author":"D\u00e9chaud","year":"2007","journal-title":"Clin Chem"},{"key":"10.1016\/j.clinre.2011.09.005_bib0160","first-page":"397","article-title":"Safety and efficacy of testosterone gel in the treatment of male hypogonadism","volume":"4","author":"Lakshman","year":"2009","journal-title":"Clin Interv Aging"},{"key":"10.1016\/j.clinre.2011.09.005_bib0165","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1592\/phco.31.3.248","article-title":"Reduction in 24-hour plasma testosterone levels in subjects who showed 15 or 30minutes after application of testosterone gel","volume":"31","author":"de Ronde","year":"2011","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.clinre.2011.09.005_bib0170","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1365-2036.1988.tb00678.x","article-title":"Effect of testosterone treatment on serum concentrations of sex steroids gonadotrophins and prolactin in alcoholic cirrhotic men","volume":"2","author":"Gluud","year":"1988","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.clinre.2011.09.005_bib0175","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/hep.1840060502","article-title":"Testosterone treatment of men with alcoholic cirrhosis: a double-blind study","volume":"6","author":"The Copenhagen study group for liver diseases","year":"1986","journal-title":"Hepatology"},{"key":"10.1016\/j.clinre.2011.09.005_bib0180","first-page":"566","article-title":"Testosterone treatment of men with idiopathic hemochromatosis","volume":"70","author":"Kley","year":"1992","journal-title":"Clin \u0130nvestig"},{"key":"10.1016\/j.clinre.2011.09.005_bib0185","first-page":"4358","article-title":"Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism","volume":"81","author":"Katznelson","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.clinre.2011.09.005_bib0190","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/jbmr.5650060108","article-title":"Effects of testosterone and venesection on spinal and peripheral bone mineral in six hypogonadal men with hemochromatosis","volume":"6","author":"Diamond","year":"1991","journal-title":"J Bone Miner Res"},{"issue":"suppl I","key":"10.1016\/j.clinre.2011.09.005_bib0195","doi-asserted-by":"crossref","first-page":"i1","DOI":"10.1136\/gut.50.suppl_1.i1","article-title":"Guidelines on the management of osteoporosis associated with chronic liver disease","volume":"50","author":"Collier","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.clinre.2011.09.005_bib0200","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1365-2265.2005.02339.x","article-title":"Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men. A meta-analysis","volume":"63","author":"Isidori","year":"2005","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.clinre.2011.09.005_bib0205","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1172\/JCI118083","article-title":"Relationships of generalized and regional adiposity to insulin sensitivity","volume":"96","author":"Abate","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.clinre.2011.09.005_bib0210","first-page":"991","article-title":"The effects of testosterone treatment on body composition and metabolism in middle-aged obese men","volume":"16","author":"Marin","year":"1992","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.clinre.2011.09.005_bib0215","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1123\/ijsnem.11.4.451","article-title":"Testosterone responses after resistance in women: influence of regional fat distribution","volume":"11","author":"Nindl","year":"2001","journal-title":"Int J Sport Nutr Exerc Metab"},{"key":"10.1016\/j.clinre.2011.09.005_bib0220","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0002-9343(01)00813-0","article-title":"Effects of transdermal testosterone treatment on serum lipid and apolipoprotein levels in men more than 65 years of age","volume":"111","author":"Snyder","year":"2001","journal-title":"Am J Med"}],"container-title":["Clinics and Research in Hepatology and Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210740111003305?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210740111003305?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:12:34Z","timestamp":1761894754000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210740111003305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S2210740111003305"],"URL":"https:\/\/doi.org\/10.1016\/j.clinre.2011.09.005","relation":{},"ISSN":["2210-7401"],"issn-type":[{"value":"2210-7401","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of testosterone gel treatment in hypogonadal men with liver cirrhosis","name":"articletitle","label":"Article Title"},{"value":"Clinics and Research in Hepatology and Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinre.2011.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}]}}