{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T08:13:07Z","timestamp":1761898387938,"version":"build-2065373602"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics and Research in Hepatology and Gastroenterology"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.clinre.2014.08.004","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T19:17:46Z","timestamp":1410808666000},"page":"222-229","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Diversity of humoral responses to the centromere proteins among HCV-related chronic liver disease, PBC and AIH patients"],"prefix":"10.1016","volume":"39","author":[{"given":"Takashi","family":"Himoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyo","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinao","family":"Muro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumitsu","family":"Sugiura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joji","family":"Tani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisaaki","family":"Miyoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asahiro","family":"Morishita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohito","family":"Yoneyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiji","family":"Haba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Masaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinre.2014.08.004_bib0005","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1073\/pnas.77.3.1627","article-title":"Autoantibody to centromere (kinetochore) in scleroderma sera","volume":"77","author":"Moroi","year":"1980","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.clinre.2014.08.004_bib0010","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/0002-9343(80)90462-3","article-title":"The CREST syndrome: a distinct serologic entity with anticentromere antibodes","volume":"69","author":"Fritzler","year":"1980","journal-title":"Am J Med"},{"key":"10.1016\/j.clinre.2014.08.004_bib0015","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/BF00328227","article-title":"Identification of a family of human centromere proteins using autoimmune sera from patients with scleroderma","volume":"91","author":"Earnshaw","year":"1985","journal-title":"Chromosoma"},{"key":"10.1016\/j.clinre.2014.08.004_bib0020","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1073\/pnas.88.9.3734","article-title":"Purification of the centromere-specific protein CENP-A and demonstration that it is a distinctive histone","volume":"88","author":"Palmer","year":"1991","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.clinre.2014.08.004_bib0025","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1083\/jcb.119.6.1413","article-title":"A human centromere protein, CENP-B, has a DNA binding domain containing four potential a helices at the NH2 terminus, which is separable from dimerzing activity","volume":"119","author":"Yoda","year":"1992","journal-title":"J Cell Biol"},{"key":"10.1016\/j.clinre.2014.08.004_bib0030","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1093\/oxfordjournals.jbchem.a123783","article-title":"Anti-helix-loop-helix domain antibodies: discovery of autoantibodies that inhibit DNA binding activity of human centromere protein B (CENP-B)","volume":"111","author":"Sugimoto","year":"1992","journal-title":"J Biochem"},{"key":"10.1016\/j.clinre.2014.08.004_bib0035","first-page":"289294","article-title":"Further evidence that CENP-C is a necessary component of active centromeres: studies of a dice (X;15) with simultaneous immunofluorescent and FISH","volume":"4","author":"Page","year":"1995","journal-title":"Hum Mil Genet"},{"key":"10.1016\/j.clinre.2014.08.004_bib0040","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1093\/intimm\/12.10.1431","article-title":"Differences in specificities of anti-centromere sera for monomeric and dimeric C-terminal peptide of human centromere protein C","volume":"12","author":"Hayashi","year":"2000","journal-title":"Int Immunol"},{"key":"10.1016\/j.clinre.2014.08.004_bib0045","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/art.1780260714","article-title":"Anticentromere antibodies in primary biliary cirrhosis","volume":"26","author":"Makinen","year":"1983","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinre.2014.08.004_bib0050","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1386-6346(01)00138-3","article-title":"Clinicolaboratory characteristics of patients with primary bililarry cirrhosis associated with CREST symptoms","volume":"22","author":"Tojo","year":"2002","journal-title":"Hepatol Res"},{"key":"10.1016\/j.clinre.2014.08.004_bib0055","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/hep.21472","article-title":"Anti-gp210 and anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis","volume":"45","author":"Nakamura","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.clinre.2014.08.004_bib0060","doi-asserted-by":"crossref","first-page":"4979","DOI":"10.1073\/pnas.84.14.4979","article-title":"Analysis of anticentromere autoantibodies using cloned autoantigen CENP-B","volume":"84","author":"Earnshaw","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.clinre.2014.08.004_bib0065","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1002\/art.1780301214","article-title":"Detection of anticentromere antibodies using cloned autoantigen CENP-B","volume":"30","author":"Rothfield","year":"1987","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinre.2014.08.004_bib0070","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/art.1780390520","article-title":"Detection of anticentromere antibodies using recombinant human CENP-A protein","volume":"39","author":"Sun","year":"1996","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinre.2014.08.004_bib0075","first-page":"142","article-title":"Circulating anticentromere CENP-A and CENP-B antibodies in patients with diffuse and limited systemic sclerosis, systemic lupus erythematosus, and rheumatoid arthritis","volume":"27","author":"Russo","year":"2000","journal-title":"J Rheumatol"},{"key":"10.1016\/j.clinre.2014.08.004_bib0080","first-page":"505","article-title":"Comparison of ELISA with CENP-A and CENP-B for the detection of anti-centromere antibody","volume":"26","author":"Hoshino","year":"2008","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.clinre.2014.08.004_bib0085","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1046\/j.1365-2249.2000.01189.x","article-title":"Autoepitopes on autoantigen centromere protein-A (CENP-A) are restricted to N-terminal region, which has no homology with histone H3","volume":"120","author":"Muro","year":"2000","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.clinre.2014.08.004_bib0090","first-page":"1121","article-title":"Centromere protein C is a target autoantibodies in Sj\u00f6gren's syndrome and is uniformly associated with antibodies to Ro and La","volume":"31","author":"Pillemer","year":"2004","journal-title":"J Rheumatol"},{"key":"10.1016\/j.clinre.2014.08.004_bib0095","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/j.1872-034X.2010.00684.x","article-title":"Clinical characteristics of patients with autoimmune hepatitis seropositive for anticentromere antibody","volume":"40","author":"Himoto","year":"2010","journal-title":"Hepatol Res"},{"key":"10.1016\/j.clinre.2014.08.004_bib0100","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s10620-008-0359-y","article-title":"Clinical characteristics of patients with hepatitis C virus-related chronic liver disease seropositive for anticentromere antibody","volume":"54","author":"Himoto","year":"2009","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.clinre.2014.08.004_bib0105","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1136\/ard.2005.046003","article-title":"Distinct recognition of antibodies to centromere proteins in primary Sj\u00f6gren's syndrome compared with limited scleroderma","volume":"65","author":"Gelber","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinre.2014.08.004_bib0110","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0168-8278(99)80297-9","article-title":"International autoimmune hepatitis group report: review of criteria for a diagnosis of autoimmune hepatitis","volume":"31","author":"Alvarez","year":"1999","journal-title":"J Hepatol"},{"key":"10.1016\/j.clinre.2014.08.004_bib0115","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/hep.510290444","article-title":"Histopathological study of primary billiary cirrhosis and the effect of ursodeoxycholic acid treatment on histological progression","volume":"29","author":"Degott","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.clinre.2014.08.004_bib0120","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/j.1346-8138.1992.tb03734.x","article-title":"The clinical expression in anticentromere antibody-positive patients is not specified by the epitope recognition of CENP-B antigen","volume":"19","author":"Muro","year":"1992","journal-title":"J Dermatol"},{"key":"10.1016\/j.clinre.2014.08.004_bib0125","first-page":"474","article-title":"Epitope mapping of human centromere autoantigen centromere protein C (CENP-C); heterogeneity of anti-CENP-C response in rheumatic disease","volume":"25","author":"Sugimoto","year":"1998","journal-title":"J Rheumatol"},{"key":"10.1016\/j.clinre.2014.08.004_bib0130","doi-asserted-by":"crossref","first-page":"781","DOI":"10.3899\/jrheum.080726","article-title":"CENP-O, a protein localized at the centromere throughout the cell cycle, is a novel target antigen in systemic sclerosis","volume":"36","author":"Saito","year":"2009","journal-title":"J Rheumatol"},{"key":"10.1016\/j.clinre.2014.08.004_bib0135","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1002\/art.20096","article-title":"Anti-DFS70 antibodies in 597 healthy hospital workers","volume":"50","author":"Watanabe","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinre.2014.08.004_bib0140","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/hep.1840010511","article-title":"Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis","volume":"1","author":"Knodell","year":"1981","journal-title":"Hepatology"},{"key":"10.1016\/j.clinre.2014.08.004_bib0145","first-page":"1257","article-title":"Primary biliary cirrhosis","volume":"60","author":"Scheuer","year":"1967","journal-title":"Proc R Soc Med"},{"key":"10.1016\/j.clinre.2014.08.004_bib0150","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.1007\/s10620-011-1771-2","article-title":"Serum immunoglobulin A concentration is an independent predictor of liver fibrosis in nonalcoholic steatohepatitis before the cirrhotic stage","volume":"56","author":"Tomita","year":"2011","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.clinre.2014.08.004_bib0155","first-page":"465","article-title":"Protein responsible for anticentromere activity found in the sera of patients with CREST-associated Raunaud's phenomenon","volume":"72","author":"Kremer","year":"1988","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.clinre.2014.08.004_bib0160","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1034\/j.1600-0676.2001.021004225.x","article-title":"Molecular mimicry and autoimmune liver disease: virtuous intentions, malign consequences","volume":"21","author":"Bogdanos","year":"2001","journal-title":"Liver"},{"key":"10.1016\/j.clinre.2014.08.004_bib0170","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.2169\/internalmedicine.31.1348","article-title":"Anti-centromere antibody and CREST syndrome in patients with primary biliary cirrhosis","volume":"31","author":"Shoji","year":"1992","journal-title":"Intern Med"}],"container-title":["Clinics and Research in Hepatology and Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210740114001843?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210740114001843?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:22:16Z","timestamp":1761895336000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210740114001843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S2210740114001843"],"URL":"https:\/\/doi.org\/10.1016\/j.clinre.2014.08.004","relation":{},"ISSN":["2210-7401"],"issn-type":[{"type":"print","value":"2210-7401"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diversity of humoral responses to the centromere proteins among HCV-related chronic liver disease, PBC and AIH patients","name":"articletitle","label":"Article Title"},{"value":"Clinics and Research in Hepatology and Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinre.2014.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}