{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:30:34Z","timestamp":1784694634663,"version":"3.55.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics and Research in Hepatology and Gastroenterology"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.clinre.2019.10.004","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T08:28:25Z","timestamp":1579768105000},"page":"932-938","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["USP9X mRNA expression predicts clinical outcome for esophageal squamous cell carcinoma treated with cisplatin-based therapy"],"prefix":"10.1016","volume":"44","author":[{"given":"Bin","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.clinre.2019.10.004_bib0150","first-page":"115","article-title":"Cancer statistics in China, 2015","volume":"66","author":"Chen","year":"2016","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.clinre.2019.10.004_bib0155","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s13046-019-1094-2","article-title":"Clinical development of targeted and immune based anti-cancer therapies","volume":"38","author":"Seebacher","year":"2019","journal-title":"J Exp Clin Cancer Res"},{"issue":"6","key":"10.1016\/j.clinre.2019.10.004_bib0160","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.drudis.2019.04.008","article-title":"Drug resistance: origins, evolution and characterization of genomic clones and the tumor ecosystem to optimize precise individualized therapy","volume":"24","author":"Kyrochristos","year":"2019","journal-title":"Drug Discov Today"},{"issue":"9","key":"10.1016\/j.clinre.2019.10.004_bib0165","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1517\/14728222.2013.815728","article-title":"Targeting the ubiquitin-proteasome system for cancer therapy","volume":"17","author":"Shen","year":"2013","journal-title":"Expert Opin Ther Targets"},{"issue":"4","key":"10.1016\/j.clinre.2019.10.004_bib0170","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s10555-017-9697-6","article-title":"Proteasome-associated deubiquitinases and cancer","volume":"36","author":"Mofers","year":"2017","journal-title":"Cancer Metastasis Rev"},{"issue":"11","key":"10.1016\/j.clinre.2019.10.004_bib0175","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1007\/s00018-015-1851-0","article-title":"La FAM fatale: USP9X in development and disease","volume":"72","author":"Murtaza","year":"2015","journal-title":"Cell Mol Life Sci"},{"issue":"7277","key":"10.1016\/j.clinre.2019.10.004_bib0180","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature08646","article-title":"Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival","volume":"463","author":"Schwickart","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.clinre.2019.10.004_bib0185","doi-asserted-by":"crossref","first-page":"14866","DOI":"10.1038\/ncomms14866","article-title":"USP9X regulates centrosome duplication and promotes breast carcinogenesis","volume":"8","author":"Li","year":"2017","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.clinre.2019.10.004_bib0190","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.clinre.2017.01.008","article-title":"Aberrant expression of deubiquitylating enzyme USP9X predicts poor prognosis in gastric cancer","volume":"41","author":"Fu","year":"2017","journal-title":"Clin Res Hepatol Gastroenterol"},{"issue":"3","key":"10.1016\/j.clinre.2019.10.004_bib0195","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1080\/15384047.2014.1002358","article-title":"USP9X inhibition promotes radiation-induced apoptosis in non-small cell lung cancer cells expressing mid-to-high MCL1","volume":"16","author":"Kushwaha","year":"2015","journal-title":"Cancer Biol Ther"},{"issue":"12","key":"10.1016\/j.clinre.2019.10.004_bib0200","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.1074\/jbc.RA118.006057","article-title":"Inhibition of the deubiquitinase USP9x induces pre-B cell homeobox 1 (PBX1) degradation and thereby stimulates prostate cancer cell apoptosis","volume":"294","author":"Liu","year":"2019","journal-title":"J Biol Chem"},{"issue":"6","key":"10.1016\/j.clinre.2019.10.004_bib0205","first-page":"3292","article-title":"Deubiquitinase USP9X regulates the invasion of prostate cancer cells by regulating the ERK pathway and mitochondrial dynamics","volume":"41","author":"Zhang","year":"2019","journal-title":"Oncol Rep"},{"issue":"4","key":"10.1016\/j.clinre.2019.10.004_bib0210","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1074\/jbc.RA117.000392","article-title":"Deubiquitylase USP9X suppresses tumorigenesis by stabilizing large tumor suppressor kinase 2 (LATS2) in the Hippo pathway","volume":"293","author":"Zhu","year":"2018","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.clinre.2019.10.004_bib0215","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1172\/JCI97325","article-title":"The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer","volume":"128","author":"Khan","year":"2018","journal-title":"J Clin Invest"},{"issue":"18","key":"10.1016\/j.clinre.2019.10.004_bib0220","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1038\/s41388-018-0134-2","article-title":"The deubiquitinase USP9X promotes tumor cell survival and confers chemoresistance through YAP1 stabilization","volume":"37","author":"Li","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.clinre.2019.10.004_bib0225","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.canlet.2018.08.010","article-title":"USP9X inhibition improves gemcitabine sensitivity in pancreatic cancer by inhibiting autophagy","volume":"436","author":"Ma","year":"2018","journal-title":"Cancer Lett"},{"key":"10.1016\/j.clinre.2019.10.004_bib0230","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/1746-1596-8-177","article-title":"USP9X expression correlates with tumor progression and poor prognosis in esophageal squamous cell carcinoma","volume":"8","author":"Peng","year":"2013","journal-title":"Diagn Pathol"},{"key":"10.1016\/j.clinre.2019.10.004_bib0235","doi-asserted-by":"crossref","first-page":"17048","DOI":"10.1038\/nrdp.2017.48","article-title":"Oesophageal cancer","volume":"3","author":"Smyth","year":"2017","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"10.1016\/j.clinre.2019.10.004_bib0240","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/14656566.2018.1551881","article-title":"Pharmacotherapy for metastatic esophageal cancer: where do we need to improve","volume":"20","author":"Lee","year":"2019","journal-title":"Expert Opin Pharmacother"},{"issue":"4","key":"10.1016\/j.clinre.2019.10.004_bib0245","first-page":"1783","article-title":"WP1130 increases cisplatin sensitivity through inhibition of usp9x in estrogen receptor-negative breast cancer cells","volume":"9","author":"Fu","year":"2017","journal-title":"Am J Transl Res"},{"issue":"7","key":"10.1016\/j.clinre.2019.10.004_bib0250","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1039\/c9mt00049f","article-title":"Unexpected therapeutic effects of cisplatin","volume":"11","author":"Raudenska","year":"2019","journal-title":"Metallomics"},{"key":"10.1016\/j.clinre.2019.10.004_bib0255","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1186\/s12885-015-1364-0","article-title":"Effects of JWA, XRCC1 and BRCA1 mRNA expression on molecular staging for personalized therapy in patients with advanced esophageal squamous cell carcinoma","volume":"15","author":"Wei","year":"2015","journal-title":"BMC Cancer"},{"issue":"9","key":"10.1016\/j.clinre.2019.10.004_bib0260","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.7150\/jca.28959","article-title":"Cisplatin based induction chemotherapy modified by ERCC1 improved the outcome of young adults with locally advanced oral squamous cell carcinoma","volume":"10","author":"Gong","year":"2019","journal-title":"J Cancer"},{"issue":"51","key":"10.1016\/j.clinre.2019.10.004_bib0265","doi-asserted-by":"crossref","first-page":"e9402","DOI":"10.1097\/MD.0000000000009402","article-title":"ERCC1 expression status predicts the response and survival of patients with metastatic or recurrent cervical cancer treated via platinum-based chemotherapy","volume":"96","author":"Ryu","year":"2017","journal-title":"Medicine (Baltimore)"},{"issue":"13","key":"10.1016\/j.clinre.2019.10.004_bib0270","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.4161\/cbt.21792","article-title":"Genetic disruption of USP9X sensitizes colorectal cancer cells to 5-fluorouracil","volume":"13","author":"Harris","year":"2012","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.clinre.2019.10.004_bib0275","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.biomaterials.2018.11.035","article-title":"Delivery of miR-212 by chimeric peptide-condensed supramolecular nanoparticles enhances the sensitivity of pancreatic ductal adenocarcinoma to doxorubicin","volume":"192","author":"Chen","year":"2019","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.clinre.2019.10.004_bib0280","first-page":"672","article-title":"Elevated expression of USP9X correlates with poor prognosis in human non-small cell lung cancer","volume":"7","author":"Wang","year":"2015","journal-title":"J Thorac Dis"},{"issue":"1","key":"10.1016\/j.clinre.2019.10.004_bib0285","first-page":"224","article-title":"miR-132 suppresses the migration and invasion of lung cancer cells by blocking USP9X-induced epithelial-mesenchymal transition","volume":"10","author":"Guo","year":"2018","journal-title":"Am J Transl Res"},{"issue":"9","key":"10.1016\/j.clinre.2019.10.004_bib0290","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.7150\/thno.22901","article-title":"A novel USP9X substrate TTK contributes to tumorigenesis in non-small-cell lung cancer","volume":"8","author":"Chen","year":"2018","journal-title":"Theranostics"}],"container-title":["Clinics and Research in Hepatology and Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210740119302475?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210740119302475?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:29:21Z","timestamp":1761895761000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210740119302475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S2210740119302475"],"URL":"https:\/\/doi.org\/10.1016\/j.clinre.2019.10.004","relation":{},"ISSN":["2210-7401"],"issn-type":[{"value":"2210-7401","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"USP9X mRNA expression predicts clinical outcome for esophageal squamous cell carcinoma treated with cisplatin-based therapy","name":"articletitle","label":"Article Title"},{"value":"Clinics and Research in Hepatology and Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinre.2019.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}