{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:54:34Z","timestamp":1773050074359,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics and Research in Hepatology and Gastroenterology"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.clinre.2020.01.011","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T04:26:24Z","timestamp":1583727984000},"page":"913-922","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["The gamma-glutamyl transpeptidase to platelet ratio predicts liver inflammation in chronic hepatitis B with normal or mildly elevated alanine transaminase"],"prefix":"10.1016","volume":"44","author":[{"given":"Jian","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yali","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weimao","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10003","key":"10.1016\/j.clinre.2020.01.011_bib0155","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/S0140-6736(15)61412-X","article-title":"Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013","volume":"386","author":"Schweitzer","year":"2015","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.clinre.2020.01.011_bib0160","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cld.2010.05.007","article-title":"Natural history of chronic hepatitis B","volume":"14","author":"McMahon","year":"2010","journal-title":"Clin Liver Dis"},{"issue":"Suppl 1","key":"10.1016\/j.clinre.2020.01.011_bib0165","doi-asserted-by":"crossref","first-page":"S90","DOI":"10.1016\/S0168-8278(02)00431-2","article-title":"Management of chronic hepatitis B","volume":"38","author":"Conjeevaram","year":"2003","journal-title":"J Hepatol"},{"issue":"2","key":"10.1016\/j.clinre.2020.01.011_bib0170","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jhep.2017.03.021","article-title":"EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection","volume":"67","author":"European Association for the Study of the Liver","year":"2017","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.clinre.2020.01.011_bib0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12072-016-9760-3","article-title":"Asian-Pacific Association for the Study of the Liver (APASL) consensus guidelines on invasive and non-invasive assessment of hepatic fibrosis: a 2016 update","volume":"11","author":"Shiha","year":"2017","journal-title":"Hepatol Int"},{"issue":"3","key":"10.1016\/j.clinre.2020.01.011_bib0180","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1053\/jhep.2000.16602","article-title":"Practices of liver biopsy in France: results of a prospective nationwide survey. For the Group of Epidemiology of the French Association for the Study of the Liver (AFEF)","volume":"32","author":"Cadranel","year":"2000","journal-title":"Hepatology"},{"issue":"10","key":"10.1016\/j.clinre.2020.01.011_bib0185","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1111\/j.1572-0241.2002.06038.x","article-title":"Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection","volume":"97","author":"Regev","year":"2002","journal-title":"Am J Gastroenterol"},{"issue":"10","key":"10.1016\/j.clinre.2020.01.011_bib0190","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1111\/liv.12808","article-title":"Accuracy of transient elastography in assessing liver fibrosis in chronic viral hepatitis: A multicentre, retrospective study","volume":"35","author":"Seo","year":"2015","journal-title":"Liver Int"},{"issue":"6","key":"10.1016\/j.clinre.2020.01.011_bib0195","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.jhep.2010.05.035","article-title":"Diagnostic accuracy of FibroScan and comparison to liver fibrosis biomarkers in chronic viral hepatitis: a multicenter prospective study (the FIBROSTIC study)","volume":"53","author":"Degos","year":"2010","journal-title":"J Hepatol"},{"issue":"3","key":"10.1016\/j.clinre.2020.01.011_bib0200","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/hep.21334","article-title":"FIB-4: a simple, inexpensive and accurate marker of fibrosis in HCV-infected patients","volume":"44","author":"Vallet-Pichard","year":"2006","journal-title":"Hepatolology"},{"issue":"1","key":"10.1016\/j.clinre.2020.01.011_bib0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12072-015-9675-4","article-title":"Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update","volume":"10","author":"Sarin","year":"2016","journal-title":"Hepatol Int"},{"issue":"4","key":"10.1016\/j.clinre.2020.01.011_bib0210","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1002\/hep.29800","article-title":"Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance","volume":"67","author":"Terrault","year":"2018","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.clinre.2020.01.011_bib0215","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.jhep.2007.07.022","article-title":"The clinical significance of persistently normal ALT in chronic hepatitis B infection","volume":"47","author":"Lai","year":"2007","journal-title":"J Hepatol"},{"issue":"Suppl 1","key":"10.1016\/j.clinre.2020.01.011_bib0220","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1365-2893.2010.01270.x","article-title":"Significant histopathology in Chinese chronic hepatitis B patients with persistently high-normal alanine aminotransferase","volume":"17","author":"Gui","year":"2010","journal-title":"J Viral Hepat"},{"issue":"11","key":"10.1016\/j.clinre.2020.01.011_bib0225","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1136\/gut.2005.065136","article-title":"Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications","volume":"54","author":"Yuen","year":"2005","journal-title":"Gut"},{"issue":"8","key":"10.1016\/j.clinre.2020.01.011_bib0230","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1136\/gutjnl-2015-309260","article-title":"The gamma-glutamyl transpeptidase to platelet ratio (GPR) predicts significant liver fibrosis and cirrhosis in patients with chronic HBV infection in West Africa","volume":"65","author":"Lemoine","year":"2016","journal-title":"Gut"},{"issue":"10","key":"10.1016\/j.clinre.2020.01.011_bib0235","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1111\/jvh.12925","article-title":"A novel index using routine clinical parameters for predicting significant liver inflammation in chronic hepatitis B","volume":"25","author":"Wang","year":"2018","journal-title":"J Viral Hepat"},{"issue":"4","key":"10.1016\/j.clinre.2020.01.011_bib0240","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/apt.12590","article-title":"Systematic review with meta-analysis: the proportion of chronic hepatitis B patients with normal alanine transaminase \u226440 IU\/L and significant hepatic fibrosis","volume":"39","author":"Chao","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"issue":"3","key":"10.1016\/j.clinre.2020.01.011_bib0245","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/0168-8278(91)90084-O","article-title":"Classification of chronic viral hepatitis: a need for reassessment","volume":"13","author":"Scheuer","year":"1991","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.clinre.2020.01.011_bib0250","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1172\/JCI88881","article-title":"Liver inflammation and fibrosis","volume":"127","author":"Koyama","year":"2017","journal-title":"J Clin Invest"},{"issue":"9204","key":"10.1016\/j.clinre.2020.01.011_bib0255","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0140-6736(99)00219-6","article-title":"Serum aminotransferase concentration as evidence of hepatocellular damage","volume":"355","author":"Kew","year":"2000","journal-title":"Lancet Lond Engl"},{"issue":"5","key":"10.1016\/j.clinre.2020.01.011_bib0260","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1053\/j.gastro.2008.02.075","article-title":"Virologic and histologic features of chronic hepatitis B virus-infected asymptomatic patients with persistently normal ALT","volume":"134","author":"Kumar","year":"2008","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1016\/j.clinre.2020.01.011_bib0265","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1365-2893.2008.00989.x","article-title":"High prevalence of significant histology in asymptomatic chronic hepatitis B patients with genotype C and high serum HBV DNA levels","volume":"15","author":"Park","year":"2008","journal-title":"J Viral Hepat"},{"issue":"4","key":"10.1016\/j.clinre.2020.01.011_bib0270","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/jmv.25364","article-title":"Serum liver fibrosis markers discriminate significant liver inflammation in chronic hepatitis B patients with normal or near-normal alanine aminotransferase","volume":"91","author":"Liao","year":"2019","journal-title":"J Med Virol"},{"issue":"1","key":"10.1016\/j.clinre.2020.01.011_bib0275","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jama.295.1.65","article-title":"Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level","volume":"295","author":"Chen","year":"2006","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.clinre.2020.01.011_bib0280","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/hep.28156","article-title":"AASLD guidelines for treatment of chronic hepatitis B","volume":"63","author":"Terrault","year":"2016","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.clinre.2020.01.011_bib0285","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/20014091084227","article-title":"Gamma glutamyl transferase","volume":"38","author":"Whitfield","year":"2001","journal-title":"Crit Rev Clin Lab Sci"},{"issue":"3","key":"10.1016\/j.clinre.2020.01.011_bib0290","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/jcla.20450","article-title":"Mean platelet volume as a fibrosis marker in patients with chronic hepatitis B","volume":"25","author":"Ekiz","year":"2011","journal-title":"J Clin Lab Anal"},{"issue":"6","key":"10.1016\/j.clinre.2020.01.011_bib0295","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1002\/hep.20960","article-title":"Prediction of significant fibrosis in HBeAg-positive patients with chronic hepatitis B by a noninvasive model","volume":"42","author":"Zeng","year":"2005","journal-title":"Hepatology"},{"issue":"77","key":"10.1016\/j.clinre.2020.01.011_bib0300","first-page":"1503","article-title":"Prediction of liver fibrosis in patients with chronic hepatitis B by serum markers","volume":"54","author":"Pan","year":"2007","journal-title":"Hepatogastroenterology"}],"container-title":["Clinics and Research in Hepatology and Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210740120300346?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210740120300346?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:29:45Z","timestamp":1761895785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210740120300346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S2210740120300346"],"URL":"https:\/\/doi.org\/10.1016\/j.clinre.2020.01.011","relation":{},"ISSN":["2210-7401"],"issn-type":[{"value":"2210-7401","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The gamma-glutamyl transpeptidase to platelet ratio predicts liver inflammation in chronic hepatitis B with normal or mildly elevated alanine transaminase","name":"articletitle","label":"Article Title"},{"value":"Clinics and Research in Hepatology and Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinre.2020.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}