{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T08:18:04Z","timestamp":1761898684412,"version":"build-2065373602"},"reference-count":28,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics and Research in Hepatology and Gastroenterology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.clinre.2022.101889","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T20:53:42Z","timestamp":1645131222000},"page":"101889","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of image-guided adaptive radiotherapy combined with hepatic artery chemoembolization in primary liver cancer patients"],"prefix":"10.1016","volume":"46","author":[{"given":"Yingchun","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changwang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changwen","family":"Bo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonghui","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhua","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changpeng","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinre.2022.101889_bib0001","first-page":"e1255","article-title":"Global incidence and mortality of liver cancers and its relationship with the human development index (HDI): an ecology study in 2018","volume":"6","author":"Goodarzi","year":"2019","journal-title":"WCRJ"},{"key":"10.1016\/j.clinre.2022.101889_bib0002","first-page":"e1537","article-title":"Hepatitis B virus infection and hepatocellular carcinoma in PLWH: epidemiology, pathogenesis and treatment","volume":"7","author":"D'Andrea","year":"2020","journal-title":"WCRJ"},{"issue":"1","key":"10.1016\/j.clinre.2022.101889_bib0003","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3350\/cmh.2020.0176","article-title":"Obesity and the risk of primary liver cancer: a systematic review and meta-analysis","volume":"27","author":"Sohn","year":"2021","journal-title":"Clin Mol Hepatol"},{"year":"2017","series-title":"Analysis of comprehensive treatment and survival prognosis of 50 cases primary liver cancer","author":"Du","key":"10.1016\/j.clinre.2022.101889_bib0004"},{"key":"10.1016\/j.clinre.2022.101889_bib0005","doi-asserted-by":"crossref","first-page":"389","DOI":"10.21873\/anticanres.11331","article-title":"The evolving role of local treatments for HCC in the third millennium","volume":"37","author":"Magistri","year":"2017","journal-title":"Anticancer Res"},{"issue":"09","key":"10.1016\/j.clinre.2022.101889_bib0006","first-page":"1221","article-title":"The practical value of dual source CT dual energy iodine map in the follow up examination of primary hepatocellular carcinoma patients post transcatheter arterial chemoembolization","volume":"36","author":"Cheng","year":"2021","journal-title":"Huaxi Med"},{"issue":"23","key":"10.1016\/j.clinre.2022.101889_bib0007","first-page":"1","article-title":"Analysis of determinants of efficacy of intensity modulated radiotherapy combined with hepatic artery chemoembolization for liver cancer with portal vein tumor thrombosis","volume":"19","author":"Li","year":"2021","journal-title":"China Med Pharm Guidelines"},{"issue":"2","key":"10.1016\/j.clinre.2022.101889_bib0008","first-page":"247","article-title":"Dosimetric study of image-guided adaptive radiotherapy in lung cancer","author":"Fang","year":"2015","journal-title":"Anhui Med Univ J"},{"issue":"5","key":"10.1016\/j.clinre.2022.101889_bib0009","first-page":"699","article-title":"Dosimetric study of ex vivo image-guided adaptive radiotherapy for carcinoma of the cervix","author":"Zhang","year":"2015","journal-title":"Anhui Med Univ J"},{"issue":"2","key":"10.1016\/j.clinre.2022.101889_bib0010","first-page":"205","article-title":"Changes in organ volumes and dositometric analysis of different stages of nasopharyngeal carcinoma treated with adaptive radiotherapy","volume":"40","author":"Zhou","year":"2019","journal-title":"Guang Dong Med"},{"issue":"11","key":"10.1016\/j.clinre.2022.101889_bib0011","first-page":"845","article-title":"Brief introduction of evaluation criteria for solid tumors","volume":"43","author":"Zhang","year":"2016","journal-title":"Int Oncol J"},{"issue":"09","key":"10.1016\/j.clinre.2022.101889_bib0012","first-page":"16","article-title":"Efficacy of hepatic artery chemoembolization combined with sorafenib for different types of primary liver cancer with portal vein tumor thrombosis","volume":"29","author":"Deng","year":"2021","journal-title":"Clin Invest"},{"issue":"13","key":"10.1016\/j.clinre.2022.101889_bib0013","first-page":"2255","article-title":"Short- and long-term efficacy of TACE combined with 3DCRT for primary liver cancer with portal vein tumor thrombosis and effect on survival","volume":"34","author":"Jing","year":"2021","journal-title":"Med Theory Pract"},{"issue":"01","key":"10.1016\/j.clinre.2022.101889_bib0014","first-page":"51","article-title":"Effect of 3D conformal radiotherapy or surgery combined with TACE on serum biomarker levels in PHC patients","volume":"42","author":"You","year":"2021","journal-title":"Forum Med Pharm Sci"},{"issue":"09","key":"10.1016\/j.clinre.2022.101889_bib0015","first-page":"728","article-title":"Differential expression spectrum of plasma exosome microRNA and bioinformatic analysis in non-small cell lung cancer patients on adaptive radiotherapy","volume":"27","author":"Yang","year":"2021","journal-title":"Oncol J"},{"issue":"02","key":"10.1016\/j.clinre.2022.101889_bib0016","first-page":"43","article-title":"Efficacy of intensity modulated radiotherapy combined with hepatic artery chemoembolization for primary liver cancer with portal vein tumor thrombosis","volume":"22","author":"Cao","year":"2020","journal-title":"Xiangnan Coll J"},{"issue":"10","key":"10.1016\/j.clinre.2022.101889_bib0017","first-page":"924","article-title":"Use of CBCT fluoroscopy for monitoring tumor movement in 5 cases of liver cancer","volume":"23","author":"Lu","year":"2017","journal-title":"Oncol J"},{"issue":"6","key":"10.1016\/j.clinre.2022.101889_bib0018","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1001\/jamaoncol.2015.2189","article-title":"Transcatheter arterial chemoembolization plus radiotherapy compared with chemoembolization alone for hepatocellular carcinoma: a systematic review and meta-analysis","volume":"1","author":"Huo","year":"2015","journal-title":"JAMA Oncol"},{"issue":"9","key":"10.1016\/j.clinre.2022.101889_bib0019","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.3389\/fonc.2019.01157","article-title":"Combined stereotactic body radiotherapy and checkpoint inhibition in unresectable hepatocellular carcinoma: a potential synergistic treatment strategy","volume":"12","author":"Chiang","year":"2019","journal-title":"Front Oncol"},{"issue":"4","key":"10.1016\/j.clinre.2022.101889_bib0020","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/s12029-020-00486-w","article-title":"The importance of AFP in liver transplantation forHCC","volume":"51","author":"\u00d6zdemir","year":"2020","journal-title":"J Gastrointest Cancer"},{"issue":"10","key":"10.1016\/j.clinre.2022.101889_bib0021","first-page":"1183","article-title":"The clinical significance of changes in CA724, CA242 and AFP after TACE for liver cancer","author":"Liang","year":"2015","journal-title":"Tianjin Med J"},{"issue":"24","key":"10.1016\/j.clinre.2022.101889_bib0022","first-page":"2629","article-title":"The diagnostic value of lysophosphatidylcholine in HBV-associated hepatocellular carcinoma patients","volume":"28","author":"Zhang","year":"2019","journal-title":"Curr Combined Tradit Chin West Med J"},{"issue":"8","key":"10.1016\/j.clinre.2022.101889_bib0023","first-page":"1406","article-title":"Changes and significance of liver cancer T lymphocyte subpopulations in the peripheral blood and spleen of mice with liver cancer","volume":"19","author":"Xu","year":"2019","journal-title":"Prog Mod Biomed"},{"issue":"10","key":"10.1016\/j.clinre.2022.101889_bib0024","first-page":"1625","article-title":"Effect of hepatic artery infusion of autologous CIK cells combined with radiochemotherapy on the immune function and quality of life of primary liver cancer patients","volume":"34","author":"Xue","year":"2019","journal-title":"Pract Cancer J"},{"issue":"10","key":"10.1016\/j.clinre.2022.101889_bib0025","first-page":"17","article-title":"Efficacy TACE combined with 3D conformal radiotherapy for primary liver cancer and effect on immune function","volume":"4","author":"Li","year":"2019","journal-title":"Clin Med Study Pract"},{"issue":"5","key":"10.1016\/j.clinre.2022.101889_bib0026","first-page":"951","article-title":"Efficacy and safety of intensity modulated radiotherapy combined with hepatic artery chemoembolization for primary liver cancer","volume":"24","author":"Ren","year":"2020","journal-title":"Anhui Med J"},{"issue":"09","key":"10.1016\/j.clinre.2022.101889_bib0027","first-page":"1032","article-title":"Effect on miR-122a and miR-221 and efficacy of 3D conformal radiotherapy for liver cancer patients treated with transcatheter arterial chemoembolization","volume":"54","author":"Li","year":"2019","journal-title":"China Med J"},{"issue":"02","key":"10.1016\/j.clinre.2022.101889_bib0028","first-page":"149","article-title":"Study on the efficacy of TACE combined with intensity modulated radiotherapy for unresectable primary liver cancer","volume":"42","author":"Zhu","year":"2019","journal-title":"Int Med Radiol J"}],"container-title":["Clinics and Research in Hepatology and Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210740122000328?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210740122000328?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:32:12Z","timestamp":1761895932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210740122000328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S2210740122000328"],"URL":"https:\/\/doi.org\/10.1016\/j.clinre.2022.101889","relation":{},"ISSN":["2210-7401"],"issn-type":[{"type":"print","value":"2210-7401"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of image-guided adaptive radiotherapy combined with hepatic artery chemoembolization in primary liver cancer patients","name":"articletitle","label":"Article Title"},{"value":"Clinics and Research in Hepatology and Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinre.2022.101889","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101889"}}