{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T12:18:47Z","timestamp":1768825127583,"version":"3.49.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics and Research in Hepatology and Gastroenterology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.clinre.2022.101896","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T02:25:26Z","timestamp":1645755926000},"page":"101896","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["The impact of metabolic health on non-alcoholic fatty liver disease (NAFLD). A single center experience"],"prefix":"10.1016","volume":"46","author":[{"given":"Anna","family":"Boulouta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioanna","family":"Aggeletopoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stavros","family":"Kanaloupitis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efthymios P","family":"Tsounis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasileios","family":"Issaris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Papantoniou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2616-7952","authenticated-orcid":false,"given":"Anastasios","family":"Apostolos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paraskevas","family":"Tsaplaris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ploutarchos","family":"Pastras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Sotiropoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aggeliki","family":"Tsintoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia","family":"Diamantopoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Thomopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Michalaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3094-8209","authenticated-orcid":false,"given":"Christos","family":"Triantos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"119220","key":"10.1016\/j.clinre.2022.101896_bib0001","first-page":"13","article-title":"Non-alcoholic fatty liver disease: an overview of risk factors, pathophysiological mechanisms, diagnostic procedures, and therapeutic interventions","volume":"271","author":"Gerges","year":"2021","journal-title":"Life Sci"},{"issue":"16","key":"10.1016\/j.clinre.2022.101896_bib0002","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJMra011775","article-title":"Nonalcoholic fatty liver disease","volume":"346","author":"Angulo","year":"2002","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1016\/j.clinre.2022.101896_bib0003","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17122082","article-title":"Pathophysiology of non alcoholic fatty liver disease","volume":"17","author":"Petta","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.clinre.2022.101896_bib0004","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s00125-016-3902-y","article-title":"EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease","volume":"59","year":"2016","journal-title":"Diabetologia"},{"issue":"3","key":"10.1016\/j.clinre.2022.101896_bib0005","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jhep.2018.10.033","article-title":"Non-alcoholic fatty liver disease\u2013A global public health perspective","volume":"70","author":"Younossi","year":"2019","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.clinre.2022.101896_bib0006","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000282080","article-title":"Epidemiology of non-alcoholic fatty liver disease","volume":"28","author":"Bellentani","year":"2010","journal-title":"Dig Dis"},{"issue":"3","key":"10.1016\/j.clinre.2022.101896_bib0007","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1365-2036.2011.04724.x","article-title":"Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults","volume":"34","author":"Vernon","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.clinre.2022.101896_bib0008","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/nyas.13230","article-title":"Metabolically healthy obesity across the life course: epidemiology, determinants, and implications","volume":"1","author":"Phillips","year":"2017","journal-title":"Ann N Y Acad Sci"},{"issue":"8","key":"10.1016\/j.clinre.2022.101896_bib0009","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ajg.2016.178","article-title":"Metabolically healthy obesity and the development of nonalcoholic fatty liver disease","volume":"111","author":"Chang","year":"2016","journal-title":"Am J Gastroenterol"},{"issue":"8","key":"10.1016\/j.clinre.2022.101896_bib0010","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nrgastro.2016.104","article-title":"Obesity: metabolically healthy obesity and NAFLD","volume":"13","author":"Targher","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.clinre.2022.101896_bib0011","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/apt.14401","article-title":"Systematic review with meta-analysis: the significance of histological disease severity in lean patients with nonalcoholic fatty liver disease","volume":"47","author":"Sookoian","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"issue":"6","key":"10.1016\/j.clinre.2022.101896_bib0012","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.jhep.2015.11.004","article-title":"EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease","volume":"64","year":"2016","journal-title":"J Hepatol"},{"issue":"6","key":"10.1016\/j.clinre.2022.101896_bib0013","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1002\/hep.25762","article-title":"The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association","volume":"55","author":"Chalasani","year":"2012","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.clinre.2022.101896_bib0014","article-title":"2018 practice Guidelines for the management of arterial hypertension of the European Society of Hypertension and the European Society of Cardiology: ESH\/ESC Task Force for the Management of Arterial Hypertension: erratum","volume":"37","year":"2019","journal-title":"J Hypertens"},{"issue":"1","key":"10.1016\/j.clinre.2022.101896_bib0015","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jhep.2020.03.039","article-title":"A new definition for metabolic dysfunction-associated fatty liver disease: an international expert consensus statement","volume":"73","author":"Eslam","year":"2020","journal-title":"J Hepatol"},{"issue":"2","key":"10.1016\/j.clinre.2022.101896_bib0016","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/eurheartj\/ehz486","article-title":"2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD","volume":"41","author":"Cosentino","year":"2020","journal-title":"Eur Heart J"},{"issue":"1","key":"10.1016\/j.clinre.2022.101896_bib0017","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/eurheartj\/ehz455","article-title":"2019 ESC\/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk","volume":"41","author":"Mach","year":"2020","journal-title":"Eur Heart J"},{"issue":"6512","key":"10.1016\/j.clinre.2022.101896_bib0018","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/bmj.292.6512.13","article-title":"Ultrasound scanning in the detection of hepatic fibrosis and steatosis","volume":"292","author":"Saverymuttu","year":"1986","journal-title":"Br Med J"},{"issue":"1","key":"10.1016\/j.clinre.2022.101896_bib0019","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/hep.29367","article-title":"The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases","volume":"67","author":"Chalasani","year":"2018","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.clinre.2022.101896_bib0020","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000496183","article-title":"European practical and patient-centred guidelines for adult obesity management in primary care","volume":"12","author":"Durrer Schutz","year":"2019","journal-title":"Obes Facts"},{"issue":"7","key":"10.1016\/j.clinre.2022.101896_bib0021","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1038\/ajg.2009.191","article-title":"Management and treatment of patients with cirrhosis and portal hypertension: recommendations from the Department of Veterans Affairs Hepatitis C Resource Center Program and the National Hepatitis C Program","volume":"104","author":"Garcia-Tsao","year":"2009","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"10.1016\/j.clinre.2022.101896_bib0022","first-page":"85","article-title":"The etiology, diagnosis and prevention of liver cirrhosis: part 1 of a series on liver cirrhosis","volume":"110","author":"Wiegand","year":"2013","journal-title":"Dtsch Arztebl Int"},{"issue":"12","key":"10.1016\/j.clinre.2022.101896_bib0023","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.2337\/dc09-0574","article-title":"Are metabolically normal but obese individuals at lower risk for all-cause mortality?","volume":"32","author":"Kuk","year":"2009","journal-title":"Diabetes Care"},{"issue":"7","key":"10.1016\/j.clinre.2022.101896_bib0024","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/ijo.2010.216","article-title":"Characterizing the profile of obese patients who are metabolically healthy","volume":"35","author":"Primeau","year":"2011","journal-title":"Int J Obes"},{"issue":"16","key":"10.1016\/j.clinre.2022.101896_bib0025","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","volume":"120","author":"Alberti","year":"2009","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.clinre.2022.101896_bib0026","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.clinre.2022.101896_bib0027","series-title":"Modelling survival data in medical research","author":"Collett","year":"2015"},{"issue":"2","key":"10.1016\/j.clinre.2022.101896_bib0028","doi-asserted-by":"crossref","first-page":"112","DOI":"10.7326\/0003-4819-132-2-200001180-00004","article-title":"Prevalence of and risk factors for hepatic steatosis in Northern Italy","volume":"132","author":"Bellentani","year":"2000","journal-title":"Ann Intern Med"},{"issue":"1","key":"10.1016\/j.clinre.2022.101896_bib0029","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.clinre.2022.101896_bib0030","doi-asserted-by":"crossref","first-page":"012","DOI":"10.1016\/j.jhep.2014.12.012","article-title":"NAFLD: a multisystem disease","volume":"62","author":"Byrne","year":"2015","journal-title":"J Hepatol"},{"issue":"4","key":"10.1016\/j.clinre.2022.101896_bib0031","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1053\/jhep.2003.50161","article-title":"Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome","volume":"37","author":"Marchesini","year":"2003","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.clinre.2022.101896_bib0032","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.numecd.2013.07.005","article-title":"Metabolically healthy obese subjects are at risk of fatty liver but not of pre-clinical atherosclerosis","volume":"24","author":"Sung","year":"2014","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"12","key":"10.1016\/j.clinre.2022.101896_bib0033","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1016\/j.soard.2020.07.009","article-title":"Prevalence of NASH\/NAFLD in people with obesity who are currently classified as metabolically healthy","volume":"16","author":"Frey","year":"2020","journal-title":"Surg Obes Relat Dis"},{"key":"10.1016\/j.clinre.2022.101896_bib0034","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.metabol.2016.10.003","article-title":"Obesity is more closely related with hepatic steatosis and fibrosis measured by transient elastography than metabolic health status","volume":"66","author":"Huh","year":"2017","journal-title":"Metabolism"},{"issue":"1","key":"10.1016\/j.clinre.2022.101896_bib0035","doi-asserted-by":"crossref","first-page":"020","DOI":"10.1186\/s12902-020-00582-9","article-title":"Impact of obesity and metabolic health status in the development of non-alcoholic fatty liver disease (NAFLD): a United Kingdom population-based cohort study using the health improvement network (THIN)","volume":"20","author":"Vusirikala","year":"2020","journal-title":"BMC Endocr Disord"},{"issue":"4","key":"10.1016\/j.clinre.2022.101896_bib0036","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.diabet.2017.02.007","article-title":"Less liver fibrosis in metabolically healthy compared with metabolically non-healthy obese patients with non-alcoholic fatty liver disease","volume":"43","author":"Guti\u00e9rrez-Grobe","year":"2017","journal-title":"Diabetes Metab"},{"issue":"6","key":"10.1016\/j.clinre.2022.101896_bib0037","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.amjcard.2008.05.010","article-title":"Relation of the number of metabolic syndrome risk factors with all-cause and cardiovascular mortality","volume":"102","author":"Ho","year":"2008","journal-title":"Am J Cardiol"},{"issue":"1","key":"10.1016\/j.clinre.2022.101896_bib0038","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.diabres.2008.07.016","article-title":"The effects of pre-disease risk factors within metabolic syndrome on all-cause and cardiovascular disease mortality","volume":"82","author":"Tsai","year":"2008","journal-title":"Diabetes Res Clin Pract"},{"issue":"20","key":"10.1016\/j.clinre.2022.101896_bib0039","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1161\/CIRCULATIONAHA.105.539528","article-title":"Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus","volume":"112","author":"Wilson","year":"2005","journal-title":"Circulation"},{"issue":"11\u201312","key":"10.1016\/j.clinre.2022.101896_bib0040","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1111\/apt.15015","article-title":"The effects of metabolic status on non-alcoholic fatty liver disease-related outcomes, beyond the presence of obesity","volume":"48","author":"Ampuero","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"issue":"4","key":"10.1016\/j.clinre.2022.101896_bib0041","doi-asserted-by":"crossref","first-page":"522","DOI":"10.3803\/EnM.2015.30.4.522","article-title":"Metabolic health is more important than obesity in the development of nonalcoholic fatty liver disease: a 4-year retrospective study","volume":"30","author":"Lee","year":"2015","journal-title":"Endocrinol Metab (Seoul)"},{"issue":"7","key":"10.1016\/j.clinre.2022.101896_bib0042","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1210\/jcem.85.7.6661","article-title":"Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans","volume":"85","author":"Katz","year":"2000","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Clinics and Research in Hepatology and Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210740122000390?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210740122000390?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:32:43Z","timestamp":1761895963000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210740122000390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S2210740122000390"],"URL":"https:\/\/doi.org\/10.1016\/j.clinre.2022.101896","relation":{},"ISSN":["2210-7401"],"issn-type":[{"value":"2210-7401","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of metabolic health on non-alcoholic fatty liver disease (NAFLD). A single center experience","name":"articletitle","label":"Article Title"},{"value":"Clinics and Research in Hepatology and Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinre.2022.101896","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101896"}}