{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T10:18:48Z","timestamp":1794651528693,"version":"4.9.1"},"reference-count":10,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017531","name":"Medical and Health Research Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2022KY964"],"award-info":[{"award-number":["2022KY964"]}],"id":[{"id":"10.13039\/501100017531","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100614"],"award-info":[{"award-number":["82100614"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LBY21H030001"],"award-info":[{"award-number":["LBY21H030001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008856","name":"Zhejiang Province Health Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics and Research in Hepatology and Gastroenterology"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.clinre.2023.102141","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T23:47:29Z","timestamp":1684367249000},"page":"102141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["PROS1 variant c.1574C>T p.Ala525Val causes portal vein thrombosis with protein S deficiency"],"prefix":"10.1016","volume":"47","author":[{"given":"Xiaoying","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiling","family":"ShenTu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingming","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junping","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gongying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4173-7178","authenticated-orcid":false,"given":"Ling","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.clinre.2023.102141_bib0001","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1182\/blood.V64.6.1297.1297","article-title":"Plasma protein S deficiency in familial thrombotic disease","volume":"64","author":"Schwarz","year":"1984","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.clinre.2023.102141_bib0002","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1111\/j.1538-7836.2008.02994.x","article-title":"Late onset thrombosis in a case of severe protein S deficiency due to compound heterozygosity for PROS1 mutations","volume":"6","author":"Heeb","year":"2008","journal-title":"J Thromb Haemost"},{"issue":"6","key":"10.1016\/j.clinre.2023.102141_bib0003","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/cld.336","article-title":"Noncirrhotic nontumoral portal vein thrombosis","volume":"3","author":"Seijo","year":"2014","journal-title":"Clin Liver Dis (Hoboken)"},{"key":"10.1016\/j.clinre.2023.102141_bib0004","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.thromres.2020.03.006","article-title":"A novel splicing mutation in the PROS1 gene causes hereditary protein S deficiency in a Chinese family with thrombotic disease","volume":"189","author":"Tan","year":"2020","journal-title":"Thromb Res"},{"issue":"4794","key":"10.1016\/j.clinre.2023.102141_bib0005","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1126\/science.3029867","article-title":"The regulation of natural anticoagulant pathways","volume":"235","author":"Esmon","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.clinre.2023.102141_bib0006","doi-asserted-by":"crossref","first-page":"15006","DOI":"10.1038\/nrdp.2015.6","article-title":"Venous thrombosis","volume":"1","author":"Wolberg","year":"2015","journal-title":"Nat Rev Dis Primers"},{"issue":"4","key":"10.1016\/j.clinre.2023.102141_bib0007","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1177\/1358863X18770529","article-title":"Great Debates in Vascular Medicine: extended duration anticoagulation for unprovoked venous thromboembolism - Coming to consensus when the debate rages on","volume":"23","author":"Kanthi","year":"2018","journal-title":"Vasc Med"},{"issue":"8","key":"10.1016\/j.clinre.2023.102141_bib0008","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1055\/s-0038-1673625","article-title":"Acquired and Genetic Thrombotic Risk Factors in the Athlete","volume":"44","author":"Zadow","year":"2018","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.clinre.2023.102141_bib0009","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.thromres.2016.12.018","article-title":"Gene analysis of six cases of congenital protein S deficiency and functional analysis of protein S mutations (A139V, C449F, R451Q, C475F, A525V and D599TfsTer13)","volume":"151","author":"Taniguchi","year":"2017","journal-title":"Thromb Res"},{"key":"10.1016\/j.clinre.2023.102141_bib0010","article-title":"Rivaroxaban Treatment for Warfarin-Refractory Thrombosis in a Patient with Hereditary Protein S Deficiency","volume":"2018","author":"Ameku","year":"2018","journal-title":"Case Rep Hematol"}],"container-title":["Clinics and Research in Hepatology and Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210740123000669?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210740123000669?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:24:34Z","timestamp":1778840674000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210740123000669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S2210740123000669"],"URL":"https:\/\/doi.org\/10.1016\/j.clinre.2023.102141","relation":{},"ISSN":["2210-7401"],"issn-type":[{"value":"2210-7401","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PROS1 variant c.1574C>T p.Ala525Val causes portal vein thrombosis with protein S deficiency","name":"articletitle","label":"Article Title"},{"value":"Clinics and Research in Hepatology and Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinre.2023.102141","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102141"}}