{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T21:07:13Z","timestamp":1781557633405,"version":"3.54.5"},"reference-count":38,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics and Research in Hepatology and Gastroenterology"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.clinre.2024.102410","type":"journal-article","created":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T05:27:37Z","timestamp":1719725257000},"page":"102410","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Modified Zhizhu Pill improves the loperamide-induced slow transit constipation via gut microbiota and neurotransmitters in microbiota-gut-brain axis"],"prefix":"10.1016","volume":"48","author":[{"given":"Xu-Long","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ting","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinre.2024.102410_bib0001","doi-asserted-by":"crossref","first-page":"17095","DOI":"10.1038\/nrdp.2017.95","article-title":"Chronic constipation","volume":"3","author":"Camilleri","year":"2017","journal-title":"Nat Rev Dis Primers"},{"issue":"10263","key":"10.1016\/j.clinre.2024.102410_bib0002","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/S0140-6736(20)32115-2","article-title":"Functional gastrointestinal disorders: advances in understanding and management","volume":"396","author":"Black","year":"2020","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.clinre.2024.102410_bib0003","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1053\/j.gastro.2016.02.031","article-title":"Bowel Disorders","volume":"150","author":"Lacy","year":"2016","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.clinre.2024.102410_bib0004","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1053\/j.gastro.2018.08.063","article-title":"Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: update 2018","volume":"156","author":"Peery","year":"2019","journal-title":"Gastroenterology"},{"issue":"11","key":"10.1016\/j.clinre.2024.102410_bib0005","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S2468-1253(19)30297-3","article-title":"The lancet gastroenterology H. The cost of constipation","volume":"4","year":"2019","journal-title":"Lancet Gastroenterol Hepatol."},{"issue":"5","key":"10.1016\/j.clinre.2024.102410_bib0006","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1053\/j.gastro.2019.12.034","article-title":"Mechanisms, evaluation, and management of chronic constipation","volume":"158","author":"Bharucha","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clinre.2024.102410_bib0007","article-title":"Action mode of gut motility, fluid and electrolyte transport in chronic constipation","volume":"12","author":"Zhao","year":"2021","journal-title":"Front Pharmacol"},{"issue":"12","key":"10.1016\/j.clinre.2024.102410_bib0008","first-page":"1120","article-title":"[Etiology and clinical classification of constipation]","volume":"25","author":"Zeng","year":"2022","journal-title":"Zhonghua Wei Chang Wai Ke Za Zhi"},{"issue":"5","key":"10.1016\/j.clinre.2024.102410_bib0009","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1097\/MOP.0000000000000938","article-title":"Medications for constipation in 2020","volume":"32","author":"Medina-Centeno","year":"2020","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.clinre.2024.102410_bib0010","article-title":"Current Applications of Fecal Microbiota Transplantation in Functional Constipation","volume":"2022","author":"Liu","year":"2022","journal-title":"Evidence-Based Complementary and Alternative Medicine: eCAM"},{"issue":"3","key":"10.1016\/j.clinre.2024.102410_bib0011","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0248584","article-title":"Improvement of loperamide-induced slow transit constipation by Bifidobacterium bifidum G9-1 is mediated by the correction of butyrate production and neurotransmitter profile due to improvement in dysbiosis","volume":"16","author":"Makizaki","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.clinre.2024.102410_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115075","article-title":"Research progress in the treatment of slow transit constipation by traditional Chinese medicine","volume":"290","author":"Wang","year":"2022","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.clinre.2024.102410_bib0013","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.nutres.2020.02.008","article-title":"Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with digestive disorders","volume":"76","author":"Ried","year":"2020","journal-title":"Nutr Res"},{"issue":"10","key":"10.1016\/j.clinre.2024.102410_bib0014","doi-asserted-by":"crossref","first-page":"23","DOI":"10.14715\/cmb\/2023.69.10.4","article-title":"Yunpi Tongbian Fang alleviates slow transit constipation induced by loperamide by regulating intestinal microbiota and short-chain fatty acids in rats","volume":"69","author":"Xu","year":"2023","journal-title":"Cell. Mol. Biol."},{"issue":"1","key":"10.1016\/j.clinre.2024.102410_bib0015","doi-asserted-by":"crossref","first-page":"e21870","DOI":"10.1016\/j.heliyon.2023.e21870","article-title":"Classical famous prescription of Jichuan decoction improved loperamide-induced slow transit constipation in rats through the cAMP\/PKA\/AQPs signaling pathway and maintained inflammatory\/intestinal flora homeostasis","volume":"10","author":"Lin","year":"2024","journal-title":"Heliyon"},{"issue":"9","key":"10.1016\/j.clinre.2024.102410_bib0016","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s11655-022-3539-2","article-title":"Zhizhu Decoction Alleviates Intestinal Barrier Damage via Regulating SIRT1\/FoxO1 Signaling Pathway in Slow Transit Constipation Model Mice","volume":"29","author":"Wen","year":"2023","journal-title":"Chin J Integr Med"},{"issue":"1","key":"10.1016\/j.clinre.2024.102410_bib0017","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/13880209.2022.2157020","article-title":"Zhizhu decoction alleviates slow transit constipation by regulating aryl hydrocarbon receptor through gut microbiota","volume":"61","author":"Wen","year":"2023","journal-title":"Pharm Biol"},{"key":"10.1016\/j.clinre.2024.102410_bib0018","article-title":"Molecular Mechanism of the Effect of Zhizhu Pill on Gastroesophageal Reflux Disease Based on Network Pharmacology and Molecular Docking","volume":"2022","author":"Huang","year":"2022","journal-title":"Evidence-Based Complementary and Alternative Medicine: eCAM"},{"issue":"2","key":"10.1016\/j.clinre.2024.102410_bib0019","first-page":"210","article-title":"[Effect of Zhizhu Pill on Gastric Smooth Muscle Contractile Response and Protein Expression of Growth Hormone Secretagogue Receptor in Functional Dyspepsia Rats]","volume":"36","author":"Li","year":"2016","journal-title":"Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese J Integrat Tradit Western Med."},{"issue":"3","key":"10.1016\/j.clinre.2024.102410_bib0020","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/apha.12374","article-title":"Brain-derived neurotrophic factor accelerates gut motility in slow-transit constipation","volume":"212","author":"Chen","year":"2014","journal-title":"Acta Physiol."},{"key":"10.1016\/j.clinre.2024.102410_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.111834","article-title":"Banha-sasim-tang improves gastrointestinal function in loperamide-induced functional dyspepsia mouse model","volume":"238","author":"Jeon","year":"2019","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.clinre.2024.102410_bib0022","article-title":"Engineered 5-HT producing gut probiotic improves gastrointestinal motility and behavior disorder","volume":"12","author":"Li","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"issue":"5","key":"10.1016\/j.clinre.2024.102410_bib0023","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.21037\/apm-20-280","article-title":"Metabolomics study on the therapeutic effect of the Chinese herb pair Fructus Aurantii Immaturus and Rhizoma Atractylodis Macrocephalae in constipated rats based on UPLC-Q\/TOF-MS analysis","volume":"9","author":"Yan","year":"2020","journal-title":"Ann Palliat Med"},{"key":"10.1016\/j.clinre.2024.102410_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115387","article-title":"Traditional uses, phytochemistry, transformation of ingredients and pharmacology of the dried seeds of Raphanus sativus L. (Raphani Semen), A comprehensive review","volume":"294","author":"Gao","year":"2022","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.clinre.2024.102410_bib0025","article-title":"Review on melanosis coli and anthraquinone-containing traditional Chinese herbs that cause melanosis coli","volume":"14","author":"Zhang","year":"2023","journal-title":"Front Pharmacol"},{"issue":"5","key":"10.1016\/j.clinre.2024.102410_bib0026","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1515\/revneuro-2017-0054","article-title":"Medicinal plants with acetylcholinesterase inhibitory activity","volume":"29","author":"Patel","year":"2018","journal-title":"Rev Neurosci"},{"key":"10.1016\/j.clinre.2024.102410_bib0027","doi-asserted-by":"crossref","first-page":"9499","DOI":"10.1038\/srep09499","article-title":"Toll-like receptor 4 contributes to the inhibitory effect of morphine on colonic motility in vitro and in vivo","volume":"5","author":"Farzi","year":"2015","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.clinre.2024.102410_bib0028","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1096\/fj.14-259721","article-title":"Gut commensal microvesicles reproduce parent bacterial signals to host immune and enteric nervous systems","volume":"29","author":"Al-Nedawi","year":"2015","journal-title":"FASEB J"},{"issue":"1","key":"10.1016\/j.clinre.2024.102410_bib0029","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/s12967-021-02995-z","article-title":"Constipation induced gut microbiota dysbiosis exacerbates experimental autoimmune encephalomyelitis in C57BL\/6 mice","volume":"19","author":"Lin","year":"2021","journal-title":"J Transl Med"},{"issue":"6","key":"10.1016\/j.clinre.2024.102410_bib0030","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1007\/BF01295719","article-title":"Impaired colonic motor response to cholinergic stimulation in patients with severe chronic idiopathic (slow transit type) constipation","volume":"38","author":"Bassotti","year":"1993","journal-title":"Dig Dis Sci"},{"issue":"3","key":"10.1016\/j.clinre.2024.102410_bib0031","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1093\/schbul\/sbac202","article-title":"Serum metabolic profile in schizophrenia patients with antipsychotic-induced constipation and its relationship with gut microbiome","volume":"49","author":"Amdanee","year":"2023","journal-title":"Schizophr Bull"},{"issue":"1","key":"10.1016\/j.clinre.2024.102410_bib0032","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1997296","article-title":"Gut microbiota-motility interregulation: insights from in vivo, ex vivo and in silico studies","volume":"14","author":"Waclawikov\u00e1","year":"2022","journal-title":"Gut Microbes"},{"key":"10.1016\/j.clinre.2024.102410_bib0033","article-title":"Roles of Chinese medicine and gut microbiota in chronic constipation. evidence-based complementary and alternative medicine","volume":"2019","author":"Xu","year":"2019","journal-title":"eCAM"},{"issue":"2","key":"10.1016\/j.clinre.2024.102410_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.clinre.2021.101794","article-title":"Homeostatic regulation of food intake","volume":"46","author":"Cifuentes","year":"2022","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"10.1016\/j.clinre.2024.102410_bib0035","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3389\/fmicb.2016.00345","article-title":"Gut microbiota: the brain peacekeeper","volume":"7","author":"Mu","year":"2016","journal-title":"Front Microbiol"},{"key":"10.1016\/j.clinre.2024.102410_bib0036","doi-asserted-by":"crossref","first-page":"17324","DOI":"10.1038\/srep17324","article-title":"Escherichia coli Nissle 1917 enhances bioavailability of serotonin in gut tissues through modulation of synthesis and clearance","volume":"5","author":"Nzakizwanayo","year":"2015","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.clinre.2024.102410_bib0037","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1096\/fj.14-259598","article-title":"Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells","volume":"29","author":"Reigstad","year":"2015","journal-title":"FASEB J"},{"issue":"2","key":"10.1016\/j.clinre.2024.102410_bib0038","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cell.2015.02.047","article-title":"Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis","volume":"161","author":"Yano","year":"2015","journal-title":"Cell"}],"container-title":["Clinics and Research in Hepatology and Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210740124001311?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210740124001311?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T06:14:13Z","timestamp":1723011253000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210740124001311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S2210740124001311"],"URL":"https:\/\/doi.org\/10.1016\/j.clinre.2024.102410","relation":{},"ISSN":["2210-7401"],"issn-type":[{"value":"2210-7401","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modified Zhizhu Pill improves the loperamide-induced slow transit constipation via gut microbiota and neurotransmitters in microbiota-gut-brain axis","name":"articletitle","label":"Article Title"},{"value":"Clinics and Research in Hepatology and Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinre.2024.102410","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102410"}}