{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T01:15:21Z","timestamp":1788225321244,"version":"build-2803163510"},"reference-count":24,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics and Research in Hepatology and Gastroenterology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.clinre.2026.102863","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T23:50:38Z","timestamp":1781049038000},"page":"102863","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary hypobetalipoproteinemia as a specific etiology of steatotic liver disease: A meta-analysis"],"prefix":"10.1016","volume":"50","author":[{"given":"Ivanna","family":"Diaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3695-9701","authenticated-orcid":false,"given":"Matheus","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.clinre.2026.102863_bib0001","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.jhep.2023.06.003","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"79","author":"Rinella","year":"2023","journal-title":"J Hepatol"},{"issue":"10464","key":"10.1016\/j.clinre.2026.102863_bib0002","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0140-6736(24)01811-7","article-title":"Steatotic liver disease","volume":"404","author":"Israelsen","year":"2024","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.clinre.2026.102863_bib0003","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.cgh.2024.06.031","article-title":"Prevalence of liver steatosis and fibrosis in adults with primary hypobetaliproteinemia: results from the HYPOCHOL study","volume":"23","author":"Smati","year":"2025","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"000","key":"10.1016\/j.clinre.2026.102863_bib0004","doi-asserted-by":"crossref","first-page":"000","DOI":"10.14218\/JCTH.2025.00360","article-title":"Current and emerging issues in familial hypobetalipoproteinemia-related steatotic liver diseases","volume":"000","author":"Lou","year":"2025","journal-title":"J Clin Transl Hepatol"},{"issue":"7","key":"10.1016\/j.clinre.2026.102863_bib0005","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s11883-014-0423-3","article-title":"Update on primary hypobetalipoproteinemia","volume":"16","author":"Hooper","year":"2014","journal-title":"Curr Atheroscler Rep"},{"issue":"6","key":"10.1016\/j.clinre.2026.102863_bib0006","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.jacl.2022.08.009","article-title":"Guidance for the diagnosis and treatment of hypolipidemia disorders","volume":"16","author":"Bredefeld","year":"2022","journal-title":"J Clin Lipidol"},{"issue":"6","key":"10.1016\/j.clinre.2026.102863_bib0007","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1053\/j.gastro.2020.11.040","article-title":"New classification and management of abetalipoproteinemia and related disorders","volume":"160","author":"Bredefeld","year":"2021","journal-title":"Gastroenterology"},{"issue":"9","key":"10.1016\/j.clinre.2026.102863_bib0008","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1161\/01.ATV.0000176191.64314.07","article-title":"Hepatic and cardiovascular consequences of familial hypobetalipoproteinemia","volume":"25","author":"Sankatsing","year":"2005","journal-title":"Arter Thromb Vasc Biol"},{"issue":"1","key":"10.1016\/j.clinre.2026.102863_bib0009","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41572-025-00599-1","article-title":"Metabolic dysfunction-associated steatotic liver disease in adults","volume":"11","author":"Huang","year":"2025","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.clinre.2026.102863_bib0010","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"issue":"3","key":"10.1016\/j.clinre.2026.102863_bib0011","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.jacl.2025.02.003","article-title":"Clinical and biochemical spectrum of APOB-related hypobetalipoproteinemia: insights from a retrospective cohort study","volume":"19","author":"\u0130","year":"2025","journal-title":"J Clin Lipidol"},{"issue":"5","key":"10.1016\/j.clinre.2026.102863_bib0012","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.jacl.2017.06.013","article-title":"Clinical and biochemical characteristics of individuals with low cholesterol syndromes: a comparison between familial hypobetalipoproteinemia and familial combined hypolipidemia","volume":"11","author":"Di Costanzo","year":"2017","journal-title":"J Clin Lipidol"},{"issue":"1\u20132","key":"10.1016\/j.clinre.2026.102863_bib0013","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.cca.2008.09.021","article-title":"Apolipoprotein B gene mutations and fatty liver in Japanese hypobetalipoproteinemia","volume":"399","author":"Katsuda","year":"2009","journal-title":"Clin Chim Acta"},{"issue":"5","key":"10.1016\/j.clinre.2026.102863_bib0014","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1194\/jlr.M300508-JLR200","article-title":"Fatty liver in familial hypobetalipoproteinemia","volume":"45","author":"Tanoli","year":"2004","journal-title":"J Lipid Res"},{"issue":"4","key":"10.1016\/j.clinre.2026.102863_bib0015","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.jacl.2022.04.009","article-title":"Comparison of two polygenic risk scores to identify non-monogenic primary hypocholesterolemias in a large cohort of Italian hypocholesterolemic subjects","volume":"16","author":"Cefal\u00f9","year":"2022","journal-title":"J Clin Lipidol"},{"issue":"1","key":"10.1016\/j.clinre.2026.102863_bib0016","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jhep.2005.06.018","article-title":"Hepatic steatosis and insulin resistance: does etiology make a difference?","volume":"44","author":"Lonardo","year":"2006","journal-title":"J Hepatol"},{"issue":"6","key":"10.1016\/j.clinre.2026.102863_bib0017","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.jhep.2024.01.030","article-title":"Primary hypocholesterolemia is associated with an increased risk of hepatic complications in the general population","volume":"80","author":"Wargny","year":"2024","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.clinre.2026.102863_bib0018","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/liv.15763","article-title":"Gastrointestinal cancers in lean individuals with non-alcoholic fatty liver disease: a systematic review and meta-analysis","volume":"44","author":"Souza","year":"2024","journal-title":"Liver Int"},{"issue":"4","key":"10.1016\/j.clinre.2026.102863_bib0019","article-title":"Genomic analysis of lean individuals with NAFLD identifies monogenic disorders in a prospective cohort study","volume":"5","author":"Zheng","year":"2023","journal-title":"JHEP Rep"},{"issue":"5","key":"10.1016\/j.clinre.2026.102863_bib0020","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1002\/hep.31988","article-title":"Familial hypobetalipoproteinemia: an underrecognized cause of lean NASH","volume":"74","author":"Buryska","year":"2021","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.clinre.2026.102863_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.jceh.2024.102495","article-title":"Global epidemiology and implications of PNPLA3 I148M variant in metabolic dysfunction\u2013Associated steatotic liver disease: a systematic review and meta-analysis","volume":"15","author":"Souza","year":"2025","journal-title":"J Clin Exp Hepatol"},{"issue":"9","key":"10.1016\/j.clinre.2026.102863_bib0022","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S2468-1253(23)00157-7","article-title":"Type 2 diabetes, hepatic decompensation, and hepatocellular carcinoma in patients with non-alcoholic fatty liver disease: an individual participant-level data meta-analysis","volume":"8","author":"Huang","year":"2023","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"5","key":"10.1016\/j.clinre.2026.102863_bib0023","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1007\/s10620-025-08912-4","article-title":"Role of alcohol in steatotic liver disease: impact on patients with cardiometabolic risk factors","volume":"70","author":"Capinha","year":"2025","journal-title":"Dig Dis Sci"},{"issue":"2","key":"10.1016\/j.clinre.2026.102863_bib0024","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.cgh.2025.02.035","article-title":"Novel noninvasive tests for liver fibrosis: moving beyond simple tests in metabolic dysfunction-associated steatotic liver disease","volume":"24","author":"Grady","year":"2026","journal-title":"Clin Gastroenterol Hepatol"}],"container-title":["Clinics and Research in Hepatology and Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210740126001099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210740126001099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:47:40Z","timestamp":1788223660000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210740126001099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2210740126001099"],"URL":"https:\/\/doi.org\/10.1016\/j.clinre.2026.102863","relation":{},"ISSN":["2210-7401"],"issn-type":[{"value":"2210-7401","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Primary hypobetalipoproteinemia as a specific etiology of steatotic liver disease: A meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Clinics and Research in Hepatology and Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinre.2026.102863","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102863"}}