{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:17:32Z","timestamp":1778901452646,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.clinsp.2022.100006","type":"journal-article","created":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T06:07:51Z","timestamp":1645250871000},"page":"100006","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Effects of ganglioside GM1 and erythropoietin on spinal cord injury in mice: Functional and immunohistochemical assessments"],"prefix":"10.1016","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0436-5168","authenticated-orcid":false,"given":"Alessandro Gonzalez","family":"Torelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7797-5274","authenticated-orcid":false,"given":"Alexandre Foga\u00e7a","family":"Cristante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7969-7845","authenticated-orcid":false,"given":"Tarc\u00edsio Eloy Pessoa","family":"de Barros-Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4774-8935","authenticated-orcid":false,"given":"Gustavo Bispo","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8521-5750","authenticated-orcid":false,"given":"Beatriz Cintra","family":"Morena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6693-4776","authenticated-orcid":false,"given":"Felipe Fernandes","family":"Correia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9417-0470","authenticated-orcid":false,"given":"Vera","family":"Paschon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinsp.2022.100006_bib0001","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/j.1749-6632.2001.tb03655.x","article-title":"Cell death in spinal cord injury (SCI) requires de novo protein synthesis. Calpain inhibitor E-64-d provides neuroprotection in SCI lesion and penumbra","volume":"939","author":"Ray","year":"2001","journal-title":"Ann N Y Acad Sci"},{"issue":"10","key":"10.1016\/j.clinsp.2022.100006_bib0002","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1089\/neu.2000.17.915","article-title":"Review of current evidence for apoptosis after spinal cord injury","volume":"17","author":"Beattie","year":"2000","journal-title":"J Neurotrauma"},{"issue":"6","key":"10.1016\/j.clinsp.2022.100006_bib0003","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0361-9230(99)00072-6","article-title":"The glial scar and central nervous system repair","volume":"49","author":"Fawcett","year":"1999","journal-title":"Brain Res Bull"},{"issue":"2","key":"10.1016\/j.clinsp.2022.100006_bib0004","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0306-4522(93)90076-R","article-title":"Prostaglandins modulate alterations of microvascular permeability, blood flow, edema and serotonin levels following spinal cord injury: an experimental study in the rat","volume":"57","author":"Sharma","year":"1993","journal-title":"Neuroscience"},{"issue":"3-4","key":"10.1016\/j.clinsp.2022.100006_bib0005","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1089\/neu.2006.23.263","article-title":"Degenerative and spontaneous regenerative processes after spinal cord injury","volume":"23","author":"Hagg","year":"2006","journal-title":"J Neurotrauma"},{"issue":"5","key":"10.1016\/j.clinsp.2022.100006_bib0006","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1097\/00006123-199905000-00052","article-title":"Pathogenesis and pharmacological strategies for mitigating secondary damage in acute spinal cord injury","volume":"44","author":"Amar","year":"1999","journal-title":"Neurosurgery"},{"issue":"2","key":"10.1016\/j.clinsp.2022.100006_bib0007","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/0304-3940(93)90287-U","article-title":"GM-1 ganglioside administration combined with physical therapy restores ambulation in humans with chronic spinal cord injury","volume":"161","author":"Walker","year":"1993","journal-title":"Neurosci Lett"},{"issue":"38","key":"10.1016\/j.clinsp.2022.100006_bib0008","doi-asserted-by":"crossref","first-page":"19939","DOI":"10.1074\/jbc.M115.710673","article-title":"Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) is constitutively expressed in adult Central Nervous System (CNS) and associated with astrocyte-mediated glial scar formation following spinal cord injury","volume":"291","author":"Coulson-Thomas","year":"2016","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.clinsp.2022.100006_bib0009","first-page":"103","article-title":"Prospects for recovery of the spinal cord injured","volume":"32","author":"Gebrin","year":"1997","journal-title":"Rev Bras Ortop"},{"issue":"6","key":"10.1016\/j.clinsp.2022.100006_bib0010","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1073\/pnas.86.6.2056","article-title":"Gangliosides potentiate in vivo and in vitro effects of nerve growth factor on central cholinergic neurons","volume":"86","author":"Cuello","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"14","key":"10.1016\/j.clinsp.2022.100006_bib0011","first-page":"1631","article-title":"Protection of erythropoietin on experimental spinal cord injury by reducing the expression of thrombospondin-1 and transforming growth factor-beta","volume":"122","author":"Fang","year":"2009","journal-title":"Chin Med J (Engl)"},{"issue":"1","key":"10.1016\/j.clinsp.2022.100006_bib0012","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.expneurol.2005.04.016","article-title":"Immunosuppressants: neuroprotection and promoting neurological recovery following peripheral nerve and spinal cord lesions","volume":"195","author":"Sosa","year":"2005","journal-title":"Exp Neurol"},{"issue":"3","key":"10.1016\/j.clinsp.2022.100006_bib0013","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1089\/neu.2017.4981","article-title":"Spatial and cellular expression patterns of erythropoietin-receptor and erythropoietin during a 42-day post-lesional time course after graded thoracic spinal cord impact lesions in the rat","volume":"35","author":"Cohrs","year":"2018","journal-title":"J Neurotrauma"},{"issue":"3","key":"10.1016\/j.clinsp.2022.100006_bib0014","doi-asserted-by":"crossref","DOI":"10.1177\/2309499017739481","article-title":"Investigation of efficacy of treatment in spinal cord injury: erythropoietin versus methylprednisolone","volume":"25","author":"Ozkunt","year":"2017","journal-title":"J Orthop Surg"},{"issue":"6","key":"10.1016\/j.clinsp.2022.100006_bib0015","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.3892\/etm.2016.3832","article-title":"Expression of adrenomedullin in rats after spinal cord injury and intervention effect of recombinant human erythropoietin","volume":"12","author":"Zhao","year":"2016","journal-title":"Exp Ther Med"},{"issue":"1","key":"10.1016\/j.clinsp.2022.100006_bib0016","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1179\/1743132811Y.0000000026","article-title":"Protective effects of erythropoietin in experimental spinal cord injury by reducing the C\/EBP-homologous protein expression","volume":"34","author":"Hong","year":"2012","journal-title":"Neurol Res"},{"issue":"3","key":"10.1016\/j.clinsp.2022.100006_bib0017","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.mcn.2007.04.009","article-title":"Microglia can be induced by IFN-gamma or IL-4 to express neural or dendritic-like markers","volume":"35","author":"Butovsky","year":"2007","journal-title":"Mol Cell Neurosci"},{"issue":"23","key":"10.1016\/j.clinsp.2022.100006_bib0018","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1097\/01.BRS.0000096674.12519.12","article-title":"ISSLS prize winner: erythropoietin inhibits spinal neuronal apoptosis and pain following nerve root crush","volume":"28","author":"Sekiguchi","year":"2003","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.clinsp.2022.100006_bib0019","unstructured":"Brasil. Minist\u00e9rio da Ci\u00eancia, Tecnologia, Inova\u00e7\u00f5es e Comunica\u00e7\u00f5es. Resolu\u00e7\u00e3o n\u00b0 37: Diretriz da Pr\u00e1tica de Eutan\u00e1sia do Conselho Nacional de Controle de Experimenta\u00e7\u00e3o Animal - CONCEA. Bras\u00edlia: Minist\u00e9rio da Ci\u00eancia, Tecnologia, Inova\u00e7\u00f5es e Comunica\u00e7\u00f5es; 2018. [acesso em 2021 set 31]. Available from: https:\/\/www.gov.br\/mcti\/pt-br\/acompanhe-o-mcti\/concea\/arquivos\/pdf\/legislacao\/resolucao-normativa-no-37-de-15-de-fevereiro-de-2018.pdf\/view"},{"issue":"1","key":"10.1016\/j.clinsp.2022.100006_bib0020","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1590\/S1413-78522010000100005","article-title":"Experimental study on the action of methylprednisolone on Wistar rats before spinal cord injury","volume":"18","author":"Marcon","year":"2010","journal-title":"Acta Ortop Bras"},{"issue":"6","key":"10.1016\/j.clinsp.2022.100006_bib0021","doi-asserted-by":"crossref","first-page":"351","DOI":"10.6061\/clinics\/2016(06)11","article-title":"Effects of ganglioside G(M1) and erythropoietin on spinal cord lesions in rats: functional and histological evaluations","volume":"71","author":"Marcon","year":"2016","journal-title":"Clinics (Sao Paulo)"},{"issue":"2","key":"10.1016\/j.clinsp.2022.100006_bib0022","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1590\/S1413-78522011000200005","article-title":"Spinal cord injury experimental model and motion evaluation protocol in Wistar rats","volume":"19","author":"Santos","year":"2011","journal-title":"Acta Ortop Bras"},{"issue":"6","key":"10.1016\/j.clinsp.2022.100006_bib0023","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1089\/neu.2006.23.882","article-title":"Robotic gait analysis of bipedal treadmill stepping by spinal contused rats: characterization of intrinsic recovery and comparison with BBB","volume":"23","author":"Nessler","year":"2006","journal-title":"J Neurotrauma"},{"issue":"7","key":"10.1016\/j.clinsp.2022.100006_bib0024","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1089\/neu.1996.13.343","article-title":"MASCIS evaluation of open field locomotor scores: effects of experience and teamwork on reliability. Multicenter animal spinal cord injury study","volume":"13","author":"Basso","year":"1996","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.clinsp.2022.100006_bib0025","doi-asserted-by":"crossref","first-page":"e293","DOI":"10.6061\/clinics\/2018\/e293","article-title":"Standardization of a spinal cord lesion model and neurologic evaluation using mice","volume":"73","author":"Borges","year":"2018","journal-title":"Clinics (Sao Paulo)"},{"issue":"1","key":"10.1016\/j.clinsp.2022.100006_bib0026","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s004010051187","article-title":"Spinal cord compression injury in the mouse: presentation of a model including assessment of motor dysfunction","volume":"100","author":"Farooque","year":"2000","journal-title":"Acta Neuropathol"},{"issue":"5","key":"10.1016\/j.clinsp.2022.100006_bib0027","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1089\/neu.2006.23.635","article-title":"Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains","volume":"23","author":"Basso","year":"2006","journal-title":"J Neurotrauma"},{"issue":"6","key":"10.1016\/j.clinsp.2022.100006_bib0028","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/pr.2013.155","article-title":"Erythropoietin signaling promotes oligodendrocyte development following prenatal systemic hypoxic-ischemic brain injury","volume":"74","author":"Jantzie","year":"2013","journal-title":"Pediatr Res"},{"issue":"6","key":"10.1016\/j.clinsp.2022.100006_bib0029","doi-asserted-by":"crossref","first-page":"e11016","DOI":"10.1371\/journal.pone.0011016","article-title":"et Erythropoietin amplifies stroke-induced oligodendrogenesis in the rat","volume":"5","author":"Zhang","year":"2010","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.clinsp.2022.100006_bib0030","doi-asserted-by":"crossref","first-page":"e28849","DOI":"10.5812\/aapm.28849","article-title":"Neuroprotective effect of erythropoietin in postoperation cervical spinal cord injury: case report and review","volume":"5","author":"Nekoui","year":"2015","journal-title":"Anesth Pain Med"},{"issue":"6","key":"10.1016\/j.clinsp.2022.100006_bib0031","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1089\/neu.2011.1827","article-title":"Neuroprotection with an erythropoietin mimetic peptide (pHBSP) in a model of mild traumatic brain injury complicated by hemorrhagic shock","volume":"29","author":"Robertson","year":"2012","journal-title":"J Neurotrauma"},{"issue":"2","key":"10.1016\/j.clinsp.2022.100006_bib0032","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3171\/spi.2006.4.2.165","article-title":"Optimization of a mouse locomotor rating system to evaluate compression-induced spinal cord injury: correlation of locomotor and morphological injury indices","volume":"4","author":"Li","year":"2006","journal-title":"J Neurosurg Spine"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222000023?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222000023?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:51:21Z","timestamp":1761720681000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593222000023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":32,"alternative-id":["S1807593222000023"],"URL":"https:\/\/doi.org\/10.1016\/j.clinsp.2022.100006","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of ganglioside GM1 and erythropoietin on spinal cord injury in mice: Functional and immunohistochemical assessments","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinsp.2022.100006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 HCFMUSP. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"100006"}}