{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T05:29:35Z","timestamp":1793165375047,"version":"4.5.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":55,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.clinsp.2022.100023","type":"journal-article","created":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T12:27:21Z","timestamp":1647692841000},"page":"100023","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Clinical features of hereditary angioedema and warning signs (H4AE) for its identification"],"prefix":"10.1016","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1034-7580","authenticated-orcid":false,"given":"Pedro","family":"Giavina-Bianchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9882-5200","authenticated-orcid":false,"given":"Marcelo Vivolo","family":"Aun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6372-5012","authenticated-orcid":false,"given":"Juliana F\u00f3es Bianchini","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5197-2043","authenticated-orcid":false,"given":"La\u00eds Souza","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8417-3544","authenticated-orcid":false,"given":"Ana J\u00falia","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9860-2223","authenticated-orcid":false,"given":"Priscila","family":"Takejima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0503-5179","authenticated-orcid":false,"given":"Rosana C\u00e2mara","family":"Agondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8415-4274","authenticated-orcid":false,"given":"Jorge","family":"Kalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0276-3362","authenticated-orcid":false,"given":"Antonio Abilio","family":"Motta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinsp.2022.100023_bib0001","doi-asserted-by":"crossref","first-page":"e310","DOI":"10.6061\/clinics\/2018\/e310","article-title":"Brazilian guidelines for hereditary angioedema management - 2017 update part 1: definition, classification and diagnosis","volume":"73","author":"Giavina-Bianchi","year":"2018","journal-title":"Clinics"},{"issue":"1","key":"10.1016\/j.clinsp.2022.100023_bib0002","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jaip.2020.08.046","article-title":"US HAEA medical advisory board 2020 guidelines for the management of hereditary angioedema","volume":"9","author":"Busse","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"3","key":"10.1016\/j.clinsp.2022.100023_bib0003","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.amjmed.2005.09.064","article-title":"Hereditary angioedema: new findings concerning symptoms, affected organs, and course","volume":"119","author":"Bork","year":"2006","journal-title":"Am J Med"},{"issue":"6","key":"10.1016\/j.clinsp.2022.100023_bib0004","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1111\/cea.12551","article-title":"Classification of angioedema by endotypes","volume":"45","author":"Giavina-Bianchi","year":"2015","journal-title":"Clin Exp Allergy"},{"issue":"12","key":"10.1016\/j.clinsp.2022.100023_bib0005","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1097\/WOX.0b013e318279affa","article-title":"WAO guideline for the management of hereditary angioedema","volume":"5","author":"Craig","year":"2012","journal-title":"World Allergy Organ J"},{"issue":"4","key":"10.1016\/j.clinsp.2022.100023_bib0006","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/00005792-199207000-00003","article-title":"Hereditary and acquired C1-inhibitor deficiency: biological and clinical characteristics in 235 patients","volume":"71","author":"Agostoni","year":"1992","journal-title":"Medicine"},{"issue":"9225","key":"10.1016\/j.clinsp.2022.100023_bib0007","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0140-6736(00)02483-1","article-title":"Hereditary angioedema with normal C1-inhibitor activity in women","volume":"356","author":"Bork","year":"2000","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.clinsp.2022.100023_bib0008","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1016\/j.jaip.2021.03.008","article-title":"The expanding spectrum of mutations in hereditary angioedema","volume":"9","author":"Veronez","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.clinsp.2022.100023_bib0009","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0002-9343(63)90162-1","article-title":"A biochemical abnormality in herediatry angioneurotic edema: absence of serum inhibitor of C' 1-esterase","volume":"35","author":"Donaldson","year":"1963","journal-title":"Am J Med"},{"issue":"1","key":"10.1016\/j.clinsp.2022.100023_bib0010","doi-asserted-by":"crossref","first-page":"S08","DOI":"10.2500\/aap.2020.41.200050","article-title":"Hereditary angioedema: Epidemiology and burden of disease","volume":"41","author":"Lumry","year":"2020","journal-title":"Allergy Asthma Proc"},{"issue":"3","key":"10.1016\/j.clinsp.2022.100023_bib0011","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.anai.2009.12.004","article-title":"Is there a need for clinical guidelines in the United States for the diagnosis of hereditary angioedema and the screening of family members of affected patients?","volume":"104","author":"Lunn","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"1","key":"10.1016\/j.clinsp.2022.100023_bib0012","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/00000441-198207000-00001","article-title":"Hereditary angioedema: an appraisal of 104 cases","volume":"284","author":"Cicardi","year":"1982","journal-title":"Am J Med Sci"},{"issue":"10","key":"10.1016\/j.clinsp.2022.100023_bib0013","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/S0196-0644(88)80450-5","article-title":"Hereditary angioedema","volume":"17","author":"Moore","year":"1988","journal-title":"Ann Emerg Med"},{"issue":"3","key":"10.1016\/j.clinsp.2022.100023_bib0014","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1572-0241.2006.00492.x","article-title":"Symptoms, course, and complications of abdominal attacks in hereditary angioedema due to C1 inhibitor deficiency","volume":"101","author":"Bork","year":"2006","journal-title":"Am J Gastroenterol"},{"issue":"9","key":"10.1016\/j.clinsp.2022.100023_bib0015","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1590\/S1807-59322011000900021","article-title":"Brazilian guidelines for the diagnosis and treatment of hereditary angioedema","volume":"66","author":"Giavina-Bianchi","year":"2011","journal-title":"Clinics"},{"issue":"1","key":"10.1016\/j.clinsp.2022.100023_bib0016","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2500\/aap.2013.34.3635","article-title":"HAE update: special considerations in the female patient with hereditary angioedema","volume":"34","author":"Geng","year":"2013","journal-title":"Allergy Asthma Proc"},{"issue":"1","key":"10.1016\/j.clinsp.2022.100023_bib0017","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.2500\/aap.2020.41.200077","article-title":"Hereditary angioedema: special considerations in women","volume":"41","author":"Yakaboski","year":"2020","journal-title":"Allergy Asthma Proc"},{"issue":"1-2","key":"10.1016\/j.clinsp.2022.100023_bib0018","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0167-4781(93)90294-N","article-title":"The 5\u2032 sequence of human factor XII gene contains transcription regulatory elements typical of liver specific, estrogen-modulated genes","volume":"1172","author":"Citarella","year":"1993","journal-title":"Biochim Biophys Acta"},{"issue":"8","key":"10.1016\/j.clinsp.2022.100023_bib0019","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1038\/sj.bjp.0701255","article-title":"Regulation of bradykinin B2-receptor expression by oestrogen","volume":"121","author":"Madeddu","year":"1997","journal-title":"Br J Pharmacol"},{"issue":"2","key":"10.1016\/j.clinsp.2022.100023_bib0020","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0167-4781(92)90069-C","article-title":"Differential regulation of kininogen gene expression by estrogen and progesterone in vivo","volume":"1131","author":"Chen","year":"1992","journal-title":"Biochim Biophys Acta"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222000199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222000199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T07:03:41Z","timestamp":1761721421000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593222000199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":20,"alternative-id":["S1807593222000199"],"URL":"https:\/\/doi.org\/10.1016\/j.clinsp.2022.100023","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical features of hereditary angioedema and warning signs (H4AE) for its identification","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinsp.2022.100023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 HCFMUSP. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"100023"}}