{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:37:12Z","timestamp":1761741432118,"version":"build-2065373602"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":247,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.clinsp.2022.100111","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T13:28:26Z","timestamp":1667914106000},"page":"100111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Monocyte-to-HDL ratio and non-HDL cholesterol were predictors of septic shock in newborns"],"prefix":"10.1016","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5095-7471","authenticated-orcid":false,"given":"Fernanda Andrade Macaferri","family":"da Fonseca","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0526-8367","authenticated-orcid":false,"given":"Aline Paulino","family":"Esp\u00f3sito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1362-0551","authenticated-orcid":false,"given":"Maria Helena Baptista Nunes","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6769-5412","authenticated-orcid":false,"given":"Val\u00e9ria Sutti","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1236-9916","authenticated-orcid":false,"given":"Patricia Miralda","family":"Cazita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7125-441X","authenticated-orcid":false,"given":"Guilherme Silva","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7605-7431","authenticated-orcid":false,"given":"Maria Esther Jurfest Rivero","family":"Ceccon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9164-616X","authenticated-orcid":false,"given":"Werther Brunow","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1924-4043","authenticated-orcid":false,"given":"Magda","family":"Carneiro-Sampaio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6268-8141","authenticated-orcid":false,"given":"Patricia","family":"Palmeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10159","key":"10.1016\/j.clinsp.2022.100111_bib0001","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","year":"2018","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.clinsp.2022.100111_bib0002","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1136\/archdischild-2020-320217","article-title":"Global incidence and mortality of neonatal sepsis: a systematic review and meta-analysis","volume":"106","author":"Fleischmann","year":"2021","journal-title":"Arch Dis Child"},{"issue":"2","key":"10.1016\/j.clinsp.2022.100111_bib0003","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.pedneo.2018.05.001","article-title":"Validity of biomarkers in screening for neonatal sepsis \u2012 a single center-hospital based study","volume":"60","author":"Rashwan","year":"2019","journal-title":"Pediatr Neonatol"},{"issue":"1","key":"10.1016\/j.clinsp.2022.100111_bib0004","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.4081\/pr.2011.e1","article-title":"Laboratory aid to the diagnosis and therapy of infection in the neonate","volume":"3","author":"Chirico","year":"2011","journal-title":"Pediatr Rep"},{"key":"10.1016\/j.clinsp.2022.100111_bib0005","unstructured":"Weinberg GA, D'Angio CT, Laboratory Aids for Diagnosis of Neonatal Sepsis, In: CB Wilson, V Nizet, YA Maldonado, JS Remington, JO Klein, Infectious diseases of the fetus and newborn infant, 8th ed, 2016, Philadelphia: Elsevier Saunders, p. 1132\u20131146."},{"issue":"5","key":"10.1016\/j.clinsp.2022.100111_bib0006","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1097\/01.CCM.0000059724.08290.51","article-title":"Lipoprotein metabolism in patients with severe sepsis","volume":"31","author":"van Leeuwen","year":"2003","journal-title":"Crit Care Med"},{"key":"10.1016\/j.clinsp.2022.100111_bib0007","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jcrc.2016.11.041","article-title":"Decreased high-density lipoprotein cholesterol level is an early prognostic marker for organ dysfunction and death in patients with suspected sepsis","volume":"38","author":"Cirstea","year":"2017","journal-title":"J Crit Care"},{"key":"10.1016\/j.clinsp.2022.100111_bib0008","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/789298","article-title":"Prognostic implications of serum lipid metabolism over time during sepsis","volume":"2015","author":"Lee","year":"2015","journal-title":"Biomed Res Int"},{"issue":"5","key":"10.1016\/j.clinsp.2022.100111_bib0009","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.jcrc.2014.04.018","article-title":"Serum lipid profile, cytokine production, and clinical outcome in patients with severe sepsis","volume":"29","author":"Lekkou","year":"2014","journal-title":"J Crit Care"},{"issue":"4","key":"10.1016\/j.clinsp.2022.100111_bib0010","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/00365540902767056","article-title":"Diagnostic values of lipid and lipoprotein levels in late onset neonatal sepsis","volume":"41","author":"Yildiz","year":"2009","journal-title":"Scand J Infect Dis"},{"issue":"4","key":"10.1016\/j.clinsp.2022.100111_bib0011","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1161\/01.STR.0000158909.07634.83","article-title":"Monocyte count is a predictor of novel plaque formation: a 7-year follow-up study of 2610 persons without carotid plaque at baseline the Troms\u00f8 Study","volume":"36","author":"Johnsen","year":"2005","journal-title":"Stroke"},{"issue":"5","key":"10.1016\/j.clinsp.2022.100111_bib0012","first-page":"476","article-title":"Association of monocyte-to-HDL cholesterol ratio with slow coronary flow is linked to systemic inflammation","volume":"22","author":"Canpolat","year":"2016","journal-title":"Clin Appl Thromb Off J Int Acad Clin Appl Thromb"},{"issue":"8","key":"10.1016\/j.clinsp.2022.100111_bib0013","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1007\/s11255-014-0730-1","article-title":"Monocyte count\/HDL cholesterol ratio and cardiovascular events in patients with chronic kidney disease","volume":"46","author":"Kanbay","year":"2014","journal-title":"Int Urol Nephrol"},{"issue":"1","key":"10.1016\/j.clinsp.2022.100111_bib0014","first-page":"2","article-title":"International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics","volume":"6","author":"Goldstein","year":"2005","journal-title":"Pediatr Crit Care Med J Soc Crit Care Med World Fed Pediatr Intensive Crit Care Soc"},{"issue":"suppl 1","key":"10.1016\/j.clinsp.2022.100111_bib0015","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s00134-019-05878-6","article-title":"Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children","volume":"46","author":"Weiss","year":"2020","journal-title":"Intensive Care Med"},{"issue":"4","key":"10.1016\/j.clinsp.2022.100111_bib0016","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2223\/1364","article-title":"Blood lactate concentration as prognostic marker in critically ill children","volume":"81","author":"Koliski","year":"2005","journal-title":"J Pediatr"},{"issue":"2","key":"10.1016\/j.clinsp.2022.100111_bib0017","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0009-8981(94)90287-9","article-title":"Lipoprotein profiling by high performance gel chromatography","volume":"228","author":"Tallis","year":"1994","journal-title":"Clin Chim Acta"},{"issue":"6","key":"10.1016\/j.clinsp.2022.100111_bib0018","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.3945\/jn.109.117937","article-title":"Intake of trans fatty acids causes nonalcoholic steatohepatitis and reduces adipose tissue fat content","volume":"140","author":"Machado","year":"2010","journal-title":"J Nutr"},{"issue":"1","key":"10.1016\/j.clinsp.2022.100111_bib0019","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00134-006-0433-x","article-title":"Lipoproteins in inflammation and sepsis. II. Clinical aspects","volume":"33","author":"Wendel","year":"2007","journal-title":"Intensive Care Med"},{"issue":"3","key":"10.1016\/j.clinsp.2022.100111_bib0020","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/01.shk.0000111661.09279.82","article-title":"High-density lipoproteins in sepsis and septic shock: metabolism, actions, and therapeutic applications","volume":"21","author":"Wu","year":"2004","journal-title":"Shock"},{"issue":"1","key":"10.1016\/j.clinsp.2022.100111_bib0021","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s13054-020-02860-3","article-title":"High-density lipoproteins during sepsis: from bench to bedside","volume":"24","author":"Tanaka","year":"2020","journal-title":"Crit Care"},{"issue":"1","key":"10.1016\/j.clinsp.2022.100111_bib0022","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00134-006-0432-y","article-title":"Lipoproteins in inflammation and sepsis. I. Basic science","volume":"33","author":"Murch","year":"2007","journal-title":"Intensive Care Med"},{"issue":"1","key":"10.1016\/j.clinsp.2022.100111_bib0023","doi-asserted-by":"crossref","first-page":"34","DOI":"10.4067\/S0716-10182014000100005","article-title":"Protective role of high density lipoproteins in sepsis: basic issues and clinical implications","volume":"31","author":"Contreras-Duarte","year":"2014","journal-title":"Rev Chil Infectol organo Of la Soc Chil Infectol"},{"key":"10.1016\/j.clinsp.2022.100111_bib0024","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/978-3-319-09665-0_15","article-title":"Norata GD. HDL in infectious diseases and sepsis","volume":"224","author":"Pirillo","year":"2015","journal-title":"Handb Exp Pharmacol"},{"issue":"3","key":"10.1016\/j.clinsp.2022.100111_bib0025","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/bph.12174","article-title":"HDL and endothelial protection","volume":"169","author":"Tran-Dinh","year":"2013","journal-title":"Br J Pharmacol"},{"issue":"Suppl","key":"10.1016\/j.clinsp.2022.100111_bib0026","doi-asserted-by":"crossref","first-page":"S462","DOI":"10.1086\/315611","article-title":"Infection and inflammation-induced proatherogenic changes of lipoproteins","volume":"181","author":"Khovidhunkit","year":"2000","journal-title":"J Infect Dis"},{"issue":"11","key":"10.1016\/j.clinsp.2022.100111_bib0027","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1007\/s00134-009-1609-y","article-title":"Changes in HDL-associated apolipoproteins relate to mortality in human sepsis and correlate to monocyte and platelet activation","volume":"35","author":"Barlage","year":"2009","journal-title":"Intensive Care Med"},{"issue":"8","key":"10.1016\/j.clinsp.2022.100111_bib0028","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1097\/01.CCM.0000171183.79525.6B","article-title":"Low serum level of high-density lipoprotein cholesterol is a poor prognostic factor for severe sepsis","volume":"33","author":"Chien","year":"2005","journal-title":"Crit Care Med"},{"issue":"4","key":"10.1016\/j.clinsp.2022.100111_bib0029","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1365-2362.2010.02269.x","article-title":"Lipoproteins and CETP levels as risk factors for severe sepsis in hospitalized patients","volume":"40","author":"Grion","year":"2010","journal-title":"Eur J Clin Invest"},{"issue":"2","key":"10.1016\/j.clinsp.2022.100111_bib0030","first-page":"153","article-title":"Changes in the concentration and composition of plasma lipoproteins during the acute phase response","volume":"5","author":"Carpentier","year":"2002","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.clinsp.2022.100111_bib0031","first-page":"147","article-title":"Is hypertriglyceridemia a prognostic factor in sepsis?","volume":"10","author":"Cetinkaya","year":"2014","journal-title":"Ther Clin Risk Manag"},{"issue":"12","key":"10.1016\/j.clinsp.2022.100111_bib0032","doi-asserted-by":"crossref","first-page":"9237","DOI":"10.1002\/jcp.27028","article-title":"Monocyte-to-HDL-cholesterol ratio as a prognostic marker in cardiovascular diseases","volume":"233","author":"Ganjali","year":"2018","journal-title":"J Cell Physiol"},{"issue":"4","key":"10.1016\/j.clinsp.2022.100111_bib0033","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1007\/s12011-020-02499-9","article-title":"The relationship between heavy metal exposure, trace element level, and monocyte to HDL cholesterol ratio with gestational diabetes mellitus","volume":"199","author":"Onat","year":"2021","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.clinsp.2022.100111_bib0034","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ajem.2020.07.026","article-title":"The new prognostic factor for pulmonary embolism: the ratio of monocyte count to HDL cholesterol","volume":"46","author":"Avci","year":"2021","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.clinsp.2022.100111_bib0035","doi-asserted-by":"crossref","first-page":"tkaa040","DOI":"10.1093\/burnst\/tkaa040","article-title":"Predictive value of immune cell counts and neutrophil-to-lymphocyte ratio for 28-day mortality in patients with sepsis caused by intra-abdominal infection","volume":"9","author":"Liu","year":"2021","journal-title":"Burns Trauma"},{"issue":"suppl 1","key":"10.1016\/j.clinsp.2022.100111_bib0036","first-page":"S45","article-title":"Use of lipids in neonates requiring parenteral nutrition","volume":"44","author":"Deshpande","year":"2020","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"5","key":"10.1016\/j.clinsp.2022.100111_bib0037","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00383-005-1385-x","article-title":"Modulation of immune cell function by polyunsaturated fatty acids","volume":"21","author":"Sweeney","year":"2005","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.clinsp.2022.100111_bib0038","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000365426","article-title":"Fatty acids, lipid emulsions and the immune and inflammatory systems","volume":"112","author":"Miles","year":"2015","journal-title":"World Rev Nutr Diet"},{"issue":"4","key":"10.1016\/j.clinsp.2022.100111_bib0039","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s003830100589","article-title":"Polyunsaturated fatty acids influence neonatal monocyte survival","volume":"17","author":"Sweeney","year":"2001","journal-title":"Pediatr Surg Int"},{"issue":"4","key":"10.1016\/j.clinsp.2022.100111_bib0040","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3390\/nu9040388","article-title":"Parenterals nutrition and lipid","volume":"9","author":"Raman","year":"2017","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.clinsp.2022.100111_bib0041","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/MPG.0000000000000174","article-title":"Fish Oil (SMOFlipid) and olive oil lipid (Clinoleic) in very preterm neonates","volume":"58","author":"Deshpande","year":"2014","journal-title":"J Pediatr Gastroenterol Nutr"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222033129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593222033129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T07:01:13Z","timestamp":1761721273000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593222033129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":41,"alternative-id":["S1807593222033129"],"URL":"https:\/\/doi.org\/10.1016\/j.clinsp.2022.100111","relation":{},"ISSN":["1807-5932"],"issn-type":[{"type":"print","value":"1807-5932"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Monocyte-to-HDL ratio and non-HDL cholesterol were predictors of septic shock in newborns","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinsp.2022.100111","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 HCFMUSP. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"100111"}}