{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:14:42Z","timestamp":1786986882063,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"vor","delay-in-days":213,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.clinsp.2023.100273","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T23:12:40Z","timestamp":1692054760000},"page":"100273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["The role of Vav3 expression for inflammation and cell death during experimental myocardial infarction"],"prefix":"10.1016","volume":"78","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonglei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3463-9285","authenticated-orcid":false,"given":"Jiming","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.clinsp.2023.100273_bib0001","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1161\/CIRCRESAHA.118.313568","article-title":"Medical therapy for heart failure caused by ischemic heart disease","volume":"124","author":"Elgendy","year":"2019","journal-title":"Circ Res"},{"issue":"6","key":"10.1016\/j.clinsp.2023.100273_bib0002","first-page":"e85","article-title":"Heart disease and stroke statistics \u2012 2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee","volume":"113","author":"Thom","year":"2006","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.clinsp.2023.100273_bib0003","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2217\/fca.14.76","article-title":"Mechanisms of myocardial ischemia-reperfusion injury and the cytoprotective role of minocycline: scope and limitations","volume":"11","author":"Thind","year":"2015","journal-title":"Fut Cardiol"},{"issue":"9","key":"10.1016\/j.clinsp.2023.100273_bib0004","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.008024","article-title":"Inflammation, autophagy, and apoptosis after myocardial infarction","volume":"7","author":"Wang","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.clinsp.2023.100273_bib0005","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13063-016-1168-9","volume":"17","author":"Li","year":"2016","journal-title":"Trials"},{"issue":"2","key":"10.1016\/j.clinsp.2023.100273_bib0006","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.ijcard.2007.11.025","article-title":"Early initiation of low-dose atorvastatin treatment after an acute ST-elevated myocardial infarction, decreases inflammatory process and prevents endothelial injury and activation","volume":"133","author":"Stefanadi","year":"2009","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.clinsp.2023.100273_bib0007","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.926281","article-title":"Peroxiredoxin2 (Prdx2) reduces oxidative stress and apoptosis of myocardial cells induced by acute myocardial infarction by inhibiting the TLR4\/Nuclear Factor kappa B (NF-\u03baB) signaling pathway","volume":"26","author":"Li","year":"2020","journal-title":"Med Sci Monit"},{"issue":"7","key":"10.1016\/j.clinsp.2023.100273_bib0008","first-page":"10420","article-title":"Resveratrol attenuates inflammation and oxidative stress induced by myocardial ischemia-reperfusion injury: role of Nrf2\/ARE pathway","volume":"8","author":"Cheng","year":"2015","journal-title":"Int J Clin Exp Med"},{"issue":"10","key":"10.1016\/j.clinsp.2023.100273_bib0009","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1016\/j.celrep.2016.11.018","article-title":"Vav proteins are key regulators of Card9 signaling for innate antifungal immunity","volume":"17","author":"Roth","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.clinsp.2023.100273_bib0010","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1476-4598-12-27","article-title":"Targeting the Vav3 oncogene enhances docetaxel-induced apoptosis through the inhibition of androgen receptor phosphorylation in LNCaP prostate cancer cells under chronic hypoxia","volume":"12","author":"Nomura","year":"2013","journal-title":"Mol Cancer"},{"issue":"15","key":"10.1016\/j.clinsp.2023.100273_bib0011","doi-asserted-by":"crossref","first-page":"15289","DOI":"10.1074\/jbc.M500275200","article-title":"Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76","volume":"280","author":"Charvet","year":"2005","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.clinsp.2023.100273_bib0012","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41392-021-00823-w","article-title":"T cell receptor (TCR) signaling in health and disease","volume":"6","author":"Shah","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.clinsp.2023.100273_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113070","article-title":"Anti-inflammatory effect of trans-anethol in a rat model of myocardial ischemia-reperfusion injury","volume":"150","author":"Matboli","year":"2022","journal-title":"Biomed Pharmacother"},{"issue":"19","key":"10.1016\/j.clinsp.2023.100273_bib0014","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1161\/CIRCULATIONAHA.106.649244","article-title":"Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes","volume":"114","author":"Yang","year":"2006","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.clinsp.2023.100273_bib0015","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0008-6363(99)00274-6","article-title":"Serial echocardiographic assessment of left ventricular dimensions and function after myocardial infarction in mice","volume":"45","author":"Gao","year":"2000","journal-title":"Cardiovasc Res"},{"issue":"3","key":"10.1016\/j.clinsp.2023.100273_bib0016","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1002\/jcb.27684","article-title":"Hydrogen gas reduces chronic intermittent hypoxia-induced hypertension by inhibiting sympathetic nerve activity and increasing vasodilator responses via the antioxidation","volume":"120","author":"Guan","year":"2019","journal-title":"J Cell Biochem"},{"issue":"4","key":"10.1016\/j.clinsp.2023.100273_bib0017","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"8","key":"10.1016\/j.clinsp.2023.100273_bib0018","doi-asserted-by":"crossref","first-page":"979","DOI":"10.7150\/ijbs.15071","article-title":"BDNF-mediates down-regulation of MicroRNA-195 inhibits ischemic cardiac apoptosis in rats","volume":"12","author":"Hang","year":"2016","journal-title":"Int J Biol Sci"},{"issue":"3","key":"10.1016\/j.clinsp.2023.100273_bib0019","doi-asserted-by":"crossref","first-page":"e296","DOI":"10.1038\/mtna.2016.12","article-title":"Combination of microRNA-21 and microRNA-146a attenuates cardiac dysfunction and apoptosis during acute myocardial infarction in mice","volume":"5","author":"Huang","year":"2016","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.clinsp.2023.100273_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153405","article-title":"Nootkatone attenuates myocardial oxidative damage, inflammation, and apoptosis in isoproterenol-induced myocardial infarction in rats","volume":"84","author":"Meeran","year":"2021","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.clinsp.2023.100273_bib0021","doi-asserted-by":"crossref","first-page":"172","DOI":"10.4161\/cam.4.2.10387","article-title":"A remarkable new target gene for the dioxin receptor: the Vav3 proto-oncogene links AhR to adhesion and migration","volume":"4","author":"Fernandez-Salguero","year":"2010","journal-title":"Cell Adh Migr"},{"issue":"3","key":"10.1016\/j.clinsp.2023.100273_bib0022","first-page":"623","article-title":"The molecular mechanism of Vav3 oncogene on upregulation of androgen receptor activity in prostate cancer cells","volume":"36","author":"Liu","year":"2010","journal-title":"Int J Oncol"},{"issue":"24","key":"10.1016\/j.clinsp.2023.100273_bib0023","doi-asserted-by":"crossref","first-page":"5795","DOI":"10.1182\/blood-2011-12-396150","article-title":"Molecular features of hepatosplenic T-cell lymphoma unravels potential novel therapeutic targets","volume":"119","author":"Travert","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.clinsp.2023.100273_bib0024","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/1471-2407-8-158","article-title":"Vav3 oncogene activates estrogen receptor and its overexpression may be involved in human breast cancer","volume":"8","author":"Lee","year":"2008","journal-title":"BMC Cancer"},{"issue":"6","key":"10.1016\/j.clinsp.2023.100273_bib0025","first-page":"1511","article-title":"Vav3 oncogene is involved in regulation of secretory phospholipase A2-IIa expression in prostate cancer","volume":"25","author":"Dong","year":"2011","journal-title":"Oncol Rep"},{"issue":"16","key":"10.1016\/j.clinsp.2023.100273_bib0028","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.2174\/092986706777585086","article-title":"Targeting the inflammatory response in healing myocardial infarcts","volume":"13","author":"Frangogiannis","year":"2006","journal-title":"Curr Med Chem"},{"issue":"5","key":"10.1016\/j.clinsp.2023.100273_bib0029","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrcardio.2014.28","article-title":"The inflammatory response in myocardial injury, repair, and remodelling","volume":"11","author":"Frangogiannis","year":"2014","journal-title":"Nat Rev Cardiol"},{"issue":"9","key":"10.1016\/j.clinsp.2023.100273_bib0030","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1111\/eci.12118","article-title":"Targeting inflammatory pathways in myocardial infarction","volume":"43","author":"Christia","year":"2013","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.clinsp.2023.100273_bib0031","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.926281","article-title":"Peroxiredoxin2 (Prdx2) reduces oxidative stress and apoptosis of myocardial cells induced by acute myocardial infarction by inhibiting the TLR4\/nuclear factor kappa B (NF-\u03baB) signaling pathway","volume":"26","author":"Li","year":"2020","journal-title":"Med Sci Monit"},{"issue":"12","key":"10.1016\/j.clinsp.2023.100273_bib0032","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.clinsp.2023.100273_bib0033","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.abb.2014.05.005","article-title":"The p65 subunit of NF-\u03baB involves in RIP140-mediated inflammatory and metabolic dysregulation in cardiomyocytes","volume":"554","author":"Zhang","year":"2014","journal-title":"Arch Biochem Biophys"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593223001096?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593223001096?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T21:37:02Z","timestamp":1725053822000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593223001096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":31,"alternative-id":["S1807593223001096"],"URL":"https:\/\/doi.org\/10.1016\/j.clinsp.2023.100273","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of Vav3 expression for inflammation and cell death during experimental myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinsp.2023.100273","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 HCFMUSP. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"100273"}}