{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:54:14Z","timestamp":1790182454385,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":67,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001721","name":"Rijksuniversiteit Groningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001721","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.clinsp.2024.100345","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T23:02:00Z","timestamp":1710975720000},"page":"100345","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Olanzapine as a prophylactic antiemetic for preventing postoperative nausea and vomiting after general anesthesia: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6271-8718","authenticated-orcid":false,"given":"Thiago Ramos","family":"Grigio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6082-9043","authenticated-orcid":false,"given":"Hans","family":"Timmerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1732-9083","authenticated-orcid":false,"given":"Angela Maria","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6240-3903","authenticated-orcid":false,"given":"Andr\u00e9 Paul","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.clinsp.2024.100345_bib0001","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1093\/bja\/89.5.760","article-title":"Patient preferences for immediate postoperative recovery","volume":"89","author":"Eberhart","year":"2002","journal-title":"Br J Anaesth"},{"issue":"2","key":"10.1016\/j.clinsp.2024.100345_bib0002","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1213\/ane.0b013e31817b842c","article-title":"The impact of current antiemetic practices on patient outcomes: a prospective study on high-risk patients","volume":"107","author":"White","year":"2008","journal-title":"Anesth Analg"},{"key":"10.1016\/j.clinsp.2024.100345_bib0003","series-title":"A Practice of Anesthesia For Infants and Children","first-page":"1095","article-title":"47 \u2013 the postanesthesia care unit and beyond","author":"Taenzer","year":"2019"},{"issue":"6","key":"10.1016\/j.clinsp.2024.100345_bib0004","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/j.1875-9114.2012.01101.x","article-title":"Relationship between potential opioid-related adverse effects and hospital length of stay in patients receiving opioids after orthopedic surgery","volume":"32","author":"Pizzi","year":"2012","journal-title":"Pharmacotherapy"},{"issue":"1","key":"10.1016\/j.clinsp.2024.100345_bib0005","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/MJT.0b013e3181e7a512","article-title":"Postoperative nausea and vomiting prophylaxis from an economic point of view","volume":"19","author":"Dzwonczyk","year":"2012","journal-title":"Am J Ther"},{"issue":"2","key":"10.1016\/j.clinsp.2024.100345_bib0006","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1213\/ANE.0000000000004833","article-title":"Fourth consensus guidelines for the management of postoperative nausea and vomiting","volume":"131","author":"Gan","year":"2020","journal-title":"Anesth Analg"},{"issue":"3","key":"10.1016\/j.clinsp.2024.100345_bib0007","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/00000542-199909000-00022","article-title":"A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers","volume":"91","author":"Apfel","year":"1999","journal-title":"Anesthesiology"},{"issue":"7","key":"10.1016\/j.clinsp.2024.100345_bib0008","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/S1701-2163(16)32895-X","article-title":"Guideline for the management of postoperative nausea and vomiting","volume":"30","author":"McCracken","year":"2008","journal-title":"J Obstet Gynaecol Can"},{"issue":"1","key":"10.1016\/j.clinsp.2024.100345_bib0009","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1213\/01.ANE.0000068580.00245.95","article-title":"Consensus guidelines for managing postoperative nausea and vomiting","volume":"97","author":"Gan","year":"2003","journal-title":"Anesth Analg"},{"issue":"6","key":"10.1016\/j.clinsp.2024.100345_bib0010","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1213\/01.ane.0000295230.55439.f4","article-title":"Society for ambulatory anesthesia guidelines for the management of postoperative nausea and vomiting","volume":"105","author":"Gan","year":"2007","journal-title":"Anesth Analg"},{"issue":"1","key":"10.1016\/j.clinsp.2024.100345_bib0011","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1213\/ANE.0000000000000002","article-title":"Consensus guidelines for the management of postoperative nausea and vomiting","volume":"118","author":"Gan","year":"2014","journal-title":"Anesth Analg"},{"issue":"Suppl 1","key":"10.1016\/j.clinsp.2024.100345_bib0012","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.4103\/joacp.JOACP_238_16","article-title":"Enhanced recovery after surgery: an anesthesiologist's perspective","volume":"35","author":"Moningi","year":"2019","journal-title":"J Anaesthesiol Clin Pharmacol"},{"issue":"2","key":"10.1016\/j.clinsp.2024.100345_bib0013","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/ALN.0b013e31827773e9","article-title":"Practice guidelines for postanesthetic care: an updated report by the American society of anesthesiologists task force on postanesthetic care","volume":"118","author":"Apfelbaum","year":"2013","journal-title":"AnesthesiologyAnesthesiology"},{"key":"10.1016\/j.clinsp.2024.100345_bib0014","article-title":"Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis","volume":"10","author":"Weibel","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.clinsp.2024.100345_bib0015","doi-asserted-by":"crossref","first-page":"e1688","DOI":"10.6061\/clinics\/2020\/e1688","article-title":"Aprepitant plus palonosetron for the prevention of postoperative nausea and vomiting after breast cancer surgery: a double blind, randomized trial","volume":"75","author":"Grigio","year":"2020","journal-title":"Clinics (Sao Paulo)"},{"key":"10.1016\/j.clinsp.2024.100345_bib0016","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.critrevonc.2017.02.017","article-title":"Efficacy and safety of olanzapine for the prevention of chemotherapy-induced nausea and vomiting: a systematic review and meta-analysis","volume":"112","author":"Yoodee","year":"2017","journal-title":"Crit Rev Oncol Hematol"},{"issue":"1","key":"10.1016\/j.clinsp.2024.100345_bib0017","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1213\/ANE.0000000000003990","article-title":"Chronic atypical antipsychotic use is associated with reduced need for postoperative nausea and vomiting rescue in the postanesthesia care unit: a propensity-matched retrospective observational study","volume":"130","author":"Jabaley","year":"2020","journal-title":"Anesth Analg"},{"issue":"1","key":"10.1016\/j.clinsp.2024.100345_bib0018","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11864-020-00804-1","article-title":"The benefits of olanzapine in palliating symptoms","volume":"22","author":"Davis","year":"2020","journal-title":"Curr Treat Options Oncol"},{"key":"10.1016\/j.clinsp.2024.100345_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijsu.2021.105906","article-title":"The prisma 2020 statement: an updated guideline for reporting systematic reviews","volume":"88","author":"Page","year":"2021","journal-title":"Int J Surg"},{"issue":"1","key":"10.1016\/j.clinsp.2024.100345_bib0020","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan-a web and mobile app for systematic reviews","volume":"5","author":"Ouzzani","year":"2016","journal-title":"Syst Rev"},{"issue":"11","key":"10.1016\/j.clinsp.2024.100345_bib0021","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.3390\/ijms22115797","article-title":"Mechanisms of nausea and vomiting: current knowledge and recent advances in intracellular emetic signaling systems","volume":"22","author":"Zhong","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.clinsp.2024.100345_bib0022","unstructured":"National Heart, Lung, and BIood institute, https:\/\/www.nhlbi.nih.gov\/health-topics\/study-quality-assessment-tools [accessed 2 September 2023]."},{"key":"10.1016\/j.clinsp.2024.100345_bib0023","unstructured":"(RevMan) RM. Version 5.4 ed: the cochrane collaboration; 2020."},{"issue":"1","key":"10.1016\/j.clinsp.2024.100345_bib0024","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ejphar.2013.09.074","article-title":"Opioid induced nausea and vomiting","volume":"722","author":"Smith","year":"2014","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"10.1016\/j.clinsp.2024.100345_bib0025","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1055\/s-0029-1222438","article-title":"Does everything remain the same in the pharmacotherapy of postoperative nausea and vomiting?","volume":"44","author":"Wallenborn","year":"2009","journal-title":"Anasthesiol Intensivmed Notfallmed Schmerzther"},{"issue":"3","key":"10.1016\/j.clinsp.2024.100345_bib0026","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/ALN.0000000000003438","article-title":"Erratum: olanzapine for the prevention of postdischarge nausea and vomiting after ambulatory surgery: a randomized controlled trial","volume":"133","year":"2020","journal-title":"Anesthesiology."},{"issue":"6","key":"10.1016\/j.clinsp.2024.100345_bib0027","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1097\/ALN.0000000000003286","article-title":"Olanzapine for the prevention of postdischarge nausea and vomiting after ambulatory surgery: a randomized controlled trial","volume":"132","author":"Hyman","year":"2020","journal-title":"Anesthesiology"},{"issue":"2","key":"10.1016\/j.clinsp.2024.100345_bib0028","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.egja.2013.01.002","article-title":"Oral olanzapine versus oral ondansetron for prevention of post-operative nausea and vomiting. a randomized, controlled study","volume":"29","author":"Ibrahim","year":"2013","journal-title":"Egypt J Anaesth"},{"issue":"7","key":"10.1016\/j.clinsp.2024.100345_bib0029","first-page":"756","article-title":"The prophylactic effect of oral olanzapine on postoperative nausea and vomiting in laparoscopic gynecological surgery: a randomized clinical trial","volume":"71","author":"Seki","year":"2022","journal-title":"Masui"},{"issue":"10","key":"10.1016\/j.clinsp.2024.100345_bib0030","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1111\/anae.16081","article-title":"Olanzapine as an add-on, pre-operative anti-emetic drug for postoperative nausea or vomiting: a randomised controlled trial","volume":"78","author":"Grigio","year":"2023","journal-title":"Anaesthesia"},{"issue":"24","key":"10.1016\/j.clinsp.2024.100345_bib0031","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1056\/NEJMoa032196","article-title":"A factorial trial of six interventions for the prevention of postoperative nausea and vomiting","volume":"350","author":"Apfel","year":"2004","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.clinsp.2024.100345_bib0032","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.bja.2023.01.005","article-title":"Aim for zero: prevention of postoperative nausea and vomiting using an off-patent five-drug multimodal approach","volume":"131","author":"Williams","year":"2023","journal-title":"Br J Anaesth"},{"issue":"1","key":"10.1016\/j.clinsp.2024.100345_bib0033","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11864-020-00804-1","article-title":"The benefits of olanzapine in palliating symptoms","volume":"22","author":"Davis","year":"2021","journal-title":"Curr Treat Options Oncol"},{"issue":"1","key":"10.1016\/j.clinsp.2024.100345_bib0034","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12874-015-0024-z","article-title":"The heterogeneity statistic I2 can be biased in small meta-analyses","volume":"15","author":"von Hippel","year":"2015","journal-title":"BMC Med Res Methodol"},{"issue":"7","key":"10.1016\/j.clinsp.2024.100345_bib0035","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s12630-021-01974-8","article-title":"Interpretation of the four risk factors for postoperative nausea and vomiting in the apfel simplified risk score: an analysis of published studies","volume":"68","author":"Darvall","year":"2021","journal-title":"Can J Anaesth"},{"issue":"8","key":"10.1016\/j.clinsp.2024.100345_bib0036","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1034\/j.1399-6576.2002.460801.x","article-title":"How to study postoperative nausea and vomiting","volume":"46","author":"Apfel","year":"2002","journal-title":"Acta Anaesthesiol Scand"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S180759322400022X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S180759322400022X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T04:21:40Z","timestamp":1735791700000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S180759322400022X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":36,"alternative-id":["S180759322400022X"],"URL":"https:\/\/doi.org\/10.1016\/j.clinsp.2024.100345","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Olanzapine as a prophylactic antiemetic for preventing postoperative nausea and vomiting after general anesthesia: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinsp.2024.100345","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 HCFMUSP. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"100345"}}