{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:35:45Z","timestamp":1792697745029,"version":"4.5.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":207,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.clinsp.2024.100476","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T07:25:36Z","timestamp":1724829936000},"page":"100476","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Effects of N-Acetylcysteine combined with Ambroxol Hydrochloride on clinical symptoms, CRP, and PCT in children with pneumonia"],"prefix":"10.1016","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0937-2592","authenticated-orcid":false,"given":"AiLi","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8871-1205","authenticated-orcid":false,"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2798-1842","authenticated-orcid":false,"given":"ShanShan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2618-9736","authenticated-orcid":false,"given":"Xia","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.clinsp.2024.100476_bib0001","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1002\/ppul.26374","article-title":"Underlying causes and outcomes of recurrent pneumonia in hospitalized children","volume":"58","author":"Mei","year":"2023","journal-title":"Pediatr Pulmonol"},{"issue":"5","key":"10.1016\/j.clinsp.2024.100476_bib0002","first-page":"188","article-title":"ChxCapsNet: deep capsule network with transfer learning for evaluating pneumonia in paediatric chest radiographs","volume":"188","author":"Bodapati","year":"2022","journal-title":"Measurement"},{"issue":"3","key":"10.1016\/j.clinsp.2024.100476_bib0003","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1002\/ppul.26269","article-title":"Disease severity of community-acquired pneumonia among children with medical complexity","volume":"58","author":"Ramgopal","year":"2023","journal-title":"Pediatr Pulmonol"},{"issue":"3","key":"10.1016\/j.clinsp.2024.100476_bib0004","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/apa.16185","article-title":"Has the time come to stop routine N-acetylcysteine treatment in young children in Denmark? A review of 300 suspected paracetamol overdoses in children aged 0\u20136 years","volume":"111","author":"Gade","year":"2022","journal-title":"Acta Paediatr"},{"issue":"7","key":"10.1016\/j.clinsp.2024.100476_bib0005","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1021\/acs.chemrestox.9b00152","article-title":"N-Acetylcysteine: antioxidant, aldehyde scavenger, and more","volume":"32","author":"Zhitkovich","year":"2019","journal-title":"Chem Res Toxicol"},{"issue":"8","key":"10.1016\/j.clinsp.2024.100476_bib0006","article-title":"N-acetylcysteine alleviates liver injury by suppressing macrophage-mediated inflammatory response post microwave ablation","volume":"85","author":"Zhou","year":"2020","journal-title":"Int Immunopharmacol"},{"issue":"8","key":"10.1016\/j.clinsp.2024.100476_bib0007","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1093\/jac\/dkz210","article-title":"N-acetylcysteine blocks SOS induction and mutagenesis produced by fluoroquinolones in Escherichia coli","volume":"74","author":"Rodr\u00edguez-Rosado","year":"2019","journal-title":"J Antimicrob Chemother"},{"issue":"5","key":"10.1016\/j.clinsp.2024.100476_bib0008","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/cns.13089","article-title":"Endoplasmic reticulum stress induces apoptosis of arginine vasopressin neurons in central diabetes insipidus via PI3K\/Akt pathway","volume":"25","author":"Zhou","year":"2019","journal-title":"CNS Neurosci Ther"},{"issue":"1","key":"10.1016\/j.clinsp.2024.100476_bib0009","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1097\/MJT.0000000000000309","article-title":"Evaluating the effect of intracoronary N-Acetylcysteine on platelet activation markers after primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction","volume":"23","author":"Eshraghi","year":"2016","journal-title":"Am J Ther"},{"issue":"2","key":"10.1016\/j.clinsp.2024.100476_bib0010","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.pan.2019.01.004","article-title":"N-Acetylcysteine enhances the therapeutic efficacy of bone marrow-derived mesenchymal stem cell transplantation in rats with severe acute pancreatitis","volume":"19","author":"Ma","year":"2019","journal-title":"Pancreatology"},{"issue":"11","key":"10.1016\/j.clinsp.2024.100476_bib0011","article-title":"Interaction of N-acetyl-l-cysteine with Na+, Ca2+, Mg2+ and Zn2+. Thermodynamic aspects, chemical speciation and sequestering ability in natural fluids","volume":"319","author":"Bretti","year":"2020","journal-title":"J Mol Liq"},{"issue":"3","key":"10.1016\/j.clinsp.2024.100476_bib0012","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.12681\/jhvms.25078","article-title":"Effect of N-acetyl cysteine on the quality of blastocyst formation rate using cultured vitrified murine embryos","volume":"71","author":"Sigenza","year":"2020","journal-title":"J Hell Vet Med Soc"},{"issue":"3","key":"10.1016\/j.clinsp.2024.100476_bib0013","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1142\/S0192415X19500307","article-title":"Thymoquinone attenuates acetaminophen overdose-induced acute liver injury and inflammation via regulation of JNK and AMPK signaling pathway","volume":"47","author":"Cui","year":"2019","journal-title":"Am J Chin Med"},{"issue":"7","key":"10.1016\/j.clinsp.2024.100476_bib0014","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1002\/jat.3606","article-title":"Size-dependent superparamagnetic iron oxide nanoparticles dictate interleukin-1\u03b2 release from mouse bone marrow-derived macrophages","volume":"38","author":"Chen","year":"2018","journal-title":"J Appl Toxicol"},{"issue":"5","key":"10.1016\/j.clinsp.2024.100476_bib0015","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1097\/INF.0000000000003065","article-title":"Application of a pneumococcal serotype-specific urinary antigen detection test for identification of pediatric pneumonia in burkina faso","volume":"40","author":"Bountogo","year":"2021","journal-title":"Pediatr Infect Dis J"},{"issue":"2","key":"10.1016\/j.clinsp.2024.100476_bib0016","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/ppul.25760","article-title":"Pediatric pneumonia (PedPne) lung ultrasound score and inflammatory markers: a pilot study","volume":"57","author":"Ciuca","year":"2022","journal-title":"Pediatr Pulmonol"},{"issue":"9","key":"10.1016\/j.clinsp.2024.100476_bib0017","article-title":"The effect of N-acetylcysteine and working memory training on glutamate concentrations in the dACC and rACC in regular cocaine users \u2013 A randomized proof of concept study","volume":"25","author":"Schulte","year":"2021","journal-title":"Neurosci Lett"},{"issue":"3","key":"10.1016\/j.clinsp.2024.100476_bib0018","first-page":"36468","article-title":"Effects of ambroxol hydrochloride on lung tissue cell apoptosis and vascular remodeling in rats with smoke induced chronic obstructive pulmonary disease","volume":"74","author":"Xie","year":"2021","journal-title":"Indian J Pharm Sci"},{"issue":"3","key":"10.1016\/j.clinsp.2024.100476_bib0019","article-title":"Probing host-guest inclusion complexes of ambroxol hydrochloride with \u03b1- & \u03b2-Cyclodextrins by physicochemical contrivance subsequently optimized by molecular modeling simulations","volume":"748","author":"Roy","year":"2020","journal-title":"Chem Phys Lett"},{"issue":"8","key":"10.1016\/j.clinsp.2024.100476_bib0020","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.201900130","article-title":"Scaffolds for sustained release of ambroxol hydrochloride, a pharmacological chaperone that increases the activity of misfolded \u03b2-glucocerebrosidase","volume":"19","author":"Enshaei","year":"2019","journal-title":"Macromol Biosci"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593224001534?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593224001534?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T04:41:42Z","timestamp":1735792902000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593224001534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":20,"alternative-id":["S1807593224001534"],"URL":"https:\/\/doi.org\/10.1016\/j.clinsp.2024.100476","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of N-Acetylcysteine combined with Ambroxol Hydrochloride on clinical symptoms, CRP, and PCT in children with pneumonia","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinsp.2024.100476","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 HCFMUSP. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"100476"}}