{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:06:57Z","timestamp":1793747217695,"version":"4.6.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":281,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.clinsp.2024.100520","type":"journal-article","created":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T16:38:50Z","timestamp":1729355930000},"page":"100520","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["The role of metabolic factors in the association between obesity and cholelithiasis: A two-step, two-sample multivariable mendelian randomization study"],"prefix":"10.1016","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3253-1136","authenticated-orcid":false,"given":"Xiangrong","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3048-8460","authenticated-orcid":false,"given":"Jiawei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6500-0706","authenticated-orcid":false,"given":"Jun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0395-7133","authenticated-orcid":false,"given":"Ruiwen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6629-6068","authenticated-orcid":false,"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinsp.2024.100520_bib0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-319-48382-5_1","article-title":"The definition and prevalence of obesity and metabolic syndrome","volume":"960","author":"Engin","year":"2017","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.clinsp.2024.100520_bib0002","doi-asserted-by":"crossref","first-page":"29937","DOI":"10.1038\/srep29937","article-title":"The association between gallstones and metabolic syndrome in urban Han Chinese: a longitudinal cohort study","volume":"6","author":"Zhu","year":"2016","journal-title":"Sci Rep"},{"issue":"9468","key":"10.1016\/j.clinsp.2024.100520_bib0003","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S0140-6736(05)66378-7","article-title":"The metabolic syndrome","volume":"365","author":"Eckel","year":"2005","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.clinsp.2024.100520_bib0004","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1002\/hep.26563","article-title":"Elevated body mass index as a risk factor for symptomatic gallstone disease: a Mendelian randomization study","volume":"58","author":"Stender","year":"2013","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.clinsp.2024.100520_bib0005","first-page":"65","article-title":"Levels of serum leptin, cholecystokinin, plasma lipid and lipoprotein differ between patients with gallstone or\/and those with hepatolithiasis","volume":"7","author":"Lei","year":"2008","journal-title":"Hepatobiliary Pancreat Dis Int"},{"issue":"14","key":"10.1016\/j.clinsp.2024.100520_bib0006","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.3748\/wjg.v18.i14.1652","article-title":"A population-based cohort study of symptomatic gallstone disease in diabetic patients","volume":"18","author":"Liu","year":"2012","journal-title":"World J Gastroenterol"},{"issue":"3","key":"10.1016\/j.clinsp.2024.100520_bib0007","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/jmwh.12959","article-title":"Cholelithiasis: presentation and Management","volume":"64","author":"Littlefield","year":"2019","journal-title":"J Midwifery Womens Health"},{"issue":"11","key":"10.1016\/j.clinsp.2024.100520_bib0008","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007081","article-title":"Orienting the relationship between imprecisely measured traits using GWAS summary data [published correction appears in PLoS Genet","volume":"13","author":"Hemani","year":"2017","journal-title":"PLoS Genet"},{"issue":"18","key":"10.1016\/j.clinsp.2024.100520_bib0009","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1136\/heartjnl-2016-310605","article-title":"Mendelian randomisation in cardiovascular research: an introduction for clinicians","volume":"103","author":"Bennett","year":"2017","journal-title":"Heart"},{"issue":"4","key":"10.1016\/j.clinsp.2024.100520_bib0010","doi-asserted-by":"crossref","first-page":"e00170","DOI":"10.14309\/ctg.0000000000000170","article-title":"The association between cholecystectomy, metabolic syndrome, and nonalcoholic fatty liver disease: a population-based study","volume":"11","author":"Latenstein","year":"2020","journal-title":"Clin Transl Gastroenterol"},{"issue":"21\u201322","key":"10.1016\/j.clinsp.2024.100520_bib0011","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.cca.2010.08.003","article-title":"Triglycerides and gallstone formation","volume":"411","author":"Smelt","year":"2010","journal-title":"Clin Chim Acta"},{"issue":"7","key":"10.1016\/j.clinsp.2024.100520_bib0012","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/gepi.21998","article-title":"Bias due to participant overlap in two-sample Mendelian randomization","volume":"40","author":"Burgess","year":"2016","journal-title":"Genet Epidemiol"},{"issue":"1","key":"10.1016\/j.clinsp.2024.100520_bib0013","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/ije\/dyh132","article-title":"Mendelian randomization: prospects, potentials, and limitations","volume":"33","author":"Smith","year":"2004","journal-title":"Int J Epidemiol"},{"issue":"6","key":"10.1016\/j.clinsp.2024.100520_bib0014","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1002\/hep.26563","article-title":"Elevated body mass index as a risk factor for symptomatic gallstone disease: a Mendelian randomization study","volume":"58","author":"Stender","year":"2013","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.clinsp.2024.100520_bib0015","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/aje\/kwu283","article-title":"Multivariable Mendelian randomization: the use of pleiotropic genetic variants to estimate effects","volume":"181","author":"Burgess","year":"2015","journal-title":"Am J Epidemiol"},{"issue":"1","key":"10.1016\/j.clinsp.2024.100520_bib0016","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12876-019-1032-y","article-title":"Strong association between metabolically-abnormal obesity and gallstone disease in adults under 50\u2009years","volume":"19","author":"Su","year":"2019","journal-title":"BMC Gastroenterol"},{"issue":"2","key":"10.1016\/j.clinsp.2024.100520_bib0017","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1002\/hep.30403","article-title":"Gallstone Disease and Type 2 Diabetes Risk: a Mendelian Randomization Study","volume":"70","author":"Wang","year":"2019","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.clinsp.2024.100520_bib0018","doi-asserted-by":"crossref","first-page":"e529","DOI":"10.1016\/j.cgh.2020.12.034","article-title":"Obesity, Type 2 diabetes, lifestyle factors, and risk of gallstone disease: a mendelian randomization investigation","volume":"20","author":"Yuan","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"5","key":"10.1016\/j.clinsp.2024.100520_bib0019","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1002\/oby.23722","article-title":"Causal effect of adiposity on the risk of 19 gastrointestinal diseases: a Mendelian randomization study","volume":"31","author":"Kim","year":"2023","journal-title":"Obesity (Silver Spring)"},{"issue":"3","key":"10.1016\/j.clinsp.2024.100520_bib0020","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/ajcn\/nqaa154","article-title":"A healthy lifestyle pattern and the risk of symptomatic gallstone disease: results from 2 prospective cohort studies","volume":"112","author":"Wirth","year":"2020","journal-title":"Am J Clin Nutr."},{"issue":"3","key":"10.1016\/j.clinsp.2024.100520_bib0021","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/jmwh.12959","article-title":"Cholelithiasis: presentation and management","volume":"64","author":"Littlefield","year":"2019","journal-title":"J Midwifery Womens Health"},{"issue":"8","key":"10.1016\/j.clinsp.2024.100520_bib0022","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1002\/oby.23802","article-title":"Weight discrimination, BMI, or weight bias internalization? Testing the best predictor of psychological distress and body dissatisfaction","volume":"31","author":"Macho","year":"2023","journal-title":"Obesity (Silver Spring)"},{"issue":"4","key":"10.1016\/j.clinsp.2024.100520_bib0023","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/hep.32183","article-title":"Insights into modifiable risk factors of cholelithiasis: a Mendelian randomization study","volume":"75","author":"Chen","year":"2022","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.clinsp.2024.100520_bib0024","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/hep.30313","article-title":"Identification and replication of six loci associated with gallstone disease","volume":"70","author":"Gellert-Kristensen","year":"2019","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.clinsp.2024.100520_bib0025","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/ijo.2017.231","article-title":"Triglycerides cross the blood-brain barrier and induce central leptin and insulin receptor resistance","volume":"42","author":"Banks","year":"2018","journal-title":"Int J Obes (Lond)"},{"issue":"5","key":"10.1016\/j.clinsp.2024.100520_bib0026","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1002\/oby.23722","article-title":"Causal effect of adiposity on the risk of 19 gastrointestinal diseases: a Mendelian randomization study","volume":"31","author":"Kim","year":"2023","journal-title":"Obesity (Silver Spring)"},{"issue":"6","key":"10.1016\/j.clinsp.2024.100520_bib0027","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s11894-020-00765-3","article-title":"Management of hepatolithiasis: review of the literature","volume":"22","author":"Lorio","year":"2020","journal-title":"Curr Gastroenterol Rep"},{"key":"10.1016\/j.clinsp.2024.100520_bib0028","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/B978-0-12-820683-6.00022-1","article-title":"Monogenic human obesity syndromes","volume":"181","author":"Farooqi","year":"2021","journal-title":"Handb Clin Neurol"},{"issue":"12","key":"10.1016\/j.clinsp.2024.100520_bib0029","doi-asserted-by":"crossref","first-page":"3524","DOI":"10.1111\/jgh.15568","article-title":"Association between metabolic syndrome and incidence of cholelithiasis in the Korean population","volume":"36","author":"Kim","year":"2021","journal-title":"J Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.clinsp.2024.100520_bib0030","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ecl.2022.02.008","article-title":"Lipid and lipoprotein metabolism","volume":"51","author":"Feingold","year":"2022","journal-title":"Endocrinol Metab Clin North Am"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593224001972?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593224001972?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T04:46:55Z","timestamp":1735793215000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593224001972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":30,"alternative-id":["S1807593224001972"],"URL":"https:\/\/doi.org\/10.1016\/j.clinsp.2024.100520","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of metabolic factors in the association between obesity and cholelithiasis: A two-step, two-sample multivariable mendelian randomization study","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinsp.2024.100520","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Espa\u00f1a, S.L.U. on behalf of HCFMUSP.","name":"copyright","label":"Copyright"}],"article-number":"100520"}}