{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:56:18Z","timestamp":1790715378984,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:00:00Z","timestamp":1743379200000},"content-version":"vor","delay-in-days":89,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005640","name":"FMUSP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005640","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.clinsp.2025.100642","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:45:16Z","timestamp":1745426716000},"page":"100642","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["LBP and iFABP mismatch in the evaluation of intestinal barrier dysfunction due to SARS-CoV-2 infection"],"prefix":"10.1016","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8209-4463","authenticated-orcid":false,"given":"Hermes Vieira","family":"Barbeiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6802-8120","authenticated-orcid":false,"given":"Denise Frediani","family":"Barbeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3256-0830","authenticated-orcid":false,"given":"Heraldo Possolo","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4898-0135","authenticated-orcid":false,"given":"Francisco Garcia","family":"Soriano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0729-1635","authenticated-orcid":false,"given":"Marcel Cerqueira","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5645-2055","authenticated-orcid":false,"given":"Ludhmila Abrah\u00e3o","family":"Hajjar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"25","key":"10.1016\/j.clinsp.2025.100642_bib0001","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1056\/NEJMcp2009575","article-title":"Severe COVID-19","volume":"383","author":"Berlin","year":"2020","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.clinsp.2025.100642_bib0002","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41577-020-0331-4","article-title":"Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages","volume":"20","author":"Merad","year":"2020","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"10.1016\/j.clinsp.2025.100642_bib0003","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/emp2.12219","article-title":"First-attempt intubation success and complications in patients with COVID-19 undergoing emergency intubation","volume":"1","author":"de Alencar","year":"2020","journal-title":"J Am Coll Emerg Physicians Open"},{"key":"10.1016\/j.clinsp.2025.100642_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2021.104303","article-title":"Endothelial injury in COVID-19 and septic patients","volume":"140","author":"Hokama","year":"2022","journal-title":"Microvasc Res"},{"issue":"Suppl E","key":"10.1016\/j.clinsp.2025.100642_bib0005","doi-asserted-by":"crossref","first-page":"E95","DOI":"10.1093\/eurheartj\/suab100","article-title":"Coagulopathy and COVID-19","volume":"23","author":"Lorini","year":"2021","journal-title":"Eur Heart J Suppl"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100642_bib0006","article-title":"COVID-19-associated acute kidney injury patients treated with renal replacement therapy in the intensive care unit: a multicenter study in S\u00e3o Paulo","volume":"17","author":"Samaan","year":"2022","journal-title":"Brazil. PLoS One."},{"issue":"1","key":"10.1016\/j.clinsp.2025.100642_bib0007","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12872-022-02534-8","article-title":"Cardiovascular disturbances in COVID-19: an updated review of the pathophysiology and clinical evidence of cardiovascular damage induced by SARS-CoV-2","volume":"22","author":"Lawal","year":"2022","journal-title":"BMC Cardiovasc Disord"},{"issue":"10","key":"10.1016\/j.clinsp.2025.100642_bib0008","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1038\/s41591-020-1051-9","article-title":"An inflammatory cytokine signature predicts COVID-19 severity and survival","volume":"26","author":"Del Valle","year":"2020","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100642_bib0009","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13054-020-03399-z","article-title":"SARS-CoV-2 pneumonia-receptor binding and lung immunopathology: a narrative review","volume":"25","author":"Menezes","year":"2021","journal-title":"Crit Care"},{"issue":"5","key":"10.1016\/j.clinsp.2025.100642_bib0010","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.healun.2020.03.012","article-title":"COVID-19 illness in native and immunosuppressed states: a clinical-therapeutic staging proposal","volume":"39","author":"Siddiqi","year":"2020","journal-title":"J Heart Lung Transplant"},{"issue":"6","key":"10.1016\/j.clinsp.2025.100642_bib0011","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41577-020-0311-8","article-title":"The trinity of COVID-19: immunity, inflammation and intervention","volume":"20","author":"Tay","year":"2020","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"10.1016\/j.clinsp.2025.100642_bib0012","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.immuni.2020.05.002","article-title":"Sinai Immunology Review Project. Immunology of COVID-19: current State of the science","volume":"52","author":"Vabret","year":"2020","journal-title":"Immunity"},{"issue":"8","key":"10.1016\/j.clinsp.2025.100642_bib0013","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.scib.2020.11.015","article-title":"SARS-CoV-2 induced intestinal responses with a biomimetic human gut-on-chip","volume":"66","author":"Guo","year":"2021","journal-title":"Sci Bull (Beijing)"},{"issue":"2","key":"10.1016\/j.clinsp.2025.100642_bib0014","first-page":"97","article-title":"The aging bowel dysfunction and elderly vulnerability towards COVID-19 infection","volume":"11","author":"Lerner","year":"2021","journal-title":"Life (Basel)"},{"issue":"10","key":"10.1016\/j.clinsp.2025.100642_bib0015","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1136\/gut.2005.085373","article-title":"Alterations in intestinal permeability","volume":"55","author":"Arrieta","year":"2006","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.clinsp.2025.100642_bib0016","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1097\/SLA.0b013e31824b1e16","article-title":"Circulating intestinal fatty acid-binding protein as an early marker of intestinal necrosis after aortic surgery: a prospective observational cohort study","volume":"255","author":"Vermeulen","year":"2012","journal-title":"Ann Surg"},{"issue":"6","key":"10.1016\/j.clinsp.2025.100642_bib0017","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1186\/cc11653","article-title":"Circulating fatty acid binding protein as a marker of intestinal failure in septic patients","volume":"16","author":"Machado","year":"2012","journal-title":"Crit Care"},{"key":"10.1016\/j.clinsp.2025.100642_bib0018","doi-asserted-by":"crossref","first-page":"G367","DOI":"10.1152\/ajpgi.00173.2003","article-title":"TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation","volume":"286","author":"Ma","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"4","key":"10.1016\/j.clinsp.2025.100642_bib0019","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.21873\/invivo.12528","article-title":"Intestinal barrier biomarker ZO1 and endotoxin are increased in blood of patients with COVID-19-associated pneumonia","volume":"35","author":"Assimakopoulos","year":"2021","journal-title":"In Vivo (Brooklyn)"},{"issue":"2","key":"10.1016\/j.clinsp.2025.100642_bib0020","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/jgh.15166","article-title":"Diarrhea and altered inflammatory cytokine pattern in severe coronavirus disease 2019: impact on disease course and in-hospital mortality","volume":"36","author":"Zhang","year":"2021","journal-title":"J Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100642_bib0021","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1177\/1074248415581176","article-title":"Intestinal barrier dysfunction: a novel therapeutic target for inflammatory response in acute Stanford type A aortic dissection","volume":"21","author":"Gu","year":"2016","journal-title":"J Cardiovas Pharmacol Ther"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100642_bib0022","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/00000658-196607000-00002","article-title":"Biosynthesis of intestinal mucin in shock: relationship to tryptic hemorrhagic enteritis and permeability to curare","volume":"164","author":"Bounous","year":"1966","journal-title":"Ann Surg"},{"issue":"4","key":"10.1016\/j.clinsp.2025.100642_bib0023","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0022-4804(73)90032-2","article-title":"Intestinal barrier function in hemorrhagic shock","volume":"14","author":"Rhodes","year":"1973","journal-title":"J Surg Res"},{"issue":"3","key":"10.1016\/j.clinsp.2025.100642_bib0024","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1001\/archsurg.1990.01410150125024","article-title":"The role of intestinal barrier failure and bacterial translocation in the development of systemic infection and multiple organ failure","volume":"125","author":"Deitch","year":"1990","journal-title":"Arch Surg"},{"issue":"5","key":"10.1016\/j.clinsp.2025.100642_bib0025","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1097\/SLA.0b013e3181bce5bd","article-title":"Dutch Acute Pancreatitis Study Group. Intestinal barrier dysfunction in a randomized trial of a specific probiotic composition in acute pancreatitis","volume":"250","author":"Besselink","year":"2009","journal-title":"Ann Surg"},{"issue":"4","key":"10.1016\/j.clinsp.2025.100642_bib0026","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/joim.13178","article-title":"Elevated markers of gut leakage and inflammasome activation in COVID-19 patients with cardiac involvement","volume":"289","author":"Hoel","year":"2021","journal-title":"J Intern Med"},{"issue":"8","key":"10.1016\/j.clinsp.2025.100642_bib0027","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1097\/MPA.0b013e3182a85af3","article-title":"A population-based study of severity in patients with acute on chronic pancreatitis","volume":"42","author":"Akshintala","year":"2013","journal-title":"Pancreas"},{"issue":"6","key":"10.1016\/j.clinsp.2025.100642_bib0028","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s11605-007-0164-5","article-title":"Co-morbidity is a strong predictor of early death and multi-organ system failure among patients with acute pancreatitis","volume":"11","author":"Frey","year":"2007","journal-title":"J Gastrointestinal Surg"},{"issue":"5","key":"10.1016\/j.clinsp.2025.100642_bib0029","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/bjs.1800750520","article-title":"Influence of age on the mortality from acute pancreatitis","volume":"75","author":"Fan","year":"1988","journal-title":"Br J Surg"},{"issue":"10","key":"10.1016\/j.clinsp.2025.100642_bib0030","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1007\/s00595-008-3766-y","article-title":"Remodeling of the immunoinflammatory network system in elderly cancer patients: implications of inflamm-aging and tumor-specific hyperinflammation","volume":"38","author":"Miki","year":"2008","journal-title":"Surg Today"},{"issue":"5","key":"10.1016\/j.clinsp.2025.100642_bib0031","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.pan.2019.06.005","article-title":"D'Albuquerque LAC. Local and systemic effects of aging on acute pancreatitis","volume":"19","author":"Coelho","year":"2019","journal-title":"Pancreatology"},{"issue":"3","key":"10.1016\/j.clinsp.2025.100642_bib0032","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1001\/archsurg.1990.01410150125024","article-title":"The role of intestinal barrier failure and bacterial translocation in the development of systemic infection and multiple organ failure","volume":"125","author":"Deitch","year":"1990","journal-title":"Arch Surg"},{"issue":"3","key":"10.1016\/j.clinsp.2025.100642_bib0033","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1097\/CCM.0b013e3181968f3a","article-title":"Effects of aging on the immunopathologic response to sepsis","volume":"37","author":"Turnbull","year":"2009","journal-title":"Critic Care Med"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100642_bib0034","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.pan.2015.10.012","article-title":"Intestinal barrier dysfunction and increased COX-2 gene expression in the gut of elderly rats with acute pancreatitis","volume":"16","author":"Barbeiro","year":"2016","journal-title":"Pancreatology"},{"issue":"2","key":"10.1016\/j.clinsp.2025.100642_bib0035","first-page":"97","article-title":"The aging bowel dysfunction and elderly vulnerability towards COVID-19 infection","volume":"11","author":"Lerner","year":"2021","journal-title":"Life (Basel)"},{"issue":"5","key":"10.1016\/j.clinsp.2025.100642_bib0036","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.3390\/microorganisms10051050","article-title":"SARS CoV-2-induced viral sepsis: the role of gut barrier dysfunction","volume":"10","author":"Assimakopoulos","year":"2022","journal-title":"Microorganisms"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593225000687?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593225000687?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:57:30Z","timestamp":1790711850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593225000687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":36,"alternative-id":["S1807593225000687"],"URL":"https:\/\/doi.org\/10.1016\/j.clinsp.2025.100642","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LBP and iFABP mismatch in the evaluation of intestinal barrier dysfunction due to SARS-CoV-2 infection","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinsp.2025.100642","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 HCFMUSP. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"100642"}}