{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:13:29Z","timestamp":1790712809302,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":182,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.clinsp.2025.100718","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T12:37:11Z","timestamp":1755002231000},"page":"100718","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["hsa_circ_0004276 inhibits osteogenic differentiation of bone marrow mesenchymal stem cells and exacerbates postmenopausal osteoporosis through interaction with ELAVL1"],"prefix":"10.1016","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7219-7338","authenticated-orcid":false,"given":"BaiQuan","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9296-0399","authenticated-orcid":false,"given":"YuXin","family":"Sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7387-7068","authenticated-orcid":false,"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5448-7410","authenticated-orcid":false,"given":"XiaoTian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7806-0888","authenticated-orcid":false,"given":"Hui","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.clinsp.2025.100718_bib0001","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1097\/GRF.0000000000000572","article-title":"Bone health and osteoporosis prevention and treatment","volume":"63","author":"Munoz","year":"2020","journal-title":"Clin Obstet Gynecol"},{"issue":"9","key":"10.1016\/j.clinsp.2025.100718_bib0002","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1097\/GME.0000000000001831","article-title":"Management of osteoporosis in postmenopausal women: the 2021 position statement of The North American Menopause Society","volume":"28","year":"2021","journal-title":"Menopause."},{"issue":"3","key":"10.1016\/j.clinsp.2025.100718_bib0003","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.ecl.2012.04.006","article-title":"Pathophysiology of osteoporosis: new mechanistic insights","volume":"41","author":"Armas","year":"2012","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.clinsp.2025.100718_bib0004","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1154927","article-title":"Low BMI, blood calcium and vitamin D, kyphosis time, and outdoor activity time are independent risk factors for osteoporosis in postmenopausal women","volume":"14","author":"Tang","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"10.1016\/j.clinsp.2025.100718_bib0005","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ecl.2021.03.009","article-title":"Postmenopausal osteoporosis: latest guidelines","volume":"50","author":"Arceo-Mendoza","year":"2021","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"4","key":"10.1016\/j.clinsp.2025.100718_bib0006","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3949\/ccjm.87a.18136","article-title":"To scan or not to scan? DXA in postmenopausal women","volume":"87","author":"DeSapri","year":"2020","journal-title":"Cleve Clin J Med"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100718_bib0007","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ecl.2016.11.001","article-title":"Novel therapies for postmenopausal osteoporosis","volume":"46","author":"Bandeira","year":"2017","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100718_bib0008","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-91248-6","article-title":"Denosumab versus romosozumab for postmenopausal osteoporosis treatment","volume":"11","author":"Kobayakawa","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.clinsp.2025.100718_bib0009","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jsbmb.2013.09.008","article-title":"Prevention and treatment of postmenopausal osteoporosis","volume":"142","author":"Tella","year":"2014","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"9","key":"10.1016\/j.clinsp.2025.100718_bib0010","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1177\/0963689717721201","article-title":"Age-related changes in bone marrow mesenchymal stromal cells: a potential impact on osteoporosis and osteoarthritis development","volume":"26","author":"Ganguly","year":"2017","journal-title":"Cell Transplant"},{"issue":"7","key":"10.1016\/j.clinsp.2025.100718_bib0011","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/cdd.2015.168","article-title":"Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?","volume":"23","author":"Chen","year":"2016","journal-title":"Cell Death Differ"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100718_bib0012","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12956","article-title":"Advances in mesenchymal stem cell transplantation for the treatment of osteoporosis","volume":"54","author":"Jiang","year":"2021","journal-title":"Cell Prolif"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100718_bib0013","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3390\/ijms18010041","article-title":"Osteogenic differentiation in healthy and pathological conditions","volume":"18","author":"Valenti","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"10","key":"10.1016\/j.clinsp.2025.100718_bib0014","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.2174\/1566524023666221025104629","article-title":"Bone marrow stromal stem cell fate decision: a potential mechanism for Bone marrow adipose increase with aging-related osteoporosis","volume":"23","author":"Tian","year":"2023","journal-title":"Curr Mol Med"},{"issue":"16","key":"10.1016\/j.clinsp.2025.100718_bib0015","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2018100836","article-title":"Past, present, and future of circRNAs","volume":"38","author":"Patop","year":"2019","journal-title":"EMBO J"},{"issue":"12","key":"10.1016\/j.clinsp.2025.100718_bib0016","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1016\/j.cell.2022.04.021","article-title":"Circular RNAs: characterization, cellular roles, and applications","volume":"185","author":"Liu","year":"2022","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.clinsp.2025.100718_bib0017","first-page":"3459","article-title":"CircRNA_0048211 protects postmenopausal osteoporosis through targeting miRNA-93-5p to regulate BMP2","volume":"24","author":"Qiao","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.clinsp.2025.100718_bib0018","first-page":"183","article-title":"Dysregulation of circRNA-0076906 and circRNA-0134944 is correlated with susceptibility to osteoporosis and osteoporotic fracture in postmenopausal females from the Chinese Han population","volume":"16","author":"Yang","year":"2023","journal-title":"Pharmgenomics Pers Med"},{"issue":"7","key":"10.1016\/j.clinsp.2025.100718_bib0019","doi-asserted-by":"crossref","first-page":"10275","DOI":"10.18632\/aging.202791","article-title":"CircRNA hsa_circ_0006215 promotes osteogenic differentiation of BMSCs and enhances osteogenesis-angiogenesis coupling by competitively binding to miR-942-5p and regulating RUNX2 and VEGF","volume":"13","author":"Ji","year":"2021","journal-title":"Aging (Albany NY)"},{"issue":"24","key":"10.1016\/j.clinsp.2025.100718_bib0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21249579","article-title":"Effects of PIN on osteoblast differentiation and matrix mineralization through runt-related transcription factor","volume":"21","author":"Park","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.clinsp.2025.100718_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2022.111559","article-title":"ELAV-like RNA binding protein 1 regulates osteogenesis in diabetic osteoporosis: involvement of divalent metal transporter 1","volume":"546","author":"Ren","year":"2022","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.clinsp.2025.100718_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2020.109747","article-title":"CircRNAs and fusion-circRNAs in cancer: new players in an old game","volume":"75","author":"Visci","year":"2020","journal-title":"Cell Signal"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100718_bib0023","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s40659-020-00309-z","article-title":"The roles of miRNA, lncRNA and circRNA in the development of osteoporosis","volume":"53","author":"Yang","year":"2020","journal-title":"Biol Res"},{"key":"10.1016\/j.clinsp.2025.100718_bib0024","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.885650","article-title":"Circular RNAs in diabetes mellitus and its complications","volume":"13","author":"Fan","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"10.1016\/j.clinsp.2025.100718_bib0025","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41418-022-00948-7","article-title":"Specific expression and functions of circular RNAs","volume":"29","author":"Misir","year":"2022","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.clinsp.2025.100718_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114672","article-title":"Mechanisms of circRNA\/lncRNA-miRNA interactions and applications in disease and drug research","volume":"162","author":"Ma","year":"2023","journal-title":"Biomed Pharmacother"},{"issue":"16","key":"10.1016\/j.clinsp.2025.100718_bib0027","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.2217\/bmm-2020-0447","article-title":"Circular RNA hsa_circ_0001445 in plasma as a novel biomarker for osteoporosis in postmenopausal women","volume":"14","author":"Xiang","year":"2020","journal-title":"Biomark Med"},{"key":"10.1016\/j.clinsp.2025.100718_bib0028","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.freeradbiomed.2024.08.014","article-title":"7,8-DHF inhibits BMSC oxidative stress via the TRKB\/PI3K\/AKT\/NRF2 pathway to improve symptoms of postmenopausal osteoporosis","volume":"223","author":"Li","year":"2024","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100718_bib0029","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1186\/s13018-023-03955-7","article-title":"CircZNF367 promotes osteoclast differentiation and osteoporosis by interacting with FUS to maintain CRY2 mRNA stability","volume":"18","author":"Deng","year":"2023","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.clinsp.2025.100718_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176192","article-title":"Circ-Plod2 destabilizes mpo mRNA by binding to IGF2BP2 to promote osteogenic differentiation of bone marrow mesenchymal stem cells","volume":"961","author":"Yao","year":"2023","journal-title":"Eur J Pharmacol"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593225001371?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593225001371?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:46:12Z","timestamp":1790711172000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593225001371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":30,"alternative-id":["S1807593225001371"],"URL":"https:\/\/doi.org\/10.1016\/j.clinsp.2025.100718","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"hsa_circ_0004276 inhibits osteogenic differentiation of bone marrow mesenchymal stem cells and exacerbates postmenopausal osteoporosis through interaction with ELAVL1","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinsp.2025.100718","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 HCFMUSP. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"100718"}}