{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:00:00Z","timestamp":1790715600282,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":191,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.clinsp.2025.100726","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:23:03Z","timestamp":1753867383000},"page":"100726","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Serum uric acid levels and the risk of hemorrhagic stroke: Insights from a two-sample Mendelian randomization study"],"prefix":"10.1016","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8975-3014","authenticated-orcid":false,"given":"Zi-Wen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5820-7585","authenticated-orcid":false,"given":"Fang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7806-1346","authenticated-orcid":false,"given":"Jin-Chao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0809-2865","authenticated-orcid":false,"given":"Dan-Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinsp.2025.100726_bib0001","article-title":"Mortality outcomes in 35,433 patients admitted for acute haemorrhagic stroke in Australia: a population - linkage study","volume":"21","author":"Hsu","year":"2024","journal-title":"Int J Cardiol Cardiovasc Risk Prev"},{"issue":"5","key":"10.1016\/j.clinsp.2025.100726_bib0002","doi-asserted-by":"crossref","first-page":"74","DOI":"10.17116\/oftalma202313905174","article-title":"Sredovye i geneticheskie faktory riska razvitiya pervichnoi otkrytougol'noi glaukomy\u201d [Assessment of environmental and genetic risk factors for the development of primary open-angle glaucoma]","volume":"139","author":"Samoylov","year":"2023","journal-title":"Vestn Oftalmol"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100726_bib0003","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s12640-018-9930-2","article-title":"Serum uric acid is highly associated with epilepsy secondary to cerebral infarction","volume":"35","author":"Wang","year":"2019","journal-title":"Neurotox Res"},{"issue":"12","key":"10.1016\/j.clinsp.2025.100726_bib0004","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1097\/CM9.0000000000002130","article-title":"Effects of secukinumab and adalimumab on serum uric acid level in patients with plaque psoriasis","volume":"135","author":"Zhao","year":"2022","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.clinsp.2025.100726_bib0005","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ijid.2021.12.324","article-title":"Baseline uric acid levels and steady-state favipiravir concentrations are associated with occurrence of hyperuricemia among COVID-19 patients","volume":"115","author":"Koseki","year":"2022","journal-title":"Int J Infect Dis"},{"issue":"3","key":"10.1016\/j.clinsp.2025.100726_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.trre.2023.100775","article-title":"Serum uric acid levels in kidney transplant recipients: a cause for concern? A review of recent literature","volume":"37","author":"Imasuen","year":"2023","journal-title":"Transplant Rev (Orlando)"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100726_bib0007","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1186\/s12872-024-04319-7","article-title":"Assessing the causal associations of atrial fibrillation with serum uric acid level and gout: insights from a bidirectional mendelian randomization study","volume":"24","author":"Zhu","year":"2024","journal-title":"BMC Cardiovasc Disord"},{"issue":"4","key":"10.1016\/j.clinsp.2025.100726_bib0008","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41440-019-0385-5","article-title":"Serum uric acid and risk of stroke and its types: the Circulatory Risk in Communities study (CIRCS)","volume":"43","author":"Li","year":"2020","journal-title":"Hypertens Res"},{"key":"10.1016\/j.clinsp.2025.100726_bib0009","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s43586-021-00092-5","article-title":"Mendelian randomization","volume":"2","author":"Sanderson","year":"2022","journal-title":"Nat Rev Methods Primers"},{"issue":"5","key":"10.1016\/j.clinsp.2025.100726_bib0010","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1177\/1745691610383505","article-title":"Mendelian randomization for strengthening causal inference in observational studies: application to gene \u00d7 environment interactions","volume":"5","author":"Smith","year":"2010","journal-title":"Perspect Psychol Sci"},{"issue":"8","key":"10.1016\/j.clinsp.2025.100726_bib0011","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a040659","article-title":"Triangulating evidence through the inclusion of genetically informed designs","volume":"11","author":"Munaf\u00f2","year":"2021","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"8","key":"10.1016\/j.clinsp.2025.100726_bib0012","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1753-4887.2009.00218.x","article-title":"Mendelian randomization in nutritional epidemiology","volume":"67","author":"Qi","year":"2009","journal-title":"Nutr Rev"},{"issue":"10","key":"10.1016\/j.clinsp.2025.100726_bib0013","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/s41588-021-00931-x","article-title":"A cross-population atlas of genetic associations for 220 human phenotypes","volume":"53","author":"Sakaue","year":"2021","journal-title":"Nat Genet"},{"issue":"D1","key":"10.1016\/j.clinsp.2025.100726_bib0014","doi-asserted-by":"crossref","first-page":"D11","DOI":"10.1093\/nar\/gkab1127","article-title":"The European Bioinformatics Institute (EMBL-EBI) in 2021","volume":"50","author":"Cantelli","year":"2022","journal-title":"Nucleic Acids Res"},{"issue":"20","key":"10.1016\/j.clinsp.2025.100726_bib0015","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1093\/bioinformatics\/btw373","article-title":"PhenoScanner: a database of human genotype-phenotype associations","volume":"32","author":"Staley","year":"2016","journal-title":"Bioinformatics"},{"issue":"19","key":"10.1016\/j.clinsp.2025.100726_bib0016","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1001\/jama.2017.17219","volume":"318","author":"Emdin","year":"2017","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.clinsp.2025.100726_bib0017","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ng.2213","volume":"44","author":"Yang","year":"2012","journal-title":"Nat Genet"},{"issue":"11","key":"10.1016\/j.clinsp.2025.100726_bib0018","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1002\/sim.7221","article-title":"A framework for the investigation of pleiotropy in two-sample summary data mendelian randomization","volume":"36","author":"Bowden","year":"2017","journal-title":"Stat Med"},{"issue":"4","key":"10.1016\/j.clinsp.2025.100726_bib0019","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent estimation in mendelian randomization with some invalid instruments using a weighted median estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet Epidemiol"},{"issue":"2","key":"10.1016\/j.clinsp.2025.100726_bib0020","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol"},{"issue":"3","key":"10.1016\/j.clinsp.2025.100726_bib0021","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1007\/s12035-023-03634-y","article-title":"Serum uric acid levels and outcome of acute ischemic stroke: a dose-response meta-analysis","volume":"61","author":"Zhang","year":"2024","journal-title":"Mol Neurobiol"},{"issue":"5","key":"10.1016\/j.clinsp.2025.100726_bib0022","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1111\/dom.15483","article-title":"Uric acid-lowering effects of sodium-glucose cotransporter 2 inhibitors for preventing cardiovascular events and mortality: a systematic review and meta-analysis","volume":"26","author":"Diallo","year":"2024","journal-title":"Diabetes Obes Metab"},{"issue":"11","key":"10.1016\/j.clinsp.2025.100726_bib0023","doi-asserted-by":"crossref","first-page":"5166","DOI":"10.1007\/s12011-024-04081-z","article-title":"The impact of the high-fructose corn syrup on cardiac damage via SIRT1\/PGC1-\u03b1 pathway: potential ameliorative effect of selenium","volume":"202","author":"\u0130lhan","year":"2024","journal-title":"Biol Trace Elem Res"},{"issue":"3\u20134","key":"10.1016\/j.clinsp.2025.100726_bib0024","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1159\/000345509","article-title":"Uric acid-induced endothelial dysfunction is associated with mitochondrial alterations and decreased intracellular ATP concentrations","volume":"121","author":"S\u00e1nchez-Lozada","year":"2012","journal-title":"Nephron Exp Nephrol"},{"issue":"8","key":"10.1016\/j.clinsp.2025.100726_bib0025","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.3390\/cells12081170","article-title":"Xanthine dehydrogenase is a modulator of dopaminergic neurodegeneration in response to bacterial metabolite exposure in C. elegans","volume":"12","author":"Thies","year":"2023","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.clinsp.2025.100726_bib0026","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1681\/ASN.2016050521","article-title":"Vascular function and uric acid-lowering in stage 3 CKD","volume":"28","author":"Jalal","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.clinsp.2025.100726_bib0027","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1223015","article-title":"Serum uric acid and prognosis in acute ischemic stroke: a dose-response meta-analysis of cohort studies","volume":"15","author":"Zhang","year":"2023","journal-title":"Front Aging Neurosci"},{"issue":"3","key":"10.1016\/j.clinsp.2025.100726_bib0028","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s12264-024-01301-3","article-title":"A new perspective on the prediction and treatment of stroke: the role of Uric acid","volume":"41","author":"Zhu","year":"2025","journal-title":"Neurosci Bull"},{"key":"10.1016\/j.clinsp.2025.100726_bib0029","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2020.609938","article-title":"Uric acid and clinical outcomes among intracerebral hemorrhage patients: results from the China Stroke Center Alliance","volume":"11","author":"Liu","year":"2020","journal-title":"Front Neurol"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100726_bib0030","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/sj.jcbfm.9600312","article-title":"Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke","volume":"27","author":"Romanos","year":"2007","journal-title":"J Cereb Blood Flow Metab"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100726_bib0031","doi-asserted-by":"crossref","first-page":"E3","DOI":"10.3171\/2019.4.FOCUS19221","article-title":"Endothelial dysfunction in cerebral aneurysms","volume":"47","author":"Sheinberg","year":"2019","journal-title":"Neurosurg Focus"},{"issue":"29","key":"10.1016\/j.clinsp.2025.100726_bib0032","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.2174\/1381612033453866","article-title":"Mechanisms of endothelial dysfunction: clinical significance and preventive non-pharmacological therapeutic strategies","volume":"9","author":"Taddei","year":"2003","journal-title":"Curr Pharm Des"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100726_bib0033","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10787-015-0255-y","article-title":"Atherosclerotic cardiovascular disease: a review of initiators and protective factors","volume":"24","author":"Ellulu","year":"2016","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.clinsp.2025.100726_bib0034","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.2147\/DDDT.S343978","article-title":"Carvacrol alleviates hyperuricemia-induced oxidative stress and inflammation by modulating the NLRP3\/NF-\u03bab pathwayt","volume":"16","author":"Riaz","year":"2022","journal-title":"Drug Des Devel Ther"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100726_bib0035","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000534929","article-title":"Impairment of autophagy mediates the uric-acid-induced phenotypic transformation of vascular smooth muscle cells","volume":"109","author":"Lu","year":"2024","journal-title":"Pharmacology"},{"key":"10.1016\/j.clinsp.2025.100726_bib0036","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.expneurol.2013.09.009","article-title":"Extensive vascular remodeling in the spinal cord of pre-symptomatic experimental autoimmune encephalomyelitis mice; increased vessel expression of fibronectin and the \u03b15\u03b21 integrin","volume":"250","author":"Boroujerdi","year":"2013","journal-title":"Exp Neurol"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100726_bib0037","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.yexcr.2019.01.005","article-title":"Translocating transcription factors in fluid shear stress-mediated vascular remodeling and disease","volume":"376","author":"Min","year":"2019","journal-title":"Exp Cell Res"},{"issue":"Pt 2","key":"10.1016\/j.clinsp.2025.100726_bib0038","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.semcancer.2022.03.001","article-title":"Nano-targeting vascular remodeling in cancer: recent developments and future directions","volume":"86","author":"Giordo","year":"2022","journal-title":"Semin Cancer Biol"},{"issue":"11","key":"10.1016\/j.clinsp.2025.100726_bib0039","doi-asserted-by":"crossref","first-page":"E1462","DOI":"10.21037\/jtd.2016.11.39","article-title":"Serum uric acid levels and cardiovascular disease: the gordian knot","volume":"8","author":"Mart\u00ednez-Quintana","year":"2016","journal-title":"J Thorac Dis"},{"key":"10.1016\/j.clinsp.2025.100726_bib0040","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2023.1129435","article-title":"Endothelial cell TRPA1 activity exacerbates cerebral hemorrhage during severe hypertension","volume":"10","author":"Sullivan","year":"2023","journal-title":"Front Mol Biosci"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593225001450?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593225001450?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:02:46Z","timestamp":1790712166000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593225001450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":40,"alternative-id":["S1807593225001450"],"URL":"https:\/\/doi.org\/10.1016\/j.clinsp.2025.100726","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum uric acid levels and the risk of hemorrhagic stroke: Insights from a two-sample Mendelian randomization study","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinsp.2025.100726","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 HCFMUSP. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"100726"}}