{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:12:34Z","timestamp":1790712754909,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":218,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["21JCYBJC01240"],"award-info":[{"award-number":["21JCYBJC01240"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.clinsp.2025.100753","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T08:54:08Z","timestamp":1755939248000},"page":"100753","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Oxycodone attenuates endotoxin-induced acute lung injury by regulating mitophagy via the HO-1 pathway"],"prefix":"10.1016","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4106-2000","authenticated-orcid":false,"given":"Cuicui","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3455-8136","authenticated-orcid":false,"given":"Yanting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2974-5814","authenticated-orcid":false,"given":"Shaona","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6912-6803","authenticated-orcid":false,"given":"Jia","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8762-3670","authenticated-orcid":false,"given":"Pei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9894-1399","authenticated-orcid":false,"given":"Yang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7775-3089","authenticated-orcid":false,"given":"Xiangkun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0530-6749","authenticated-orcid":false,"given":"Jianbo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.clinsp.2025.100753_bib0001","doi-asserted-by":"crossref","first-page":"868","DOI":"10.3892\/mmr.2021.12508","article-title":"Alltrans retinoic acid promotes macrophage phagocytosis and decreases inflammation via inhibiting CD14\/TLR4 in acute lung injury","volume":"24","author":"Li","year":"2021","journal-title":"Mol Med Rep"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100753_bib0002","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s13054-024-04943-x","article-title":"Causes and attributable fraction of death from ARDS in inflammatory phenotypes of sepsis","volume":"28","author":"Evrard","year":"2024","journal-title":"Crit Care"},{"issue":"7","key":"10.1016\/j.clinsp.2025.100753_bib0003","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1001\/jama.2017.21907","article-title":"Acute Respiratory distress syndrome: advances in diagnosis and treatment","volume":"319","author":"Fan","year":"2018","journal-title":"JAMA"},{"issue":"10141","key":"10.1016\/j.clinsp.2025.100753_bib0004","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","article-title":"Sepsis and septic shock","volume":"392","author":"Cecconi","year":"2018","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.clinsp.2025.100753_bib0005","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.ccc.2011.05.006","article-title":"Definition of ALI\/ARDS","volume":"27","author":"Raghavendran","year":"2011","journal-title":"Crit Care Clin"},{"issue":"4","key":"10.1016\/j.clinsp.2025.100753_bib0006","doi-asserted-by":"crossref","first-page":"345","DOI":"10.5858\/arpa.2015-0519-RA","article-title":"Acute Lung Injury: A clinical and molecular review","volume":"140","author":"Butt","year":"2016","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.clinsp.2025.100753_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101954","article-title":"Dexmedetomidine ameliorates endotoxin-induced acute lung injury in vivo and in vitro by preserving mitochondrial dynamic equilibrium through the HIF-1a\/HO-1 signaling pathway","volume":"41","author":"Shi","year":"2021","journal-title":"Redox Biol"},{"issue":"63-75","key":"10.1016\/j.clinsp.2025.100753_bib0008","article-title":"The role of mitophagy in pulmonary sepsis","volume":"59","author":"Mohsin","year":"2021","journal-title":"Mitochondrion"},{"issue":"8","key":"10.1016\/j.clinsp.2025.100753_bib0009","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1093\/jas\/skz219","article-title":"BOARD INVITED REVIEW: oxidative stress and efficiency: the tightrope act of mitochondria in health and disease1,2","volume":"97","author":"Bottje","year":"2019","journal-title":"J Anim Sci"},{"key":"10.1016\/j.clinsp.2025.100753_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2024.105830","article-title":"Chlorantraniliprole induces mitophagy, ferroptosis, and cytokine homeostasis imbalance in grass carp (Ctenopharyngodon idella) hepatocytes via the mtROS-mitochondrial fission\/fusion axis","volume":"200","author":"Shi","year":"2024","journal-title":"Pestic Biochem Physiol"},{"issue":"9","key":"10.1016\/j.clinsp.2025.100753_bib0011","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1080\/15548627.2019.1591672","article-title":"Mitophagy regulates mitochondrial network signaling, oxidative stress, and apoptosis during myoblast differentiation","volume":"15","author":"Baechler","year":"2019","journal-title":"Autophagy"},{"issue":"8","key":"10.1016\/j.clinsp.2025.100753_bib0012","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s00011-021-01481-y","article-title":"Hydrogen alleviates cell damage and acute lung injury in sepsis via PINK1\/Parkin-mediated mitophagy","volume":"70","author":"Chen","year":"2021","journal-title":"Inflamm Res"},{"issue":"4","key":"10.1016\/j.clinsp.2025.100753_bib0013","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14703","article-title":"SIRT3 alleviates painful diabetic neuropathy by mediating the FoxO3a-PINK1-Parkin signaling pathway to activate mitophagy","volume":"30","author":"Yang","year":"2024","journal-title":"CNS Neurosci Ther"},{"issue":"8","key":"10.1016\/j.clinsp.2025.100753_bib0014","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1164\/rccm.201106-1152OC","article-title":"Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis","volume":"185","author":"MacGarvey","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"issue":"48","key":"10.1016\/j.clinsp.2025.100753_bib0015","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.1093\/eurheartj\/ehv544","article-title":"Heme oxygenase-1 suppresses a pro-inflammatory phenotype in monocytes and determines endothelial function and arterial hypertension in mice and humans","volume":"36","author":"Wenzel","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.clinsp.2025.100753_bib0016","article-title":"Effect of Heme Oxygenase-1 on mitofusin-1 protein in LPS-induced ALI\/ARDS in rats","volume":"6","author":"Yu","year":"2016","journal-title":"Sci Rep"},{"issue":"8","key":"10.1016\/j.clinsp.2025.100753_bib0017","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1007\/s00011-023-01769-1","article-title":"5-Methoxytryptophan ameliorates endotoxin-induced acute lung injury in vivo and in vitro by inhibiting NLRP3 inflammasome-mediated pyroptosis through the Nrf2\/HO-1 signaling pathway","volume":"72","author":"Ma","year":"2023","journal-title":"Inflamm Res"},{"issue":"12","key":"10.1016\/j.clinsp.2025.100753_bib0018","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1038\/s41374-019-0286-x","article-title":"PI3K\/Akt pathway-mediated HO-1 induction regulates mitochondrial quality control and attenuates endotoxin-induced acute lung injury","volume":"99","author":"Shi","year":"2019","journal-title":"Lab Invest"},{"issue":"5","key":"10.1016\/j.clinsp.2025.100753_bib0019","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1097\/SHK.0000000000000541","article-title":"Impact of the timing of morphine administration on lipopolysaccharide-mediated lethal endotoxic shock in mice","volume":"45","author":"Fukada","year":"2016","journal-title":"Shock."},{"issue":"5","key":"10.1016\/j.clinsp.2025.100753_bib0020","first-page":"4298","article-title":"Sufentanil attenuates inflammation and oxidative stress in sepsis-induced acute lung injury by downregulating KNG1 expression","volume":"22","author":"Hu","year":"2020","journal-title":"Mol Med Rep"},{"issue":"11","key":"10.1016\/j.clinsp.2025.100753_bib0021","first-page":"6371","article-title":"Oxycodone inhibits myocardial cell apoptosis after myocardial ischemia-reperfusion injury in rats via RhoA\/ROCK1 signaling pathway","volume":"24","author":"Xie","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.clinsp.2025.100753_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2019.146319","article-title":"Oxycodone suppresses the apoptosis of hippocampal neurons induced by oxygen-glucose deprivation\/recovery through caspase-dependent and caspase-independent pathways via kappa- and delta-opioid receptors in rats","volume":"1721","author":"Kong","year":"2019","journal-title":"Brain Res"},{"issue":"155346","key":"10.1016\/j.clinsp.2025.100753_bib0023","article-title":"Oxycodone attenuates vascular leak and lung inflammation in a clinically relevant two-hit rat model of acute lung injury","volume":"138","author":"Li","year":"2021","journal-title":"Cytokine"},{"issue":"9","key":"10.1016\/j.clinsp.2025.100753_bib0024","doi-asserted-by":"crossref","first-page":"e1008","DOI":"10.1002\/iid3.1008","article-title":"Oxycodone alleviates mifepristone-stimulated human endometrial stromal cell injury by activating the Keap1\/Nrf2\/HO-1 signaling pathway","volume":"11","author":"Zhu","year":"2023","journal-title":"Immun Inflamm Dis"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100753_bib0025","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/01.CCM.0000104954.22016.D2","article-title":"Efficacy of partial liquid ventilation in improving acute lung injury induced by intratracheal acidified infant formula: determination of optimal dose and positive end-expiratory pressure level","volume":"32","author":"Mikawa","year":"2004","journal-title":"Crit Care Med"},{"issue":"6","key":"10.1016\/j.clinsp.2025.100753_bib0026","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1093\/humrep\/dem030","article-title":"The expression of polymerase gamma and mitochondrial transcription factor A and the regulation of mitochondrial DNA content in mature human sperm","volume":"22","author":"Amaral","year":"2007","journal-title":"Hum Reprod"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100753_bib0027","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/s12890-023-02585-3","article-title":"Tetramethylpyrazine ameliorates endotoxin-induced acute lung injury by relieving Golgi stress via the Nrf2\/HO-1 signaling pathway","volume":"23","author":"Li","year":"2023","journal-title":"BMC Pulm Med"},{"issue":"6","key":"10.1016\/j.clinsp.2025.100753_bib0028","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1177\/1535370213489487","article-title":"Role of HO-1 in protective effect of electro-acupuncture against endotoxin shock-induced acute lung injury in rabbits","volume":"238","author":"Yu","year":"2013","journal-title":"Exp Biol Med (Maywood)"},{"issue":"3","key":"10.1016\/j.clinsp.2025.100753_bib0029","doi-asserted-by":"crossref","first-page":"5205","DOI":"10.1080\/21655979.2022.2037371","volume":"13","author":"Shao","year":"2022","journal-title":"Bioengineered"},{"issue":"2","key":"10.1016\/j.clinsp.2025.100753_bib0030","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/WNR.0000000000001376","article-title":"Oxycodone suppresses the lipopolysaccharide-induced neuroinflammation by downregulating nuclear factor-kappaB in hippocampal astrocytes of Sprague-Dawley rats","volume":"31","author":"Zhou","year":"2020","journal-title":"Neuroreport"},{"key":"10.1016\/j.clinsp.2025.100753_bib0031","article-title":"Retinal vein occlusion and the risk of acute myocardial infarction development: a 12-year nationwide cohort study","volume":"6","author":"Rim","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.clinsp.2025.100753_bib0032","article-title":"The pharmacology of acute lung injury in sepsis","volume":"2011","author":"Varisco","year":"2011","journal-title":"Adv Pharmacol Sci"},{"issue":"4","key":"10.1016\/j.clinsp.2025.100753_bib0033","doi-asserted-by":"crossref","first-page":"R170","DOI":"10.1016\/j.cub.2018.01.004","article-title":"Mitophagy and quality control mechanisms in mitochondrial maintenance","volume":"28","author":"Pickles","year":"2018","journal-title":"Curr Biol"},{"issue":"5","key":"10.1016\/j.clinsp.2025.100753_bib0034","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.surg.2012.11.021","article-title":"Enhancing autophagy with activated protein C and rapamycin protects against sepsis-induced acute lung injury","volume":"153","author":"Yen","year":"2013","journal-title":"Surgery"},{"key":"10.1016\/j.clinsp.2025.100753_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116337","article-title":"The Janus face of mitophagy in myocardial ischemia\/reperfusion injury and recovery","volume":"173","author":"Deng","year":"2024","journal-title":"Biomed Pharmacother"},{"issue":"24","key":"10.1016\/j.clinsp.2025.100753_bib0036","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022111115","article-title":"BNIP3L\/NIX regulates both mitophagy and pexophagy","volume":"41","author":"Wilhelm","year":"2022","journal-title":"EMBO J"},{"key":"10.1016\/j.clinsp.2025.100753_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119876","article-title":"Mitochondrial dynamics and mitophagy in lung disorders","volume":"284","author":"Sharma","year":"2021","journal-title":"Life Sci"},{"issue":"2","key":"10.1016\/j.clinsp.2025.100753_bib0038","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s11011-022-01077-3","article-title":"The protective effect of inhibiting mitochondrial fission on the juvenile rat brain following PTZ kindling through inhibiting the BCL2L13\/LC3 mitophagy pathway","volume":"38","author":"Fang","year":"2023","journal-title":"Metab Brain Dis"},{"issue":"3","key":"10.1016\/j.clinsp.2025.100753_bib0039","doi-asserted-by":"crossref","first-page":"509","DOI":"10.21037\/cdt-22-468","article-title":"FUNDC1: a key mediator of adenosine A2BR activation-induced inhibition of cardiac mitophagy under ischemia\/reperfusion conditions","volume":"13","author":"Tian","year":"2023","journal-title":"Cardiovasc Diagn Ther."},{"key":"10.1016\/j.clinsp.2025.100753_bib0040","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ceb.2017.03.013","article-title":"PINK1 and Parkin: emerging themes in mitochondrial homeostasis","volume":"45","author":"McWilliams","year":"2017","journal-title":"Curr Opin Cell Biol"},{"issue":"2","key":"10.1016\/j.clinsp.2025.100753_bib0041","doi-asserted-by":"crossref","first-page":"C308","DOI":"10.1152\/ajpcell.00056.2010","article-title":"Mitochondrial degradation by autophagy (mitophagy) in GFP-LC3 transgenic hepatocytes during nutrient deprivation","volume":"300","author":"Kim","year":"2011","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.clinsp.2025.100753_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108439","article-title":"Comparison of morphine, oxycodone and the biased MOR agonist SR-17018 for tolerance and efficacy in mouse models of pain","volume":"185","author":"Pantouli","year":"2021","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.clinsp.2025.100753_bib0043","doi-asserted-by":"crossref","first-page":"9628","DOI":"10.1080\/21655979.2022.2057632","article-title":"Oxycodone protects cardiac microvascular endothelial cells against ischemia\/reperfusion injury by binding to Sigma-1 Receptor","volume":"13","author":"Ji","year":"2022","journal-title":"Bioengineered"},{"issue":"9","key":"10.1016\/j.clinsp.2025.100753_bib0044","doi-asserted-by":"crossref","DOI":"10.1111\/1440-1681.13910","article-title":"Oxycodone attenuates lipopolysaccharide-induced myocardial injury by inhibiting inflammation, oxidation and pyroptosis via Nrf2\/HO-1 signalling pathway","volume":"51","author":"Wang","year":"2024","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"6","key":"10.1016\/j.clinsp.2025.100753_bib0045","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1097\/ALN.0000000000001333","article-title":"Heme oxygenase-1\/carbon monoxide-regulated mitochondrial dynamic equilibrium contributes to the attenuation of endotoxin-induced acute lung injury in rats and in lipopolysaccharide-activated macrophages","volume":"125","author":"Yu","year":"2016","journal-title":"Anesthesiology"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593225001723?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593225001723?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:50:06Z","timestamp":1790711406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593225001723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":45,"alternative-id":["S1807593225001723"],"URL":"https:\/\/doi.org\/10.1016\/j.clinsp.2025.100753","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxycodone attenuates endotoxin-induced acute lung injury by regulating mitophagy via the HO-1 pathway","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinsp.2025.100753","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 HCFMUSP. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"100753"}}