{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T05:31:37Z","timestamp":1794375097713,"version":"4.9.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":250,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.clinsp.2025.100783","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:28:35Z","timestamp":1760545715000},"page":"100783","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Aprepitant and fosaprepitant as a prophylactic antiemetic for preventing postoperative nausea and vomiting after general anaesthesia: a systematic review and meta-analysis"],"prefix":"10.1016","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6271-8718","authenticated-orcid":false,"given":"Thiago Ramos","family":"Grigio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6082-9043","authenticated-orcid":false,"given":"Hans","family":"Timmerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4640-7178","authenticated-orcid":false,"given":"Natanael Pietroski","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2320-4607","authenticated-orcid":false,"given":"Jos\u00e9 Eduardo Guimar\u00e3es","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1732-9083","authenticated-orcid":false,"given":"Angela Maria","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6240-3903","authenticated-orcid":false,"given":"Andr\u00e9 Paul","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.clinsp.2025.100783_bib0001","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.bja.2019.02.007","article-title":"Patient-important outcomes and core outcome sets: increased attention needed!","volume":"122","author":"M\u00f8ller","year":"2019","journal-title":"Br J Anaesth"},{"issue":"5","key":"10.1016\/j.clinsp.2025.100783_bib0002","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1093\/bja\/89.5.760","article-title":"Patient preferences for immediate postoperative recovery","volume":"89","author":"Eberhart","year":"2002","journal-title":"Br J Anaesth"},{"issue":"10","key":"10.1016\/j.clinsp.2025.100783_bib0003","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1111\/anae.16081","article-title":"Olanzapine as an add-on, pre-operative anti-emetic drug for postoperative nausea or vomiting: a randomised controlled trial","volume":"78","author":"Grigio","year":"2023","journal-title":"Anaesthesia"},{"issue":"3","key":"10.1016\/j.clinsp.2025.100783_bib0004","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/00000542-199909000-00022","article-title":"A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers","volume":"91","author":"Apfel","year":"1999","journal-title":"Anesthesiology"},{"issue":"3","key":"10.1016\/j.clinsp.2025.100783_bib0005","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1213\/00000539-199909000-00022","article-title":"Which clinical anesthesia outcomes are important to avoid? The perspective of patients","volume":"89","author":"Macario","year":"1999","journal-title":"Anesth Analg"},{"key":"10.1016\/j.clinsp.2025.100783_bib0006","series-title":"Postoperative Nausea and Vomiting: A Practical Guide","first-page":"1","article-title":"History of postoperative nausea and vomiting","author":"Raeder","year":"2016"},{"issue":"10","key":"10.1016\/j.clinsp.2025.100783_bib0007","article-title":"Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis","volume":"10","author":"Weibel","year":"2020","journal-title":"Cochran Datab Syst Rev"},{"key":"10.1016\/j.clinsp.2025.100783_bib0008","series-title":"FDA Approval of APONVIE\u2122 (HTX-019) For the Prevention of Postoperative Nausea and Vomiting (PONV)","year":"2022"},{"key":"10.1016\/j.clinsp.2025.100783_bib0009","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2147\/CE.S6012","article-title":"Fosaprepitant and aprepitant: an update of the evidence for their place in the prevention of chemotherapy-induced nausea and vomiting","volume":"5","author":"Langford","year":"2010","journal-title":"Core Evid"},{"issue":"7","key":"10.1016\/j.clinsp.2025.100783_bib0010","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1177\/0091270007301800","article-title":"Tolerability of fosaprepitant and bioequivalency to aprepitant in healthy subjects","volume":"47","author":"Lasseter","year":"2007","journal-title":"J Clin Pharmacol"},{"issue":"29","key":"10.1016\/j.clinsp.2025.100783_bib0011","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000034385","article-title":"The efficacy of aprepitant for the prevention of postoperative nausea and vomiting: a meta-analysis","volume":"102","author":"Liu","year":"2023","journal-title":"Medicine"},{"issue":"5","key":"10.1016\/j.clinsp.2025.100783_bib0012","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.bjan.2020.04.005","article-title":"Neurokinin-1 receptor antagonists for postoperative nausea and vomiting: a systematic review and meta-analysis","volume":"70","author":"Murakami","year":"2020","journal-title":"Braz J Anesthesiol"},{"key":"10.1016\/j.clinsp.2025.100783_bib0013","doi-asserted-by":"crossref","first-page":"b2700","DOI":"10.1136\/bmj.b2700","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration","volume":"339","author":"Liberati","year":"2009","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100783_bib0014","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan-a web and mobile app for systematic reviews","volume":"5","author":"Ouzzani","year":"2016","journal-title":"Syst Rev"},{"issue":"11","key":"10.1016\/j.clinsp.2025.100783_bib0015","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.3390\/ijms22115797","article-title":"Mechanisms of nausea and vomiting: current knowledge and recent advances in intracellular emetic signaling systems","volume":"22","author":"Zhong","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.clinsp.2025.100783_bib0016","unstructured":"National Heart LaBI. In."},{"key":"10.1016\/j.clinsp.2025.100783_bib0017","unstructured":"(RevMan) RM. In: the Cochrane Collaboration, 2020."},{"issue":"1","key":"10.1016\/j.clinsp.2025.100783_bib0018","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1186\/s12871-023-02371-y","article-title":"Assessing the impact of aprepitant and ondansetron on postoperative nausea and vomiting in orthognathic surgeries: a randomized controlled trial","volume":"23","author":"Alam","year":"2023","journal-title":"BMC Anesthesiol"},{"key":"10.1016\/j.clinsp.2025.100783_bib0019","first-page":"8","article-title":"Aprepitant to ondansetron in preventing postoperative nausea and vomiting in patients undergoing open cholecystectomy","volume":"35","author":"Alonso-Dami\u00e1n","year":"2012","journal-title":"Revista Mexicana de Anestesiologia"},{"key":"10.1016\/j.clinsp.2025.100783_bib0020","article-title":"A randomized controlled trial for prevention of postoperative nausea and vomiting after laparoscopic sleeve gastrectomy: aprepitant\/Dexamethasone vs. Mirtazapine\/Dexamethasone","volume":"2022","author":"Ashoor","year":"2022","journal-title":"Anesthesiol Res Pract"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100783_bib0021","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s00540-016-2267-1","article-title":"Fosaprepitant versus droperidol for prevention of PONV in craniotomy: a randomized double-blind study","volume":"31","author":"Atsuta","year":"2017","journal-title":"J Anesth"},{"key":"10.1016\/j.clinsp.2025.100783_bib0022","first-page":"29","volume":"3","author":"Bergese","year":"2016","journal-title":"Front Med (Lausanne)"},{"issue":"5","key":"10.1016\/j.clinsp.2025.100783_bib0023","doi-asserted-by":"crossref","first-page":"373","DOI":"10.5152\/TJAR.2018.53179","article-title":"Effect of the Dexamethasone-Ondansetron combination versus dexamethasone-aprepitant combination to prevent postoperative nausea and vomiting","volume":"46","author":"Bilgen","year":"2018","journal-title":"Turk J Anaesthesiol Reanim"},{"key":"10.1016\/j.clinsp.2025.100783_bib0024","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.915347","article-title":"Comparative study between fosaprepitant and palonosetron in the prophylaxis of postoperative nausea and vomiting in women undergoing laparoscopic cholecystectomy: prospective, randomized and double-blind study","volume":"13","author":"Braga","year":"2022","journal-title":"Front Pharmacol"},{"issue":"4","key":"10.1016\/j.clinsp.2025.100783_bib0025","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/aas.13064","article-title":"Aprepitant as a fourth antiemetic prophylactic strategy in high-risk patients: a double-blind, randomized trial","volume":"62","author":"de Morais","year":"2018","journal-title":"Acta Anaesthesiol Scand"},{"issue":"2","key":"10.1016\/j.clinsp.2025.100783_bib0026","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/bja\/aem133","article-title":"Aprepitant-PONV Protocol 091 International Study Group. Single-dose aprepitant vs ondansetron for the prevention of postoperative nausea and vomiting: a randomized, double-blind phase III trial in patients undergoing open abdominal surgery","volume":"99","author":"Diemunsch","year":"2007","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.clinsp.2025.100783_bib0027","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1213\/01.ane.0000263277.35140.a3","article-title":"Aprepitant-PONV Study Group. A randomized, double-blind comparison of the NK1 antagonist, aprepitant, versus ondansetron for the prevention of postoperative nausea and vomiting","volume":"104","author":"Gan","year":"2007","journal-title":"Anesth Analg"},{"key":"10.1016\/j.clinsp.2025.100783_bib0028","doi-asserted-by":"crossref","first-page":"e1688","DOI":"10.6061\/clinics\/2020\/e1688","article-title":"Aprepitant plus palonosetron for the prevention of postoperative nausea and vomiting after breast cancer surgery: a double blind, randomized trial","volume":"75","author":"Grigio","year":"2020","journal-title":"Clinic (Sao Paulo)"},{"issue":"4","key":"10.1016\/j.clinsp.2025.100783_bib0029","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1213\/ANE.0b013e3181ff47e2","article-title":"A comparison of the combination of aprepitant and dexamethasone versus the combination of ondansetron and dexamethasone for the prevention of postoperative nausea and vomiting in patients undergoing craniotomy","volume":"112","author":"Habib","year":"2011","journal-title":"Anesth Analg"},{"issue":"2","key":"10.1016\/j.clinsp.2025.100783_bib0030","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/EJA.0000000000000242","article-title":"Aprepitant for antiemesis after laparoscopic gynaecological surgery: a randomised controlled trial","volume":"33","author":"Ham","year":"2016","journal-title":"Eur J Anaesthesiol"},{"issue":"4","key":"10.1016\/j.clinsp.2025.100783_bib0031","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.bja.2023.06.029","article-title":"Fosaprepitant for postoperative nausea and vomiting in patients undergoing laparoscopic gastrointestinal surgery: a randomised trial","volume":"131","author":"Huang","year":"2023","journal-title":"Br J Anaesth"},{"issue":"4","key":"10.1016\/j.clinsp.2025.100783_bib0032","doi-asserted-by":"crossref","first-page":"289","DOI":"10.4103\/ija.IJA_724_18","article-title":"Comparing the efficacy of aprepitant and ondansetron for the prevention of postoperative nausea and vomiting (PONV): a double blinded, randomised control trial in patients undergoing breast and thyroid surgeries","volume":"63","author":"Jeyabalan","year":"2019","journal-title":"India J Anaesth"},{"issue":"3","key":"10.1016\/j.clinsp.2025.100783_bib0033","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s00540-012-1529-9","article-title":"Oral administration of aprepitant to prevent postoperative nausea in highly susceptible patients after gynecological laparoscopy","volume":"27","author":"Jung","year":"2013","journal-title":"J Anesth"},{"issue":"3\u20134","key":"10.1016\/j.clinsp.2025.100783_bib0034","doi-asserted-by":"crossref","first-page":"246","DOI":"10.2152\/jmi.58.246","article-title":"Neurokinin-1 receptor antagonism, aprepitant, effectively diminishes post-operative nausea and vomiting while increasing analgesic tolerance in laparoscopic gynecological procedures","volume":"58","author":"Kakuta","year":"2011","journal-title":"J Med Invest"},{"issue":"6","key":"10.1016\/j.clinsp.2025.100783_bib0035","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1007\/s00540-015-2054-4","article-title":"The effects of intravenous fosaprepitant and ondansetron in the prevention of postoperative nausea and vomiting in patients who underwent lower limb surgery: a prospective, randomized, double-blind study","volume":"29","author":"Kakuta","year":"2015","journal-title":"J Anesth"},{"key":"10.1016\/j.clinsp.2025.100783_bib0036","first-page":"362","article-title":"Antiemetic efficacy of combined aprepitant and dexamethasone in patients at high-risk of postoperative nausea and vomiting from epidural fentanyl analgesia","volume":"81","author":"Kawano","year":"2015","journal-title":"Minerva Anestesiol"},{"key":"10.1016\/j.clinsp.2025.100783_bib0037","doi-asserted-by":"crossref","first-page":"221","DOI":"10.4097\/kjae.2012.63.3.221","article-title":"The effect of aprepitant for the prevention of postoperative nausea and vomiting in patients undergoing gynecologic surgery with intravenous patient controlled analgesia using fentanyl: aprepitant plus ramosetron vs ramosetron alone","volume":"63","author":"Lee","year":"2012","journal-title":"Korea J Anesthesiol"},{"issue":"3","key":"10.1016\/j.clinsp.2025.100783_bib0038","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4097\/kjae.2013.64.3.212","article-title":"Efficacy of the oral neurokinin-1 receptor antagonist aprepitant administered with ondansetron for the prevention of postoperative nausea and vomiting","volume":"64","author":"Lim","year":"2013","journal-title":"Korea J Anesthesiol"},{"key":"10.1016\/j.clinsp.2025.100783_bib0039","doi-asserted-by":"crossref","first-page":"301","DOI":"10.4236\/ojanes.2014.412043","article-title":"Prevention of postoperative nausea and vomiting in elective hysterectomy: a prospective, randomized, placebo controlled outcomes trial of aprepitant NK-1-receptor antagonist","volume":"4","author":"Long","year":"2014","journal-title":"Open J Anesthesiol"},{"key":"10.1016\/j.clinsp.2025.100783_bib0040","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.53730\/ijhs.v6nS2.6136","article-title":"A comparison of palonosetron and aprepitant for prevention of post operative nausea and vomiting in females undergoing laparoscopic hysterectomy under general anesthesia","author":"Patro","year":"2022","journal-title":"Int J Health Sci"},{"issue":"2","key":"10.1016\/j.clinsp.2025.100783_bib0041","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s11695-013-1065-1","article-title":"Aprepitant's prophylactic efficacy in decreasing postoperative nausea and vomiting in morbidly obese patients undergoing bariatric surgery","volume":"24","author":"Sinha","year":"2014","journal-title":"Obes Surg"},{"issue":"5","key":"10.1016\/j.clinsp.2025.100783_bib0042","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1007\/s00540-015-2006-z","article-title":"Fosaprepitant versus ondansetron for the prevention of postoperative nausea and vomiting in patients who undergo gynecologic abdominal surgery with patient-controlled epidural analgesia: a prospective, randomized, double-blind study","volume":"29","author":"Soga","year":"2015","journal-title":"J Anesth"},{"issue":"6","key":"10.1016\/j.clinsp.2025.100783_bib0043","doi-asserted-by":"crossref","first-page":"465","DOI":"10.4103\/ija.IJA_119_21","article-title":"Effect of combinations of dexamethasone-ondansetron and dexamethasone-ondansetron-aprepitant versus aprepitant alone for early postoperative nausea and vomiting after day care gynaecological laparoscopy: a randomised clinical trial","volume":"65","author":"Thanuja","year":"2021","journal-title":"India J Anaesth"},{"key":"10.1016\/j.clinsp.2025.100783_bib0044","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/307025","article-title":"The effects of intravenous fosaprepitant and ondansetron for the prevention of postoperative nausea and vomiting in neurosurgery patients: a prospective, randomized, double-blinded study","volume":"2014","author":"Tsutsumi","year":"2014","journal-title":"Biomed Res Int"},{"issue":"2","key":"10.1016\/j.clinsp.2025.100783_bib0045","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/PRS.0b013e31822b6932","article-title":"Aprepitant plus ondansetron compared with ondansetron alone in reducing postoperative nausea and vomiting in ambulatory patients undergoing plastic surgery","volume":"129","author":"Vallejo","year":"2012","journal-title":"Plast Reconstr Surg"},{"issue":"12","key":"10.1016\/j.clinsp.2025.100783_bib0046","doi-asserted-by":"crossref","first-page":"582","DOI":"10.53350\/pjmhs20221612582","article-title":"A comparative study between the effects of aprepitant and Ondansetron for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy","volume":"16","author":"Wajid","year":"2022","journal-title":"Pak J Med Health Sci"},{"key":"10.1016\/j.clinsp.2025.100783_bib0047","doi-asserted-by":"crossref","first-page":"256","DOI":"10.17085\/apm.2018.13.3.256","article-title":"Aprepitant prophylaxis effectively reduces preventing postoperative nausea and vomiting in patients receiving opioid based intravenous patient-controlled analgesia","volume":"13","author":"Yeo","year":"2018","journal-title":"Anesth Pain Med"},{"issue":"6","key":"10.1016\/j.clinsp.2025.100783_bib0048","doi-asserted-by":"crossref","first-page":"440","DOI":"10.4097\/kja.d.18.00011","article-title":"Aprepitant in combination with palonosetron for the prevention of postoperative nausea and vomiting in female patients using intravenous patient-controlled analgesia","volume":"71","author":"Yoo","year":"2018","journal-title":"Korea J Anesthesiol"},{"key":"10.1016\/j.clinsp.2025.100783_bib0049","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1471-2253-14-68","article-title":"Palonosetron and aprepitant for the prevention of postoperative nausea and vomiting in patients indicated for laparoscopic gynaecologic surgery: a double-blind randomised trial","volume":"14","author":"Moon","year":"2014","journal-title":"BMC Anesthesiol"},{"issue":"4","key":"10.1016\/j.clinsp.2025.100783_bib0050","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1007\/s11695-024-07129-0","article-title":"The impact of aprepitant on nausea and vomiting following laparoscopic sleeve gastrectomy: a blinded randomized controlled trial","volume":"34","author":"Ortiz","year":"2024","journal-title":"Obes Surg"},{"key":"10.1016\/j.clinsp.2025.100783_bib0051","first-page":"1559","article-title":"A comparison study of the efficacy of oral aprepitant versus intravenous ondansetron in the prevention\/reduction of post-operative nausea and vomiting after elective surgeries done under general anaesthesia","volume":"15","author":"Shivakarmar","year":"2024","journal-title":"J Cardiovasc Dis Res"},{"key":"10.1016\/j.clinsp.2025.100783_bib0052","doi-asserted-by":"crossref","first-page":"187","DOI":"10.56126\/75.3.51","article-title":"Comparison of the effects of Aprepitant and Granisetron in preventing postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic cholecystectomy: a double-blind, randomized, controlled study","volume":"75","author":"G\u00f6kdemir","year":"2024","journal-title":"Acta Anaesthesiol Belgica"},{"issue":"1084","key":"10.1016\/j.clinsp.2025.100783_bib0053","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/postgradmedj-2015-133515","article-title":"Aprepitant for postoperative nausea and vomiting: a systematic review and meta-analysis","volume":"92","author":"Singh","year":"2016","journal-title":"Postgrad Med J"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100783_bib0054","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4103\/joacp.JOACP_464_20","article-title":"NK1 receptor antagonists versus other antiemetics in the prevention of postoperative nausea and vomiting following laparoscopic surgical procedures: a systematic review and meta-analysis","volume":"38","author":"Cavaye","year":"2022","journal-title":"J Anaesthesiol Clin Pharmacol"},{"issue":"19","key":"10.1016\/j.clinsp.2025.100783_bib0055","doi-asserted-by":"crossref","first-page":"e762","DOI":"10.1097\/MD.0000000000000762","article-title":"Neurokinin-1 receptor antagonists in preventing postoperative nausea and vomiting A systematic review and meta-analysis","volume":"94","author":"Liu","year":"2015","journal-title":"Medicine"},{"key":"10.1016\/j.clinsp.2025.100783_bib0056","first-page":"386","article-title":"Efficacy of aprepitant for prevention of postoperative nausea and vomiting. Systematic review and meta-analysis of randomized clinical trials","volume":"27","author":"Valencia","year":"2014","journal-title":"Iatreia"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593225002017?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593225002017?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:49:49Z","timestamp":1790711389000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593225002017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":56,"alternative-id":["S1807593225002017"],"URL":"https:\/\/doi.org\/10.1016\/j.clinsp.2025.100783","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aprepitant and fosaprepitant as a prophylactic antiemetic for preventing postoperative nausea and vomiting after general anaesthesia: a systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinsp.2025.100783","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 HCFMUSP. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"100783"}}