{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T11:29:29Z","timestamp":1793964569789,"version":"4.8.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.clinsp.2025.100816","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T04:26:24Z","timestamp":1770956784000},"page":"100816","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Clinical significance and mechanistic role of Hsa_circ_0005075 in recurrent spontaneous abortion: Regulation of trophoblast proliferation and invasion through the Wnt\/\u03b2-catenin pathway"],"prefix":"10.1016","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7753-0608","authenticated-orcid":false,"given":"Meng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9873-6322","authenticated-orcid":false,"given":"Shuyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0259-560X","authenticated-orcid":false,"given":"Xuan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.clinsp.2025.100816_bib0001","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/OGX.0000000000001033","article-title":"Recent advances in treatment of recurrent spontaneous abortion","volume":"77","author":"Deng","year":"2022","journal-title":"Obstet Gynecol Surv"},{"key":"10.1016\/j.clinsp.2025.100816_bib0002","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.994888","article-title":"Decidual macrophages in recurrent spontaneous abortion","volume":"13","author":"Zhao","year":"2022","journal-title":"Front Immunol"},{"issue":"6","key":"10.1016\/j.clinsp.2025.100816_bib0003","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13631","article-title":"Immunologic deviations in recurrent spontaneous abortion mouse model","volume":"88","author":"Ansariniya","year":"2022","journal-title":"Am J Reprod Immunol"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100816_bib0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/gtmb.2021.0173","article-title":"Has_Circ_0002490 Circular RNA: a potential novel biomarker for lung cancer","volume":"26","author":"Yang","year":"2022","journal-title":"Genet Test Mol Biomarkers"},{"key":"10.1016\/j.clinsp.2025.100816_bib0005","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.12659\/MSM.912801","article-title":"Identification of key circRNAs\/lncRNAs\/miRNAs\/mRNAs and pathways in preeclampsia using bioinformatics analysis","volume":"25","author":"Liu","year":"2019","journal-title":"Med Sci Monit"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100816_bib0006","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40659-021-00337-3","article-title":"The role of circular RNA circ_0008285 in gestational diabetes mellitus by regulating the biological functions of trophoblasts","volume":"54","author":"Chen","year":"2021","journal-title":"Biol Res"},{"issue":"3","key":"10.1016\/j.clinsp.2025.100816_bib0007","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1177\/1724600819872765","article-title":"Hsa_circ_0005075 promotes the proliferation and invasion of colorectal cancer cells","volume":"34","author":"Zhong","year":"2019","journal-title":"Int J Biol Markers"},{"issue":"5","key":"10.1016\/j.clinsp.2025.100816_bib0008","first-page":"2545","article-title":"Effect of circ_0005075 on drug-resistant ovarian cancer cells","volume":"37","author":"Wang","year":"2021","journal-title":"Acta Medica Mediterranea"},{"key":"10.1016\/j.clinsp.2025.100816_bib0009","series-title":"StatPearls. Treasure Island (FL) Ineligible Companies. Disclosure: Suzanne Jenkins Declares no Relevant Financial Relationships With Ineligible companies. Disclosure: Amanda Rapp Declares No Relevant Financial Relationships With Ineligible Companies","article-title":"Early pregnancy loss (spontaneous abortion)","author":"Alves","year":"2024"},{"issue":"12","key":"10.1016\/j.clinsp.2025.100816_bib0010","doi-asserted-by":"crossref","first-page":"21937","DOI":"10.1002\/jcp.28757","article-title":"Circ_0005075 promotes hepatocellular carcinoma progression by suppression of microRNA-335","volume":"234","author":"Yang","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.clinsp.2025.100816_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111721","article-title":"Function of circular RNAs in the pathogenesis of colorectal cancer","volume":"140","author":"Ghafouri-Fard","year":"2021","journal-title":"Biomed Pharmacother"},{"issue":"12","key":"10.1016\/j.clinsp.2025.100816_bib0012","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13139","article-title":"Emerging roles of circular RNAs in neuropathic pain","volume":"54","author":"Xu","year":"2021","journal-title":"Cell Prolif"},{"key":"10.1016\/j.clinsp.2025.100816_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2020.145079","article-title":"Circ_0005075 targeting miR-151a-3p promotes neuropathic pain in CCI rats via inducing NOTCH2 expression","volume":"767","author":"Zhang","year":"2021","journal-title":"Gene"},{"issue":"5","key":"10.1016\/j.clinsp.2025.100816_bib0014","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13615","article-title":"Efficacy of intravenous immunoglobulin in the treatment of recurrent spontaneous abortion: a systematic review and meta-analysis","volume":"88","author":"Shi","year":"2022","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.clinsp.2025.100816_bib0015","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.cca.2021.03.010","article-title":"Circular RNA circ_ABCB10 in cancer","volume":"518","author":"Liu","year":"2021","journal-title":"Clin Chim Acta"},{"issue":"7","key":"10.1016\/j.clinsp.2025.100816_bib0016","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1002\/cam4.1574","article-title":"Circular RNAs in hepatocellular carcinoma: functions and implications","volume":"7","author":"Fu","year":"2018","journal-title":"Cancer Med"},{"issue":"12","key":"10.1016\/j.clinsp.2025.100816_bib0017","doi-asserted-by":"crossref","first-page":"5813","DOI":"10.7150\/thno.58731","article-title":"Extracellular vesicles derived from M1 macrophages deliver miR-146a-5p and miR-146b-5p to suppress trophoblast migration and invasion by targeting TRAF6 in recurrent spontaneous abortion","volume":"11","author":"Ding","year":"2021","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100816_bib0018","first-page":"258","article-title":"Circ_0005075 stimulates the proliferation and metastasis of glioma via downregulating SIRT1","volume":"24","author":"Fang","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"8","key":"10.1016\/j.clinsp.2025.100816_bib0019","first-page":"3311","article-title":"Hsa_circ_0005075 predicts a poor prognosis and acts as an oncogene in colorectal cancer via activating wnt\/beta-catenin pathway","volume":"23","author":"Jin","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"2","key":"10.1016\/j.clinsp.2025.100816_bib0020","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1093\/biolre\/ioad053","article-title":"Ubiquitin-specific protease 7 prevents recurrent spontaneous abortion by targeting enhancer of zeste homolog 2 to regulate trophoblast proliferation, apoptosis, migration, and invasion through the Wnt\/beta-catenin pathwaydagger","volume":"109","author":"Zhou","year":"2023","journal-title":"Biol Reprod"},{"issue":"8","key":"10.1016\/j.clinsp.2025.100816_bib0021","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/cbin.10807","article-title":"Decreased expression of WNT2 in villi of unexplained recurrent spontaneous abortion patients may cause trophoblast cell dysfunction via downregulated wnt\/beta-catenin signaling pathway","volume":"41","author":"Li","year":"2017","journal-title":"Cell Biol Int"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593225002340?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593225002340?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T11:19:55Z","timestamp":1793963995000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593225002340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":21,"alternative-id":["S1807593225002340"],"URL":"https:\/\/doi.org\/10.1016\/j.clinsp.2025.100816","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical significance and mechanistic role of Hsa_circ_0005075 in recurrent spontaneous abortion: Regulation of trophoblast proliferation and invasion through the Wnt\/\u03b2-catenin pathway","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinsp.2025.100816","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 HCFMUSP. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"100816"}}