{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:15:39Z","timestamp":1790712939289,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":307,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.clinsp.2025.100832","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T17:05:10Z","timestamp":1763658310000},"page":"100832","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Sinomenine ameliorates lipopolysaccharide-induced acute lung injury by stimulating M2 polarization and suppressing pyroptosis in alveolar macrophages"],"prefix":"10.1016","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5705-2632","authenticated-orcid":false,"given":"Xiaoli","family":"Jian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9530-5270","authenticated-orcid":false,"given":"Liang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6781-7576","authenticated-orcid":false,"given":"Jiawu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9787-6232","authenticated-orcid":false,"given":"Peilong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9129-1933","authenticated-orcid":false,"given":"Chuxiong","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3630-3747","authenticated-orcid":false,"given":"Qiong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5456-023X","authenticated-orcid":false,"given":"Zhu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9696-7109","authenticated-orcid":false,"given":"Enli","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9469-2788","authenticated-orcid":false,"given":"Tingyun","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1074-4056","authenticated-orcid":false,"given":"Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"16","key":"10.1016\/j.clinsp.2025.100832_bib0001","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMoa050333","article-title":"Incidence and outcomes of acute lung injury","volume":"353","author":"Rubenfeld","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinsp.2025.100832_bib0002","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev-pathol-011110-130158","article-title":"The acute respiratory distress syndrome: pathogenesis and treatment","volume":"6","author":"Matthay","year":"2011","journal-title":"Annu Rev Pathol"},{"issue":"8","key":"10.1016\/j.clinsp.2025.100832_bib0003","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1172\/JCI60331","article-title":"The acute respiratory distress syndrome","volume":"122","author":"Matthay","year":"2012","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.clinsp.2025.100832_bib0004","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s10753-018-0731-9","article-title":"Involvement of alveolar macrophages and neutrophils in acute lung injury after scorpion envenomation: new pharmacological targets","volume":"41","author":"Saidi","year":"2018","journal-title":"Inflammation"},{"issue":"8","key":"10.1016\/j.clinsp.2025.100832_bib0005","doi-asserted-by":"crossref","first-page":"L709","DOI":"10.1152\/ajplung.00341.2013","article-title":"Diverse macrophage populations mediate acute lung inflammation and resolution","volume":"306","author":"Aggarwal","year":"2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"9","key":"10.1016\/j.clinsp.2025.100832_bib0006","doi-asserted-by":"crossref","first-page":"6073","DOI":"10.1002\/jcp.29536","article-title":"Anti-inflammatory effect of octyl gallate in alveolar macrophages cells and mice with acute lung injury","volume":"235","author":"Haute","year":"2020","journal-title":"J Cell Physiol"},{"issue":"2","key":"10.1016\/j.clinsp.2025.100832_bib0007","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nri3600","article-title":"Alveolar macrophages: plasticity in a tissue-specific context","volume":"14","author":"Hussell","year":"2014","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"10.1016\/j.clinsp.2025.100832_bib0008","doi-asserted-by":"crossref","first-page":"L632","DOI":"10.1152\/ajplung.00262.2007","article-title":"Acute lung injury and cell death: how many ways can cells die?","volume":"294","author":"Tang","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"6","key":"10.1016\/j.clinsp.2025.100832_bib0009","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.immuni.2019.04.003","article-title":"Inflammasome activation triggers blood clotting and host death through pyroptosis","volume":"50","author":"Wu","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.clinsp.2025.100832_bib0010","article-title":"Inflammatory caspases drive pyroptosis in acute lung injury","volume":"12","author":"Liu","year":"2021","journal-title":"Front Pharmacol"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100832_bib0011","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12931-018-0756-5","article-title":"Regulation of alveolar macrophage death in acute lung inflammation","volume":"19","author":"Fan","year":"2018","journal-title":"Respir Res"},{"issue":"12","key":"10.1016\/j.clinsp.2025.100832_bib0012","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1055\/s-2008-1081346","article-title":"Sinomenine versus NSAIDs for the treatment of rheumatoid arthritis: a systematic review and meta-analysis","volume":"74","author":"Xu","year":"2008","journal-title":"Planta Med"},{"key":"10.1016\/j.clinsp.2025.100832_bib0013","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.biopha.2018.08.048","article-title":"Sinomenine protects against E.coli-induced acute lung injury in mice through Nrf2-NF-\u03bab pathway","volume":"107","author":"Liu","year":"2018","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"10.1016\/j.clinsp.2025.100832_bib0014","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/jphp.13202","article-title":"Sinomenine attenuates septic-associated lung injury through the Nrf2-Keap1 and autophagy","volume":"72","author":"Wang","year":"2020","journal-title":"J Pharm Pharmacol"},{"issue":"50","key":"10.1016\/j.clinsp.2025.100832_bib0015","doi-asserted-by":"crossref","first-page":"E8151","DOI":"10.1073\/pnas.1614935113","article-title":"TNF\u03b1-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury","volume":"113","author":"Mittal","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.clinsp.2025.100832_bib0016","article-title":"Sinomenine protects against lipopolysaccharide-induced acute lung injury in mice via adenosine A(2A) receptor signaling","volume":"8","author":"Li","year":"2013","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.clinsp.2025.100832_bib0017","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/s41374-018-0073-0","article-title":"NLRP3\/ASC-mediated alveolar macrophage pyroptosis enhances HMGB1 secretion in acute lung injury induced by cardiopulmonary bypass","volume":"98","author":"Hou","year":"2018","journal-title":"Lab Invest"},{"issue":"2","key":"10.1016\/j.clinsp.2025.100832_bib0018","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1006\/pupt.2000.0231","article-title":"Lipopolysaccharide-induced lung injury in mice. I. Concomitant evaluation of inflammatory cells and haemorrhagic lung damage","volume":"13","author":"Asti","year":"2000","journal-title":"Pulm Pharmacol Ther"},{"issue":"2","key":"10.1016\/j.clinsp.2025.100832_bib0019","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20171555","article-title":"Activation of M1 macrophages plays a critical role in the initiation of acute lung injury","volume":"38","author":"Lu","year":"2018","journal-title":"Biosci Rep"},{"key":"10.1016\/j.clinsp.2025.100832_bib0020","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1146\/annurev.immunol.021908.132641","article-title":"Regulation and function of NF-kappaB transcription factors in the immune system","volume":"27","author":"Vallabhapurapu","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.clinsp.2025.100832_bib0021","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.freeradbiomed.2016.01.011","article-title":"Sinomenine activation of Nrf2 signaling prevents hyperactive inflammation and kidney injury in a mouse model of obstructive nephropathy","volume":"92","author":"Qin","year":"2016","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.clinsp.2025.100832_bib0022","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jconrel.2020.04.036","article-title":"Dendrimer mediated targeted delivery of sinomenine for the treatment of acute neuroinflammation in traumatic brain injury","volume":"323","author":"Sharma","year":"2020","journal-title":"J Control Release"},{"issue":"3","key":"10.1016\/j.clinsp.2025.100832_bib0023","doi-asserted-by":"crossref","first-page":"L379","DOI":"10.1152\/ajplung.00010.2008","article-title":"Animal models of acute lung injury","volume":"295","author":"Matute-Bello","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"10","key":"10.1016\/j.clinsp.2025.100832_bib0024","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0078051","article-title":"Bupleurum polysaccharides attenuates lipopolysaccharide-induced inflammation via modulating toll-like receptor 4 signaling","volume":"8","author":"Wu","year":"2013","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.clinsp.2025.100832_bib0025","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.3390\/molecules25122853","article-title":"Epigallocatechin-3-gallate (EGCG), an active compound of green tea attenuates acute lung injury regulating macrophage polarization and kr\u00fcpple-like-factor 4 (KLF4) expression","volume":"25","author":"Almatroodi","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.clinsp.2025.100832_bib0026","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.molimm.2017.12.008","article-title":"The protective effect of dexmedetomidine on LPS-induced acute lung injury through the HMGB1-mediated TLR4\/NF-\u03bab and PI3K\/akt\/mTOR pathways","volume":"94","author":"Meng","year":"2018","journal-title":"Mol Immunol"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100832_bib0027","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s12931-014-0150-x","article-title":"Protective effects of intratracheally administered quercetin on lipopolysaccharide-induced acute lung injury","volume":"15","author":"Takashima","year":"2014","journal-title":"Respir Res"},{"issue":"1","key":"10.1016\/j.clinsp.2025.100832_bib0028","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1165\/rcmb.2008-0202OC","article-title":"Effect of IL-10 on neutrophil recruitment and survival after pseudomonas aeruginosa challenge","volume":"41","author":"Sun","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"10","key":"10.1016\/j.clinsp.2025.100832_bib0029","doi-asserted-by":"crossref","first-page":"L665","DOI":"10.1152\/ajplung.00232.2013","article-title":"Novel concepts of acute lung injury and alveolar-capillary barrier dysfunction","volume":"305","author":"Herold","year":"2013","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.clinsp.2025.100832_bib0030","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3389\/fimmu.2014.00491","article-title":"Macrophage cytokines: involvement in immunity and infectious diseases","volume":"5","author":"Arango Duque","year":"2014","journal-title":"Front Immunol"},{"key":"10.1016\/j.clinsp.2025.100832_bib0031","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jneuroim.2016.08.010","article-title":"Sinomenine enhances microglia M2 polarization and attenuates inflammatory injury in intracerebral hemorrhage","volume":"299","author":"Shi","year":"2016","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.clinsp.2025.100832_bib0032","doi-asserted-by":"crossref","DOI":"10.1177\/20587384211026786","article-title":"C16, a novel sinomenine derivatives, promoted macrophage reprogramming toward M2-like phenotype and protected mice from endotoxemia","volume":"35","author":"Ni","year":"2021","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"4","key":"10.1016\/j.clinsp.2025.100832_bib0033","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/s10753-019-00986-3","article-title":"Sinomenine attenuates cartilage degeneration by regulating miR-223-3p\/NLRP3 inflammasome signaling","volume":"42","author":"Dong","year":"2019","journal-title":"Inflammation"},{"issue":"6","key":"10.1016\/j.clinsp.2025.100832_bib0034","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a001651","article-title":"The nuclear factor NF-kappaB pathway in inflammation","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"2","key":"10.1016\/j.clinsp.2025.100832_bib0035","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1164\/ajrccm.163.2.2004187","article-title":"Nitric oxide and nitrotyrosine in the lungs of patients with acute respiratory distress syndrome","volume":"163","author":"Sittipunt","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.clinsp.2025.100832_bib0036","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3892\/etm.2014.1738","article-title":"Regulatory mechanism of pyrrolidine dithiocarbamate is mediated by nuclear factor-\u03bab and inhibits neutrophil accumulation in ARDS mice","volume":"8","author":"Wang","year":"2014","journal-title":"Exp Ther Med"},{"issue":"2","key":"10.1016\/j.clinsp.2025.100832_bib0037","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3109\/01902148.2014.977461","article-title":"Alveolar NF-\u03bab signaling regulates endotoxin-induced lung inflammation","volume":"41","author":"Lopez","year":"2015","journal-title":"Exp Lung Res"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593225002509?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593225002509?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:54:23Z","timestamp":1790711663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593225002509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":37,"alternative-id":["S1807593225002509"],"URL":"https:\/\/doi.org\/10.1016\/j.clinsp.2025.100832","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sinomenine ameliorates lipopolysaccharide-induced acute lung injury by stimulating M2 polarization and suppressing pyroptosis in alveolar macrophages","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinsp.2025.100832","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 HCFMUSP. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"100832"}}