{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T11:29:32Z","timestamp":1793964572623,"version":"4.8.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["28700"],"award-info":[{"award-number":["28700"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.clinsp.2026.100878","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:45:23Z","timestamp":1771461923000},"page":"100878","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Resveratrol protects against isoflurane-induced testicular injury: a stereological and molecular study in mice"],"prefix":"10.1016","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1695-8475","authenticated-orcid":false,"given":"Zahra","family":"Mohammadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4490-8830","authenticated-orcid":false,"given":"Sanaz","family":"Alaee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0709-4065","authenticated-orcid":false,"given":"Majid Kamali-Dolat","family":"Abadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6256-6550","authenticated-orcid":false,"given":"Somayyeh","family":"Karami-Mohajeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2276-2674","authenticated-orcid":false,"given":"Zahra","family":"Khodabandeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4925-9748","authenticated-orcid":false,"given":"Saeed","family":"Shokri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7893-5282","authenticated-orcid":false,"given":"Sulagna","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1928-5048","authenticated-orcid":false,"given":"Pallav","family":"Sengupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5272-2297","authenticated-orcid":false,"given":"Hesam","family":"Kamyab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinsp.2026.100878_bib0001","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1515\/aiht-2017-68-2941","article-title":"Sevoflurane and isoflurane genotoxicity in kidney cells of mice","volume":"68","author":"Brozovi\u0107","year":"2017","journal-title":"Arh Hig Rada Toksikol"},{"key":"10.1016\/j.clinsp.2026.100878_bib0002","series-title":"Pharmacology and Physiology for Anesthesia","first-page":"44","article-title":"Pharmacokinetics of inhaled anesthetics","author":"Hudson","year":"2019"},{"issue":"1","key":"10.1016\/j.clinsp.2026.100878_bib0003","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/bja\/aer122","article-title":"Are anaesthetics toxic to the brain?","volume":"107","author":"Hudson","year":"2011","journal-title":"Br J Anaesth"},{"issue":"1","key":"10.1016\/j.clinsp.2026.100878_bib0004","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ijheh.2007.09.001","article-title":"Genotoxic effects of anaesthetics in operating theatre personnel evaluated by the comet assay and micronucleus test","volume":"212","author":"Rozgaj","year":"2009","journal-title":"Int J Hyg Environ Health"},{"issue":"3","key":"10.1016\/j.clinsp.2026.100878_bib0005","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.etap.2012.09.020","article-title":"Effects of isoflurane inhalation on the male reproductive system in rats","volume":"34","author":"Xu","year":"2012","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1016\/j.clinsp.2026.100878_bib0006","doi-asserted-by":"crossref","DOI":"10.1177\/09603271241269019","article-title":"The effects of Wharton\u2019s jelly MSCs secretomes for restoring busulfan-induced reproductive toxicity in male mice","volume":"43","author":"Bahmyari","year":"2024","journal-title":"Human Exp Toxicol"},{"key":"10.1016\/j.clinsp.2026.100878_bib0007","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ntt.2016.09.002","article-title":"Carbon monoxide and anesthesia-induced neurotoxicity","volume":"60","author":"Levy","year":"2017","journal-title":"Neurotoxicol Teratol"},{"issue":"4","key":"10.1016\/j.clinsp.2026.100878_bib0008","first-page":"107","article-title":"The impacts of noise pollution on sperm quality and The suggestive mechanisms","volume":"11","author":"Talaei-Khozani","year":"2023","journal-title":"J Infertil Reprod Biol"},{"issue":"1","key":"10.1016\/j.clinsp.2026.100878_bib0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18502\/jirb.v13i1.18779","article-title":"Sleep and circadian rhythm association with sperm head defects in infertile males","volume":"13","author":"Garg","year":"2025","journal-title":"J Infertil Reprod Biol"},{"issue":"5\u20136","key":"10.1016\/j.clinsp.2026.100878_bib0010","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1177\/07482337251335541","article-title":"Taurine alleviated acrylamide-induced ovarian toxicity via suppression of oxidative stress and apoptosis in mice","volume":"41","author":"Khodabandeh","year":"2025","journal-title":"Toxicol Ind Health"},{"issue":"3","key":"10.1016\/j.clinsp.2026.100878_bib0011","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3390\/biochem1030011","article-title":"Natural products as protective agents for male fertility","volume":"1","author":"Martins","year":"2021","journal-title":"BioChem"},{"issue":"7","key":"10.1016\/j.clinsp.2026.100878_bib0012","doi-asserted-by":"crossref","DOI":"10.1002\/fsn3.70638","article-title":"Protective effects of gallic acid against lead acetate-induced toxicity in mice ovary: focus on apoptosis, inflammation, and folliculogenesis","volume":"13","author":"Zahedi","year":"2025","journal-title":"Food Sci Nutr"},{"key":"10.1016\/j.clinsp.2026.100878_bib0013","article-title":"Plant-based bioactives and oxidative stress in reproduction: anti-inflammatory and metabolic protection mechanisms","volume":"12","author":"Liu","year":"2025","journal-title":"Front Nutr"},{"key":"10.1016\/j.clinsp.2026.100878_bib0014","first-page":"130","article-title":"Dose-dependent effect of garlic (Allium sativum) extract feeding on semen characteristics and testes in wistar rats","volume":"9","author":"Emokpae","year":"2021","journal-title":"J Infert Reprod Biol"},{"issue":"3","key":"10.1016\/j.clinsp.2026.100878_bib0015","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1007\/s12013-024-01398-3","article-title":"Effect of sunset yellow on testis: molecular evaluation, and protective role of Coenzyme Q10 in male sprague-dawley rats","volume":"82","author":"Dara","year":"2024","journal-title":"Cell Biochem Biophys"},{"issue":"4","key":"10.1016\/j.clinsp.2026.100878_bib0016","doi-asserted-by":"crossref","first-page":"R189","DOI":"10.1530\/REP-19-0452","article-title":"Impact of oxidative stress on male and female germ cells: implications for fertility","volume":"59","author":"Aitken","year":"2020","journal-title":"Reproduction"},{"key":"10.1016\/j.clinsp.2026.100878_bib0017","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/837042","article-title":"Properties of resveratrol: in vitro and in vivo studies about metabolism, bioavailability, and biological effects in animal models and humans","volume":"2015","author":"Gambini","year":"2015","journal-title":"Oxid Med Cell Longev"},{"issue":"3","key":"10.1016\/j.clinsp.2026.100878_bib0018","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3390\/nu10030329","article-title":"Resveratrol in patients with minimal hepatic encephalopathy","volume":"10","author":"Malaguarnera","year":"2018","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.clinsp.2026.100878_bib0019","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/biof.1399","article-title":"Role of resveratrol in regulation of cellular defense systems against oxidative stress","volume":"44","author":"Truong","year":"2018","journal-title":"Biofactors"},{"issue":"7","key":"10.1016\/j.clinsp.2026.100878_bib0020","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0006-2952(99)00380-9","article-title":"Effect of resveratrol, a natural polyphenolic compound, on reactive oxygen species and prostaglandin production","volume":"59","author":"Martinez","year":"2000","journal-title":"Biochem Pharmacol"},{"issue":"2","key":"10.1016\/j.clinsp.2026.100878_bib0021","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.reprotox.2010.11.010","article-title":"Effect of trans-resveratrol on induced oxidative stress in human sperm and in rat germinal cells","volume":"31","author":"Collodel","year":"2011","journal-title":"Reprod Toxicol"},{"issue":"9","key":"10.1016\/j.clinsp.2026.100878_bib0022","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1507\/endocrj.EJ20-0149","article-title":"Cisplatin induced testicular damage through mitochondria mediated apoptosis, inflammation and oxidative stress in rats: impact of resveratrol","volume":"67","author":"Aly","year":"2020","journal-title":"Endocr J"},{"issue":"1","key":"10.1016\/j.clinsp.2026.100878_bib0023","first-page":"57","article-title":"A simple method for volumetry of organs in quantitative stereology","volume":"26","author":"Scherle","year":"1970","journal-title":"Mikroskopie"},{"issue":"5","key":"10.1016\/j.clinsp.2026.100878_bib0024","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1681\/ASN.V1051100","article-title":"Stereologic methods and their application in kidney research","volume":"10","author":"Nyengaard","year":"1999","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"10.1016\/j.clinsp.2026.100878_bib0025","first-page":"467","article-title":"Stereological study of the effect of ginger's alcoholic extract on the testis in busulfan-induced infertility in rats","volume":"11","author":"Bordbar","year":"2013","journal-title":"Iran J Reprod Med"},{"issue":"5","key":"10.1016\/j.clinsp.2026.100878_bib0026","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1699-0463.1988.tb05320.x","article-title":"Some new, simple and efficient stereological methods and their use in pathological research and diagnosis","volume":"96","author":"Gundersen","year":"1988","journal-title":"Apmis"},{"key":"10.1016\/j.clinsp.2026.100878_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2025.127789","article-title":"Gallic acid mitigates cadmium-induced reproductive damage: effects on sperm, antioxidants, and apoptosis in mice","volume":"92","author":"Alaee","year":"2025","journal-title":"J Trace Elem Med Biol"},{"issue":"10","key":"10.1016\/j.clinsp.2026.100878_bib0028","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.3390\/medicina59101769","article-title":"Oxidative stress and male infertility: the protective role of antioxidants","volume":"59","author":"Kaltsas","year":"2023","journal-title":"Medicina (Kaunas)."},{"key":"10.1016\/j.clinsp.2026.100878_bib0029","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/6500587","article-title":"The flavonoid chrysin protects against testicular apoptosis induced by torsion\/detorsion in adult rats","volume":"2023","author":"Abadi","year":"2023","journal-title":"Andrologia"},{"issue":"2","key":"10.1016\/j.clinsp.2026.100878_bib0030","first-page":"294","article-title":"Resveratrol and reproductive health","volume":"12","author":"Novakovic","year":"2022","journal-title":"Life (Basel)"},{"key":"10.1016\/j.clinsp.2026.100878_bib0031","doi-asserted-by":"crossref","DOI":"10.1177\/09603271231215036","article-title":"The antioxidant properties of resveratrol on sperm parameters, testicular tissue, antioxidant capacity, and lipid peroxidation in isoflurane-induced toxicity in mice","volume":"42","author":"Mohammadi","year":"2023","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.clinsp.2026.100878_bib0032","doi-asserted-by":"crossref","DOI":"10.1071\/RD24161","article-title":"Spermatogenic cell apoptosis and impaired spermatogenesis in prepubertal mice: time-and dose-dependent toxicity of silver nanoparticles","volume":"37","author":"Maowa","year":"2025","journal-title":"Reprod Fertil Dev"},{"key":"10.1016\/j.clinsp.2026.100878_bib0033","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-14929-6","article-title":"Reproductive toxicity in male rats induced by chronic arsenic exposure involves hormonal and structural changes","volume":"15","author":"Mahboob","year":"2025","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.clinsp.2026.100878_bib0034","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/cbin.10441","article-title":"Effect of resveratrol on restoring spermatogenesis in experimental cryptorchid mice and analysis of related differentially expressed proteins","volume":"39","author":"Li","year":"2015","journal-title":"Cell Biol Int"},{"issue":"14","key":"10.1016\/j.clinsp.2026.100878_bib0035","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.3390\/cells14141122","article-title":"Beneficial effects of resveratrol on testicular functions: focus on its antioxidant properties","volume":"14","author":"Chimento","year":"2025","journal-title":"Cells"},{"issue":"19","key":"10.1016\/j.clinsp.2026.100878_bib0036","doi-asserted-by":"crossref","first-page":"4554","DOI":"10.3390\/molecules25194554","article-title":"The role of resveratrol in mammalian reproduction","volume":"25","author":"Pasquariello","year":"2020","journal-title":"Molecules"},{"issue":"Pt B","key":"10.1016\/j.clinsp.2026.100878_bib0037","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.fct.2018.04.026","article-title":"Alleviative effect of resveratrol on polyvinyl chloride-induced reproductive toxicity in male Wistar rats","volume":"116","author":"Archana","year":"2018","journal-title":"Food Chem Toxicol"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593226000190?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593226000190?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T11:20:13Z","timestamp":1793964013000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593226000190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":37,"alternative-id":["S1807593226000190"],"URL":"https:\/\/doi.org\/10.1016\/j.clinsp.2026.100878","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resveratrol protects against isoflurane-induced testicular injury: a stereological and molecular study in mice","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinsp.2026.100878","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 HCFMUSP. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"100878"}}