{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T11:29:11Z","timestamp":1793964551772,"version":"4.8.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":131,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025JJ50712"],"award-info":[{"award-number":["2025JJ50712"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023JJ20087"],"award-info":[{"award-number":["2023JJ20087"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.clinsp.2026.100998","type":"journal-article","created":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T03:42:25Z","timestamp":1779594145000},"page":"100998","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Allergen-specific immunotherapy in rhinitis patients is associated with milder COVID-19 symptoms and improved quality of life"],"prefix":"10.1016","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4267-0721","authenticated-orcid":false,"given":"Hanqiao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3863-8539","authenticated-orcid":false,"given":"Renkang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5986-4669","authenticated-orcid":false,"given":"Benquan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4625-5281","authenticated-orcid":false,"given":"Jun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6070-0461","authenticated-orcid":false,"given":"Yibo","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7114-4464","authenticated-orcid":false,"given":"Zuozhong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3479-6223","authenticated-orcid":false,"given":"Zi'an","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.clinsp.2026.100998_bib0001","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.jaci.2017.03.050","article-title":"Allergic rhinitis and its impact on asthma (ARIA) guidelines-2016 revision","volume":"140","author":"Bro\u017cek","year":"2017","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"10.1016\/j.clinsp.2026.100998_bib0002","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.jaip.2017.09.002","article-title":"Impact of rhinitis on work productivity: a systematic review","volume":"6","author":"Vandenplas","year":"2018","journal-title":"J Allergy Clin Immunol Pr"},{"issue":"2","key":"10.1016\/j.clinsp.2026.100998_bib0003","first-page":"106","article-title":"Subspecialty group of rhinology, society of otorhinolaryngology head and neck surgery, Chinese medical association","volume":"57","year":"2022","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"issue":"3","key":"10.1016\/j.clinsp.2026.100998_bib0004","first-page":"E304","article-title":"Determine the most common clinical symptoms in COVID-19 patients: a systematic review and meta-analysis","volume":"61","author":"Alimohamadi","year":"2020","journal-title":"J Prev Med Hyg"},{"issue":"1","key":"10.1016\/j.clinsp.2026.100998_bib0005","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s12016-022-08921-5","article-title":"Risk and protective factors for COVID-19 morbidity, severity, and mortality","volume":"64","author":"Zhang","year":"2023","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.clinsp.2026.100998_bib0006","series-title":"COVID-19 Dashboard","year":"2020"},{"issue":"1","key":"10.1016\/j.clinsp.2026.100998_bib0007","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jaip.2021.10.049","article-title":"Impact of allergic rhinitis and Asthma on COVID-19 infection, hospitalization, and mortality","volume":"10","author":"Ren","year":"2022","journal-title":"J Allergy Clin Immunol Pr"},{"key":"10.1016\/j.clinsp.2026.100998_bib0008","article-title":"The association between allergic rhinitis and COVID-19: a systematic review and meta-analysis","volume":"2022","author":"Xu","year":"2022","journal-title":"Int J Clin Pr"},{"issue":"6","key":"10.1016\/j.clinsp.2026.100998_bib0009","doi-asserted-by":"crossref","first-page":"522","DOI":"10.2500\/aap.2021.42.210087","article-title":"Does aeroallergen sensitivity and allergic rhinitis in children cause milder COVID-19 infection?","volume":"42","author":"Vezir","year":"2021","journal-title":"Allergy Asthma Proc"},{"issue":"1","key":"10.1016\/j.clinsp.2026.100998_bib0010","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.anai.2018.03.028","article-title":"The burden of allergic rhinitis and allergic rhinoconjunctivitis on adolescents: a literature review","volume":"121","author":"Blaiss","year":"2018","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"1","key":"10.1016\/j.clinsp.2026.100998_bib0011","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s11882-020-00977-7","article-title":"Mechanisms of allergen immunotherapy in Allergic rhinitis","volume":"21","author":"Drazdauskait\u0117","year":"2021","journal-title":"Curr Allergy Asthma Rep"},{"issue":"4","key":"10.1016\/j.clinsp.2026.100998_bib0012","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.jaip.2017.09.002","article-title":"Impact of rhinitis on work productivity: a systematic review","volume":"6","author":"Vandenplas","year":"2018","journal-title":"J Allergy Clin Immunol Pr"},{"issue":"6","key":"10.1016\/j.clinsp.2026.100998_bib0013","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1185\/030079906X112552","article-title":"Economic impact of workplace productivity losses due to allergic rhinitis compared with select medical conditions in the United States from an employer perspective","volume":"22","author":"Lamb","year":"2006","journal-title":"Curr Med Res Opin"},{"issue":"4","key":"10.1016\/j.clinsp.2026.100998_bib0014","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.anorl.2017.06.005","article-title":"Specific immunotherapy in allergic rhinitis","volume":"134","author":"Mortuaire","year":"2017","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"issue":"4","key":"10.1016\/j.clinsp.2026.100998_bib0015","doi-asserted-by":"crossref","DOI":"10.1002\/clt2.12247","article-title":"Does allergen immunotherapy impact the susceptibility and severity of COVID-19?","volume":"13","author":"Wang","year":"2023","journal-title":"Clin Transl Allergy"},{"issue":"3","key":"10.1016\/j.clinsp.2026.100998_bib0016","doi-asserted-by":"crossref","first-page":"163","DOI":"10.5415\/apallergy.2015.5.3.163","article-title":"Effect of high-dose sublingual immunotherapy on respiratory infections in children allergic to house dust mite","volume":"5","author":"Barberi","year":"2015","journal-title":"Asia Pac Allergy"},{"issue":"5","key":"10.1016\/j.clinsp.2026.100998_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.waojou.2023.100779","article-title":"Aeroallergen immunotherapy associated with reduced risk of severe COVID-19 in 1095 allergic patients","volume":"16","author":"Larenas-Linnemann","year":"2023","journal-title":"World Allergy Organ J"},{"issue":"2","key":"10.1016\/j.clinsp.2026.100998_bib0018","doi-asserted-by":"crossref","DOI":"10.1080\/21645515.2023.2236538","article-title":"The relationship between sublingual immunotherapy for allergic rhinitis and the risk of symptoms in patients with COVID-19 infection","volume":"19","author":"Zhang","year":"2023","journal-title":"Hum Vaccin Immunother"},{"issue":"5","key":"10.1016\/j.clinsp.2026.100998_bib0019","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41577-022-00786-1","article-title":"Allergen immunotherapy: past, present and future","volume":"23","author":"Durham","year":"2023","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"10.1016\/j.clinsp.2026.100998_bib0020","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2500\/aap.2021.42.210013","article-title":"Coronavirus disease 2019, allergic diseases, and allergen immunotherapy: possible favorable mechanisms of interaction","volume":"42","author":"Larenas-Linnemann","year":"2021","journal-title":"Allergy Asthma Proc"},{"issue":"1","key":"10.1016\/j.clinsp.2026.100998_bib0021","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jaci.2020.04.009","article-title":"Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2","volume":"146","author":"Jackson","year":"2020","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"10.1016\/j.clinsp.2026.100998_bib0022","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.jaip.2020.12.045","article-title":"Eosinophilia in Asthma patients is protective against severe COVID-19 illness","volume":"9","author":"Ferastraoaru","year":"2021","journal-title":"J Allergy Clin Immunol Pr"},{"issue":"11","key":"10.1016\/j.clinsp.2026.100998_bib0023","doi-asserted-by":"crossref","first-page":"3934","DOI":"10.1016\/j.jaip.2021.08.007","article-title":"Intranasal corticosteroids are associated with better outcomes in coronavirus disease","volume":"9","author":"Strauss","year":"2021","journal-title":"J Allergy Clin Immunol Pr"},{"issue":"1","key":"10.1016\/j.clinsp.2026.100998_bib0024","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01648-20","article-title":"The Inhaled Steroid Ciclesonide Blocks SARS-CoV-2 RNA Replication by Targeting the Viral Replication-Transcription Complex in Cultured Cells","volume":"95","author":"Matsuyama","year":"2020","journal-title":"J Virol"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593226001262?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593226001262?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T11:16:34Z","timestamp":1793963794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593226001262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":24,"alternative-id":["S1807593226001262"],"URL":"https:\/\/doi.org\/10.1016\/j.clinsp.2026.100998","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Allergen-specific immunotherapy in rhinitis patients is associated with milder COVID-19 symptoms and improved quality of life","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinsp.2026.100998","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 HCFMUSP. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"100998"}}