{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T20:27:18Z","timestamp":1793564838054,"version":"4.5.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":216,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018932","name":"Huai'an Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["HAB2024017"],"award-info":[{"award-number":["HAB2024017"]}],"id":[{"id":"10.13039\/100018932","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.clinsp.2026.101080","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:35:09Z","timestamp":1786628109000},"page":"101080","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["NRP1 silencing induces ROS-mediated cell cycle arrest and mitochondrial apoptosis in non-small cell lung cancer via upregulation of AGER"],"prefix":"10.1016","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0870-2133","authenticated-orcid":false,"given":"Ya","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9946-9470","authenticated-orcid":false,"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0496-0287","authenticated-orcid":false,"given":"Yongjuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0740-7463","authenticated-orcid":false,"given":"Wenwen","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8669-6308","authenticated-orcid":false,"given":"Pengcheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1970-1129","authenticated-orcid":false,"given":"Shan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5589-604X","authenticated-orcid":false,"given":"Zongli","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.clinsp.2026.101080_bib0001","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1186\/s13019-024-02922-5","article-title":"Surgical intervention for lung cancer in patients aged 75 and above: potential associations with increased mortality rates-a single-center observational study","volume":"19","author":"Kaprin","year":"2024","journal-title":"J Cardiothorac Surg"},{"issue":"6","key":"10.1016\/j.clinsp.2026.101080_bib0002","doi-asserted-by":"crossref","first-page":"e183","DOI":"10.1016\/j.cllc.2015.04.007","article-title":"Defining the high-risk population for mortality after resection of early stage NSCLC","volume":"16","author":"Husain","year":"2015","journal-title":"Clin Lung Cancer"},{"issue":"4","key":"10.1016\/j.clinsp.2026.101080_bib0003","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/s41419-020-2428-x","article-title":"The regulatory mechanism and biological significance of the Snail-miR590-VEGFR-NRP1 axis in the angiogenesis, growth and metastasis of gastric cancer","volume":"11","author":"Mei","year":"2020","journal-title":"Cell Death Dis"},{"issue":"2","key":"10.1016\/j.clinsp.2026.101080_bib0004","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41419-023-05696-1","article-title":"NRP1 promotes prostate cancer progression via modulating EGFR-dependent AKT pathway activation","volume":"14","author":"Zhang","year":"2023","journal-title":"Cell Death Dis"},{"issue":"4","key":"10.1016\/j.clinsp.2026.101080_bib0005","first-page":"487","article-title":"Down-regulation of HBXIP inhibits non-small cell lung cancer growth and enhances the anti-tumor immunity of mice by reducing NRP-1","volume":"51","author":"Wang","year":"2021","journal-title":"Ann Clin Lab Sci"},{"issue":"4","key":"10.1016\/j.clinsp.2026.101080_bib0006","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/s41419-021-03682-z","article-title":"HIF-1\u03b1 promoted vasculogenic mimicry formation in lung adenocarcinoma through NRP1 upregulation in the hypoxic tumor microenvironment","volume":"12","author":"Fu","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.clinsp.2026.101080_bib0007","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.isci.2018.12.005","article-title":"Neuropilin-1 controls endothelial homeostasis by regulating mitochondrial function and iron-dependent oxidative stress","volume":"11","author":"Issitt","year":"2019","journal-title":"iScience"},{"issue":"1","key":"10.1016\/j.clinsp.2026.101080_bib0008","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/s12967-023-04125-3","article-title":"Neuropilin-1 promotes mitochondrial structural repair and functional recovery in rats with cerebral ischemia","volume":"21","author":"Guo","year":"2023","journal-title":"J Transl Med"},{"issue":"4","key":"10.1016\/j.clinsp.2026.101080_bib0009","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.21873\/invivo.11589","article-title":"Peroxiredoxin V inhibits emodin-induced gastric cancer cell apoptosis via the ROS\/Bcl2 pathway","volume":"33","author":"Jin","year":"2019","journal-title":"In Vivo"},{"issue":"2","key":"10.1016\/j.clinsp.2026.101080_bib0010","doi-asserted-by":"crossref","first-page":"810","DOI":"10.3892\/mmr.2020.11176","article-title":"Effect of AGER on the biological behavior of non\u2011small cell lung cancer H1299 cells","volume":"22","author":"Wang","year":"2020","journal-title":"Mol Med Rep"},{"issue":"7","key":"10.1016\/j.clinsp.2026.101080_bib0011","first-page":"2079","article-title":"Pyrazole derivatives induce apoptosis via ROS generation in the triple negative breast cancer cells, MDA-MB-468. Asian Pacific journal of cancer prevention","volume":"22","author":"Ashourpour","year":"2021","journal-title":"APJCP"},{"issue":"21","key":"10.1016\/j.clinsp.2026.101080_bib0012","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1056\/NEJMoa1810865","article-title":"Pembrolizumab plus chemotherapy for squamous non-small-cell lung cancer","volume":"379","author":"Paz-Ares","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinsp.2026.101080_bib0013","article-title":"Neuropilin-1: a key protein to consider in the progression of pediatric brain tumors","volume":"11","author":"Douy\u00e8re","year":"2021","journal-title":"Front Front Oncol"},{"issue":"8","key":"10.1016\/j.clinsp.2026.101080_bib0014","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1007\/s00432-021-03635-1","article-title":"Soluble neuropilin-1 is an independent marker of poor prognosis in early breast cancer","volume":"147","author":"Rachner","year":"2021","journal-title":"J Cancer Res Clin Oncol"},{"issue":"21","key":"10.1016\/j.clinsp.2026.101080_bib0015","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.167049","article-title":"The semaphorin 3A\/neuropilin-1 pathway promotes clonogenic growth of glioblastoma via activation of TGF-\u03b2 signaling","volume":"8","author":"Jeon","year":"2023","journal-title":"JCI Insight"},{"issue":"4","key":"10.1016\/j.clinsp.2026.101080_bib0016","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/s41419-021-03672-1","article-title":"Impaired AGO2\/miR-185-3p\/NRP1 axis promotes colorectal cancer metastasis","volume":"12","author":"Liu","year":"2021","journal-title":"Cell Death Dis"},{"issue":"12","key":"10.1016\/j.clinsp.2026.101080_bib0017","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s12032-023-02202-7","article-title":"VEGF\/Nrp1\/HIF-1\u03b1 promotes proliferation of hepatocellular carcinoma through a positive feedback loop","volume":"40","author":"Wang","year":"2023","journal-title":"Med Oncol"},{"key":"10.1016\/j.clinsp.2026.101080_bib0018","first-page":"1","article-title":"Solasonine induces apoptosis and inhibits proliferation of bladder cancer cells by suppressing NRP1 expression","volume":"2022","author":"Dong","year":"2022","journal-title":"J Oncol"},{"issue":"1","key":"10.1016\/j.clinsp.2026.101080_bib0019","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00383-024-05808-8","article-title":"NRP1 knockdown inhibits the invasion and migration of rhabdoid tumor of the kidney cells","volume":"40","author":"Yamaoka","year":"2024","journal-title":"Pediatr Surg Int"},{"issue":"12","key":"10.1016\/j.clinsp.2026.101080_bib0020","doi-asserted-by":"crossref","first-page":"5680","DOI":"10.62347\/RLVZ6860","article-title":"NRP1 overexpression potentially enhances osimertinib resistance in NSCLC via activation of the PI3K\/AKT signaling pathway","volume":"14","author":"Wang","year":"2024","journal-title":"Am J Cancer Res"},{"issue":"10","key":"10.1016\/j.clinsp.2026.101080_bib0021","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1080\/09553002.2020.1793015","article-title":"NRP1 regulates radiation-induced EMT via TGF-\u03b2\/smad signaling in lung adenocarcinoma cells","volume":"96","author":"Chen","year":"2020","journal-title":"Int J Radiat Biol"},{"issue":"10","key":"10.1016\/j.clinsp.2026.101080_bib0022","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11101995","article-title":"The complex interplay between mitochondria, ROS and entire cellular metabolism","volume":"11","author":"Kuznetsov","year":"2022","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.clinsp.2026.101080_bib0023","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/13510002.2022.2046423","article-title":"Role of mitochondrial reactive oxygen species in homeostasis regulation","volume":"27","author":"Zhang","year":"2022","journal-title":"Redox Rep"},{"issue":"9","key":"10.1016\/j.clinsp.2026.101080_bib0024","doi-asserted-by":"crossref","first-page":"7792","DOI":"10.3390\/ijms24097792","article-title":"Neuropilin-1 knockout and rescue confirms its role to promote metastasis in MDA-MB-231 breast cancer cells","volume":"24","author":"Al-Zeheimi","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.clinsp.2026.101080_bib0025","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.3390\/biom14121550","article-title":"Role of the receptor for advanced glycation end products (RAGE) and its ligands in inflammatory responses","volume":"14","author":"Cross","year":"2024","journal-title":"Biomolecules"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593226002073?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593226002073?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T19:34:54Z","timestamp":1793561694000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593226002073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":25,"alternative-id":["S1807593226002073"],"URL":"https:\/\/doi.org\/10.1016\/j.clinsp.2026.101080","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NRP1 silencing induces ROS-mediated cell cycle arrest and mitochondrial apoptosis in non-small cell lung cancer via upregulation of AGER","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinsp.2026.101080","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 HCFMUSP. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"101080"}}