{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T12:25:11Z","timestamp":1793967911822,"version":"4.8.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":287,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013043","name":"Ariel University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013043","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.clinsp.2026.101218","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T06:51:53Z","timestamp":1792565513000},"page":"101218","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["COVID-19 severity among individuals with chronic diseases"],"prefix":"10.1016","volume":"81","author":[{"given":"Yael","family":"Reichenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior","family":"Hasson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Leibovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernice","family":"Oberman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Strahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4327-1084","authenticated-orcid":false,"given":"Dekel","family":"Shlomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.clinsp.2026.101218_bib0001","first-page":"157","article-title":"WHO declares COVID-19 a pandemic","volume":"91","author":"Cucinotta","year":"2020","journal-title":"Acta Biomed"},{"key":"10.1016\/j.clinsp.2026.101218_bib0002","doi-asserted-by":"crossref","first-page":"m1985","DOI":"10.1136\/bmj.m1985","article-title":"Features of 20 133 UK patients in hospital with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study","volume":"369","author":"Docherty","year":"2020","journal-title":"BMJ"},{"issue":"7","key":"10.1016\/j.clinsp.2026.101218_bib0003","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.16901","article-title":"Clinical characterization and prediction of clinical severity of SARS-CoV-2 infection among US adults using data from the National COVID Cohort Collaborative","volume":"4","author":"Bennett","year":"2021","journal-title":"JAMA Netw Open"},{"issue":"1","key":"10.1016\/j.clinsp.2026.101218_bib0004","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41597-022-01534-9","article-title":"ISARIC-COVID-19 dataset: a prospective, standardized, multinational clinical characterization protocol for hospitalized patients with COVID-19","volume":"9","author":"Garcia-Gallo","year":"2022","journal-title":"Sci Data"},{"issue":"37","key":"10.1016\/j.clinsp.2026.101218_bib0005","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.15585\/mmwr.mm7137a4","article-title":"Mortality risk factors for COVID-19 among patients with underlying medical conditions","volume":"71","author":"Adjei","year":"2022","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"6","key":"10.1016\/j.clinsp.2026.101218_bib0006","first-page":"e48","article-title":"Prevalence and predictors of death in COVID-19 patients: a systematic review and meta-analysis","volume":"81","author":"Dorjee","year":"2020","journal-title":"J Infect"},{"issue":"3","key":"10.1016\/j.clinsp.2026.101218_bib0007","article-title":"Risk factors for severe COVID-19 in patients with chronic respiratory diseases: a systematic review and meta-analysis","volume":"32","author":"Mattey-Mora","year":"2022","journal-title":"Rev Med Virol"},{"issue":"1","key":"10.1016\/j.clinsp.2026.101218_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12916-022-02715-4","article-title":"Individual and neighborhood risk factors of hospital admission and death during the COVID-19 pandemic: a population-based cohort study","volume":"21","author":"Bell","year":"2023","journal-title":"BMC Med"},{"issue":"1","key":"10.1016\/j.clinsp.2026.101218_bib0009","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1159\/000512592","article-title":"Association of sex, age, and comorbidities with mortality in COVID-19 patients: a systematic review and meta-analysis","volume":"64","author":"Biswas","year":"2021","journal-title":"Intervirology"},{"issue":"3","key":"10.1016\/j.clinsp.2026.101218_bib0010","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S1470-2045(20)30096-6","article-title":"Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China","volume":"21","author":"Liang","year":"2020","journal-title":"Lancet Oncol"},{"issue":"1","key":"10.1016\/j.clinsp.2026.101218_bib0011","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s10461-020-02983-2","article-title":"COVID-19 Among People Living with HIV: A Systematic Review","volume":"25","author":"Mirzaei","year":"2021","journal-title":"AIDS Behav"},{"issue":"3","key":"10.1016\/j.clinsp.2026.101218_bib0012","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jinf.2021.01.022","article-title":"Persistence of sleep disturbances and insomnia symptoms during the COVID-19 pandemic","volume":"82","author":"Belsky","year":"2021","journal-title":"J Infect"},{"issue":"6","key":"10.1016\/j.clinsp.2026.101218_bib0014","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/aje\/kwq433","article-title":"Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries","volume":"173","author":"Quan","year":"2011","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.clinsp.2026.101218_bib0015","article-title":"Characteristics associated with the development of long COVID in the first wave of the COVID-19 pandemic in France: a population-based study","volume":"8","author":"Semenzato","year":"2021","journal-title":"Lancet Reg Health Eur"},{"issue":"10","key":"10.1016\/j.clinsp.2026.101218_bib0016","doi-asserted-by":"crossref","first-page":"355","DOI":"10.15585\/mmwr.mm7010e4","article-title":"Underlying medical conditions and severe illness among 540,667 adults hospitalized with COVID-19, 11 states, March 2020-March 2021","volume":"70","author":"Kompaniyets","year":"2021","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"6","key":"10.1016\/j.clinsp.2026.101218_bib0017","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1016\/j.dsx.2020.10.022","article-title":"COVID-19 mortality in patients with comorbidities and the use of renin-angiotensin-aldosterone system inhibitors: a meta-analysis","volume":"14","author":"Tuty Kuswardhani","year":"2020","journal-title":"Diabetes Metab Syndr"},{"issue":"11","key":"10.1016\/j.clinsp.2026.101218_bib0018","first-page":"2458","article-title":"Smoking and COVID-19: a systematic review and meta-analysis","volume":"51","author":"Zhu","year":"2022","journal-title":"Iran J Public Health"},{"issue":"167","key":"10.1016\/j.clinsp.2026.101218_bib0019","article-title":"Smoking prevalence and COVID-19: a global perspective","volume":"32","author":"Gallus","year":"2023","journal-title":"Eur Respir Rev"},{"issue":"1","key":"10.1016\/j.clinsp.2026.101218_bib0021","doi-asserted-by":"crossref","first-page":"6317","DOI":"10.1038\/s41467-020-19741-6","article-title":"Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission","volume":"11","author":"Peckham","year":"2020","journal-title":"Nat Commun"},{"issue":"8","key":"10.1016\/j.clinsp.2026.101218_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.104949","article-title":"Impact of cerebrovascular and cardiovascular diseases on mortality and severity of COVID-19: a systematic review, meta-analysis, and meta-regression","volume":"29","author":"Pranata","year":"2020","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.clinsp.2026.101218_bib0023","article-title":"Chronic kidney disease and COVID-19: a systematic review and meta-analysis","volume":"10","author":"He","year":"2023","journal-title":"Front Med (Lausanne)"},{"issue":"1","key":"10.1016\/j.clinsp.2026.101218_bib0024","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1038\/s41598-022-06276-7","article-title":"Mortality and disease severity of COVID-19 in patients with kidney disease: a systematic review and meta-analysis","volume":"12","author":"Appelman","year":"2022","journal-title":"Sci Rep"},{"issue":"10","key":"10.1016\/j.clinsp.2026.101218_bib0025","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.3390\/vaccines12101190","article-title":"COVID-19 vaccination and risk of kidney outcomes in patients with chronic kidney disease","volume":"12","author":"Sung","year":"2024","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.clinsp.2026.101218_bib0026","article-title":"COVID-19 outcomes in kidney transplant recipients: a systematic review and meta-analysis","volume":"55","author":"Mahalingasivam","year":"2025","journal-title":"Lancet Reg Health Eur"},{"issue":"1","key":"10.1016\/j.clinsp.2026.101218_bib0027","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-99713-y","article-title":"Mortality risk factors of COVID-19 in kidney transplant recipients: a systematic review and meta-analysis","volume":"11","author":"Udomkarnjananun","year":"2021","journal-title":"Sci Rep"},{"issue":"10","key":"10.1016\/j.clinsp.2026.101218_bib0028","article-title":"Association of pre-existing hypertension and its treatment with the risk of severe COVID-19: a systematic review and meta-analysis","volume":"16","author":"Ge","year":"2021","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.clinsp.2026.101218_bib0029","article-title":"Comorbidities and COVID-19 outcomes in patients with chronic kidney disease","volume":"12","author":"Bucholc","year":"2022","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.clinsp.2026.101218_bib0030","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1186\/s12879-021-06378-z","article-title":"Chronic kidney disease and the risk of severe COVID-19 outcomes: a systematic review and meta-analysis","volume":"21","author":"Liu","year":"2021","journal-title":"BMC Infect Dis"},{"issue":"5","key":"10.1016\/j.clinsp.2026.101218_bib0031","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/irv.12864","article-title":"The impact of COVID-19 on people with chronic respiratory disease","volume":"15","author":"Cummins","year":"2021","journal-title":"Influenza Other Respir Viruses"},{"issue":"7","key":"10.1016\/j.clinsp.2026.101218_bib0032","doi-asserted-by":"crossref","first-page":"3808","DOI":"10.3390\/ijerph19073808","article-title":"Body mass index and risk of COVID-19: a systematic review and meta-analysis","volume":"19","author":"Carmona-P\u00edrez","year":"2022","journal-title":"Int J Environ Res Public Health"}],"container-title":["Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593226003285?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1807593226003285?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T11:32:13Z","timestamp":1793964733000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1807593226003285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":30,"alternative-id":["S1807593226003285"],"URL":"https:\/\/doi.org\/10.1016\/j.clinsp.2026.101218","relation":{},"ISSN":["1807-5932"],"issn-type":[{"value":"1807-5932","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"COVID-19 severity among individuals with chronic diseases","name":"articletitle","label":"Article Title"},{"value":"Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinsp.2026.101218","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 HCFMUSP. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"101218"}}