{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:43:00Z","timestamp":1762864980124},"reference-count":34,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2005,6]]},"DOI":"10.1016\/j.clinthera.2005.06.012","type":"journal-article","created":{"date-parts":[[2005,8,23]],"date-time":"2005-08-23T14:13:25Z","timestamp":1124806405000},"page":"786-794","source":"Crossref","is-referenced-by-count":13,"title":["A comparison of 5 days of therapy with cefdinir or azithromycin in children with acute otitis media: A multicenter, prospective, single-blind study"],"prefix":"10.1016","volume":"27","author":[{"given":"Stan L.","family":"Block","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Cifaldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihua","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria M.","family":"Paris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2005.06.012_bib1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1093\/clinids\/19.5.823","article-title":"Otitis media","volume":"19","author":"Klein","year":"1994","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.clinthera.2005.06.012_bib2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0165-5876(01)00550-X","article-title":"Restricted use of antibiotic prophylaxis for recurrent acute otitis media in the era of penicillin non-susceptible Streptococcus pneumoniae","volume":"61","author":"Block","year":"2001","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"10.1016\/j.clinthera.2005.06.012_bib3","first-page":"1","article-title":"National Ambulatory Medical Care Survey: 2000 Summary","volume":"328","author":"Cherry","year":"2002","journal-title":"Adv Data"},{"key":"10.1016\/j.clinthera.2005.06.012_bib4","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1001\/jama.287.23.3096","article-title":"Trends in antimicrobial prescribing rates for children and adolescents","volume":"287","author":"McCaig","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.clinthera.2005.06.012_bib5","doi-asserted-by":"crossref","first-page":"E72","DOI":"10.1542\/peds.105.6.e72","article-title":"Direct expenditures related to otitis media diagnoses: Extrapolations from a pediatric Medicaid cohort","volume":"105","author":"Bondy","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2005.06.012_bib6","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1542\/peds.113.5.1451","article-title":"Diagnosis and management of acute otitis media","volume":"113","author":"American Academy of Pediatrics Subcommittee on Management of Acute Otitis Media","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2005.06.012_bib7","series-title":"Pediatric Otolaryngology","first-page":"388","article-title":"Otitis media, atelectasis, and eustachian tube dysfunction","author":"Bluestone","year":"1996"},{"key":"10.1016\/j.clinthera.2005.06.012_bib8","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1128\/AAC.45.6.1721-1729.2001","article-title":"Antimicrobial resistance among clinical isolates of Streptococcus pneumoniae in the United States during 1999\u20132000, including a comparison of resistance rates since 1994\u20131995","volume":"45","author":"Doern","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"issue":"Suppl 1","key":"10.1016\/j.clinthera.2005.06.012_bib9","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1086\/324525","article-title":"Regional trends in antimicrobial resistance among clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in the United States: Results from the TRUST Surveillance Program, 1999\u20132000","volume":"34","author":"Thornsberry","year":"2002","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.clinthera.2005.06.012_bib10","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1056\/NEJM200012283432603","article-title":"Increasing prevalence of multidrug-resistant Streptococcus pneumoniae in the United States","volume":"343","author":"Whitney","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2005.06.012_bib11","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1097\/01.inf.0000136868.91756.80","article-title":"Community-wide vaccination with the heptavalent pneumococcal conjugate significantly alters the microbiology of acute otitis media","volume":"23","author":"Block","year":"2004","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.clinthera.2005.06.012_bib12","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1097\/01.inf.0000136871.51792.19","article-title":"Changes in frequency and pathogens causing acute otitis media in 1995\u20132003","volume":"23","author":"Casey","year":"2004","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.clinthera.2005.06.012_bib13","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0732-8893(03)00165-2","article-title":"Contemporary evaluation of the in vitro activity and spectrum of cefdinir compared with other orally administered antimicrobials tested against common respiratory tract pathogens (2000\u20132002)","volume":"47","author":"Sader","year":"2003","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"Suppl 12","key":"10.1016\/j.clinthera.2005.06.012_bib14","doi-asserted-by":"crossref","first-page":"S166","DOI":"10.1097\/00006454-200012001-00006","article-title":"Cefdinir vs. amoxicillin\/clavulanate in the treatment of suppurative acute otitis media in children","volume":"19","author":"Adler","year":"2000","journal-title":"Pediatr Infect Dis J"},{"issue":"Suppl 12","key":"10.1016\/j.clinthera.2005.06.012_bib15","doi-asserted-by":"crossref","first-page":"S159","DOI":"10.1097\/00006454-200012001-00005","article-title":"Comparative safety and efficacy of cefdinir vs. amoxicillin\/clavulanate for treatment of suppurative acute otitis media in children","volume":"19","author":"Block","year":"2000","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.clinthera.2005.06.012_bib16","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.2165\/00003495-200363200-00002","article-title":"Short-course antimicrobial therapy of respiratory tract infections","volume":"63","author":"Guay","year":"2003","journal-title":"Drugs"},{"issue":"Suppl 12","key":"10.1016\/j.clinthera.2005.06.012_bib17","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.1097\/00006454-200012001-00003","article-title":"Five-day cefdinir course vs. ten-day cefprozil course for treatment of acute otitis media","volume":"19","author":"Block","year":"2000","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.clinthera.2005.06.012_bib18","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1097\/01.inf.0000137574.28711.c4","article-title":"Comparison of five-day cefdinir treatment with ten-day low dose amoxicillin\/clavulanate treatment for acute otitis media","volume":"23","author":"Block","year":"2004","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.clinthera.2005.06.012_bib19","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJM200102083440602","article-title":"Efficacy of a pneumococcal conjugate vaccine against acute otitis media","volume":"344","author":"Eskola","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2005.06.012_bib20","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/01.inf.0000069759.79176.e1","article-title":"Can acute otitis media caused by Haemophilus influenzae be distinguished from that caused by Streptococcus pneumoniae?","volume":"22","author":"Leibovitz","year":"2003","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.clinthera.2005.06.012_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00006454-199901000-00002","article-title":"Acute otitis media: Management and surveillance in an era of pneumococcal resistance\u2014a report from the Drug-Resistant Streptococcus pneumoniae Therapeutic Working Group [published correction appears in Pediatr Infect Dis J. 1999;18:341]","volume":"18","author":"Dowell","year":"1999","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.clinthera.2005.06.012_bib22","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/j.1552-4604.1992.tb03873.x","article-title":"Cost effectiveness of once-daily oral antimicrobial therapy","volume":"32","author":"Davey","year":"1992","journal-title":"J Clin Pharmacol"},{"issue":"Suppl 9","key":"10.1016\/j.clinthera.2005.06.012_bib23","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1097\/00006454-199609009-00003","article-title":"A multicenter, open label trial of azithromycin vs. amoxicillin\/clavulanate for the management of acute otitis media in children","volume":"15","author":"Aronovitz","year":"1996","journal-title":"Pediatr Infect Dis J"},{"issue":"Suppl 9","key":"10.1016\/j.clinthera.2005.06.012_bib24","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1097\/00006454-199609009-00005","article-title":"A multicenter, randomized, open label comparison of azithromycin and amoxicillin\/clavulanate in acute otitis media among children attending day care or school","volume":"15","author":"Khurana","year":"1996","journal-title":"Pediatr Infect Dis J"},{"issue":"Suppl 9","key":"10.1016\/j.clinthera.2005.06.012_bib25","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1097\/00006454-199609009-00004","article-title":"A multicenter, double blind comparison of azithromycin and amoxicillin\/clavulanate for the treatment of acute otitis media in children","volume":"15","author":"McLinn","year":"1996","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.clinthera.2005.06.012_bib26","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00006454-200002000-00002","article-title":"Bacteriologic and clinical efficacy of amoxicillin\/clavulanate vs. azithromycin in acute otitis media [published correction appears in Pediatr Infect Dis J. 2000;19:275]","volume":"19","author":"Dagan","year":"2000","journal-title":"Pediatr Infect Dis J"},{"issue":"Suppl E","key":"10.1016\/j.clinthera.2005.06.012_bib27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/jac\/31.suppl_E.65","article-title":"Comparison of azithromycin and co-amoxiclav in the treatment of otitis media in children","volume":"31","author":"Daniel","year":"1993","journal-title":"J Anti-microb Chemother"},{"key":"10.1016\/j.clinthera.2005.06.012_bib28","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/jac\/dkg358","article-title":"Randomized, double-blind study of the clinical efficacy of 3 days of azithromycin compared with co-amoxiclav for the treatment of acute otitis media","volume":"52","author":"Dunne","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.clinthera.2005.06.012_bib29","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/BF01690872","article-title":"Multicentre comparative study of the efficacy and safety of azithromycin compared with amoxicillin\/clavulanic acid in the treatment of paediatric patients with otitis media","volume":"14","author":"Principi","year":"1995","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"Suppl E","key":"10.1016\/j.clinthera.2005.06.012_bib30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/jac\/31.suppl_E.81","article-title":"Multicentre evaluation of azithromycin in comparison with co-amoxiclav for the treatment of acute otitis media in children","volume":"31","author":"Schaad","year":"1993","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.clinthera.2005.06.012_bib31","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/00006454-199705000-00002","article-title":"Equivalent efficacy and reduced occurrence of diarrhea from a new formulation of amoxicillin\/clavulanate potassium (Augmentin) for treatment of acute otitis media in children","volume":"16","author":"Hoberman","year":"1997","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.clinthera.2005.06.012_bib32","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0022-3476(05)80479-2","article-title":"Host factors and early therapeutic response in acute otitis media","volume":"118","author":"Carlin","year":"1991","journal-title":"J Pediatr"},{"issue":"Suppl 12","key":"10.1016\/j.clinthera.2005.06.012_bib33","doi-asserted-by":"crossref","first-page":"S174","DOI":"10.1097\/00006454-200012001-00008","article-title":"Comparison of the palatability of the oral suspension of cefdinir vs. amoxicillin\/clavulanate potassium, cefprozil and azithromycin in pediatric patients","volume":"19","author":"Powers","year":"2000","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.clinthera.2005.06.012_bib34","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/00006454-199705000-00003","article-title":"Cefprozil treatment of persistent and recurrent acute otitis media","volume":"16","author":"Pichichero","year":"1997","journal-title":"Pediatr Infect Dis J"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291805001050?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291805001050?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T01:35:05Z","timestamp":1529544905000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291805001050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["S0149291805001050"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2005.06.012","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}