{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:54:20Z","timestamp":1792853660124,"version":"4.5.0"},"reference-count":187,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1016\/j.clinthera.2005.09.005","type":"journal-article","created":{"date-parts":[[2005,11,13]],"date-time":"2005-11-13T12:12:02Z","timestamp":1131883922000},"page":"1329-1342","source":"Crossref","is-referenced-by-count":292,"title":["Safety of doxycycline and minocycline: A systematic review"],"prefix":"10.1016","volume":"27","author":[{"given":"Kelly","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Leyden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2005.09.005_bib1","first-page":"105","article-title":"A new tetracycline minocycline compared with ampicillin in general practice","volume":"83","author":"Gallagher","year":"1976","journal-title":"N Z Med J"},{"key":"10.1016\/j.clinthera.2005.09.005_bib2","first-page":"49","article-title":"Antimicrobial spectrum, pharmacology and therapeutic use of antibiotics. Part 1: Tetracyclines","volume":"34","author":"Barza","year":"1977","journal-title":"Am J Hosp Pharm"},{"issue":"Suppl 4","key":"10.1016\/j.clinthera.2005.09.005_bib3","first-page":"7","article-title":"Systemic therapy for rosacea: Focus on oral antibiotic therapy and safety","volume":"66","author":"Del Rosso","year":"2000","journal-title":"Cutis"},{"issue":"Suppl 1","key":"10.1016\/j.clinthera.2005.09.005_bib4","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1159\/000221894","article-title":"Doxycycline in respiratory tract infections. Report of a retrospective study in Spain during the winter 1972\u20131973","volume":"21","author":"Casado","year":"1975","journal-title":"Chemotherapy"},{"key":"10.1016\/j.clinthera.2005.09.005_bib5","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1128\/AAC.11.4.712","article-title":"Side effects of minocycline: A double-blind study","volume":"11","author":"Fanning","year":"1977","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.clinthera.2005.09.005_bib6","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1128\/AAC.12.5.642","article-title":"Side effects of minocycline: Different dosage regimens","volume":"12","author":"Gump","year":"1977","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.clinthera.2005.09.005_bib7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2288-1-7","article-title":"Incomplete evidence: The inadequacy of databases in tracing published adverse reactions in clinical trials","volume":"1","author":"Derry","year":"2001","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib8","unstructured":"Doxycycline and minocycline [prescription data]. Plymouth Meeting, Pa: IMS Health Incorporated; December 1998\u2013August 2003."},{"key":"10.1016\/j.clinthera.2005.09.005_bib9","doi-asserted-by":"crossref","first-page":"236","DOI":"10.5694\/j.1326-5377.1975.tb111346.x","article-title":"Oesophageal ulceration associated with doxycycline therapy","volume":"1","author":"Bokey","year":"1975","journal-title":"Med J Aust"},{"key":"10.1016\/j.clinthera.2005.09.005_bib10","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/BF01694511","article-title":"Doxycycline esophageal ulcers","volume":"22","author":"Schneider","year":"1977","journal-title":"Am J Dig Dis"},{"key":"10.1016\/j.clinthera.2005.09.005_bib11","first-page":"27","article-title":"Oesophageal ulceration associated with ingestion of doxycycline","volume":"91","author":"Aarons","year":"1980","journal-title":"N Z Med J"},{"key":"10.1016\/j.clinthera.2005.09.005_bib12","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1177\/106002808201601116","article-title":"Doxycycline-induced esophagitis","volume":"16","author":"Hatheway","year":"1982","journal-title":"Drug Intell Clin Pharm"},{"key":"10.1016\/j.clinthera.2005.09.005_bib13","doi-asserted-by":"crossref","first-page":"223","DOI":"10.5694\/j.1326-5377.1984.tb104003.x","article-title":"Oesophagitis and oesophageal ulceration following ingestion of doxycycline tablets","volume":"140","author":"Geschwind","year":"1984","journal-title":"Med J Aust"},{"key":"10.1016\/j.clinthera.2005.09.005_bib14","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1001\/jama.253.7.1009","article-title":"Doxycycline-induced esophagitis","volume":"253","author":"Amendola","year":"1985","journal-title":"JAMA"},{"key":"10.1016\/j.clinthera.2005.09.005_bib15","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1259\/0007-1285-58-696-1209","article-title":"Oesophageal ulceration due to doxycycline","volume":"58","author":"Daunt","year":"1985","journal-title":"Br J Radiol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib16","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0016-5107(85)72270-5","article-title":"Doxycycline esophageal ulcer","volume":"31","author":"Llanos","year":"1985","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.clinthera.2005.09.005_bib17","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1001\/jama.256.14.1893b","article-title":"Doxycycline-induced esophageal ulcers in physicians","volume":"256","author":"Shiff","year":"1986","journal-title":"JAMA"},{"key":"10.1016\/j.clinthera.2005.09.005_bib18","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1055\/s-2007-1018244","article-title":"Severe localised esophagitis due to doxycycline","volume":"19","author":"Fraser","year":"1987","journal-title":"Endoscopy"},{"key":"10.1016\/j.clinthera.2005.09.005_bib19","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1097\/00005176-198809000-00023","article-title":"Doxycycline-induced hemorrhagic esophagitis: A pediatric case","volume":"7","author":"Kato","year":"1988","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.clinthera.2005.09.005_bib20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3109\/09546638909086703","article-title":"Unusual side-effects in patients receiving doxycycline","volume":"1","author":"Henderson","year":"1989","journal-title":"J Dermatol Treat"},{"key":"10.1016\/j.clinthera.2005.09.005_bib21","first-page":"902","article-title":"Doxycycline-induced esophagitis: Treatment with liquid sucralphate","volume":"85","author":"Pinos","year":"1990","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib22","first-page":"443","article-title":"Tetracycline-induced esophageal ulcer: A condition that probably is more common than it appears to be","volume":"74","author":"Ovartlarnporn","year":"1991","journal-title":"J Med Assoc Thai"},{"key":"10.1016\/j.clinthera.2005.09.005_bib23","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/00325481.1992.11701175","article-title":"Esophageal ulceration following doxycycline ingestion","volume":"91","author":"Markin","year":"1992","journal-title":"Postgrad Med"},{"key":"10.1016\/j.clinthera.2005.09.005_bib24","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1055\/s-2007-1005772","article-title":"Severe, long-lasting symptoms from doxycycline-induced esophageal injury","volume":"27","author":"Tankurt","year":"1995","journal-title":"Endoscopy"},{"key":"10.1016\/j.clinthera.2005.09.005_bib25","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/milmed\/165.4.316","article-title":"Doxycycline-induced esophageal ulceration in the U.S. military service","volume":"165","author":"Morris","year":"2000","journal-title":"Mil Med"},{"key":"10.1016\/j.clinthera.2005.09.005_bib26","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1258\/0022215001905878","article-title":"Oesophageal ulceration caused by doxycycline: An unusual complication","volume":"114","author":"Ullah","year":"2000","journal-title":"J Laryngol Otol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib27_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/milmed\/166.3.203a","article-title":"Doxycycline-induced esophageal ulceration","volume":"166","author":"Isler","year":"2001","journal-title":"Mil Med"},{"key":"10.1016\/j.clinthera.2005.09.005_bib27_2","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1093\/milmed\/166.3.203a","article-title":"Doxycycline-induced esophageal ulceration","volume":"166","author":"Isler","year":"2001","journal-title":"Mil Med"},{"key":"10.1016\/j.clinthera.2005.09.005_bib28","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3748\/wjg.v9.i3.609","article-title":"Esophageal ulceration complicating doxycycline therapy","volume":"9","author":"Al-Mofarreh","year":"2003","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib29","first-page":"640","article-title":"Doxycycline and photosensitivity","volume":"100","author":"Edwards","year":"1987","journal-title":"N Z Med J"},{"key":"10.1016\/j.clinthera.2005.09.005_bib30","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1365-2230.1993.tb02242.x","article-title":"Phototoxic eruptions due to doxycycline-a dose-related phenomenon","volume":"18","author":"Layton","year":"1993","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib31","doi-asserted-by":"crossref","first-page":"E13","DOI":"10.1542\/peds.106.1.e13","article-title":"An unusual presentation of doxycycline-induced photosensitivity","volume":"106","author":"Yong","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2005.09.005_bib32","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1001\/archderm.103.5.520","article-title":"Photo-onycholysis due to tetracycline hydrochloride and doxycycline","volume":"103","author":"Frank","year":"1971","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib33","first-page":"53","article-title":"Onycholysis of the thumbs probably due to a phototoxic reaction from doxycycline","volume":"27","author":"Cavens","year":"1981","journal-title":"Cutis"},{"key":"10.1016\/j.clinthera.2005.09.005_bib34","doi-asserted-by":"crossref","first-page":"440","DOI":"10.5694\/j.1326-5377.1990.tb125275.x","article-title":"Anosmia after doxycycline use","volume":"152","author":"Bleasel","year":"1990","journal-title":"Med J Aust"},{"key":"10.1016\/j.clinthera.2005.09.005_bib35","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000247308","article-title":"Acute generalized exanthematous pustulosis due to doxycycline","volume":"186","author":"Trueb","year":"1993","journal-title":"Dermatology"},{"key":"10.1016\/j.clinthera.2005.09.005_bib36","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1177\/009127000004001012","article-title":"Doxycycline-induced hypoglycemia","volume":"40","author":"Odeh","year":"2000","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib37","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1097\/00007611-200211000-00025","article-title":"Doxycycline-induced hypoglycemia in a nondiabetic young man","volume":"95","author":"Basaria","year":"2002","journal-title":"South Med J"},{"key":"10.1016\/j.clinthera.2005.09.005_bib38","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1136\/bmj.326.7390.641","article-title":"Doxycycline induced intracranial hypertension","volume":"326","author":"Lochhead","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.clinthera.2005.09.005_bib39","doi-asserted-by":"crossref","first-page":"273","DOI":"10.7326\/0003-4819-117-4-273","article-title":"Comparison of cefuroxime axetil and doxycycline in the treatment of early Lyme disease","volume":"117","author":"Nadelman","year":"1992","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.clinthera.2005.09.005_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1067\/mva.2002.125018","article-title":"Prolonged administration of doxycycline in patients with small asymptomatic abdominal aortic aneurysms: Report of a prospective (Phase II) multicenter study","volume":"36","author":"Baxter","year":"2002","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.clinthera.2005.09.005_bib41","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1080\/1120009X.1993.11741112","article-title":"Brodimoprim in acute respiratory tract infections","volume":"5","author":"Salmi","year":"1993","journal-title":"J Chemother"},{"key":"10.1016\/j.clinthera.2005.09.005_bib42","doi-asserted-by":"crossref","first-page":"697","DOI":"10.7326\/0003-4819-138-9-200305060-00005","article-title":"Duration of antibiotic therapy for early Lyme disease. A randomized, double-blind, placebo-controlled trial","volume":"138","author":"Wormser","year":"2003","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.clinthera.2005.09.005_bib43","doi-asserted-by":"crossref","first-page":"483","DOI":"10.5694\/j.1326-5377.1989.tb136591.x","article-title":"A prospective single-blind trial of minocycline and doxycycline in the treatment of genital Chlamydia trachomatis infection in women","volume":"150","author":"Kovacs","year":"1989","journal-title":"Med J Aust"},{"key":"10.1016\/j.clinthera.2005.09.005_bib44","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1093\/jac\/31.6.949","article-title":"Loracarbef versus doxycycline in the treatment of acute bacterial maxillary sinusitis","volume":"31","year":"1993","journal-title":"J Antimicrob Chemother"},{"issue":"Suppl E","key":"10.1016\/j.clinthera.2005.09.005_bib45","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/jac\/31.suppl_E.185","article-title":"Comparison of azithromycin and doxycycline in the treatment of non-gonococcal urethritis in men","volume":"31","author":"Lister","year":"1993","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.clinthera.2005.09.005_bib46","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/(SICI)1098-0997(1998)6:3<109::AID-IDOG3>3.0.CO;2-S","article-title":"Daily oral grepafloxacin vs. twice daily oral doxycycline in the treatment of Chlamydia trachomatis endocervical infection","volume":"6","author":"McCormack","year":"1998","journal-title":"Infect Dis Obstet Gynecol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib47","first-page":"41","article-title":"Oral ofloxacin once daily and doxycycline in the treatment of acute exacerbations of chronic bronchitis","volume":"68","author":"Punakivi","year":"1990","journal-title":"Scand J Infect Dis Suppl"},{"issue":"Suppl 1","key":"10.1016\/j.clinthera.2005.09.005_bib48","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1159\/000221893","article-title":"A comparative trial of doxycycline and ampicillin in the treatment of acute sinusitis","volume":"21","author":"Agbim","year":"1975","journal-title":"Chemotherapy"},{"key":"10.1016\/j.clinthera.2005.09.005_bib49","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0016-5085(83)80123-1","article-title":"Brief prophylaxis with doxycycline for the prevention of traveler's diarrhea","volume":"84","author":"Freeman","year":"1983","journal-title":"Gastroenterology"},{"issue":"Suppl B","key":"10.1016\/j.clinthera.2005.09.005_bib50","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/jac\/22.Supplement_B.155","article-title":"Comparison of spiramycin and doxycycline in the treatment of lower respiratory infections in general practice","volume":"22","author":"Biermann","year":"1988","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.clinthera.2005.09.005_bib51","first-page":"794","article-title":"The end of antibiotic treatment in adults with acute sinusitis-like complaints in general practice? A placebo-controlled double-blind randomized doxycycline trial","volume":"47","author":"Stalman","year":"1997","journal-title":"Br J Gen Pract"},{"key":"10.1016\/j.clinthera.2005.09.005_bib52","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1185\/03007998009109479","article-title":"A comparison of two different dosages of pivampicillin and doxycycline in patients with gynaecological infections","volume":"6","author":"Andersson","year":"1980","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.clinthera.2005.09.005_bib53","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1056\/NEJM199707313370501","article-title":"Ceftriaxone compared with doxycycline for the treatment of acute disseminated Lyme disease","volume":"337","author":"Dattwyler","year":"1997","journal-title":"N Engl J Med"},{"issue":"Suppl E","key":"10.1016\/j.clinthera.2005.09.005_bib54","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/jac\/31.suppl_E.177","article-title":"Single-dose oral azithromycin versus seven-day doxycycline in the treatment of nongonococcal urethritis in males","volume":"31","author":"Lauharanta","year":"1993","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.clinthera.2005.09.005_bib55","first-page":"325","article-title":"A double blind study of single dose azithromycin and doxycycline in the treatment of chlamydial urethritis in males","volume":"68","author":"Nilsen","year":"1992","journal-title":"Genitourin Med"},{"key":"10.1016\/j.clinthera.2005.09.005_bib56","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1056\/NEJM199209243271304","article-title":"A controlled trial of a single dose of azithromycin for the treatment of chlamydial urethritis and cervicitis","volume":"327","author":"Martin","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2005.09.005_bib57","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1001\/jama.274.7.545","article-title":"Azithromycin for empirical treatment of the nongonococcal urethritis syndrome in men. A randomized double-blind study","volume":"274","author":"Stamm","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.clinthera.2005.09.005_bib58","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/S0022-3476(09)90029-4","article-title":"Single dose of azithromycin for the treatment of genital chlamydial infections in adolescents","volume":"122","author":"Hammerschlag","year":"1993","journal-title":"J Pediatr"},{"key":"10.1016\/j.clinthera.2005.09.005_bib59","first-page":"93","article-title":"Chlamydial cervicitis and urethritis: Single dose treatment compared with doxycycline for seven days in community based practises","volume":"72","author":"Thorpe","year":"1996","journal-title":"Genitourin Med"},{"key":"10.1016\/j.clinthera.2005.09.005_bib60","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1046\/j.1365-4362.2000.00749.x","article-title":"Azithromycin for the treatment of acne","volume":"39","author":"Fernandez-Obregon","year":"2000","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib61","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00007435-199401000-00009","article-title":"Single dose azithromycin treatment of gonorrhea and infections caused by C. trachomatis and U. urealyticum in men","volume":"21","author":"Steingr\u00edmsson","year":"1994","journal-title":"Sex Transm Dis"},{"key":"10.1016\/j.clinthera.2005.09.005_bib62","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/S0140-6736(74)91173-8","article-title":"Minocycline: Possible vestibular side-effects","volume":"2","author":"Doyle","year":"1974","journal-title":"Lancet"},{"key":"10.1016\/j.clinthera.2005.09.005_bib63","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/S0140-6736(74)90767-3","article-title":"Minocycline: Possible vestibular side-effects","volume":"2","author":"Nicol","year":"1974","journal-title":"Lancet"},{"key":"10.1016\/j.clinthera.2005.09.005_bib64","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S0140-6736(74)90941-6","article-title":"Minocycline: Possible vestibular side-effects","volume":"2","author":"Williams","year":"1974","journal-title":"Lancet"},{"key":"10.1016\/j.clinthera.2005.09.005_bib65","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1136\/bmj.2.6044.1109","article-title":"A black thyroid and minocycline treatment","volume":"2","author":"Attwood","year":"1976","journal-title":"Br Med J"},{"key":"10.1016\/j.clinthera.2005.09.005_bib66","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1001\/jama.249.14.1887","article-title":"Minocycline and black thyroid","volume":"249","author":"Billano","year":"1983","journal-title":"JAMA"},{"key":"10.1016\/j.clinthera.2005.09.005_bib67","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1093\/ajcp\/79.6.738","article-title":"The black thyroid associated with minocycline therapy: A local manifestation of a drug-induced lysosome\/substrate disorder","volume":"79","author":"Reid","year":"1983","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib68","first-page":"173","article-title":"The black thyroid: Its relation to minocycline use in man","volume":"107","author":"Saul","year":"1983","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.clinthera.2005.09.005_bib69","first-page":"268","article-title":"Black thyroid associated with minocycline therapy","volume":"108","author":"Medeiros","year":"1984","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.clinthera.2005.09.005_bib70","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3109\/00313028409068548","article-title":"Minocycline hydrochloride and thyroid pigmentation: A case report with histological and ultrastructural study","volume":"16","author":"Delprado","year":"1984","journal-title":"Pathology"},{"key":"10.1016\/j.clinthera.2005.09.005_bib71","first-page":"1367","article-title":"\u201cBlack thyroid\u201d associated with minocycline therapy. A report of an autopsy case and review of the literature","volume":"36","author":"Ohaki","year":"1986","journal-title":"Acta Pathol Jpn"},{"key":"10.1016\/j.clinthera.2005.09.005_bib72","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1346-8138.1977.tb01015.x","article-title":"A case of minocycline-induced fixed drug eruption","volume":"4","author":"Shimizu","year":"1977","journal-title":"J Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib73","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0190-9622(83)80199-6","article-title":"Fixed drug eruption due to minocycline-report of one case","volume":"8","author":"LePaw","year":"1983","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib74","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1159\/000114921","article-title":"Benign intracranial hypertension after minocycline therapy","volume":"17","author":"Monaco","year":"1978","journal-title":"Eur Neurol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib75","first-page":"161","article-title":"Minocycline-induced benign intracranial hypertension","volume":"26","author":"Lander","year":"1989","journal-title":"Clin Exp Neurol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib76","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0753-3322(92)90026-4","article-title":"Minocycline and benign intracranial hypertension","volume":"46","author":"Donnet","year":"1992","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.clinthera.2005.09.005_bib77","doi-asserted-by":"crossref","first-page":"168","DOI":"10.7326\/0003-4819-127-2-199707150-00030","article-title":"Intracranial hypertension and minocycline","volume":"127","author":"Shiri","year":"1997","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.clinthera.2005.09.005_bib78","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1444-0938.2000.tb05015.x","article-title":"Benign intracranial hypertension with minocycline therapy","volume":"83","author":"Chapman-Davies","year":"2000","journal-title":"Clin Exp Optom"},{"key":"10.1016\/j.clinthera.2005.09.005_bib79","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1136\/bmj.1.6162.524","article-title":"Minocycline-induced acute interstitial nephritis","volume":"1","author":"Walker","year":"1979","journal-title":"Br Med J"},{"key":"10.1016\/j.clinthera.2005.09.005_bib80","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1136\/pgmj.65.759.53","article-title":"Protracted systemic illness and interstitial nephritis due to minocycline","volume":"65","author":"Wilkinson","year":"1989","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.clinthera.2005.09.005_bib81","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/oxfordjournals.ndt.a027327","article-title":"Minocycline-induced chronic interstitial nephritis?","volume":"11","author":"Fletcher","year":"1996","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.clinthera.2005.09.005_bib82","doi-asserted-by":"crossref","first-page":"E36","DOI":"10.1053\/ajkd.2001.29292","article-title":"Interstitial nephritis, hepatic failure, and systemic eosinophilia after minocycline treatment","volume":"38","author":"Kiessling","year":"2001","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.clinthera.2005.09.005_bib83","doi-asserted-by":"crossref","first-page":"323","DOI":"10.5694\/j.1326-5377.1980.tb134884.x","article-title":"Pseudotumour cerebri associated with minocycline therapy for acne","volume":"1","author":"Beran","year":"1980","journal-title":"Med J Aust"},{"key":"10.1016\/j.clinthera.2005.09.005_bib84","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2340\/0001555577083","article-title":"Pseudotumor cerebri induced by minocycline treatment for acne vulgaris","volume":"77","author":"Lewis","year":"1997","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib85","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0002-9394(98)00063-4","article-title":"Minocycline treatment and pseudotumor cerebri syndrome","volume":"126","author":"Chiu","year":"1998","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib86","first-page":"229","article-title":"Pseudotumor cerebri secondary to minocycline intake","volume":"15","author":"Ang","year":"2002","journal-title":"J Am Board Fam Pract"},{"key":"10.1016\/j.clinthera.2005.09.005_bib87","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0190-9622(80)80200-3","article-title":"Discoloration of the teeth related to minocycline therapy for acne","volume":"3","author":"Caro","year":"1980","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib88","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1001\/jama.244.10.1103","article-title":"Minocycline-induced pigmentation at sites of cutaneous inflammation","volume":"244","author":"Fenske","year":"1980","journal-title":"JAMA"},{"key":"10.1016\/j.clinthera.2005.09.005_bib89","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1001\/archderm.116.11.1262","article-title":"Skin pigmentation secondary to minocycline therapy","volume":"116","author":"McGrae","year":"1980","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib90","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0190-9622(80)80186-1","article-title":"Minocycline and generalized cutaneous pigmentation","volume":"3","author":"Simons","year":"1980","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib91","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1365-2133.1982.tb00296.x","article-title":"Hyperpigmentation associated with oral minocycline","volume":"107","author":"Ridgway","year":"1982","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib92","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/0030-4220(84)90056-2","article-title":"An unusual case of oral pigmentation","volume":"58","author":"Fendrich","year":"1984","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib93","first-page":"457","article-title":"Minocycline hyperpigmentation: Skin, tooth, nail, and bone involvement","volume":"33","author":"Wolfe","year":"1984","journal-title":"Cutis"},{"key":"10.1016\/j.clinthera.2005.09.005_bib94","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1365-2230.1985.tb00600.x","article-title":"Cutaneous and cardiac valvular pigmentation with minocycline","volume":"10","author":"Butler","year":"1985","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib95","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1001\/archderm.121.5.618","article-title":"Hyperpigmentation of the skin associated with minocycline therapy","volume":"121","author":"Gordon","year":"1985","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib96","first-page":"254","article-title":"Pigmentary changes due to long-term minocycline therapy","volume":"35","author":"Liu","year":"1985","journal-title":"Cutis"},{"key":"10.1016\/j.clinthera.2005.09.005_bib97","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1001\/jama.254.20.2930","article-title":"Minocycline-associated tooth discoloration in young adults","volume":"254","author":"Poliak","year":"1985","journal-title":"JAMA"},{"key":"10.1016\/j.clinthera.2005.09.005_bib98","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S0278-2391(86)80104-5","article-title":"Oral pigmentation secondary to minocycline therapy","volume":"44","author":"Beehner","year":"1986","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.clinthera.2005.09.005_bib99","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1902\/jop.1988.59.2.112","article-title":"Pigmentation of the jawbones and teeth secondary to minocycline hydrochloride therapy","volume":"59","author":"Cale","year":"1988","journal-title":"J Periodontol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib100","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1111\/j.1524-4725.1988.tb03739.x","article-title":"Periungual hyperpigmentation mimicking Hutchinson's sign associated with minocycline administration","volume":"14","author":"Mooney","year":"1988","journal-title":"J Dermatol Surg Oncol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib101","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1365-2133.1989.tb01807.x","article-title":"Skin pigmentation associated with minocycline therapy","volume":"121","author":"Okada","year":"1989","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib102","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/0190-9622(90)70135-5","article-title":"Hyperpigmentation, neutrophilic alveolitis, and erythema nodosum resulting from minocycline","volume":"22","author":"Bridges","year":"1990","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib103","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-2230.1991.tb00299.x","article-title":"Minocycline-induced pigmentation occurring in two sisters","volume":"16","author":"Eedy","year":"1991","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib104","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0190-9622(08)80077-1","article-title":"Minocycline hydrochloride hyperpigmentation complicating treatment of venous ectasia of the extremities","volume":"24","author":"Leffell","year":"1991","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib105","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1365-2133.1993.tb03519.x","article-title":"Skin pigmentation due to minocycline treatment of facial dermatoses","volume":"129","author":"Dwyer","year":"1993","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib106","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/0190-9622(93)70037-T","article-title":"Extensive cutaneous hyperpigmentation caused by minocycline","volume":"28","author":"Pepine","year":"1993","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib107","first-page":"173","article-title":"Minocycline induced skin pigmentation","volume":"43","author":"Schofield","year":"1993","journal-title":"Br J Gen Pract"},{"key":"10.1016\/j.clinthera.2005.09.005_bib108","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/S0190-9622(08)81521-6","article-title":"Minocycline hyperpigmentation localized to the lips: An unusual fixed drug reaction?","volume":"30","author":"Chu","year":"1994","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib109","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/j.1365-2133.1994.tb03422.x","article-title":"Longitudinal melanonychia induced by minocycline","volume":"130","author":"Mallon","year":"1994","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib110","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/j.1346-8138.1994.tb03320.x","article-title":"Minocycline hydrochloride hyperpigmentation complicating treatment of pyoderma gangrenosum","volume":"21","author":"Miralles","year":"1994","journal-title":"J Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib111","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0190-9622(94)70038-9","article-title":"Minocycline-induced oral pigmentation","volume":"30","author":"Siller","year":"1994","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib112","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S1079-2104(05)80279-3","article-title":"Lingual hyperpigmentation associated with minocycline therapy","volume":"79","author":"Meyerson","year":"1995","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.clinthera.2005.09.005_bib113","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1079-2104(05)80128-3","article-title":"Oral presentation of minocycline-induced black bone disease","volume":"79","author":"Odell","year":"1995","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.clinthera.2005.09.005_bib114","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1365-2133.1996.tb01170.x","article-title":"Minocycline-induced discolouration of the sclerae","volume":"135","author":"Sabroe","year":"1996","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib115","first-page":"53","article-title":"Photo-onycholysis from minocycline. Side effects of minocycline therapy","volume":"28","author":"Kestel","year":"1981","journal-title":"Cutis"},{"key":"10.1016\/j.clinthera.2005.09.005_bib116","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1001\/jama.250.19.2602b","article-title":"Pulmonary infiltrates and eosinophilia from minocycline","volume":"250","author":"Otero","year":"1983","journal-title":"JAMA"},{"key":"10.1016\/j.clinthera.2005.09.005_bib117","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2169\/internalmedicine1962.29.195","article-title":"Acute eosinophilic pneumonia induced by minocycline: Prominent Kerley B lines as a feature of positive re-challenge test","volume":"29","author":"Yokoyama","year":"1990","journal-title":"Jpn J Med"},{"key":"10.1016\/j.clinthera.2005.09.005_bib118","doi-asserted-by":"crossref","first-page":"476","DOI":"10.7326\/0003-4819-117-6-476","article-title":"Minocycline-induced cell-mediated hypersensitivity pneumonitis","volume":"117","author":"Guillon","year":"1992","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.clinthera.2005.09.005_bib119","doi-asserted-by":"crossref","first-page":"749","DOI":"10.7326\/0003-4819-118-9-199305010-00028","article-title":"Minocycline-induced pneumonia","volume":"118","author":"Bridges","year":"1993","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.clinthera.2005.09.005_bib120","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1001\/archinte.154.14.1633","article-title":"Minocycline pneumonitis and eosinophilia. A report on eight patients","volume":"154","author":"Sitbon","year":"1994","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.clinthera.2005.09.005_bib121","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1183\/09031936.95.08061018","article-title":"Bronchiolitis obliterans organizing pneumonia associated with minocycline therapy: A possible cause","volume":"8","author":"Piperno","year":"1995","journal-title":"Eur Respir J"},{"key":"10.1016\/j.clinthera.2005.09.005_bib122","doi-asserted-by":"crossref","first-page":"176","DOI":"10.2169\/internalmedicine.35.176","article-title":"A clinical study of minocycline-induced pneumonitis","volume":"35","author":"Toyoshima","year":"1996","journal-title":"Intern Med"},{"key":"10.1016\/j.clinthera.2005.09.005_bib123","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1177\/106002809703100612","article-title":"Severe minocycline-induced eosinophilic pneumonia: Extrapulmonary manifestations and the use of in vitro immunoassays","volume":"31","author":"Bentur","year":"1997","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.clinthera.2005.09.005_bib124","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1001\/archinte.144.7.1491","article-title":"Acute hepatic injury associated with minocycline","volume":"144","author":"Burette","year":"1984","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.clinthera.2005.09.005_bib125","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1136\/bmj.298.6686.1523-c","article-title":"Acute hepatitis and exfoliative dermatitis associated with minocycline","volume":"298","author":"Davies","year":"1989","journal-title":"BMJ"},{"key":"10.1016\/j.clinthera.2005.09.005_bib126","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/j.1875-9114.1992.tb02674.x","article-title":"Acute hepatic failure associated with oral minocycline: A case report","volume":"12","author":"Min","year":"1992","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.clinthera.2005.09.005_bib127","first-page":"1873","article-title":"Fulminant hepatic failure, hepatorenal syndrome, and necrotizing pancreatitis after minocycline hepatotoxicity","volume":"25","author":"Boudreaux","year":"1993"},{"key":"10.1016\/j.clinthera.2005.09.005_bib128","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1365-2230.1996.tb00077.x","article-title":"Minocycline and hepatitis","volume":"21","author":"Hardman","year":"1996","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib129","first-page":"1641","article-title":"Minocycline-induced liver injury","volume":"91","author":"Malcolm","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib130","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1111\/j.1572-0241.2000.03222.x","article-title":"Minocycline-induced hepatitis","volume":"95","author":"Nietsch","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib131","first-page":"143","article-title":"Acute hepatitis and drug-related lupus induced by minocycline treatment","volume":"92","author":"Golstein","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib132","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0190-9622(97)80414-8","article-title":"Fever, lymphadenopathy, eosinophilia, lymphocytosis, hepatitis, and dermatitis: A severe adverse reaction to minocycline","volume":"36","author":"MacNeil","year":"1997","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib133","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1136\/bmj.312.7024.169","article-title":"Minocycline induced autoimmune hepatitis and systemic lupus erythematosus-like syndrome","volume":"312","author":"Gough","year":"1996","journal-title":"BMJ"},{"key":"10.1016\/j.clinthera.2005.09.005_bib134","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/00004836-199807000-00016","article-title":"Minocycline-induced hepatitis with autoimmune features and neutropenia","volume":"27","author":"Bhat","year":"1998","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib135","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1001\/archpedi.152.11.1132","article-title":"Minocycline-related autoimmune hepatitis: Case series and literature review","volume":"152","author":"Teitelbaum","year":"1998","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.clinthera.2005.09.005_bib136","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1309\/KV2J-VX6Q-L95V-VDE4","article-title":"Minocycline as a cause of drug-induced autoimmune hepatitis. Report of four cases and comparison with autoimmune hepatitis","volume":"114","author":"Goldstein","year":"2000","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib137","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1136\/pgmj.66.775.404","article-title":"Late-onset drug fever associated with minocycline","volume":"66","author":"Gorard","year":"1990","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.clinthera.2005.09.005_bib138","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1001\/archinte.154.17.1983","article-title":"Severe episode of high fever with rash, lymphadenopathy, neutropenia, and eosinophilia after minocycline therapy for acne","volume":"154","author":"Kaufmann","year":"1994","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.clinthera.2005.09.005_bib139","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1001\/archderm.131.4.490","article-title":"Minocycline as possible cause of severe and protracted hypersensitivity drug reaction","volume":"131","author":"Parneix-Spake","year":"1995","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib140","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1001\/archderm.132.8.934","article-title":"Serious adverse reactions induced by minocycline. Report of 13 patients and review of the literature","volume":"132","author":"Knowles","year":"1996","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib141","first-page":"403","article-title":"Severe hypersensitivity reaction to minocycline","volume":"9","author":"de Paz","year":"1999","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib142","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1046\/j.1525-1470.2001.01931.x","article-title":"Minocycline hypersensitivity syndrome with hypotension mimicking septic shock","volume":"18","author":"Colvin","year":"2001","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib143","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1046\/j.1365-4362.2002.15636.x","article-title":"Minocycline hypersensitivity syndrome manifesting with rhabdomyolysis","volume":"41","author":"Rahman","year":"2002","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib144","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1046\/j.1365-4362.2003.01778.x","article-title":"Minocycline-induced central nervous system-pulmonary hypersensitivity syndrome","volume":"42","author":"Settgast","year":"2003","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib145","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000247736","article-title":"Acute febrile neutrophilic dermatosis (Sweet's syndrome) caused by minocycline","volume":"182","author":"Mensing","year":"1991","journal-title":"Dermatologica"},{"key":"10.1016\/j.clinthera.2005.09.005_bib146","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0190-9622(92)70251-A","article-title":"Minocycline-induced Sweet's syndrome","volume":"27","author":"Thibault","year":"1992","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib147","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1398-9995.1990.tb00502.x","article-title":"Serum sickness-like syndrome associated with minocycline therapy","volume":"45","author":"Puyana","year":"1990","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2005.09.005_bib148","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1177\/106002809603000509","article-title":"Serum-sickness-like reaction associated with minocycline therapy in adolescents","volume":"30","author":"Harel","year":"1996","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.clinthera.2005.09.005_bib149","first-page":"79","article-title":"Minocycline-induced serum sickness","volume":"17","author":"Levenson","year":"1996"},{"key":"10.1016\/j.clinthera.2005.09.005_bib150","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/0140-6736(92)92810-3","article-title":"Minocycline-related lupus","volume":"340","author":"Matsuura","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.clinthera.2005.09.005_bib151","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1093\/rheumatology\/33.7.674","article-title":"Minocycline-related lupus","volume":"33","author":"Byrne","year":"1994","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib152","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1093\/rheumatology\/33.12.1197-a","article-title":"Lupus-like syndrome associated with the use of minocycline","volume":"33","author":"Quilty","year":"1994","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib153","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/rheumatology\/34.4.398","article-title":"Minocycline-related lupus","volume":"34","author":"Bulgen","year":"1995","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib154","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1365-2133.1995.tb08636.x","article-title":"Minocycline-associated lupus erythematosus","volume":"132","author":"Gordon","year":"1995","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib155","first-page":"S69","article-title":"Lupus-like syndrome following minocycline consumption","volume":"39","author":"Lawson","year":"1996","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2005.09.005_bib156","first-page":"S69","article-title":"Minocycline-related lupus: A review of 23 definite cases","volume":"39","author":"Masson","year":"1996","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2005.09.005_bib157","first-page":"2160","article-title":"Minocycline-related lupus","volume":"23","author":"Masson","year":"1996","journal-title":"J Rheumatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib158","first-page":"S110","article-title":"Anti-myeloperoxidase antibodies in minocycline-induced lupus syndrome and myeloperoxidase-dependent drug cytotoxicity","volume":"39","author":"McHugh","year":"1996","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2005.09.005_bib159","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0190-9622(97)70043-4","article-title":"Minocycline-related lupus erythematosus with associated liver disease","volume":"36","author":"Crosson","year":"1997","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib160","first-page":"1851","article-title":"Minocycline related lupus","volume":"24","author":"Pointud","year":"1997","journal-title":"J Rheumatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib161","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1001\/jama.277.4.295a","article-title":"Lupuslike reaction associated with minocycline","volume":"277","author":"Singer","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.clinthera.2005.09.005_bib162","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1191\/096120399678841025","article-title":"Minocycline-induced clinical and biological lupus-like disease","volume":"8","author":"Tournigand","year":"1999","journal-title":"Lupus"},{"key":"10.1016\/j.clinthera.2005.09.005_bib163","first-page":"1004","article-title":"Minocycline induced lupus: Case series in the West of Scotland","volume":"28","author":"Gordon","year":"2001","journal-title":"J Rheumatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib164","first-page":"239","article-title":"Severe complication of a commonly prescribed drug: Minocycline-induced lupus","volume":"15","author":"Shepherd","year":"2002","journal-title":"J Am Board Fam Pract"},{"key":"10.1016\/j.clinthera.2005.09.005_bib165","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1136\/ard.55.10.769","article-title":"Minocycline induced arthritis associated with fever, livedo reticularis, and pANCA","volume":"55","author":"Elkayam","year":"1996","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2005.09.005_bib166","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1093\/rheumatology\/35.12.1327","article-title":"Antineutrophil cytoplasmic antibody-positive polyarthritis associated with minocycline therapy","volume":"35","author":"Gaffney","year":"1996","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib167","first-page":"587","article-title":"Minocycline-induced arthritis","volume":"16","author":"Knights","year":"1998","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib168","first-page":"91","article-title":"An infectious mononucleosis-like syndrome induced by minocycline: A third pattern of adverse drug reaction","volume":"64","author":"Lupton","year":"1999","journal-title":"Cutis"},{"key":"10.1016\/j.clinthera.2005.09.005_bib169","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1542\/peds.103.2.503","article-title":"Polyarteritis nodosa attributable to minocycline treatment for acne vulgaris","volume":"103","author":"Schrodt","year":"1999","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2005.09.005_bib170","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1067\/mjd.2001.112218","article-title":"Perinuclear anti-neutrophilic cytoplasmic antibody-positive cutaneous polyarteritis nodosa associated with minocycline therapy for acne vulgaris","volume":"44","author":"Schaffer","year":"2001","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib171","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/j.1442-200X.1994.tb03274.x","article-title":"Minocycline-induced hemolytic anemia","volume":"36","author":"Kudoh","year":"1994","journal-title":"Acta Paediatr Jpn"},{"key":"10.1016\/j.clinthera.2005.09.005_bib172","first-page":"320","article-title":"Minocycline-induced immune thrombocytopenia presenting as Schamberg's disease","volume":"2","author":"D'Addario","year":"2003","journal-title":"J Drugs Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib173","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1001\/archpedi.1995.02170140099020","article-title":"Minocycline-induced rash in an 18-year-old patient","volume":"149","author":"Karofsky","year":"1995","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.clinthera.2005.09.005_bib174","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1902\/jop.1992.63.1.13","article-title":"Gingival crevicular fluid concentration and side effects of minocycline: A comparison of two dose regimens","volume":"63","author":"Freeman","year":"1992","journal-title":"J Periodontol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib175","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1001\/archderm.118.12.989","article-title":"Efficacy of minocycline compared with tetracycline in treatment of acne vulgaris","volume":"118","author":"Hubbell","year":"1982","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib176","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1177\/030006058501300404","article-title":"A general practice study investigating the effect of Minocin 50 mg b.d. for 12 weeks in the treatment of acne vulgaris","volume":"13","author":"Cohen","year":"1985","journal-title":"J Int Med Res"},{"key":"10.1016\/j.clinthera.2005.09.005_bib177","first-page":"161","article-title":"A comparison of the efficacy and safety of lymecycline and minocycline in patients with moderately severe acne vulgaris","volume":"8","author":"Grosshans","year":"1998","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib178","first-page":"245","article-title":"Comparison of tetracycline and minocycline in the treatment of non-gonococcal urethritis","volume":"59","author":"Oriel","year":"1983","journal-title":"Br J Vener Dis"},{"key":"10.1016\/j.clinthera.2005.09.005_bib179","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1179\/joc.1998.10.6.469","article-title":"Azithromycin compared with minocycline in the treatment of acne comedonica and papulo-pustulosa","volume":"10","author":"Gruber","year":"1998","journal-title":"J Chemother"},{"key":"10.1016\/j.clinthera.2005.09.005_bib180","doi-asserted-by":"crossref","first-page":"16","DOI":"10.7326\/0003-4819-119-1-199307010-00003","article-title":"Minocycline compared with doxycycline in the treatment of nongonococcal urethritis and mucopurulent cervicitis","volume":"119","author":"Romanowski","year":"1993","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.clinthera.2005.09.005_bib181","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000250830","article-title":"Minocycline versus doxycycline in the treatment of acne vulgaris. A double-blind study","volume":"157","author":"Smit","year":"1978","journal-title":"Dermatologica"},{"key":"10.1016\/j.clinthera.2005.09.005_bib182","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1365-2230.1988.tb00689.x","article-title":"A comparison of doxycycline and minocycline in the treatment of acne vulgaris","volume":"13","author":"Harrison","year":"1988","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib183","first-page":"19","article-title":"Comparative clinical study of doxycycline and minocycline","volume":"11","author":"Klastersky","year":"1975","journal-title":"Int J Clin Pharmacol Biopharm"},{"key":"10.1016\/j.clinthera.2005.09.005_bib184","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/jac\/23.1.123","article-title":"Doxycycline and minocycline in the treatment of respiratory infections: A double-blind comparative clinical, microbiological and pharmacokinetic study","volume":"23","author":"Maesen","year":"1989","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.clinthera.2005.09.005_bib185","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1001\/archderm.118.1.19","article-title":"Tetracycline and minocycline treatment","volume":"118","author":"Leyden","year":"1982","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.clinthera.2005.09.005_bib186","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3109\/09546639609089553","article-title":"The antimicrobial effects in vivo of minocycline, doxycycline and tetracycline in humans","volume":"7","author":"Leyden","year":"1996","journal-title":"J Dermatol Treat"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291805001700?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291805001700?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T16:58:29Z","timestamp":1706720309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291805001700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":187,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["S0149291805001700"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2005.09.005","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}