{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:06:00Z","timestamp":1774742760907,"version":"3.50.1"},"reference-count":58,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.clinthera.2006.01.006","type":"journal-article","created":{"date-parts":[[2006,2,19]],"date-time":"2006-02-19T12:15:17Z","timestamp":1140351317000},"page":"99-109","source":"Crossref","is-referenced-by-count":13,"title":["Oral clindamycin 300 mg BID compared with oral amoxicillin\/clavulanic acid 1 g BID in the outpatient treatment of acute recurrent pharyngotonsillitis caused by group a \u03b2-hemolytic streptococci: An international, multicenter, randomized, investigator-blinded, prospective trial in patients between the ages of 12 and 60 years"],"prefix":"10.1016","volume":"28","author":[{"given":"Prasit","family":"Mahakit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Gil Vicente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Igbal Butt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"German","family":"Angeli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Zambrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2006.01.006_bib1","first-page":"769","article-title":"Streptococcal diseases worldwide: Present status and prospects","volume":"65","author":"Rotta","year":"1987","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.clinthera.2006.01.006_bib2","first-page":"619","article-title":"Current management of streptococcal pharyngitis","volume":"35","author":"Denny","year":"1992","journal-title":"J Fam Pract"},{"key":"10.1016\/j.clinthera.2006.01.006_bib3","series-title":"Infectious Diseases","first-page":"540","article-title":"Infections of the pharynx, larynx, epiglottis, trachea, and thyroid","author":"Baker","year":"1998"},{"key":"10.1016\/j.clinthera.2006.01.006_bib4","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/00006454-198507000-00003","article-title":"Effect of treatment on streptococcal pharyngitis: Is the issue really settled?","volume":"4","author":"Denny","year":"1985","journal-title":"Pediatr Infect Dis"},{"key":"10.1016\/j.clinthera.2006.01.006_bib5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/00006454-198401000-00003","article-title":"Does penicillin make Johnny's strep throat better?","volume":"3","author":"Hall","year":"1984","journal-title":"Pediatr Infect Dis"},{"key":"10.1016\/j.clinthera.2006.01.006_bib6","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1001\/jama.253.9.1271","article-title":"Streptococcal pharyngitis: Placebo-controlled double-blind evaluation of clinical response to penicillin therapy","volume":"253","author":"Krober","year":"1985","journal-title":"JAMA"},{"key":"10.1016\/j.clinthera.2006.01.006_bib7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/00006454-198401000-00004","article-title":"The effect of penicillin therapy on the symptoms and signs of streptococcal pharyngitis","volume":"3","author":"Nelson","year":"1984","journal-title":"Pediatr Infect Dis"},{"key":"10.1016\/j.clinthera.2006.01.006_bib8","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1093\/clinids\/11.6.928","article-title":"Comprehensive review of morbidity and mortality trends for rheumatic fever, streptococcal disease, and scarlet fever: The decline of rheumatic fever","volume":"11","author":"Quinn","year":"1989","journal-title":"Rev Infect Dis"},{"key":"10.1016\/j.clinthera.2006.01.006_bib9","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1161\/01.CIR.78.4.1082","article-title":"Prevention of rheumatic fever. A statement for health professionals by the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young, the American Heart Association","volume":"78","author":"Danjani","year":"1988","journal-title":"Circulation"},{"key":"10.1016\/j.clinthera.2006.01.006_bib10","series-title":"Beta-HemoOc Streptococcal Diseases","first-page":"79","article-title":"Diagnosis of streptococcal pharyngitis","author":"Breese","year":"1978"},{"key":"10.1016\/j.clinthera.2006.01.006_bib11","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/00325481.1988.11700348","article-title":"Streptococcal pharyngitis. What's new","volume":"84","author":"Tanz","year":"1988","journal-title":"Postgrad Med"},{"key":"10.1016\/j.clinthera.2006.01.006_bib12","series-title":"Pharyngitis: Management in an Era of Declining Rheumatic Fever","first-page":"33","article-title":"Diagnosis of pharyngitis: Clinical and epidemiologic features","author":"Wannamaker","year":"1984"},{"key":"10.1016\/j.clinthera.2006.01.006_bib13","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/00006454-198701000-00053","article-title":"Streptococcal pharyngitis in the 1980s","volume":"6","author":"Dillon","year":"1987","journal-title":"Pediatr Infect Dis J."},{"key":"10.1016\/j.clinthera.2006.01.006_bib14","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/S0140-6736(80)91832-2","article-title":"Failure of penicillin to eradicate group A streptococci during an outbreak of pharyngitis","volume":"2","author":"Gastanaduy","year":"1980","journal-title":"Lancet"},{"key":"10.1016\/j.clinthera.2006.01.006_bib15","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0022-3476(87)80023-9","article-title":"Efficacy of beta-lactamase-resistant penicillin and influence of penicillin tolerance in eradicating streptococci from the phar ynx after failureof penicillin therapy for group A streptococcal pharyngitis","volume":"110","author":"Smith","year":"1987","journal-title":"J Pediatr"},{"key":"10.1016\/j.clinthera.2006.01.006_bib16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3109\/00365548809117215","article-title":"Five versus ten days treatment of group A streptococcal pharyngotonsillitis: A randomized controlled clinical trial with phenoxymethyl penicillinand cefadroxil","volume":"20","author":"Stromberg","year":"1998","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.clinthera.2006.01.006_bib17","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1542\/peds.108.5.1180","article-title":"Unexplained reduced microbiological efficacy of intramuscular benzathine penicillin G and of oral penicillin V in eradication of group a streptococci from children with acute pharyngitis","volume":"108","author":"Kaplan","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2006.01.006_bib18","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3109\/00365549709035874","article-title":"Loracarbefversus phenoxymethylpenicillin in the treatment of recurrent streptococcal pharyngotonsillitis","volume":"29","author":"Roos","year":"1997","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.clinthera.2006.01.006_bib19","doi-asserted-by":"crossref","first-page":"324","DOI":"10.2310\/7070.2001.19359","article-title":"Failure of penicillin to eradicate group A betahemolytic streptococci tonsillitis: Causes and management","volume":"30","author":"Brook","year":"2001","journal-title":"J Otolaryngol"},{"key":"10.1016\/j.clinthera.2006.01.006_bib20","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/BF01971304","article-title":"Tonsil surface and core cultures in recurrent tonsillitis: Prevalence of anaerobes and beta-lactamase producing organisms","volume":"13","author":"Mitchelmore","year":"1994","journal-title":"Eurj Clin Microbiol Infect Dis"},{"key":"10.1016\/j.clinthera.2006.01.006_bib21","first-page":"139","article-title":"Microbiology and management of respiratory tract infections","volume":"15","author":"Brook","year":"1998","journal-title":"J Infect Dis Antimicrob Agents"},{"key":"10.1016\/j.clinthera.2006.01.006_bib22","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/clinids\/21.1.171","article-title":"Changes in the core tonsillar bacteriology of recurrent tonsillitis: 1997\u20131993","volume":"21","author":"Brook","year":"1995","journal-title":"Clin Infect Dis."},{"key":"10.1016\/j.clinthera.2006.01.006_bib23","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/clinids\/6.5.601","article-title":"The role of beta-lactamase-producing bacteria in the persistence of streptococcal tonsillar infection","volume":"6","author":"Brook","year":"1984","journal-title":"Rev Infect Dis"},{"key":"10.1016\/j.clinthera.2006.01.006_bib24","first-page":"83","article-title":"Beta lactamase-producing microorganisms in recurrent tonsillitis","volume":"39","author":"Tuner","year":"1983","journal-title":"Scand J Infect Dis Suppl"},{"key":"10.1016\/j.clinthera.2006.01.006_bib25","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3109\/00365549409011811","article-title":"Clindamycin in persisting streptococcal pharyngotonsillitis after penicillin treatment","volume":"26","author":"Onrling","year":"1994","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.clinthera.2006.01.006_bib26","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1001\/archpedi.1979.02130110051007","article-title":"Sensitivity of group A streptococci to antibiotics. Prevalence of resistance to erythromycin in Japan","volume":"133","author":"Maruyama","year":"1979","journal-title":"Am J Dis Child"},{"key":"10.1016\/j.clinthera.2006.01.006_bib27","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/00006454-199304000-00023","article-title":"Group A beta-hemolytic Streptococcus: Issue of resistance","volume":"12","author":"Rathore","year":"1993","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.clinthera.2006.01.006_bib28","doi-asserted-by":"crossref","first-page":"618","DOI":"10.3109\/00016489709113448","article-title":"Clindamycin in recurrent group A streptococcal pharyngo tonsillitis\u2014an alternative to tonsillectomy?","volume":"117","author":"Orrling","year":"1997","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.clinthera.2006.01.006_bib29","first-page":"87","article-title":"Streptococcal pharyngitis. 3. Streptococcal recurrence rates follow ing therapy with penicillin or with clindamycin (7-cholorolincomycin)","volume":"42","author":"Randolph","year":"1970","journal-title":"Del Med J"},{"key":"10.1016\/j.clinthera.2006.01.006_bib30","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0149-2918(95)80038-7","article-title":"A double-blind, multicenter comparative study of two regimens ofclindamycin hydrochloride in the treatment of patients with acute streptococcaltonsillitis\/pharyngitis","volume":"17","author":"Gallegos","year":"1995","journal-title":"Clin Ther"},{"key":"10.1016\/j.clinthera.2006.01.006_bib31","first-page":"50","article-title":"Clindamycin in the upper respiratory tract infections","volume":"43","author":"Lundberg","year":"1984","journal-title":"Scand J Infect Dis Suppl."},{"key":"10.1016\/j.clinthera.2006.01.006_bib32","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1001\/archotol.1989.01860310094031","article-title":"Penicillin and clindamycin therapy in recurrent tonsillitis. Effect of microbial flora","volume":"115","author":"Foote","year":"1989","journal-title":"Arch Otolaryngol Head Neck Surg."},{"key":"10.1016\/j.clinthera.2006.01.006_bib33","first-page":"677","article-title":"The use of clindamycin-2-palmitate and of erythromycin in infantile tonsillitis and pharyngotonsillitis [in Italian]","volume":"139","author":"Boscarelli","year":"1980","journal-title":"Gazz Med Ital"},{"key":"10.1016\/j.clinthera.2006.01.006_bib34","doi-asserted-by":"crossref","first-page":"356","DOI":"10.7326\/0003-4819-90-3-356","article-title":"Diagnosis and treatment: Drugs five years later. Amoxicillin","volume":"90","author":"Neu","year":"1979","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.clinthera.2006.01.006_bib35","doi-asserted-by":"crossref","first-page":"264","DOI":"10.2165\/00003495-199039020-00008","article-title":"Amoxicillin\/clavulanic acid. An update of its antibacterial activity, pharmacokinetic properties and therapeutic use","volume":"39","author":"Todd","year":"1990","journal-title":"Drugs"},{"key":"10.1016\/j.clinthera.2006.01.006_bib36","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1128\/JCM.25.3.504-508.1987","article-title":"Specificity study of kits for detection of group A streptococci directly from throat swabs","volume":"25","author":"Facklam","year":"1987","journal-title":"J Clin Microbiol."},{"key":"10.1016\/j.clinthera.2006.01.006_bib37","series-title":"Essential Procedures for Clinical Microbiology","first-page":"122","article-title":"Aerobic bacteriology","author":"Pezzio","year":"1998"},{"key":"10.1016\/j.clinthera.2006.01.006_bib38","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1177\/000348948509400312","article-title":"Impact of phenoxymethylpenicillin and clindamycin on microflora in recurrent tonsillitis","volume":"94","author":"Tuner","year":"1985","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/j.clinthera.2006.01.006_bib39","doi-asserted-by":"crossref","first-page":"691","DOI":"10.3109\/00365549009027122","article-title":"Effect of amoxycillin\/clavulanic acid on the aerobic and anaerobic tonsillar microflora in the treatment of recurrent tonsillitis","volume":"22","author":"Agren","year":"1990","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.clinthera.2006.01.006_bib40","series-title":"Nonparametric Statistical Methods","author":"Hollander","year":"1999"},{"key":"10.1016\/j.clinthera.2006.01.006_bib41","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0022-3476(05)81052-2","article-title":"Clindamycin treatment of chronic pharyngeal carriage of group A streptococci","volume":"119","author":"Tanz","year":"1991","journal-title":"J Pediatr"},{"key":"10.1016\/j.clinthera.2006.01.006_bib42","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.5631\/jibirin.78.2891","article-title":"Study of tissue concentration of clindamycin-2-phosphate and its clinical usefulness [in Japanese]","volume":"78","author":"Yokoi","year":"1985","journal-title":"Pract Otol."},{"key":"10.1016\/j.clinthera.2006.01.006_bib43","first-page":"967","article-title":"Treatment of recurrent tonsillitis in children with clindamycin: A multicen ter study [in French]","volume":"106","author":"Martin du Pan","year":"1986","journal-title":"Rev Med Suisse Romande"},{"key":"10.1016\/j.clinthera.2006.01.006_bib44","series-title":"Protocol 313","article-title":"Serum clindamycin levels study following multiple oral doses of Cleocin HCI given accord ing to a Q.6H. dosage regimen","author":"Disanto","year":"1972"},{"issue":"Suppl A","key":"10.1016\/j.clinthera.2006.01.006_bib45","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/jac\/7.suppl_A.3","article-title":"Antibacterial activity and pharmacokinetics of clindamycin","volume":"7","author":"Leigh","year":"1981","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.clinthera.2006.01.006_bib46","article-title":"Bioavailability evaluation of clindamycin following two multiple dose regimens of Cleocin HCI capsules","author":"Jungbluth","year":"1989"},{"key":"10.1016\/j.clinthera.2006.01.006_bib47","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1128\/AAC.22.3.353","article-title":"Pharmacokinetics of amoxicillin and clavulanic acid administered alone and in combination","volume":"22","author":"Adam","year":"1982","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.clinthera.2006.01.006_bib48","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2165\/00044011-199918030-00006","article-title":"Comparative bioavailability of two oral 875\/125mg sachet formulations of amoxicillin\/clavulanic acid in healthy volunteers","volume":"18","author":"G\u00e1lvez-M\u00fagica","year":"1999","journal-title":"Clin Drug Invest"},{"key":"10.1016\/j.clinthera.2006.01.006_bib49","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1093\/clind\/24.4.570","article-title":"Dosing of amoxicillin\/clavulanate given every 12 hours is as effective as dosing every 8 hours for treatment of lower respiratory tract infection","volume":"24","author":"Calver","year":"1997","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.clinthera.2006.01.006_bib50","first-page":"359","article-title":"Use of the combination of amoxicillin and clavulanic acid in infec tions of the ENT tract [in Italian]","volume":"8","author":"Catalano","year":"1988","journal-title":"Riv Ital Otorinolaringol Audiol Foniatr"},{"key":"10.1016\/j.clinthera.2006.01.006_bib51","first-page":"P129","article-title":"A comparative study of cefaclor vs amoxicillin\/clavulanate in pediat ric pharyngotonsillitis","volume":"9","author":"Haczynski","year":"2003","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.clinthera.2006.01.006_bib52","series-title":"Program and abstracts of the 6th Mediterranean Congress on Chemotherapy","article-title":"Study of efficacy of amoxicillin plus clavulanic acid in the treatment of ear, nose and throat infections","author":"Ottaviani","year":"1988"},{"key":"10.1016\/j.clinthera.2006.01.006_bib53","series-title":"Presented at: 25th National Congress of the Italian Society for the Study of Infective and Parasitic Diseases","article-title":"Amoxicillin\/clavulanic acid in the treatment of ENT infec tions [in Italian]","author":"Esposito","year":"1989"},{"key":"10.1016\/j.clinthera.2006.01.006_bib54","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0022-3476(88)80291-9","article-title":"Eradication of group A streptococci from the upper respiratory tract by amoxicillin with clavulanate after oral penicillin V treatment failure","volume":"113","author":"Kaplan","year":"1988","journal-title":"J Pediatr"},{"key":"10.1016\/j.clinthera.2006.01.006_bib55","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1177\/000992288502400606","article-title":"Treatment of patients with a history of recurrent tonsillitis due to group A beta hemolytic streptococci. A prospective randomized study comparing penicillin, erythromycin, and clindamycin","volume":"24","author":"Brook","year":"1985","journal-title":"Clin Pediatr (Phila)"},{"key":"10.1016\/j.clinthera.2006.01.006_bib56","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/jac\/24.2.227","article-title":"Treatment of patients with acute recurrent tonsillitis due to group A beta-haemolytic streptococci: A prospective randomized study comparing penicillin and amoxycillin\/clavulanate potassium","volume":"24","author":"Brook","year":"1989","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.clinthera.2006.01.006_bib57","first-page":"1","article-title":"Clindamycin: Toxicity and side effects","author":"Silva","year":"1997"},{"issue":"Suppl 1","key":"10.1016\/j.clinthera.2006.01.006_bib58","first-page":"67","article-title":"A worldwide survey of clinical experience with Augmentin","volume":"2","author":"Croydon","year":"1989","journal-title":"J Drug Dev"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291806000208?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291806000208?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T14:42:16Z","timestamp":1683384136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291806000208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0149291806000208"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2006.01.006","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}