{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T19:15:00Z","timestamp":1793819700091,"version":"4.6.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1016\/j.clinthera.2006.09.004","type":"journal-article","created":{"date-parts":[[2006,10,24]],"date-time":"2006-10-24T17:57:34Z","timestamp":1161712654000},"page":"1342-1352","source":"Crossref","is-referenced-by-count":14,"title":["The newborn drug development initiative workshop: Summary proceedings from the neurology group on neonatal seizures"],"prefix":"10.1016","volume":"28","author":[{"given":"Robert R.","family":"Clancy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2006.09.004_bib1","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1001\/archneur.55.12.1533","article-title":"Anticoagulation therapy in pediatric patients with sinovenous thrombosis: A cohort study","volume":"55","author":"deVeber","year":"1998","journal-title":"Arch Neurol."},{"key":"10.1016\/j.clinthera.2006.09.004_bib2","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1182\/asheducation-2001.1.358","article-title":"Thromboembolic disease and antithrombotic therapy in newborns","author":"Andrew","year":"2001","journal-title":"Hematology Am Soc Hematol Educ Program."},{"key":"10.1016\/j.clinthera.2006.09.004_bib3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0887-8994(98)00127-1","article-title":"Acetazolamide and furosemide for posthemorrhagic hydrocephalus of the newborn","volume":"20","author":"Libenson","year":"1999","journal-title":"Ped Neurol."},{"issue":"Suppl 1","key":"10.1016\/j.clinthera.2006.09.004_bib4","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1177\/088307380502000101","article-title":"Treatment of pediatric epilepsy: Expert opinion, 2005","volume":"20","author":"Wheless","year":"2005","journal-title":"J Child Neurol."},{"key":"10.1016\/j.clinthera.2006.09.004_bib5","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1111\/j.1651-2227.1979.tb08216.x","article-title":"Neonatal convulsions. Incidence and causes in the Stockholm area","volume":"68","author":"Eriksson","year":"1979","journal-title":"Acta Paediatr Scand."},{"key":"10.1016\/j.clinthera.2006.09.004_bib6","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1212\/WNL.45.4.724","article-title":"A population-based study of neonatal seizures in Fayette County, Kentucky","volume":"45","author":"Lanska","year":"1995","journal-title":"Neurology"},{"key":"10.1016\/j.clinthera.2006.09.004_bib7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0022-3476(99)70374-4","article-title":"The epidemiology of clinical neonatal seizures in Newfoundland: A populationbased study","volume":"134","author":"Ronen","year":"1999","journal-title":"J Pediatr."},{"key":"10.1016\/j.clinthera.2006.09.004_bib8","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/oxfordjournals.aje.a010079","article-title":"Incidence of neonatal seizures in Harris County, Texas, 1992\u20131994","volume":"150","author":"Saliba","year":"1996","journal-title":"Am J Epidemiol"},{"issue":"Suppl 3","key":"10.1016\/j.clinthera.2006.09.004_bib9","first-page":"112","article-title":"Very early onset epilepsy","author":"Clancy","year":"1992","journal-title":"Epilepsia"},{"key":"10.1016\/j.clinthera.2006.09.004_bib10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0887-8994(92)90026-U","article-title":"Problems with definitions and classifications of newborn encephalopathy","volume":"8","author":"Leviton","year":"1992","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.clinthera.2006.09.004_bib11","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/ana.410140607","article-title":"Outcomes in neonates with convulsions treated in an intensive care unit","volume":"14","author":"Bergman","year":"1983","journal-title":"Ann Neurol"},{"key":"10.1016\/j.clinthera.2006.09.004_bib12","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S0022-3476(88)80649-8","article-title":"Cluster of perinatal events identifying infants at high risk for death or disability","volume":"113","author":"Ellenberg","year":"1988","journal-title":"J Pediatr"},{"key":"10.1016\/j.clinthera.2006.09.004_bib13","first-page":"583","article-title":"Neurologic outcome after electroencephalographically proven neonatal seizures","volume":"88","author":"Legido","year":"1991","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2006.09.004_bib14","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/ana.410020505","article-title":"Perinatal risk factors in children with serious motor and mental handicaps","volume":"2","author":"Nelson","year":"1977","journal-title":"Ann Neurol."},{"issue":"Suppl 7","key":"10.1016\/j.clinthera.2006.09.004_bib15","first-page":"102","article-title":"Neurologic impairment, developmental delay and postneonatal seizures 2 years after EEG-video documented seizures in near-term and term neonates: Report of the Clinical Research Centers for Neonatal Seizures","volume":"42","author":"Mizrahi","year":"2001","journal-title":"Epilepsia"},{"key":"10.1016\/j.clinthera.2006.09.004_bib16","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/ana.410440602","article-title":"Consequences of neonatal seizures in the rat: Morphological and behavioral effects","volume":"44","author":"Holmes","year":"1998","journal-title":"Ann Neurol"},{"issue":"Suppl 5","key":"10.1016\/j.clinthera.2006.09.004_bib17","first-page":"S3","article-title":"Seizure-induced neuronal injury: Animal data","volume":"59","author":"Holmes","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.clinthera.2006.09.004_bib18","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1212\/WNL.58.4.542","article-title":"Seizure-associated brain injury in term newborns with perinatal asphyxia","volume":"58","author":"Miller","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.clinthera.2006.09.004_bib19","doi-asserted-by":"crossref","first-page":"F19","DOI":"10.1136\/fn.81.1.F19","article-title":"Amplitude integrated EEG 3 and 6 hours after birth in full term neonates with hypoxic-ischaemic encephalopathy","volume":"81","author":"Toet","year":"1999","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.clinthera.2006.09.004_bib20","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0022-3476(86)80713-2","article-title":"Use of barbiturate therapy in severe perinatal asphyxia: A randomized controlled trial","volume":"109","author":"Goldberg","year":"1986","journal-title":"J Pediatr."},{"key":"10.1016\/j.clinthera.2006.09.004_bib21","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0022-3476(98)70458-5","article-title":"High-dose Phenobarbital therapy in term newborn infants with severe perinatal asphyxia: A randomized, prospective study with three-year follow-up","volume":"132","author":"Hall","year":"1998","journal-title":"J Pediatr"},{"key":"10.1016\/j.clinthera.2006.09.004_bib22","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1136\/adc.64.4_Spec_No.459","article-title":"Clinical and EEG response to anticonvulsants in neonatal seizures","volume":"64","author":"Connell","year":"1989","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.clinthera.2006.09.004_bib23","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0887-8994(91)90067-U","article-title":"Neonatal seizures: Electroclinical dissociation","volume":"7","author":"Weiner","year":"1991","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.clinthera.2006.09.004_bib24","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/j.1528-1157.1995.tb00960.x","article-title":"Spatial and temporal characteristics of neonatal seizures","volume":"36","author":"Bye","year":"1995","journal-title":"Epilepsia"},{"key":"10.1016\/j.clinthera.2006.09.004_bib25","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1212\/01.WNL.0000106944.59990.E6","article-title":"Second-line anticonvulsant treatment of neonatal seizures. A video EEG monitoring study","volume":"62","author":"Boylan","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.clinthera.2006.09.004_bib26","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1056\/NEJM199908123410704","article-title":"Phenobarbital compared with phenytoin for the treatment of neo natal seizures","volume":"341","author":"Painter","year":"1999","journal-title":"N Engl J Med."},{"key":"10.1016\/j.clinthera.2006.09.004_bib27","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1212\/01.WNL.0000152891.58694.71","article-title":"Midazolam in neonatal seizures with no response to Phenobarbital","volume":"64","author":"Castro Conde","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.clinthera.2006.09.004_bib28","first-page":"CD001240","article-title":"Anticonvulsants for preventing mortality and morbidity in full term newborns with perinatal asphyxia","volume":"3","author":"Evans","year":"2001","journal-title":"Cochrane Database Syst Rev."},{"key":"10.1016\/j.clinthera.2006.09.004_bib29","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1212\/01.WNL.0000157320.78071.6D","article-title":"Neonatal seizures: After all these years we still love what doesn't work","volume":"64","author":"Sankar","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.clinthera.2006.09.004_bib30","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1212\/WNL.37.12.1837","article-title":"Characterization and classification of neonatal seizures","volume":"37","author":"Mizrahi","year":"1987","journal-title":"Neurology"},{"key":"10.1016\/j.clinthera.2006.09.004_bib31","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1542\/peds.109.5.772","article-title":"Comparison between simultaneously recorded amplitude inte grated electroencephalogram (cerebral function monitor) and standard electroencephalogram in neonates","volume":"109","author":"Toet","year":"2002","journal-title":"Pediatrics"},{"issue":"Suppl 1","key":"10.1016\/j.clinthera.2006.09.004_bib32","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1111\/j.1528-1157.1996.tb06022.x","article-title":"The contribution of EEG to the understanding of neonatal seizures","volume":"37","author":"Clancy","year":"1996","journal-title":"Epilepsia"},{"key":"10.1016\/j.clinthera.2006.09.004_bib33","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/0887-8994(95)00047-J","article-title":"MRI, MRA, and neurodevelopmental outcome following neonatal ECMO","volume":"12","author":"Lago","year":"1995","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.clinthera.2006.09.004_bib34","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1542\/peds.111.3.592","article-title":"Risk of seizures in survivors of newborn heart surgery using deep hypothermic circulatory arrest","volume":"111","author":"Clancy","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2006.09.004_bib35","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.0013-9580.2005.22504.x","article-title":"Electrographic neonatal seizures after infant heart surgery","volume":"46","author":"Clancy","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.clinthera.2006.09.004_bib36","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/BF01958419","article-title":"Pyridoxine-dependent seizures, clinical and therapeutic aspects","volume":"150","author":"Haenggeli","year":"1991","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.clinthera.2006.09.004_bib37","doi-asserted-by":"crossref","first-page":"F34","DOI":"10.1136\/fn.72.1.F34","article-title":"Predictive value of early continuous amplitude inte grated EEG recordings on outcome after severe birth asphyxia in full term infants","volume":"72","author":"Hellstrom-Westas","year":"1995","journal-title":"Arch Dis Child Fetal Neonatal Ed."},{"key":"10.1016\/j.clinthera.2006.09.004_bib38","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0304-3940(92)90183-8","article-title":"Enhancement of the excitatory actions of GABA by barbiturates and benzodiazepines","volume":"146","author":"Staley","year":"1992","journal-title":"Neurosci Lett."},{"key":"10.1016\/j.clinthera.2006.09.004_bib39","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s11940-001-0005-x","article-title":"Neonatal seizures","volume":"3","author":"Painter","year":"2001","journal-title":"Curr Treat Options Neurol"},{"key":"10.1016\/j.clinthera.2006.09.004_bib40","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1528-1157.1987.tb03685.x","article-title":"The exact ictal and interictal duration of electroencephalographic neonatal seizures","volume":"28","author":"Clancy","year":"1987","journal-title":"Epilepsia"},{"key":"10.1016\/j.clinthera.2006.09.004_bib41","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1528-1157.1988.tb03715.x","article-title":"Occult neonatal seizures","volume":"29","author":"Clancy","year":"1988","journal-title":"Epilepsia"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291806002116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291806002116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T00:03:59Z","timestamp":1555891439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291806002116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["S0149291806002116"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2006.09.004","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}