{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:24:28Z","timestamp":1792725868136,"version":"4.5.0"},"reference-count":74,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1016\/j.clinthera.2006.09.005","type":"journal-article","created":{"date-parts":[[2006,10,24]],"date-time":"2006-10-24T13:57:34Z","timestamp":1161698254000},"page":"1353-1365","source":"Crossref","is-referenced-by-count":192,"title":["Intervention strategies for neonatal hypoxic-ischemic cerebral injury"],"prefix":"10.1016","volume":"28","author":[{"given":"Jeffrey M.","family":"Perlman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2006.09.005_bib1","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1542\/peds.99.6.851","article-title":"Intrapartum hypoxic-ischemic cerebral injury and subsequent cerebral palsy: Medicolegal issues","volume":"99","author":"Perlman","year":"1997","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2006.09.005_bib2","series-title":"Neurology of the Newborn","article-title":"Hypoxic-ischemic encephalopathy","author":"Volpe","year":"2001"},{"key":"10.1016\/j.clinthera.2006.09.005_bib3","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1542\/peds.100.6.1004","article-title":"Interventions for perinatal hypoxic-ischemic encephalopathy","volume":"100","author":"Vannucci","year":"1997","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2006.09.005_bib4","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1136\/adc.64.7_Spec_No.953","article-title":"Magnetic resonance and near infrared spectroscopy for investigation of perinatal hypoxic-ischaemic brain injury","volume":"64","author":"Wyatt","year":"1989","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.clinthera.2006.09.005_bib5","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0095-5108(02)00059-3","article-title":"Pathogenesis of hypoxic-ischemic cerebral injury in the term infant: Current concepts","volume":"29","author":"Grow","year":"2002","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.clinthera.2006.09.005_bib6","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1203\/00006450-199412000-00003","article-title":"Delayed (\u201csecondary\u201d) cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: Continuous 48-hour studies by phosphorus magnetic resonance spectroscopy","volume":"36","author":"Lorek","year":"1994","journal-title":"Pediatr Res."},{"key":"10.1016\/j.clinthera.2006.09.005_bib7","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1469-8749.1997.tb07372.x","article-title":"Relation of deranged neonatal cerebral oxidative metabolism with neurodevelopmental outcome and head circumference at 4 years","volume":"39","author":"Roth","year":"1997","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.clinthera.2006.09.005_bib8","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0095-5108(18)30294-X","article-title":"Hypoxic-ischemic encephalopathy. Therapeutic approaches against microvascular injury, and role of neutrophils, PAF, and free radicals","volume":"22","author":"Palmer","year":"1995","journal-title":"Clin Perinatol."},{"key":"10.1016\/j.clinthera.2006.09.005_bib9","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1203\/00006450-199610000-00015","article-title":"Enhanced expression of interleukin (IL)-1 and IL-6 messenger RNA and bioactive protein after hypoxia-ischemia in neonatal rats","volume":"40","author":"Hagberg","year":"1996","journal-title":"Pediatr Res."},{"key":"10.1016\/j.clinthera.2006.09.005_bib10","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1203\/00006450-199904010-00008","article-title":"Chemokine and inflammatory cell response to hypoxia-ischemia in immature rats","volume":"45","author":"Bona","year":"1999","journal-title":"Pediatr Res."},{"key":"10.1016\/j.clinthera.2006.09.005_bib11","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1046\/j.0953-816x.2001.01474.x","article-title":"Bacterial endotoxin sensitizes the immature brain to hypoxic-ischaemic injury","volume":"13","author":"Eklind","year":"2001","journal-title":"Eur J Neurosci."},{"key":"10.1016\/j.clinthera.2006.09.005_bib12","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/0306-4522(96)00225-4","article-title":"Adenovirus-mediated over-expression of interleukin-1 receptor antagonist reduces susceptibility to excitotoxic brain injury in perinatal rats","volume":"75","author":"Hagan","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.clinthera.2006.09.005_bib13","first-page":"300","article-title":"Blocking of interleukin-1 activity is a beneficial approach to ischemia brain edema formation","volume":"60","author":"Yamasaki","year":"1994","journal-title":"Acta Neurochir Suppl (Wien)"},{"key":"10.1016\/j.clinthera.2006.09.005_bib14","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/nm0796-788","article-title":"Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors","volume":"2","author":"Bruce","year":"1996","journal-title":"Nat Med."},{"key":"10.1016\/j.clinthera.2006.09.005_bib15","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/00004647-199802000-00008","article-title":"Cerebral interleukin-6 is neuroprotective during permanent focal cerebral ischemia in the rat","volume":"18","author":"Loddick","year":"1998","journal-title":"J Cereb Blood Flow Metab."},{"key":"10.1016\/j.clinthera.2006.09.005_bib16","first-page":"7162","article-title":"Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-methyl-o-aspartate or nitric oxide\/ superoxide in cortical cell cultures","volume":"92","author":"Bonfoco","year":"1995"},{"key":"10.1016\/j.clinthera.2006.09.005_bib17","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/j.1365-2990.1996.tb01122.x","article-title":"Apoptosis in perinatal hypoxic-ischaemic cerebral damage","volume":"22","author":"Edwards","year":"1996","journal-title":"Neuropathol Appl Neurobiol."},{"key":"10.1016\/j.clinthera.2006.09.005_bib18","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1542\/peds.97.4.456","article-title":"Can asphyxiated infants at risk for neonatal seizures be rapidly identified by cur rent high-risk markers?","volume":"97","author":"Perlman","year":"1996","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2006.09.005_bib19","doi-asserted-by":"crossref","first-page":"F34","DOI":"10.1136\/fn.72.1.F34","article-title":"Predictive value of early continuous amplitude inte grated EEG recordings on outcome after severe birth asphyxia in full term infants","volume":"72","author":"Hellstrom-Westas","year":"1995","journal-title":"Arch Dis Child Fetal Neonatal Ed."},{"key":"10.1016\/j.clinthera.2006.09.005_bib20","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1542\/peds.103.6.1263","article-title":"Assessment of neonatal encephalopathy by amplitude integrated electroencephalography","volume":"103","author":"al Naqeeb","year":"1999","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2006.09.005_bib21","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1542\/peds.111.2.351","article-title":"Amplitude-integrated electroencephalography coupled with an early neurologic examination enhances prediction of term infants at risk for persistent encephalopathy","volume":"111","author":"Shalak","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2006.09.005_bib22","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0006-8993(03)02276-5","article-title":"The glucose paradox of cerebral ischemia: Evidence for corticosterone involvement","volume":"971","author":"Payne","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.clinthera.2006.09.005_bib23","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000243874","article-title":"Effect of glucose on perinatal hypoxicischemic brain damage","volume":"62","author":"Vannucci","year":"1992","journal-title":"Biol Neonate"},{"key":"10.1016\/j.clinthera.2006.09.005_bib24","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0095-5108(02)00054-4","article-title":"Hypoglycemic injury to the immature brain","volume":"29","author":"Yager","year":"2002","journal-title":"Clin Perinatol."},{"key":"10.1016\/j.clinthera.2006.09.005_bib25","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1542\/peds.114.2.361","article-title":"Initial hypoglycemia and neonatal brain injury in term infants with severe fetal acidemia","volume":"114","author":"Salhab","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2006.09.005_bib26","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/1531-8249(200010)48:4<632::AID-ANA10>3.0.CO;2-3","article-title":"Seizures accelerate anoxia-induced neuronal death in the neonatal rat hippocampus","volume":"48","author":"Dzhala","year":"2000","journal-title":"Ann Neurol"},{"key":"10.1016\/j.clinthera.2006.09.005_bib27","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/ana.410440602","article-title":"Consequences of neonatal seizures in the rat: Morphological and behavioral effects","volume":"44","author":"Holmes","year":"1998","journal-title":"Ann Neurol"},{"key":"10.1016\/j.clinthera.2006.09.005_bib28","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0095-5108(18)30643-2","article-title":"Consensus and controversy in the clinical management of neonatal seizures","volume":"16","author":"Mizrahi","year":"1989","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.clinthera.2006.09.005_bib29","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1542\/peds.91.1.128","article-title":"Electrographic seizures in preterm and full-term neonates: Clinical cor relates, associated brain lesions, and risk for neurologic sequelae","volume":"91","author":"Scher","year":"1993","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2006.09.005_bib30","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0022-3476(86)80713-2","article-title":"Use of barbiturate therapy in severe perinatal asphyxia: A ran domized controlled trial","volume":"109","author":"Goldberg","year":"1986","journal-title":"J Pediatr"},{"key":"10.1016\/j.clinthera.2006.09.005_bib31","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0022-3476(98)70458-5","article-title":"Highdose phenobarbital therapy in term newborn infants with severe perina tal asphyxia: A randomized, prospective study with three-year follow-up","volume":"132","author":"Hall","year":"1998","journal-title":"J Pediatr"},{"key":"10.1016\/j.clinthera.2006.09.005_bib32","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/ana.410280107","article-title":"The effect of mild hyperthermia and hypothermia on brain damage following 5, 10, and 15 minutes of forebrain ischemia","volume":"28","author":"Minamisawa","year":"1990","journal-title":"Ann Neurol"},{"key":"10.1016\/j.clinthera.2006.09.005_bib33","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1203\/00006450-199310000-00029","article-title":"Influence of mild hypothermia on hypoxic-ischemic brain damage in the immature rat","volume":"34","author":"Yager","year":"1993","journal-title":"Pediatr Res."},{"key":"10.1016\/j.clinthera.2006.09.005_bib34","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1203\/00006450-199404000-00011","article-title":"Modest hypothermia provides partial neuroprotection for ischemic neonatal brain","volume":"35","author":"Laptook","year":"1994","journal-title":"Pediatr Res"},{"key":"10.1016\/j.clinthera.2006.09.005_bib35","doi-asserted-by":"crossref","first-page":"F3","DOI":"10.1136\/fn.74.1.F3","article-title":"Posthypoxic cooling of neonatal rats provides protection against brain injury","volume":"74","author":"Thoresen","year":"1996","journal-title":"Arch Dis Child Fetal Neonatal Ed."},{"key":"10.1016\/j.clinthera.2006.09.005_bib36","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1172\/JCI119153","article-title":"Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs","volume":"99","author":"Gunn","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.clinthera.2006.09.005_bib37","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1542\/peds.102.5.1098","article-title":"Neuroprotection with prolonged head cooling started before post ischemic seizures in fetal sheep","volume":"102","author":"Gunn","year":"1998","journal-title":"Pediatrics."},{"key":"10.1016\/j.clinthera.2006.09.005_bib38","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/BF02740655","article-title":"Postischemic hypothermia. A critical appraisal with implications for clinical treatment","volume":"14","author":"Colbourne","year":"1997","journal-title":"Mol Neurobiol."},{"key":"10.1016\/j.clinthera.2006.09.005_bib39","doi-asserted-by":"crossref","first-page":"F85","DOI":"10.1136\/fn.78.2.F85","article-title":"Treatment of hypoxic-ischaemic brain damage by moderate hypo thermia","volume":"78","author":"Edwards","year":"1998","journal-title":"Arch Dis Child Fetal Neonatal Ed."},{"key":"10.1016\/j.clinthera.2006.09.005_bib40","first-page":"199","article-title":"Therapeutic hypothermia: A potential neuroprotective and resuscitative strategy for neonatal hypoxia-ischemia","volume":"1","author":"Laptook","year":"1996","journal-title":"Prenat Neonat Med."},{"key":"10.1016\/j.clinthera.2006.09.005_bib41","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1007\/BF00293321","article-title":"The effect of focal cerebral cooling on perinatal hypoxic ischemic brain damage","volume":"87","author":"Towfighi","year":"1994","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.1016\/j.clinthera.2006.09.005_bib42","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0095-5108(02)00057-X","article-title":"The effects of temperature on hypoxic-ischemic brain injury","volume":"29","author":"Laptook","year":"2002","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.clinthera.2006.09.005_bib43","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1056\/NEJM199702203360803","article-title":"Treatment of traumatic brain injury with moderate hypothermia","volume":"336","author":"Marion","year":"1997","journal-title":"N Engl J Med."},{"key":"10.1016\/j.clinthera.2006.09.005_bib44","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1056\/NEJMoa003289","article-title":"Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia","volume":"346","author":"Bernard","year":"2002","journal-title":"N Engl J Med."},{"key":"10.1016\/j.clinthera.2006.09.005_bib45","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1056\/NEJMoa012689","article-title":"Mild therapeutic hypothermia to improve the neuro logic outcome after cardiac arrest","volume":"346","year":"2002","journal-title":"NEngl J Med."},{"key":"10.1016\/j.clinthera.2006.09.005_bib46","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1056\/NEJM200202213460811","article-title":"Therapeutic hypothermia after cardiac arrest","volume":"346","author":"Safar","year":"2002","journal-title":"N Engl J Med."},{"key":"10.1016\/j.clinthera.2006.09.005_bib47","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1542\/peds.108.5.1103","article-title":"Differences in brain temperature and cerebral blood flow during selective head versus whole-body cooling","volume":"108","author":"Laptook","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2006.09.005_bib48","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1542\/peds.106.1.92","article-title":"Cardiovascular changes during mild therapeutic hypothermia and rewarming in infants with hypoxic-ischemic encephalopathy","volume":"106","author":"Thoresen","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2006.09.005_bib49","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1542\/peds.102.4.885","article-title":"Selective head cooling in newborn infants after perinatal asphyxia: A safety study","volume":"102","author":"Gunn","year":"1998","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2006.09.005_bib50","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1542\/peds.106.4.684","article-title":"Pilot study of treatment with whole body hypothermia for neonatal encephalopathy","volume":"106","author":"Azzopardi","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2006.09.005_bib51","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1542\/peds.110.2.377","article-title":"Whole-body hypothermia for neonatal encephalopathy: Animal observations as a basis for a randomized, controlled pilot study in term infants","volume":"110","author":"Shankaran","year":"2002","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2006.09.005_bib52","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s001340051020","article-title":"Induced brain hypothermia in asphyxiated human newborn in fants: A retrospective chart analysis of physiological and adverse effects","volume":"25","author":"Simbruner","year":"1999","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.clinthera.2006.09.005_bib53","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.pediatrneurol.2004.06.015","article-title":"Moderate hypothermia in neonatal encephalopathy: Safety outcomes","volume":"32","author":"Eicher","year":"2005","journal-title":"Pediatr Neurol."},{"key":"10.1016\/j.clinthera.2006.09.005_bib54","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0140-6736(05)17946-X","article-title":"Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: Multicentre randomised trial","volume":"365","author":"Gluckman","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.clinthera.2006.09.005_bib55","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole-body hypothermia for neonates with hypoxicischemic encephalopathy","volume":"353","author":"Shankaran","year":"2005","journal-title":"N Engl J Med."},{"key":"10.1016\/j.clinthera.2006.09.005_bib56","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0304-3940(03)00558-5","article-title":"Neuroprotection against hypoxia-ischemia in neonatal rat brain by novel superoxide dismutase mimetics","volume":"346","author":"Shimizu","year":"2003","journal-title":"Neurosci Lett."},{"key":"10.1016\/j.clinthera.2006.09.005_bib57","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1542\/peds.101.2.185","article-title":"Effect of allopurinol on postasphyxial free radical formation, cere bral hemodynamics, and electrical brain activity","volume":"101","author":"Van Bel","year":"1998","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2006.09.005_bib58","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1203\/01.PDR.0000081297.53793.C6","article-title":"Effects of allopurinol and deferoxamine on reperfusion injury of the brain in newborn piglets after neonatal hypoxia-ischemia","volume":"54","author":"Peeters-Scholte","year":"2003","journal-title":"Pediatr Res."},{"key":"10.1016\/j.clinthera.2006.09.005_bib59","first-page":"473","article-title":"Prevention by magnesium of excitotoxic neuronal death in the developing brain: An animal model of clinical intervention studies","volume":"37","author":"Marret","year":"1995","journal-title":"Dev Med Child Neurol."},{"key":"10.1016\/j.clinthera.2006.09.005_bib60","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1203\/00006450-199703000-00024","article-title":"Magnesium sulfate after transient hypoxia-ischemia fails to prevent delayed cerebral energy failure in the newborn piglet","volume":"41","author":"Penrice","year":"1997","journal-title":"Pediatr Res."},{"key":"10.1016\/j.clinthera.2006.09.005_bib61","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0002-9378(97)80005-1","article-title":"Magnesium sulfate therapy during asphyxia in near-term fetal lambs does not compromise the fetus but does not reduce cerebral injury","volume":"176","author":"de Haan","year":"1997","journal-title":"Am J Obstet Gynecol."},{"key":"10.1016\/j.clinthera.2006.09.005_bib62","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1542\/peds.95.2.263","article-title":"Can magnesium sulfate reduce the risk of cerebral palsy in very low birthweight infants?","volume":"95","author":"Nelson","year":"1995","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2006.09.005_bib63","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1046\/j.1442-200X.2002.01610.x","article-title":"Randomized controlled trial of magnesium sulfate infusion for severe birth asphyxia","volume":"44","author":"Ichiba","year":"2002","journal-title":"Pediatr Int."},{"key":"10.1016\/j.clinthera.2006.09.005_bib64","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1469-8749.1990.tb08540.x","article-title":"The use of a calcium-channel blocker, nicardipine, for severely as phyxiated newborn infants","volume":"32","author":"Levene","year":"1990","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.clinthera.2006.09.005_bib65","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00246-003-0692-z","article-title":"The pediatric cardiology pharmacopoeia: 2004 Update","volume":"25","author":"Barnes","year":"2004","journal-title":"Ped Cardiol"},{"key":"10.1016\/j.clinthera.2006.09.005_bib66","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1203\/00006450-199612000-00004","article-title":"The platelet-activating factor antagonist BN 52021 attenuates hypoxic-ischemic brain injury in the immature rat","volume":"40","author":"Liu","year":"1996","journal-title":"Pediatr Res."},{"key":"10.1016\/j.clinthera.2006.09.005_bib67","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0006-8993(97)00364-8","article-title":"Enhancing adenosine Al receptor binding reduces hypoxic ischemic brain injury in newborn rats","volume":"759","author":"Halle","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.clinthera.2006.09.005_bib68","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0002-9378(94)70245-4","article-title":"Monosialoganglioside GM 1 treatment after a hypoxicischemic episode reduces the vulnerability of the fetal sheep brain to subsequent injuries","volume":"170","author":"Tan","year":"1994","journal-title":"Am J Obstet Gynecol."},{"key":"10.1016\/j.clinthera.2006.09.005_bib69","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/ana.410390117","article-title":"Nerve growth factor protects the neonatal brain against hypoxic-ischemic injury","volume":"39","author":"Holtzman","year":"1996","journal-title":"Ann Neurol."},{"key":"10.1016\/j.clinthera.2006.09.005_bib70","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1172\/JCI118416","article-title":"Insulin-like growth factor-1 is a potent neuronal rescue agent after hypoxic-ischemic injury in fetal lambs","volume":"97","author":"Johnston","year":"1996","journal-title":"J Clin Invest."},{"key":"10.1016\/j.clinthera.2006.09.005_bib71","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/ana.10242","article-title":"Minocycline markedly protects the neonatal brain against hypoxicischemic injury","volume":"52","author":"Arvin","year":"2002","journal-title":"Ann Neurol."},{"key":"10.1016\/j.clinthera.2006.09.005_bib72","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/S0387-7604(03)00039-1","article-title":"Erythropoietin exerts neuroprotective effect in neonatal rat model of hypoxic-ischemic brain injury","volume":"25","author":"Aydin","year":"2003","journal-title":"Brain Dev."},{"key":"10.1016\/j.clinthera.2006.09.005_bib73","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1159\/000068926","article-title":"Neuroprotective effect of erythropoietin on hypoxic-ischemic brain injury in neonatal rats","volume":"83","author":"Kumral","year":"2003","journal-title":"Biol Neonate."},{"key":"10.1016\/j.clinthera.2006.09.005_bib74","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1203\/01.PDR.0000163616.89767.69","article-title":"Erythropoietin improves functional and histological outcome in neonatal stroke","volume":"58","author":"Chang","year":"2005","journal-title":"Pediatr Res."}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291806002128?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291806002128?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T09:45:54Z","timestamp":1683625554000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291806002128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":74,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["S0149291806002128"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2006.09.005","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}