{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T03:18:35Z","timestamp":1775099915803,"version":"3.50.1"},"reference-count":10,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.clinthera.2007.07.028","type":"journal-article","created":{"date-parts":[[2007,9,5]],"date-time":"2007-09-05T07:24:06Z","timestamp":1188977046000},"page":"1415-1420","source":"Crossref","is-referenced-by-count":39,"title":["Absolute Bioavailability of Intranasal Fluticasone Furoate in Healthy Subjects"],"prefix":"10.1016","volume":"29","author":[{"given":"Ann","family":"Allen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoff","family":"Down","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Newland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Reynard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicki","family":"Rousell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Salmon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2007.07.028_bib1","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1001\/archinte.159.9.941","article-title":"Systemic adverse effects of inhaled corticosteroid therapy: A systemic review and meta-analysis","volume":"159","author":"Lipworth","year":"1999","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.clinthera.2007.07.028_bib2","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1016\/j.clinthera.2004.11.017","article-title":"Relationship between systemic corticosteroid exposure and growth velocity: Development and validation of a pharmacokinetic\/pharmacodynamic model","volume":"26","author":"Daley-Yates","year":"2004","journal-title":"Clin Ther"},{"key":"10.1016\/j.clinthera.2007.07.028_bib3","first-page":"265","article-title":"Bioavailability of fluticasone propionate and mometasone furoate aqueous nasal sprays","volume":"60","author":"Daley-Yates","year":"2004","journal-title":"EurJ Clin Pharmacol"},{"issue":"Suppl 1","key":"10.1016\/j.clinthera.2007.07.028_bib4","first-page":"A89","article-title":"Tolerability, safety, pharmacokinetics and bioavailability of the novel intranasal corticosteroid fluticasone furoate in healthy subjects","volume":"98","author":"Allen","year":"2007","journal-title":"Ann Allergy Asthma Immunol."},{"key":"10.1016\/j.clinthera.2007.07.028_bib5","series-title":"A part-randomised, single dose, open label, 6-way cross-over study to assess the relative systemic pharmacokinetics and absolute bioavailability of 2 and 3 m GW685698X (2000 g), FTIM GW685698X material (2000 g) and FP (1000 g) administered via Diskhaler in healthy male subjects","author":"Upward","year":"2003"},{"key":"10.1016\/j.clinthera.2007.07.028_bib6","series-title":"A randomised, single dose, open label, 3-way cross-over study to assess the systemic pharmacokinetics of GW685698X (2000 g) administered via Diskhaler with or without charcoal and an intravenous dose (250 g) in healthy male subjects","author":"Wessels","year":"2003"},{"issue":"Suppl 1","key":"10.1016\/j.clinthera.2007.07.028_bib7","first-page":"A93","article-title":"Validation of a method for the determination of fluticasone furoate and two potential metabolites using liquid chromatography-mass spectrometry","volume":"98","author":"Scott","year":"2007","journal-title":"Ann Allergy Asthma Immunol."},{"issue":"Suppl 1","key":"10.1016\/j.clinthera.2007.07.028_bib8","first-page":"A90","article-title":"Disposition and metabolism of a novel enhanced affinity glucocorticoid, [14C]-fluticasone furoate (FF) after oral and intravenous (IV) administration in healthy male subjects","volume":"98","author":"Hughes","year":"2007","journal-title":"Ann Allergy Asthma Immunol."},{"key":"10.1016\/j.clinthera.2007.07.028_bib9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1046\/j.1365-2125.2001.01325.x","article-title":"Systemic bioavailability offluticasone propionate administered as nasal drops and aqueous nasal spray","volume":"51","author":"Daley-Yates","year":"2001","journal-title":"Br J Clin Pkarmacol."},{"key":"10.1016\/j.clinthera.2007.07.028_bib10","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1023\/A:1018943613122","article-title":"Physiological parameters in laboratory animals and humans","volume":"10","author":"Davies","year":"1993","journal-title":"Pharm Res."}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291807002202?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291807002202?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T16:57:32Z","timestamp":1556816252000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291807002202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0149291807002202"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2007.07.028","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}