{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:01:27Z","timestamp":1790870487103,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2007,10]]},"DOI":"10.1016\/j.clinthera.2007.10.012","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T21:27:33Z","timestamp":1196112453000},"page":"2204-2214","source":"Crossref","is-referenced-by-count":91,"title":["Efficacy of Multivitamin Supplementation Containing Vitamins B6 and B12 and Folic Acid as Adjunctive Treatment with a Cholinesterase Inhibitor in Alzheimer's Disease: A 26-Week, Randomized, Double-Blind, Placebo-Controlled Study in Taiwanese Patients"],"prefix":"10.1016","volume":"29","author":[{"given":"Yu","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Jung","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Liong","family":"Chien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sien-Tsong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-Chi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2007.10.012_bib1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1532-5415.1995.tb06379.x","article-title":"Prevalence and subtypes of dementia in Taiwan: A community survey of 5297 individuals","volume":"43","author":"Liu","year":"1995","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.clinthera.2007.10.012_bib2","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.amjmed.2006.08.036","article-title":"Effective pharmacologic management of Alzheimer's disease","volume":"120","author":"Farlow","year":"2007","journal-title":"Am J Med"},{"key":"10.1016\/j.clinthera.2007.10.012_bib3","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1017\/S026646230200034X","article-title":"Clinical and costeffectiveness of donepezil, rivastigmine, and galantamine for Alzheimer's disease","volume":"18","author":"Clegg","year":"2002","journal-title":"Int J Technol Assess Health Care"},{"key":"10.1016\/j.clinthera.2007.10.012_bib4","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1079\/BJN2001388","article-title":"Nutrition and cognitive impairment in the elderly","volume":"86","author":"Gonzalez-Gross","year":"2001","journal-title":"Br J Nutr"},{"key":"10.1016\/j.clinthera.2007.10.012_bib5","first-page":"310","article-title":"Vitamin B12 and folate depletion in cognition: A review","volume":"52","author":"Moretti","year":"2004","journal-title":"Neurol India"},{"key":"10.1016\/j.clinthera.2007.10.012_bib6","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S1474-4422(04)00878-6","article-title":"Dietary factors and Alzheimer's disease","volume":"3","author":"Luchsinger","year":"2004","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.clinthera.2007.10.012_bib7","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/gps.388","article-title":"Improvement of cognitive functions after cobalamin\/folate supplementation in elderly patients with dementia and elevated plasma homocysteine","volume":"16","author":"Nilsson","year":"2001","journal-title":"Int J Geriatr Psychiatry"},{"issue":"Suppl 2","key":"10.1016\/j.clinthera.2007.10.012_bib8","doi-asserted-by":"crossref","first-page":"S135","DOI":"10.1007\/PL00014298","article-title":"Vitamins B12, B6 and folate as determinants of homocysteine concentration in the healthy population","volume":"157","author":"Pietrzik","year":"1998","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.clinthera.2007.10.012_bib9","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1001\/jama.270.22.2693","article-title":"Vitamin status and intake as primary determinants of homocysteinemia in an elderly population","volume":"270","author":"Selhub","year":"1993","journal-title":"JAMA"},{"key":"10.1016\/j.clinthera.2007.10.012_bib10","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1056\/NEJMoa011613","article-title":"Plasma homocysteine as a risk factor for dementia and Alzheimer's disease","volume":"346","author":"Seshadri","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2007.10.012_bib11","doi-asserted-by":"crossref","first-page":"643S","DOI":"10.1093\/ajcn\/71.2.643s","article-title":"Alzheimer disease: Protective factors","volume":"71","author":"Nourhashemi","year":"2000","journal-title":"Am J Clin Nutr."},{"key":"10.1016\/j.clinthera.2007.10.012_bib12","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0899-9007(00)00307-5","article-title":"Homocysteine, Alzheimer's disease, and cognitive function","volume":"16","author":"Miller","year":"2000","journal-title":"Nutrition"},{"key":"10.1016\/j.clinthera.2007.10.012_bib13","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1515\/CCLM.2001.119","article-title":"Homocysteine, vascular dementia and Alzheimer's disease","volume":"39","author":"Joosten","year":"2001","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.clinthera.2007.10.012_bib14","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.archger.2004.07.001","article-title":"Plasma homocysteine levels and cognitive status in long-term stay geriatric patients: A cross-sectional study","volume":"40","author":"Adunsky","year":"2005","journal-title":"Arch Gerontol Geriatr"},{"key":"10.1016\/j.clinthera.2007.10.012_bib15","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1515\/CCLM.2005.190","article-title":"Homocysteine in relation to cognitive performance in pathological and non-pathological conditions","volume":"43","author":"Teunissen","year":"2005","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.clinthera.2007.10.012_bib16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000085856","article-title":"Hyperhomocysteinemia is associated with lower performance on memory tasks in post-menopausal women","volume":"20","author":"Clark","year":"2005","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1016\/j.clinthera.2007.10.012_bib17","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1136\/bmj.316.7135.894","article-title":"Lowering blood homocysteine with folic acid based supplements: Meta-analysis of randomised trials","volume":"316","year":"1998","journal-title":"BMJ"},{"key":"10.1016\/j.clinthera.2007.10.012_bib18","first-page":"283","article-title":"WMA will continue to revise policy as medicine and research changes","volume":"323","author":"Human","year":"2001","journal-title":"BMJ"},{"key":"10.1016\/j.clinthera.2007.10.012_bib19","unstructured":"European Agency for the Evaluation of Medicinal Products, International Conference on Harmonisation-World Health Organization. Guideline for Good Clinical Practice [EMEA Web site]. ICH Topic E6. Geneva, Switzerland: WHO; 2002. http:\/\/www.emea.eu.int. Accessed January 2007."},{"key":"10.1016\/j.clinthera.2007.10.012_bib20","unstructured":"American Psychiatry Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision. Washington, DC: American Psychiatric Association; 2000."},{"key":"10.1016\/j.clinthera.2007.10.012_bib21","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state.\u201d A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.clinthera.2007.10.012_bib22","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1212\/WNL.57.3.489","article-title":"A 1-year, randomized, placebocontrolled study of donepezil in patients with mild to moderate AD","volume":"57","author":"Winblad","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.clinthera.2007.10.012_bib23","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The Clinical Dementia Rating (CDR): Current version and scoring rules","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.clinthera.2007.10.012_bib24","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1093\/clinchem\/41.7.991","article-title":"Rapid, fully automated measurement of plasma homocyst(e)ine with the Abbott IMx analyzer","volume":"41","author":"Shipchandler","year":"1995","journal-title":"Clin Chem"},{"key":"10.1016\/j.clinthera.2007.10.012_bib25","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/S0002-9149(99)00575-5","article-title":"Effect of short-term vitamin (folic acid, vitamins B6 and B12) administration on endothelial dysfunction induced by post-methionine load hyperhomocysteinemia.","volume":"84","author":"Chao","year":"1999","journal-title":"Am J Cardiol."},{"key":"10.1016\/j.clinthera.2007.10.012_bib26","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1176\/ajp.141.11.1356","article-title":"A new rating scale for Alzheimer's disease","volume":"141","author":"Rosen","year":"1984","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.clinthera.2007.10.012_bib27","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1017\/S1041610296002578","article-title":"The Alzheimer's Disease Assessment Scale","volume":"8","author":"Mohs","year":"1996","journal-title":"Int Psychogeriatr"},{"key":"10.1016\/j.clinthera.2007.10.012_bib28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000048629","article-title":"The Alzheimer's Disease Assessment Scale: Findings from a low-education population","volume":"13","author":"Liu","year":"2002","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1016\/j.clinthera.2007.10.012_bib29","first-page":"69","article-title":"The Cognitive Abilities Screening Instrument and preliminary findings of its Chinese version, CASI C-2.0","volume":"2","author":"Teng","year":"1994","journal-title":"Chinese J Clin Psychiatry"},{"key":"10.1016\/j.clinthera.2007.10.012_bib30","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1159\/000057703","article-title":"Performance on the cognitive abilities screening instrument at different stages of Alzheimer's disease","volume":"13","author":"Liu","year":"2002","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1016\/j.clinthera.2007.10.012_bib31","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1159\/000066024","article-title":"Cutoff scores of the cognitive abilities screening instrument, Chinese version in screening of dementia","volume":"14","author":"Lin","year":"2002","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1016\/j.clinthera.2007.10.012_bib32","first-page":"61","article-title":"Functional evaluation: The Barthel index","volume":"14","author":"Mahoney","year":"1965","journal-title":"Md State Med J"},{"key":"10.1016\/j.clinthera.2007.10.012_bib33","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/geront\/9.3_Part_1.179","article-title":"Assessment of older people: Self-maintaining and instrumental activities of daily living","volume":"9","author":"Lawton","year":"1969","journal-title":"Gerontologist"},{"key":"10.1016\/j.clinthera.2007.10.012_bib34","unstructured":"US Food and Drug Administration. Medical Dictionary for Regulatory Activities [MedDRA Web site]. http:\/\/www.meddramsso.com\/MSSOWeb\/index.htm. Accessed January 2007."},{"key":"10.1016\/j.clinthera.2007.10.012_bib35","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1159\/000052767","article-title":"Long-term effects of vitamin B(12), folate, and vitamin B(6) supplements in elderly people with normal serum vitamin B(12) concentrations","volume":"47","author":"Henning","year":"2001","journal-title":"Gerontology"},{"key":"10.1016\/j.clinthera.2007.10.012_bib36","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1093\/jn\/124.10.1927","article-title":"Vitamin requirements for the treatment of hyperhomocysteinemia in humans","volume":"124","author":"Ubbink","year":"1994","journal-title":"J Nutr"},{"key":"10.1016\/j.clinthera.2007.10.012_bib37","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/BF00180030","article-title":"Hyperhomocysteinemia and the response to vitamin supplementation","volume":"71","author":"Ubbink","year":"1993","journal-title":"Clin Investig"},{"key":"10.1016\/j.clinthera.2007.10.012_bib38","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0140-6736(95)92113-3","article-title":"Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations","volume":"346","author":"Naurath","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.clinthera.2007.10.012_bib39","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/ajcn\/57.1.47","article-title":"Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia","volume":"57","author":"Ubbink","year":"1993","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clinthera.2007.10.012_bib40","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000046735","article-title":"Plasma folate but not vitamin B(12) or homocysteine concentrations are reduced after short-term vitamin B(6) supplementation","volume":"45","author":"Bosy-Westphal","year":"2001","journal-title":"Ann Nutr Metab"},{"key":"10.1016\/j.clinthera.2007.10.012_bib41","first-page":"CD004514","article-title":"Folic acid with or without vitamin B12 for cognition and dementia","volume":"4","author":"Malouf","year":"2003","journal-title":"Cochrane Database Syst Rev."},{"key":"10.1016\/j.clinthera.2007.10.012_bib42","first-page":"CD004393","article-title":"The effect of vitamin B6 on cognition","volume":"4","author":"Malouf","year":"2003","journal-title":"Cochrane Database Syst Rev."},{"key":"10.1016\/j.clinthera.2007.10.012_bib43","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1056\/NEJMoa054025","article-title":"A controlled trial of homocysteine lowering and cognitive performance","volume":"354","author":"McMahon","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2007.10.012_bib44","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ypmed.2004.11.007","article-title":"Cognitive performance in relation to vitamin status in healthy elderly German women\u2014the effect of 6-month multivitamin supplementation","volume":"41","author":"Wolters","year":"2005","journal-title":"Prev Med"},{"key":"10.1016\/j.clinthera.2007.10.012_bib45","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1159\/000091790","article-title":"3-Year study of donepezil therapy in Alzheimer's disease: Effects of early and continuous therapy","volume":"21","author":"Winblad","year":"2006","journal-title":"Dement Geriatr Cogn Disord"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291807003360?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291807003360?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T19:18:19Z","timestamp":1588101499000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291807003360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["S0149291807003360"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2007.10.012","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2007,10]]}}}