{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:54:24Z","timestamp":1791572064948,"version":"4.3.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.clinthera.2008.01.010","type":"journal-article","created":{"date-parts":[[2008,4,17]],"date-time":"2008-04-17T11:11:31Z","timestamp":1208430691000},"page":"182-189","source":"Crossref","is-referenced-by-count":46,"title":["Donepezil use in children and adolescents with tics and attention-deficit\/hyperactivity disorder: An 18-week, single-center, dose-escalating, prospective, open-label study"],"prefix":"10.1016","volume":"30","author":[{"given":"Esther","family":"Cubo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Fern\u00a1ndez Ja\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Anaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Gonz\u00a1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Kompoliti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2008.01.010_bib1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1474-4422(05)01012-4","article-title":"Tourette's syndrome: From behaviour to biology","volume":"4","author":"Singer","year":"2005","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.clinthera.2008.01.010_bib2","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1111\/j.1651-2227.2005.tb01837.x","article-title":"Tourette syndrome and other tic disorders in a total population of children: Clinical assessment and background","volume":"94","author":"Khalifa","year":"2005","journal-title":"Acta Paediatr"},{"issue":"Suppl 1","key":"10.1016\/j.clinthera.2008.01.010_bib3","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/S0387-7604(03)90004-0","article-title":"Phenomenology of tics and natural history of tic disorders","volume":"25","author":"Leckman","year":"2003","journal-title":"Brain Dev"},{"key":"10.1016\/j.clinthera.2008.01.010_bib4","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1136\/adc.29.148.537","article-title":"The treatment of tics in childhood: A review and a follow-up study","volume":"29","author":"Zausmer","year":"1954","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.clinthera.2008.01.010_bib5","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1471-2431-5-34","article-title":"Tourette syndrome and learning disabilities","volume":"5","author":"Burd","year":"2005","journal-title":"BMC Pediatrics"},{"key":"10.1016\/j.clinthera.2008.01.010_bib6","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1097\/chi.0b013e318068fbcc","article-title":"Tourette syndrome and tic disorders: A decade of progress","volume":"46","author":"Swain","year":"2007","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.clinthera.2008.01.010_bib7","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1089\/cap.2006.0098","article-title":"Alpha2-adrenergic receptor agonists for the treatment of attention-deficit\/hyperactivity disorder: Emerging concepts from new data","volume":"17","author":"Arnsten","year":"2007","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"10.1016\/j.clinthera.2008.01.010_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00787-006-0505-z","article-title":"Attention deficit hyperactivity disorder, tics and Tourette's syndrome: The relationship and treatment implications. A commentary","volume":"15","author":"Robertson","year":"2006","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"10.1016\/j.clinthera.2008.01.010_bib9","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1017\/S1092852900018460","article-title":"Non-stimulant treatment of attention-deficit\/hyperactivity disorder","volume":"8","author":"Pliszka","year":"2003","journal-title":"CNS Spectr"},{"key":"10.1016\/j.clinthera.2008.01.010_bib10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2165\/00002018-200730010-00003","article-title":"Treatment of attention deficit hyperactivity disorder in children and adolescents: Safety considerations","volume":"30","author":"Wolraich","year":"2007","journal-title":"Drug Saf"},{"key":"10.1016\/j.clinthera.2008.01.010_bib11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/00004714-200302000-00012","article-title":"Clozapine pharmacokinetics in children and adolescents with childhood-onset schizophrenia","volume":"23","author":"Frazier","year":"2003","journal-title":"Clin Psychopharmacol"},{"key":"10.1016\/j.clinthera.2008.01.010_bib12","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1517\/14656566.3.10.1381","article-title":"Antipsychotics: Impact on prolactin levels","volume":"3","author":"Goodnick","year":"2002","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.clinthera.2008.01.010_bib13","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1212\/WNL.32.11.1315","article-title":"Cholinergic mechanisms in Tourette syndrome","volume":"32","author":"Tanner","year":"1982","journal-title":"Neurology"},{"key":"10.1016\/j.clinthera.2008.01.010_bib14","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1176\/ajp.138.2.240","article-title":"Physostigmine in Tourette syndrome: Evidence for cholinergic underactivity","volume":"138","author":"Stahl","year":"1981","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.clinthera.2008.01.010_bib15","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.pbb.2003.08.015","article-title":"Effects of donepezil on DOI-induced head twitch response in mice: Implications for Tourette syndrome","volume":"76","author":"Hayslett","year":"2003","journal-title":"Pharmacol Biochem Behav"},{"issue":"Suppl 3","key":"10.1016\/j.clinthera.2008.01.010_bib16","first-page":"117","article-title":"Donepezil for tics in Tourette syndrome","volume":"50","author":"Riback","year":"2001","journal-title":"Ann Neurol"},{"key":"10.1016\/j.clinthera.2008.01.010_bib17","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/00004714-199908000-00019","article-title":"Donepezil for Tourette's disorder and ADHD","volume":"19","author":"Hoopes","year":"1999","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.clinthera.2008.01.010_bib18","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1089\/10445460050167322","article-title":"Adjunctive donepezil in attention deficit hyperactivity disorder youth: Cases series","volume":"10","author":"Wilens","year":"2000","journal-title":"J Child Adolesc Psycho-pharmacol"},{"key":"10.1016\/j.clinthera.2008.01.010_bib19","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1212\/WNL.50.1.136","article-title":"A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease","volume":"50","author":"Rogers","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.clinthera.2008.01.010_bib20","series-title":"Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR)","year":"2000"},{"key":"10.1016\/j.clinthera.2008.01.010_bib21","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1023\/A:1022602400621","article-title":"The revised Conners' Parent Rating Scale (CPRS-R): Factor structure, reliability, and criterion validity","volume":"26","author":"Conners","year":"1998","journal-title":"J Abnorm Child Psychol"},{"key":"10.1016\/j.clinthera.2008.01.010_bib22","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1089\/cap.2005.15.947","article-title":"An open trial of adjunctive donepezil in attention-deficit\/hyperactivity disorder","volume":"15","author":"Wilens","year":"2005","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"10.1016\/j.clinthera.2008.01.010_bib23","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1001\/archpsyc.1983.01790100074010","article-title":"A Children's Global Assessment Scale (CGAS)","volume":"40","author":"Shaffer","year":"1983","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.clinthera.2008.01.010_bib24","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1097\/00004583-198907000-00015","article-title":"The Yale Global Tic Severity Scale: Initial testing of a clinician-rated scale of tic severity","volume":"28","author":"Leckman","year":"1989","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.clinthera.2008.01.010_bib25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/BF00916464","article-title":"A comparison of cognitive\/neuropsychological impairments of nonretarded autistic and schizophrenic children","volume":"15","author":"Schneider","year":"1987","journal-title":"J Abnorm Child Psychol"},{"key":"10.1016\/j.clinthera.2008.01.010_bib26","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1037\/h0054651","article-title":"Studies of interference in serial verbal reaction","volume":"18","author":"Stroop","year":"1935","journal-title":"Exp Psychol"},{"key":"10.1016\/j.clinthera.2008.01.010_bib27","first-page":"729","article-title":"Perception and memory after a cycle of electroshocks, studied by means of the Rey figure complex test. II. Application of the Rey test in a group of patients before and after a cycle of electroshocks. Comparison with the results obtained in control subjects","volume":"86","author":"Lanzi","year":"1965","journal-title":"Riv Patol Nerv Ment"},{"key":"10.1016\/j.clinthera.2008.01.010_bib28","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1097\/00004583-199706000-00023","article-title":"Children's Yale-Brown Obsessive Compulsive Scale: Reliability and validity","volume":"36","author":"Scahill","year":"1997","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.clinthera.2008.01.010_bib30","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.pbb.2005.06.010","article-title":"Effects of donepezil, nicotine and haloperidol on the central serotoninergic system in mice: Implications for Tourette's syndrome","volume":"81","author":"Hayslett","year":"2005","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.clinthera.2008.01.010_bib31","first-page":"249","article-title":"Obsessive-compulsive disorder in Tourette's syndrome","volume":"96","author":"Como","year":"2005","journal-title":"Adv Neurol"},{"key":"10.1016\/j.clinthera.2008.01.010_bib32","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1177\/1087054705284091","article-title":"Donepezil in the treatment of ADHD-like symptoms in youths with pervasive developmental disorder: A case series","volume":"9","author":"Doyle","year":"2006","journal-title":"J Atten Disord"},{"key":"10.1016\/j.clinthera.2008.01.010_bib33","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0306-4522(99)00487-X","article-title":"Cortical cholinergic inputs mediating arousal, attentional processing and dreaming: Differential afferent regulation of the basal forebrain by telencephalic and brainstem afferents","volume":"95","author":"Sarter","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.clinthera.2008.01.010_bib34","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/ajmg.a.30184","article-title":"Donepezil effects on language in children with Down syndrome: Results of the first 22-week pilot clinical trial","volume":"130","author":"Heller","year":"2004","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.clinthera.2008.01.010_bib35","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1345\/aph.1K139","article-title":"Evaluation of centrally acting cholinesterase inhibitor exposures in adults","volume":"41","author":"McCain","year":"2007","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.clinthera.2008.01.010_bib36","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.annfar.2006.02.009","article-title":"Butyrylcholinesterase deficiency: How to analyze the cholinesterase activity in small children","volume":"25","author":"Lejus","year":"2006","journal-title":"Ann Fr Anesth Reanim"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291808000581?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291808000581?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,29]],"date-time":"2018-12-29T20:50:15Z","timestamp":1546116615000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291808000581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0149291808000581"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2008.01.010","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}