{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T13:05:37Z","timestamp":1697547937027},"reference-count":18,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.clinthera.2009.03.006","type":"journal-article","created":{"date-parts":[[2009,4,23]],"date-time":"2009-04-23T04:28:42Z","timestamp":1240460922000},"page":"575-579","source":"Crossref","is-referenced-by-count":5,"title":["Effects of pitavastatin on cerebral blood flow"],"prefix":"10.1016","volume":"31","author":[{"given":"Yoshihiko","family":"Horimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michitaka","family":"Matsubara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Mizutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Hibino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihisa","family":"Tajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutoshi","family":"Fukagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiro","family":"Kabasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2009.03.006_bib1","first-page":"904","article-title":"Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase","volume":"47","author":"Aoki","year":"1997","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.clinthera.2009.03.006_bib2","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1517\/14656566.8.14.2315","article-title":"Pitavastatin: Efficacy and safety in intensive lipid lowering","volume":"8","author":"Hayashi","year":"2007","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.clinthera.2009.03.006_bib3","first-page":"1383","article-title":"Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)","volume":"344","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.clinthera.2009.03.006_bib4","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1056\/NEJM199610033351401","article-title":"The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels","volume":"335","author":"Sacks","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2009.03.006_bib5","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJM199811053391902","article-title":"Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels","volume":"339","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2009.03.006_bib6","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1001\/jama.288.11.1388","article-title":"New evidence for stroke prevention: Scientific review","volume":"288","author":"Straus","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.clinthera.2009.03.006_bib7","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1016\/j.jacc.2005.04.070","article-title":"Stabilization of carotid atheroma assessed by quantitative ultrasound analysis in nonhypercholesterolemic patients with coronary artery disease","volume":"46","author":"Watanabe","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.clinthera.2009.03.006_bib8","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0140-6736(06)69472-5","article-title":"Primary prevention of cardiovascular disease with pravastatin in Japan (MEGA Study): A prospective randomised controlled trial","volume":"368","author":"Nakamura","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.clinthera.2009.03.006_bib9","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s00259-004-1491-3","article-title":"Effects of partial volume correction on discrimination between very early Alzheimer's dementia and controls using brain perfusion SPECT","volume":"31","author":"Kanetaka","year":"2004","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.clinthera.2009.03.006_bib10","first-page":"731","article-title":"Automated discrimination between very early Alzheimer's disease and controls using an easy Z-score imaging system for multicenter brain perfusion SPECT","volume":"28","author":"Matsuda","year":"2007","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.clinthera.2009.03.006_bib11","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1161\/01.CIR.103.7.926","article-title":"Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metal loproteinases, and cell death in human carotid plaques: Implications for plaque stabilization","volume":"103","author":"Crisby","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.clinthera.2009.03.006_bib12","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.bbrc.2003.12.104","article-title":"Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: A new insight into adipocytokine-endothelial cell interactions","volume":"314","author":"Kawanami","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.clinthera.2009.03.006_bib13","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.pharmthera.2006.09.003","article-title":"Prevention of stroke and dementia by statin therapy: Experimental and clinical evidence of their pleiotropic effects","volume":"113","author":"Miida","year":"2007","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.clinthera.2009.03.006_bib14","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1161\/01.ATV.0000099786.99623.EF","article-title":"Adiponectin and metabolic syndrome","volume":"24","author":"Matsuzawa","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.clinthera.2009.03.006_bib15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.thromres.2007.08.013","article-title":"Correlation between adiponectin and reduction of cell adhesion molecules after pitavastatin treatment in hyperlipidemic patients with type 2 diabetes mellitus","volume":"122","author":"Nomura","year":"2008","journal-title":"Thromb Res"},{"key":"10.1016\/j.clinthera.2009.03.006_bib16","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/01.fjc.0000245989.89771.1b","article-title":"A therapeutic dose of the lipophilic statin pitavastatin enhances oxidant-induced apoptosis in human vascular smooth muscle cells","volume":"48","author":"Tsujimoto","year":"2006","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.clinthera.2009.03.006_bib17","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.atherosclerosis.2003.12.034","article-title":"A new HMG-CoA reductase inhibitor, pitavastatin remarkably retards the progression of high cholesterol induced atherosclerosis in rabbits","volume":"176","author":"Hayashi","year":"2004","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.clinthera.2009.03.006_bib18","doi-asserted-by":"crossref","first-page":"8880","DOI":"10.1073\/pnas.95.15.8880","article-title":"Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase","volume":"95","author":"Endres","year":"1998","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291809000812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291809000812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T04:26:04Z","timestamp":1545279964000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291809000812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S0149291809000812"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2009.03.006","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}