{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:10:54Z","timestamp":1791267054618,"version":"4.1.0"},"reference-count":102,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1016\/j.clinthera.2009.08.006","type":"journal-article","created":{"date-parts":[[2009,10,6]],"date-time":"2009-10-06T08:47:47Z","timestamp":1254818867000},"page":"1826-1843","source":"Crossref","is-referenced-by-count":71,"title":["Management of fever in children: Summary of the Italian pediatric society guidelines"],"prefix":"10.1016","volume":"31","author":[{"given":"Elena","family":"Chiappini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Principi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Longhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier-Angelo","family":"Tovo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Becherucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Bonsignori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Festini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Galli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bice","family":"Lucchesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Mugelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"de Martino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2009.08.006_bib1","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1111\/j.1365-2702.2006.01890.x","article-title":"Influences on parents' fever management: Beliefs, experiences and information sources","volume":"16","author":"Walsh","year":"2007","journal-title":"J Clin Nurs."},{"key":"10.1016\/j.clinthera.2009.08.006_bib2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/01.mej.0000194401.15335.c7","article-title":"\u2018Fever phobia\u2019 in the emergency department: A survey of children's caregivers","volume":"13","author":"Betz","year":"2006","journal-title":"Eur J Emerg Med."},{"key":"10.1016\/j.clinthera.2009.08.006_bib3","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.emc.2007.07.012","article-title":"The evolving approach to the young child who has fever and no obvious source","volume":"25","author":"Ishimine","year":"2007","journal-title":"Emerg Med Clin North Am."},{"key":"10.1016\/j.clinthera.2009.08.006_bib4","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1136\/adc.2007.127225","article-title":"Feverish illness in children under 5 years","volume":"93","author":"Richardson","year":"2008","journal-title":"Arch Dis Child Educ Pract Ed."},{"key":"10.1016\/j.clinthera.2009.08.006_bib5","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.ajem.2007.03.001","article-title":"Comparing different patterns for managing febrile children in the ED between emergency and pediatric physicians: Impact on patient outcome","volume":"25","author":"Seow","year":"2007","journal-title":"Am J Emerg Med."},{"key":"10.1016\/j.clinthera.2009.08.006_bib6","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.pedhc.2006.07.001","article-title":"Appropriate use of nonprescription analgesics in pediatric patients","volume":"20","author":"Dlugosz","year":"2006","journal-title":"J Pediatr Health Care."},{"key":"10.1016\/j.clinthera.2009.08.006_bib8","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1542\/peds.108.2.354","article-title":"Comparative practice patterns of emergency medicine physicians and pediatric emergency medicine physicians managing fever in young children","volume":"108","author":"Isaacman","year":"2001","journal-title":"Pediatrics."},{"key":"10.1016\/j.clinthera.2009.08.006_bib9","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1067\/S0196-0644(03)00754-6","article-title":"Editorial: Clinical policy for children younger than three years presenting to the emergency department with fever","volume":"42","author":"Baraff","year":"2003","journal-title":"Ann Emerg Med."},{"key":"10.1016\/j.clinthera.2009.08.006_bib10","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/MOP.0b013e32832130d2","article-title":"Fever","volume":"21","author":"Rampersad","year":"2009","journal-title":"Curr Opin Pediatr."},{"key":"10.1016\/j.clinthera.2009.08.006_bib11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1136\/ebn.12.2.41","article-title":"Paracetamol plus ibuprofen increased time without fever compared with paracetamol but did not differ from ibuprofen in children","volume":"12","author":"Smaldone","year":"2009","journal-title":"Evid Based Nurs."},{"key":"10.1016\/j.clinthera.2009.08.006_bib15","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1136\/adc.2005.088831","article-title":"Thermometry in paediatric practice","volume":"91","author":"El-Radhi","year":"2006","journal-title":"Arch Dis Child."},{"key":"10.1016\/j.clinthera.2009.08.006_bib16","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/00044067-200404000-00011","article-title":"Can there be a standard for temperature measurement in the pediatric intensive care unit?","volume":"15","author":"Martin","year":"2004","journal-title":"AACN Clin Issues."},{"key":"10.1016\/j.clinthera.2009.08.006_bib17","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/01.PCC.0000185476.35550.B2","article-title":"Infrared tympanic thermometry in comparison with other temperature measurement techniques in febrile children","volume":"7","author":"Nimah","year":"2006","journal-title":"Pediatr Crit Care Med."},{"key":"10.1016\/j.clinthera.2009.08.006_bib18","first-page":"600","article-title":"Comparison of axillary temperature with rectal or oral temperature and determination of optimum placement time in children","volume":"41","author":"Chaturvedi","year":"2004","journal-title":"Indian Pediatr."},{"key":"10.1016\/j.clinthera.2009.08.006_bib19","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1136\/bmj.320.7243.1174","article-title":"Temperature measured at the axilla compared with rectum in children and young people: Systematic review","volume":"320","author":"Craig","year":"2000","journal-title":"BMJ."},{"key":"10.1016\/j.clinthera.2009.08.006_bib20","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1651-2227.2003.tb00551.x","article-title":"How reliable is axillary temperature measurement?","volume":"92","author":"Falzon","year":"2003","journal-title":"Acta Pediatr."},{"key":"10.1016\/j.clinthera.2009.08.006_bib21","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1177\/1367493506062550","article-title":"Is tympanic membrane thermometry the best method for recording temperature in children?","volume":"10","author":"Dew","year":"2006","journal-title":"J Child Health Care."},{"key":"10.1016\/j.clinthera.2009.08.006_bib22","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1086\/588290","article-title":"The influence of mucositis on oral thermometry: When fever may not reflect infection","volume":"46","author":"Ciuraru","year":"2008","journal-title":"Clin Infect Dis."},{"key":"10.1016\/j.clinthera.2009.08.006_bib23","first-page":"26","article-title":"Measuring infants' temperature","volume":"105","author":"Morley","year":"1992","journal-title":"Midwives Chron."},{"key":"10.1016\/j.clinthera.2009.08.006_bib24","series-title":"Report on the proposal for a regulation of the European Parliament and of the Council on the banning of exports and the safe storage of metallic mercury","year":"2007"},{"key":"10.1016\/j.clinthera.2009.08.006_bib25","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.jclinepi.2005.10.004","article-title":"In a systematic review, infrared ear thermometry for fever diagnosis in children finds poor sensitivity","volume":"59","author":"Dodd","year":"2006","journal-title":"J Clin Epidemiol."},{"key":"10.1016\/j.clinthera.2009.08.006_bib26","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0022-3476(98)70067-8","article-title":"Comparison of esopha-geal, rectal, axillary, bladder, tympanic, and pulmonary artery temperatures in children","volume":"133","author":"Robinson","year":"1998","journal-title":"J Pediatr."},{"key":"10.1016\/j.clinthera.2009.08.006_bib27","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00005721-199503000-00007","article-title":"Does tympanic temperature measure up?","volume":"20","author":"Wells","year":"1995","journal-title":"MCN Am J Matern Child Nurs."},{"key":"10.1016\/j.clinthera.2009.08.006_bib28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1136\/emj.2004.022764","article-title":"An evaluation of tympanic thermometry in a paediatric emergency department","volume":"23","author":"El-Radhi","year":"2006","journal-title":"Emerg Med J."},{"key":"10.1016\/j.clinthera.2009.08.006_bib29","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/PEC.0b013e31802c61e6","article-title":"Measurement accuracy of fever by tympanic and axillary thermometry","volume":"23","author":"Devrim","year":"2007","journal-title":"Pediatr Emerg Care."},{"key":"10.1016\/j.clinthera.2009.08.006_bib30","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0140-6736(02)09783-0","article-title":"Infrared ear thermometry compared with rectal thermometry in children: A systematic review","volume":"360","author":"Craig","year":"2002","journal-title":"Lancet."},{"key":"10.1016\/j.clinthera.2009.08.006_bib31","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1542\/peds.85.5.854","article-title":"Evaluation of an infrared tympanic membrane thermometer in pediatric patients","volume":"85","author":"Kenney","year":"1990","journal-title":"Pediatrics."},{"key":"10.1016\/j.clinthera.2009.08.006_bib32","doi-asserted-by":"crossref","first-page":"F55","DOI":"10.1136\/adc.2006.114314","article-title":"Comparison between rectal and infrared skin temperature in the newborn","volume":"93","author":"De Curtis","year":"2008","journal-title":"Arch Dis Fetal Neonatal Ed."},{"key":"10.1016\/j.clinthera.2009.08.006_bib33","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.arcped.2005.01.034","article-title":"Body temperature measurement in daily practice [in French]","volume":"12","author":"Sermet-Gaudelus","year":"2005","journal-title":"Arch Pediatr."},{"key":"10.1016\/j.clinthera.2009.08.006_bib34","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1542\/peds.107.6.1241","article-title":"Fever phobia revisited: Have parental misconceptions about fever changed in 20 years?","volume":"107","author":"Crocetti","year":"2001","journal-title":"Pediatrics."},{"key":"10.1016\/j.clinthera.2009.08.006_bib35","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1365-2648.2006.03802.x","article-title":"Management of childhood fever by parents: Literature review","volume":"54","author":"Walsh","year":"2006","journal-title":"J Adv Nurs."},{"key":"10.1016\/j.clinthera.2009.08.006_bib36","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1097\/01.pec.0000139739.46591.dd","article-title":"Parents' beliefs and practices regarding childhood fever: A study of a multiethnic and socioeconomically diverse sample of parents","volume":"20","author":"Taveras","year":"2004","journal-title":"Pediatr Emerg Care"},{"key":"10.1016\/j.clinthera.2009.08.006_bib37","first-page":"CD004264","article-title":"Physical methods for treating fever in children","volume":"2","author":"Meremikwu","year":"2003","journal-title":"Cochrane Database Syst Rev."},{"key":"10.1016\/j.clinthera.2009.08.006_bib38","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1136\/bmj.305.6862.1134","article-title":"Management of feverish children at home","volume":"305","author":"Kinmonth","year":"1992","journal-title":"BMJ"},{"key":"10.1016\/j.clinthera.2009.08.006_bib39","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/000992289403300407","article-title":"Tepid sponging to reduce temperature in febrile children in a tropical climate","volume":"33","author":"Mahar","year":"1994","journal-title":"Clin Pediatr (Phila)"},{"key":"10.1016\/j.clinthera.2009.08.006_bib40","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0735-6757(97)90099-1","article-title":"The efficacy of tepid sponge bathing to reduce fever in young children","volume":"15","author":"Sharber","year":"1997","journal-title":"Am J Emerg Med."},{"key":"10.1016\/j.clinthera.2009.08.006_bib41","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/00006565-199003000-00003","article-title":"Efficacy of sponging vs acetaminophen for reduction of fever","volume":"6","author":"Friedman","year":"1990","journal-title":"Pediatr Emerg Care"},{"key":"10.1016\/j.clinthera.2009.08.006_bib42","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1136\/adc.82.3.238","article-title":"Physical treatment of fever","volume":"82","author":"Purssell","year":"2000","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.clinthera.2009.08.006_bib43","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/00006454-199003000-00003","article-title":"Case-control study of hyperpyrexia in children","volume":"9","author":"Alpert","year":"1990","journal-title":"Pediatr Infect Dis J."},{"key":"10.1016\/j.clinthera.2009.08.006_bib44","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1542\/peds.2005-2823","article-title":"Prospective evaluation of the risk of serious bacterial infection in children who present to the emergency department with hyperpyrexia (temperature of 106 degrees F or higher)","volume":"118","author":"Trautner","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2009.08.006_bib45","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/01.pec.0000159073.47691.38","article-title":"Hyperpyrexia among infants younger than 3 months","volume":"21","author":"Stanley","year":"2005","journal-title":"Pediatr Emerg Care"},{"key":"10.1016\/j.clinthera.2009.08.006_bib46","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/000992289403300104","article-title":"Association of hyperpyrexia with serious disease in children","volume":"33","author":"Press","year":"1994","journal-title":"Clin Pediatr (Phila)"},{"key":"10.1016\/j.clinthera.2009.08.006_bib47","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1542\/peds.108.2.311","article-title":"Predictive model for serious bacterial infections among infants younger than 3 months of age","volume":"108","author":"Bachur","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2009.08.006_bib48","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1067\/mem.2000.110820","article-title":"Management of fever without source in infants and children","volume":"36","author":"Baraff","year":"2000","journal-title":"Ann Emerg Med."},{"issue":"Suppl 5","key":"10.1016\/j.clinthera.2009.08.006_bib49","doi-asserted-by":"crossref","first-page":"S230","DOI":"10.1086\/317512","article-title":"Diagnostic implications and clinical consequences of antipyretic therapy","volume":"31","author":"Mackowiak","year":"2000","journal-title":"Clin Infect Dis."},{"key":"10.1016\/j.clinthera.2009.08.006_bib50","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/0140-6736(91)91648-E","article-title":"Risks and benefits of paracetamol antipyresis in young children with fever of presumed viral origin","volume":"337","author":"Kramer","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.clinthera.2009.08.006_bib51","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S0022-3476(89)80461-5","article-title":"Acetaminophen: More harm than good for chicken-pox?","volume":"114","author":"Doran","year":"1989","journal-title":"J Pediatr"},{"key":"10.1016\/j.clinthera.2009.08.006_bib52","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1136\/adc.2008.139949","article-title":"Why is the evidence not affecting the practice of fever management?","volume":"93","author":"El-Radhi","year":"2008","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.clinthera.2009.08.006_bib53","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1136\/adc.63.7.857","article-title":"Preadmission antipyretics in Reye's syndrome","volume":"63","author":"Hall","year":"1998","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.clinthera.2009.08.006_bib54","first-page":"18861","article-title":"Labeling for oral and rectal over-the-counter drug products containing aspirin and nonaspirin salicylates: Reye's Syndrome warning. Final rule","volume":"68","year":"2003","journal-title":"Fed Regist."},{"key":"10.1016\/j.clinthera.2009.08.006_bib55","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1136\/adc.65.8.826","article-title":"Trends in the incidence of Reye's syndrome and the use of aspirin","volume":"65","author":"Porter","year":"1990","journal-title":"Arch Dis Child."},{"key":"10.1016\/j.clinthera.2009.08.006_bib57","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1136\/bmj.39218.495255.AE","article-title":"NICE guidelines: Assessment and initial management of feverish illness in children younger than 5 years: Summary of NICE guidance","volume":"334","author":"Richardson","year":"2007","journal-title":"BMJ"},{"key":"10.1016\/j.clinthera.2009.08.006_bib58","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0002-9343(01)00834-8","article-title":"Antipyretics: Mechanisms of action and clinical use in fever suppression","volume":"111","author":"Aronoff","year":"2001","journal-title":"Am J Med."},{"key":"10.1016\/j.clinthera.2009.08.006_bib59","first-page":"337","article-title":"Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): Randomised controlled trial","author":"Hay","year":"2008","journal-title":"BMJ"},{"key":"10.1016\/j.clinthera.2009.08.006_bib61","first-page":"367","article-title":"Evidence on the use of paracetamol in febrile children","volume":"81","author":"Russell","year":"2003","journal-title":"Bull World Health Organ."},{"key":"10.1016\/j.clinthera.2009.08.006_bib62","doi-asserted-by":"crossref","first-page":"316","DOI":"10.12968\/bjcn.2002.7.6.10477","article-title":"Treating fever in children: Paracetamol or ibuprofen?","volume":"7","author":"Purssell","year":"2002","journal-title":"Br J Community Nurs."},{"key":"10.1016\/j.clinthera.2009.08.006_bib63","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1001\/archpedi.158.6.521","article-title":"Efficacy and safety of acetaminophen vs ibuprofen for treating children's pain or fever: A meta-analysis","volume":"158","author":"Perrot","year":"2004","journal-title":"Arch Pediatr Adolesc Med."},{"key":"10.1016\/j.clinthera.2009.08.006_bib64","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1345\/aph.1C391","article-title":"Antipyretic efficacy and safety of ibuprofen and acetaminophen in children","volume":"38","author":"Goldman","year":"2004","journal-title":"Ann Pharmacother."},{"key":"10.1016\/j.clinthera.2009.08.006_bib65","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1185\/030079907X223323","article-title":"Ibuprofen versus paracetamol in pediatric fever: Objective and subjective findings from a randomized, blinded study","volume":"23","author":"Autret-Leca","year":"2007","journal-title":"Curr Med Res Opin."},{"key":"10.1016\/j.clinthera.2009.08.006_bib66","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1136\/adc.2005.087874","article-title":"Randomised controlled trial of combined paracetamol and ibuprofen for fever","volume":"91","author":"Erlewyn-Lajeunesse","year":"2006","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.clinthera.2009.08.006_bib67","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/BF02723945","article-title":"Antipyretic effects of nimesulide, paracetamol and ibuprofen-paracetamol","volume":"67","author":"Lal","year":"2000","journal-title":"Indian J Pediatr"},{"key":"10.1016\/j.clinthera.2009.08.006_bib68","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1741-7015-4-4","article-title":"Alternating ibuprofen and acetaminophen in the treatment of febrile children: A pilot study [ISRCTN30487061]","volume":"4","author":"Nabulsi","year":"2006","journal-title":"BMC Med."},{"key":"10.1016\/j.clinthera.2009.08.006_bib69","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1001\/archpedi.160.2.197","article-title":"Antipyretic treatment in young children with fever: Acetaminophen, ibuprofen, or both alternating in a randomized, double-blind study","volume":"160","author":"Sarrell","year":"2006","journal-title":"Arch Pediatr Adolesc Med."},{"key":"10.1016\/j.clinthera.2009.08.006_bib70","doi-asserted-by":"crossref","first-page":"E73","DOI":"10.1542\/peds.108.4.e73","article-title":"Antipyretic efficacy of an initial 30-mg\/kg loading dose of acetaminophen versus a 15-mg\/kg maintenance dose","volume":"108","author":"Tr\u00e9luyer","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2009.08.006_bib71","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1136\/adc.2007.126896","article-title":"Paracetamol (acetaminophen) pharmacodynamics: Interpreting the plasma concentration","volume":"93","author":"Gibb","year":"2008","journal-title":"Arch Dis Child."},{"key":"10.1016\/j.clinthera.2009.08.006_bib72","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1542\/peds.110.3.553","article-title":"Comparison of oral versus normal and high-dose rectal acetaminophen in the treatment of febrile children","volume":"110","author":"Scolnik","year":"2002","journal-title":"Pediatrics."},{"key":"10.1016\/j.clinthera.2009.08.006_bib73","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1471-2431-5-35","article-title":"Equal antipyretic effectiveness of oral and rectal acetaminophen: A randomized controlled trial [ISRCTN11886401]","volume":"5","author":"Nabulsi","year":"2005","journal-title":"BMC Pediatr."},{"key":"10.1016\/j.clinthera.2009.08.006_bib74","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.clinthera.2006.05.010","article-title":"Determinants of antipyretic misuse in children up to 5 years of age: A cross-sectional study","volume":"28","author":"Bilenko","year":"2006","journal-title":"Clin Ther."},{"key":"10.1016\/j.clinthera.2009.08.006_bib75","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1542\/peds.104.4.e39","article-title":"The safety of acetaminophen and ibuprofen among children younger than two years old","volume":"104","author":"Lesko","year":"1999","journal-title":"Pediatrics."},{"key":"10.1016\/j.clinthera.2009.08.006_bib76","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1001\/jama.273.12.929","article-title":"An assessment of the safety of pediatric ibuprofen. A practitioner-based randomized clinical trial","volume":"273","author":"Lesko","year":"1995","journal-title":"JAMA."},{"key":"10.1016\/j.clinthera.2009.08.006_bib77","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1086\/338460","article-title":"An epidemiological investigation of a sustained high rate of pediatric parapneumonic empyema: Risk factors and microbiological associations","volume":"34","author":"Byington","year":"2002","journal-title":"Clin Infect Dis."},{"key":"10.1016\/j.clinthera.2009.08.006_bib78","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00246-007-9123-x","article-title":"Accelerated thrombotic occlusion of a medium-sized coronary aneurysm in Kawasaki disease by the inhibitory effect of ibuprofen on aspirin","volume":"29","author":"Sohn","year":"2008","journal-title":"Pediatr Cardiol."},{"key":"10.1016\/j.clinthera.2009.08.006_bib79","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1542\/peds.108.4.1020","article-title":"Acetaminophen toxicity in children","volume":"108","year":"2001","journal-title":"Pediatrics."},{"key":"10.1016\/j.clinthera.2009.08.006_bib80","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/00006565-200012000-00003","article-title":"Acetaminophen and ibuprofen dosing by parents","volume":"16","author":"Li","year":"2000","journal-title":"Pediatr Emerg Care."},{"key":"10.1016\/j.clinthera.2009.08.006_bib81","first-page":"741","article-title":"Liquid medication dosing errors","volume":"49","author":"Madlon-Kay","year":"2000","journal-title":"J Fam Pract."},{"issue":"2","key":"10.1016\/j.clinthera.2009.08.006_bib82","first-page":"CD003328","article-title":"Interventions for paracetamol (acetaminophen) overdose","author":"Brok","year":"2006","journal-title":"Cochrane Database Syst Rev."},{"key":"10.1016\/j.clinthera.2009.08.006_bib83","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/BF03160908","article-title":"A report of two deaths from massive ibuprofen ingestion","volume":"3","author":"Holubek","year":"2007","journal-title":"J Med Toxicol."},{"key":"10.1016\/j.clinthera.2009.08.006_bib84","first-page":"54","article-title":"Ibuprofen overdose","volume":"135","author":"Volans","year":"2003","journal-title":"Int J Clin Pract Suppl."},{"key":"10.1016\/j.clinthera.2009.08.006_bib85","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/00006565-200002000-00012","article-title":"Central nervous system manifestations of an ibuprofen overdose reversed by naloxone","volume":"16","author":"Easley","year":"2000","journal-title":"Pediatr Emerg Care."},{"key":"10.1016\/j.clinthera.2009.08.006_bib86","first-page":"293","article-title":"Care in the use of ibuprofen as an antipyretic in children","volume":"49","author":"Moghal","year":"1998","journal-title":"Clin Nephrol."},{"key":"10.1016\/j.clinthera.2009.08.006_bib87","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1046\/j.1365-2796.2003.01097.x","article-title":"Paracetamol-induced hepatotoxicity at recommended dosage","volume":"253","author":"Kurtovic","year":"2003","journal-title":"J Intern Med."},{"key":"10.1016\/j.clinthera.2009.08.006_bib88","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1016\/j.clinthera.2007.12.021","article-title":"A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms","volume":"29","author":"Kanabar","year":"2007","journal-title":"Clin Ther."},{"key":"10.1016\/j.clinthera.2009.08.006_bib89","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1136\/adc.74.2.164","article-title":"Comparing efficacy and tolerability of ibuprofen and paracetamol in fever","volume":"74","author":"McIntyre","year":"1996","journal-title":"Arch Dis Child."},{"key":"10.1016\/j.clinthera.2009.08.006_bib90","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S0140-6736(08)61445-2","article-title":"Association between paracetamol use in infancy and childhood, and risk of asthma, rhinocon-junctivitis, and eczema in children aged 6\u20137 years: Analysis from Phase Three of the ISAAC programme","volume":"372","author":"Beasley","year":"2008","journal-title":"Lancet."},{"key":"10.1016\/j.clinthera.2009.08.006_bib91","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s11882-009-0024-3","article-title":"Acetaminophen use: A risk for asthma?","volume":"9","author":"Allmers","year":"2009","journal-title":"Curr Allergy Asthma Rep."},{"key":"10.1016\/j.clinthera.2009.08.006_bib92","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.arcped.2007.03.009","article-title":"Allergic and pseudoallergic reactions to analgesics, antipyretics and non-steroidal anti-inflammatory drugs [in French]","volume":"14","author":"Ponvert","year":"2007","journal-title":"Arch Pediatr."},{"key":"10.1016\/j.clinthera.2009.08.006_bib93","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s002280050071","article-title":"Metabolism of paracetamol in children with chronic liver disease","volume":"50","author":"al-Obaidy","year":"1996","journal-title":"Eur J Clin Pharmacol."},{"key":"10.1016\/j.clinthera.2009.08.006_bib94","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1460-9592.2005.01789.x","article-title":"The pharmacokinetics of a single rectal dose of paracetamol (40 mg \u00d7 kg(-1)) in children with liver disease [published correction appears in Paediatr Anaesth. 2006; 16:708]","volume":"16","author":"Cormack","year":"2006","journal-title":"Paediatr Anaesth."},{"key":"10.1016\/j.clinthera.2009.08.006_bib95","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.arcped.2007.01.012","article-title":"Ibuprofen in childhood: Evidence-based review of efficacy and safety [in French]","volume":"14","author":"Leroy","year":"2007","journal-title":"Arch Pediatr."},{"key":"10.1016\/j.clinthera.2009.08.006_bib96","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1111\/j.1572-0241.1998.00484.x","article-title":"Ibuprofen-induced hepatotoxicity in patients with chronic hepatitis C: A case series","volume":"93","author":"Riley","year":"1998","journal-title":"Am J Gastroenterol."},{"key":"10.1016\/j.clinthera.2009.08.006_bib97","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1111\/j.1572-0241.2002.05874.x","article-title":"Chronic hepatitis C, ibuprofen, and liver damage","volume":"97","author":"Andrade","year":"2002","journal-title":"Am J Gastroenterol."},{"key":"10.1016\/j.clinthera.2009.08.006_bib98","first-page":"e372","article-title":"Interaction between antihypertensives and NSAIDs in primary care: A controlled trial","volume":"15","author":"Pavlicevi\u2019c","year":"2008","journal-title":"Can J Clin Pharmacol."},{"key":"10.1016\/j.clinthera.2009.08.006_bib99","doi-asserted-by":"crossref","first-page":"673","DOI":"10.3928\/00904481-20081001-01","article-title":"Management of infants and young children with fever without source","volume":"37","author":"Baraff","year":"2008","journal-title":"Pediatr Ann."},{"key":"10.1016\/j.clinthera.2009.08.006_bib100","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1097\/00000542-200206000-00012","article-title":"Acetaminophen developmental pharmacokinetics in premature neonates and infants: A pooled population analysis","volume":"96","author":"Anderson","year":"2002","journal-title":"Anesthesiology."},{"key":"10.1016\/j.clinthera.2009.08.006_bib101","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/bja\/aen208","article-title":"I.V. acetaminophen pharmacokinetics in neonates after multiple doses","volume":"101","author":"Palmer","year":"2008","journal-title":"Br J Anaesth."},{"key":"10.1016\/j.clinthera.2009.08.006_bib102","author":"Lago"},{"key":"10.1016\/j.clinthera.2009.08.006_bib103","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1345\/aph.1H647","article-title":"Acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunization","volume":"41","author":"Manley","year":"2007","journal-title":"Ann Pharmacother."},{"key":"10.1016\/j.clinthera.2009.08.006_bib104","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1542\/peds.2005-1217","article-title":"Prophylaxis with acetaminophen or ibuprofen for prevention of local reactions to the fifth diphtheriatetanus toxoids-acellular pertussis vaccination: A randomized, controlled trial","volume":"117","author":"Jackson","year":"2006","journal-title":"Pediatrics."},{"key":"10.1016\/j.clinthera.2009.08.006_bib105","doi-asserted-by":"crossref","first-page":"e637","DOI":"10.1542\/peds.2006-3351","article-title":"Routine immunization practices: Use of topical anesthetics and oral analgesics","volume":"120","author":"Taddio","year":"2007","journal-title":"Pediatrics."},{"key":"10.1016\/j.clinthera.2009.08.006_bib106","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1136\/adc.88.7.641","article-title":"Do antipyretics prevent febrile convulsions?","volume":"88","author":"El-Radhi","year":"2003","journal-title":"Arch Dis Child."},{"key":"10.1016\/j.clinthera.2009.08.006_bib107","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S0022-3476(95)70231-8","article-title":"Effect of acetaminophen and of low intermittent doses of diazepam on prevention of recurrences of febrile seizures","volume":"126","author":"Uhari","year":"1995","journal-title":"J Pediatr."},{"key":"10.1016\/j.clinthera.2009.08.006_bib108","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/BF01953992","article-title":"Antipyretic effectiveness of acetaminophen in febrile seizures: Ongoing prophylaxis versus sporadic usage","volume":"152","author":"Schnaiderman","year":"1993","journal-title":"Eur J Pediatr."}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291809002823?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291809002823?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T01:58:04Z","timestamp":1685152684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291809002823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":102,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["S0149291809002823"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2009.08.006","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8]]}}}