{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:06:39Z","timestamp":1777539999644,"version":"3.51.4"},"reference-count":18,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.clinthera.2009.12.008","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T04:59:17Z","timestamp":1264481957000},"page":"2894-2899","source":"Crossref","is-referenced-by-count":8,"title":["Unexplained high fever in an elderly patient treated with clonidine, duloxetine, and atorvastatin"],"prefix":"10.1016","volume":"31","author":[{"given":"Theodoros","family":"Kelesidis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iosif","family":"Kelesidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2009.12.008_bib1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.psyneuen.2008.08.016","article-title":"Effects of clozapine and olanzapine on cytokine systems are closely linked to weight gain and drug-induced fever","volume":"34","author":"Kluge","year":"2009","journal-title":"Psychoneuroendocrinology."},{"key":"10.1016\/j.clinthera.2009.12.008_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.bjp.0706320","article-title":"Role of alpha2A-adrenoceptors in the effects of MDMA on body temperature in the mouse","volume":"146","author":"Bexis","year":"2005","journal-title":"Br J Pharmacol."},{"key":"10.1016\/j.clinthera.2009.12.008_bib3","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s00213-002-1261-5","article-title":"Pharmacological characterization of the effects of 3,4-methylenedioxymethamphetamine (\u201cecstasy\u201d) and its enantiomers on lethality, core temperature, and locomotor activity in singly housed and crowded mice","volume":"166","author":"Fantegrossi","year":"2003","journal-title":"Psychopharmacology (Berl)."},{"key":"10.1016\/j.clinthera.2009.12.008_bib4","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0031-6989(88)80074-2","article-title":"Antagonism of clonidine-induced hypothermia by alpha adrenoceptor antagonists in electrically stimulated mice","volume":"20","author":"Junnarkar","year":"1988","journal-title":"Pharmacol Res Commun."},{"key":"10.1016\/j.clinthera.2009.12.008_bib5","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1034\/j.1600-0773.2003.930107.x","article-title":"Influence of alpha-adrenoceptor agonists and antagonists on imipramine-induced hypothermia in mice","volume":"93","author":"Zarrindast","year":"2003","journal-title":"Pharmacol Toxicol."},{"issue":"Suppl 3","key":"10.1016\/j.clinthera.2009.12.008_bib6","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1097\/00005344-199627003-00007","article-title":"Aspects of tolerability of centrally acting antihypertensive drugs","volume":"27","author":"Webster","year":"1996","journal-title":"J Cardiovasc Pharmacol."},{"key":"10.1016\/j.clinthera.2009.12.008_bib7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1055\/s-2004-815526","article-title":"Memantine, an NMDA antagonist, prevents the development of hyperthermia in an animal model for serotonin syndrome","volume":"37","author":"Nisijima","year":"2004","journal-title":"Pharmacopsychiatry."},{"key":"10.1016\/j.clinthera.2009.12.008_bib8","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1378\/chest.06-1659","article-title":"Eosinophilic pneumonia due to duloxetine","volume":"131","author":"Espeleta","year":"2007","journal-title":"Chest."},{"key":"10.1016\/j.clinthera.2009.12.008_bib9","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.clpt.2004.01.012","article-title":"Simvastatin treatment for inflammatory attacks of the hyperimmunoglobulinemia D and periodic fever syndrome","volume":"75","author":"Simon","year":"2004","journal-title":"Clin Pharmacol Ther."},{"key":"10.1016\/j.clinthera.2009.12.008_bib10","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.annder.2008.07.063","article-title":"Atorvastatininduced drug reaction with eosinophilia and systemic symptoms (DRESS) [in French]","volume":"136","author":"Gressier","year":"2009","journal-title":"Ann Dermatol Venereol."},{"key":"10.1016\/j.clinthera.2009.12.008_bib11","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/00000542-200207000-00022","article-title":"Differences in systemic opioid use do not explain increased fever incidence in parturients receiving epidural analgesia","volume":"97","author":"Gross","year":"2002","journal-title":"Anesthesiology."},{"key":"10.1016\/j.clinthera.2009.12.008_bib12","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/01.SMJ.0000145285.28124.66","article-title":"Atypical neuroleptic malignant syndrome presenting as fever of unknown origin in the elderly","volume":"98","author":"Hall","year":"2005","journal-title":"South Med J."},{"key":"10.1016\/j.clinthera.2009.12.008_bib13","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/clpt.1981.154","article-title":"A method for estimating the probability of adverse drug reactions","volume":"30","author":"Naranjo","year":"1981","journal-title":"Clin Pharmacol Ther."},{"key":"10.1016\/j.clinthera.2009.12.008_bib14","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1081\/CLT-120004402","article-title":"Clonidine toxicity revisited","volume":"40","author":"Seger","year":"2002","journal-title":"J Toxicol Clin Toxicol."},{"key":"10.1016\/j.clinthera.2009.12.008_bib15","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF01252027","article-title":"Clonidine and a beta-agonists induce hyperthermia in rats at high ambient temperature","volume":"63","author":"Mogilnicka","year":"1985","journal-title":"J Neural Transm."},{"key":"10.1016\/j.clinthera.2009.12.008_bib16","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1111\/j.1476-5381.1996.tb15284.x","article-title":"Altered thermoregulatory responses to clonidine in streptozotocindiabetic rats","volume":"117","author":"O\u2019Donnell","year":"1996","journal-title":"Br J Pharmacol."},{"key":"10.1016\/j.clinthera.2009.12.008_bib17","doi-asserted-by":"crossref","first-page":"R1156","DOI":"10.1152\/ajpregu.00486.2003","article-title":"Preoptic alpha 1- and alpha 2-noradrenergic agonists induce, respectively, PGE2-independent and PGE2-dependent hyperthermic responses in guinea pigs","volume":"286","author":"Feleder","year":"2004","journal-title":"Am J Physiol Regul Integr Comp Physiol."},{"key":"10.1016\/j.clinthera.2009.12.008_bib18","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1093\/bja\/aep034","article-title":"Interaction between clonidine and escitalopram","volume":"102","author":"Nikolic","year":"2009","journal-title":"Br J Anaesth."}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291809004706?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291809004706?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T14:51:04Z","timestamp":1544712664000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291809004706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0149291809004706"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2009.12.008","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}