{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T15:16:12Z","timestamp":1773242172834,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.clinthera.2009.12.012","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T09:59:17Z","timestamp":1264499957000},"page":"3009-3020","source":"Crossref","is-referenced-by-count":16,"title":["The effects of ketoconazole and rifampicin on the pharmacokinetics of mirodenafil in healthy Korean male volunteers: An open-label, one-sequence, three-period, three-treatment crossover study"],"prefix":"10.1016","volume":"31","author":[{"given":"Kwang-Hee","family":"Shin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-Hyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Eun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Woo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SoJeong","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seo-Hyun","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo-Youn","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Goo","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In-Jin","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung-Sang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2009.12.012_bib1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/j.1745-7262.2008.00422.x","article-title":"Efficacy and safety of oral SK3530 for the treatment of erectile dysfunction in Korean men: A multicenter, randomized, double-blind, placebo-controlled, fixed dose, parallel group clinical trial","volume":"10","author":"Paick","year":"2008","journal-title":"Asian J Androl."},{"key":"10.1016\/j.clinthera.2009.12.012_bib2","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1111\/j.1743-6109.2008.00945.x","article-title":"Efficacy and safety of mirodenafil, a new oral phosphodiesterase type 5 inhibitor, for treatment of erectile dysfunction","volume":"5","author":"Paick","year":"2008","journal-title":"J Sex Med."},{"key":"10.1016\/j.clinthera.2009.12.012_bib3","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2165\/00003495-200868020-00006","article-title":"Looking to the future for erectile dysfunction therapies","volume":"68","author":"Hatzimouratidis","year":"2008","journal-title":"Drugs."},{"key":"10.1016\/j.clinthera.2009.12.012_bib4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/00498250701708521","article-title":"Identification of cytochrome P450 enzymes responsible for N-dealkylation of a new oral erectogenic, mirodenafil","volume":"38","author":"Lee","year":"2008","journal-title":"Xenobiotica."},{"key":"10.1016\/j.clinthera.2009.12.012_bib5","series-title":"Human Drug Metabolism: An Introduction","author":"Coleman","year":"2005"},{"key":"10.1016\/j.clinthera.2009.12.012_bib6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2165\/00003088-200038020-00002","article-title":"Effects of the antifungal agents on oxidative drug metabolism: Clinical relevance","volume":"38","author":"Venkatakrishnan","year":"2000","journal-title":"Clin Pharmacokinet."},{"key":"10.1016\/j.clinthera.2009.12.012_bib7","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/01.fpc.0000215070.52212.0e","article-title":"Effect of SLCO1B1 polymorphism on induction of CYP3A4 by rifampicin","volume":"16","author":"Niemi","year":"2006","journal-title":"Pharmacogenet Genomics."},{"key":"10.1016\/j.clinthera.2009.12.012_bib8","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1111\/j.1745-7254.2007.00611.x","article-title":"Pharmacokinetics and tissue distribution of a novel PDE5 inhibitor, SK-3530, in rats","volume":"28","author":"Yoo","year":"2007","journal-title":"Acta Pharmacol Sin."},{"key":"10.1016\/j.clinthera.2009.12.012_bib9","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.bcp.2007.05.009","article-title":"Expression of drug metabolizing enzymes in hepatocytelike cells derived from human embryonic stem cells","volume":"74","author":"Ek","year":"2007","journal-title":"Biochem Pharmacol."},{"key":"10.1016\/j.clinthera.2009.12.012_bib12","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jpba.2007.06.021","article-title":"Development of LC\/MS\/MS assay for the determination of 5-ethyl-2-{5-[4-(2-hydroxyethyl)piperazine-1-sulfonyl]-2-propoxyphenyl}-7-propyl-3,5-dihydropyrrolo[3,2-d] pyrimidin-4-one (SK3530) in human plasma: Application to a clinical pharmacokinetic study","volume":"45","author":"Shin","year":"2007","journal-title":"J Pharm BiomedAnal."},{"key":"10.1016\/j.clinthera.2009.12.012_bib13","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.jpba.2006.10.011","article-title":"Validation of a HPLC method for the quantification and purity determination of SK3530 in drug substance and tablet","volume":"43","author":"Oh","year":"2007","journal-title":"J Pharm Biomed Anal."},{"key":"10.1016\/j.clinthera.2009.12.012_bib15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.clpt.2004.09.006","article-title":"Effect of tadalafil on cytochrome P450 3A4-mediated clearance: Studies in vitro and in vivo","volume":"77","author":"Ring","year":"2005","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.clinthera.2009.12.012_bib16","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1046\/j.1365-2125.2000.00245.x","article-title":"Pharmacokinetic interactions between sildenafil and saquinavir\/ritonavir","volume":"50","author":"Muirhead","year":"2000","journal-title":"Br J Clin Pharmacol."},{"key":"10.1016\/j.clinthera.2009.12.012_bib17","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/sj.ijir.3901522","article-title":"The role of pharmacokinetics and pharmacodynamics in phosphodiesterase-5 inhibitor therapy","volume":"19","author":"Mehrotra","year":"2007","journal-title":"Int J Impot Res."},{"key":"10.1016\/j.clinthera.2009.12.012_bib18","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1080\/00498250400010898","article-title":"Role of human cytochrome P450 3A4 in the metabolism of DA-8159, a new erectogenic","volume":"34","author":"Ji","year":"2004","journal-title":"Xenobiotica."},{"key":"10.1016\/j.clinthera.2009.12.012_bib19","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1177\/0091270005276847","article-title":"The clinical pharmacokinetics of phosphodiesterase-5 inhibitors for erectile dysfunction","volume":"45","author":"Gupta","year":"2005","journal-title":"J Clin Pharmacol."},{"key":"10.1016\/j.clinthera.2009.12.012_bib20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1067\/mcp.2002.121236","article-title":"Effects of grapefruit juice on the pharmacokinetics of sildenafil","volume":"71","author":"Jetter","year":"2002","journal-title":"Clin Pharmacol Ther."},{"key":"10.1016\/j.clinthera.2009.12.012_bib21","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0090-4295(01)01306-1","article-title":"Interactions of sildenafil and tacrolimus in men with erectile dysfunction after kidney transplantation","volume":"58","author":"Christ","year":"2001","journal-title":"Urology."},{"issue":"Suppl 1","key":"10.1016\/j.clinthera.2009.12.012_bib22","doi-asserted-by":"crossref","first-page":"31S","DOI":"10.1046\/j.0306-5251.2001.00030.x","article-title":"The effects of cimetidine and antacid on the pharmacokinetic profile of sildenafil citrate in healthy male volunteers","volume":"53","author":"Wilner","year":"2002","journal-title":"Br J Clin Pharmacol."},{"key":"10.1016\/j.clinthera.2009.12.012_bib23","series-title":"NDA 021368 Cialis (Tadalafil) Tablet. Clinical Pharmacology\/ Biopharmaceutics Review","year":"2003"},{"key":"10.1016\/j.clinthera.2009.12.012_bib24","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/mc.2940130302","article-title":"Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy","volume":"13","author":"Wacher","year":"1995","journal-title":"Mol Carcinog."},{"key":"10.1016\/j.clinthera.2009.12.012_bib25","first-page":"3944","article-title":"P-glycoprotein and cytochrome P-450 3A inhibition: Dissociation of inhibitory potencies","volume":"59","author":"Wandel","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.clinthera.2009.12.012_bib26","first-page":"360","article-title":"Overlapping substrate specificities of cytochrome P450 3A and P-glycoprotein for a novel cysteine protease inhibitor","volume":"26","author":"Zhang","year":"1998","journal-title":"Drug Metab Dispos."},{"key":"10.1016\/j.clinthera.2009.12.012_bib27","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1128\/AAC.46.1.160-165.2002","article-title":"Interaction of common azole antifungals with P glycoprotein","volume":"46","author":"Wang","year":"2002","journal-title":"Antimicrob Agents Chemother."},{"key":"10.1016\/j.clinthera.2009.12.012_bib28","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/S0090-9556(24)02985-4","article-title":"Effect of prototypical inducing agents on P-glycoprotein and CYP3A expression in mouse tissues","volume":"32","author":"Matheny","year":"2004","journal-title":"Drug Metab Dispos."},{"key":"10.1016\/j.clinthera.2009.12.012_bib29","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1172\/JCI6663","article-title":"The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin [published correction appears in J Clin Invest. 2002;110:571]","volume":"104","author":"Greiner","year":"1999","journal-title":"J Clin Invest."},{"key":"10.1016\/j.clinthera.2009.12.012_bib30","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0026-895X(25)08713-9","article-title":"Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells","volume":"49","author":"Schuetz","year":"1996","journal-title":"Mol Pharmacol."},{"key":"10.1016\/j.clinthera.2009.12.012_bib31","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1177\/0091270007309888","article-title":"Effect of rifampin, an inducer of CYP3A and P-glycoprotein, on the pharmacokinetics of risperidone","volume":"48","author":"Kim","year":"2008","journal-title":"J Clin Pharmacol."},{"key":"10.1016\/j.clinthera.2009.12.012_bib32","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1007\/BF02980254","article-title":"Transport of a new erectogenic udenafil in Caco-2 cells","volume":"30","author":"Ji","year":"2007","journal-title":"Arch Pharm Res."},{"key":"10.1016\/j.clinthera.2009.12.012_bib33","series-title":"Presented at: The 110th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics","article-title":"Characterization of efflux transport of PDE5 inhibitors, sildenafil, vardenafil, and udenafil [PII-40]","author":"Jian-Wei","year":"2009"},{"key":"10.1016\/j.clinthera.2009.12.012_bib34","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1023\/A:1018877803319","article-title":"Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein","volume":"16","author":"Kim","year":"1999","journal-title":"Pharm Res."},{"key":"10.1016\/j.clinthera.2009.12.012_bib35","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/brain\/awg009","article-title":"Migraine can be induced by sildenafil without changes in middle cerebral artery diameter","volume":"126","author":"Kruuse","year":"2003","journal-title":"Brain."},{"key":"10.1016\/j.clinthera.2009.12.012_bib36","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1023\/A:1007550717526","article-title":"Persistent inhibition of CYP3A4 by ketoconazole in modified Caco-2 cells","volume":"17","author":"Gibbs","year":"2000","journal-title":"Pharm Res."},{"key":"10.1016\/j.clinthera.2009.12.012_bib37","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1007\/BF01296501","article-title":"Effects of gender, age, and body mass index on gastrointestinal transit times","volume":"37","author":"Madsen","year":"1992","journal-title":"Dig Dis Sci."},{"key":"10.1016\/j.clinthera.2009.12.012_bib38","doi-asserted-by":"crossref","first-page":"819","DOI":"10.2165\/00003088-200342090-00003","article-title":"Pharmacokinetic interactions with rifampicin: Clinical relevance","volume":"42","author":"Niemi","year":"2003","journal-title":"Clin Pharmacokinet."},{"key":"10.1016\/j.clinthera.2009.12.012_bib39","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1124\/dmd.107.020099","article-title":"The contributions of cytochromes P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors sildenafil, udenafil, and vardenafil","volume":"36","author":"Ku","year":"2008","journal-title":"DrugMetab Dispos."}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291809004743?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291809004743?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T23:43:31Z","timestamp":1739749411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291809004743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":36,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0149291809004743"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2009.12.012","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}