{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:34:18Z","timestamp":1791646458862,"version":"4.3.4"},"reference-count":12,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.clinthera.2010.01.004","type":"journal-article","created":{"date-parts":[[2010,2,18]],"date-time":"2010-02-18T04:27:14Z","timestamp":1266467234000},"page":"53-56","source":"Crossref","is-referenced-by-count":19,"title":["Warfarin and bosentan interaction in a patient with pulmonary hypertension secondary to bilateral pulmonary emboli"],"prefix":"10.1016","volume":"32","author":[{"given":"Mikayla L.","family":"Spangler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailendra","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2010.01.004_bib1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0011-3840(00)80005-2","article-title":"Pulmonary endarterectomy","volume":"37","author":"Jamieson","year":"2000","journal-title":"Curr Probl Surg."},{"key":"10.1016\/j.clinthera.2010.01.004_bib2","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1056\/NEJMoa032274","article-title":"Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism","volume":"350","author":"Pengo","year":"2004","journal-title":"N Engl J Med."},{"key":"10.1016\/j.clinthera.2010.01.004_bib3","first-page":"573","article-title":"Bosentan therapy for chronic thromboembolic pulmonary hypertension. A national open label study assessing the effect of bosentan on haemodynamics, exercise capacity, quality of life, safety and tolerability in patients with chronic thromboembolic pulmonary hypertension (BOCTEPH-Study)","volume":"137","author":"Ulrich","year":"2007","journal-title":"Swiss Med Wkly."},{"key":"10.1016\/j.clinthera.2010.01.004_bib4","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1513\/pats.200605-106LR","article-title":"Assessment of operability in chronic thromboembolic pulmonary hypertension","volume":"3","author":"Kim","year":"2006","journal-title":"Proc Am Thorac Soc."},{"key":"10.1016\/j.clinthera.2010.01.004_bib7","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1177\/00912709922008380","article-title":"Effect of the endothelin-receptor antagonist bosentan on the pharmacokinetics and pharmacodynamics of warfarin","volume":"39","author":"Weber","year":"1999","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.clinthera.2010.01.004_bib8","first-page":"1789","article-title":"Diagnosis and treatment of pulmonary hypertension","volume":"63","author":"Nauser","year":"2001","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.clinthera.2010.01.004_bib9","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1345\/aph.1H423","article-title":"Proposal for a new tool to evaluate drug interaction cases","volume":"41","author":"Horn","year":"2007","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.clinthera.2010.01.004_bib10","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1378\/chest.128.4.2363","article-title":"Bosentan therapy for inoperable chronic thromboembolic pulmonary hypertension","volume":"128","author":"Hoeper","year":"2005","journal-title":"Chest."},{"issue":"Suppl 6","key":"10.1016\/j.clinthera.2010.01.004_bib11","doi-asserted-by":"crossref","first-page":"160S","DOI":"10.1378\/chest.08-0670","article-title":"Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)","volume":"133","author":"Ansell","year":"2008","journal-title":"Chest."},{"key":"10.1016\/j.clinthera.2010.01.004_bib12","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1345\/aph.1C398","article-title":"Bosentan and warfarin interaction","volume":"37","author":"Murphey","year":"2003","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.clinthera.2010.01.004_bib13","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.2165\/00003088-200443150-00003","article-title":"Clinical pharmacology of bosentan, a dual endothelin receptor antagonist","volume":"43","author":"Dingemanse","year":"2004","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.clinthera.2010.01.004_bib14","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1056\/NEJMoa012212","article-title":"Bosentan therapy for pulmonary arterial hypertension [published correction appears in N Engl J Med. 2002;346:1258]","volume":"346","author":"Rubin","year":"2002","journal-title":"N Engl J Med."}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291810000056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291810000056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T00:51:48Z","timestamp":1544662308000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291810000056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S0149291810000056"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2010.01.004","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}