{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:36:03Z","timestamp":1769517363462,"version":"3.49.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.clinthera.2010.04.012","type":"journal-article","created":{"date-parts":[[2010,4,30]],"date-time":"2010-04-30T08:57:25Z","timestamp":1272617845000},"page":"626-636","source":"Crossref","is-referenced-by-count":16,"title":["Rationale and design of the PREVENT-HIT study: A randomized, open-label pilot study to compare desirudin and argatroban in patients with suspected heparin-induced thrombocytopenia with or without thrombosis"],"prefix":"10.1016","volume":"32","author":[{"given":"James N.","family":"Frame","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Rice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Bartholomew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Whelton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl 6","key":"10.1016\/j.clinthera.2010.04.012_bib1","doi-asserted-by":"crossref","first-page":"340S","DOI":"10.1378\/chest.08-0677","article-title":"Treatment and prevention of heparin-induced thrombocytopenia: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)","volume":"133","author":"Warkentin","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.clinthera.2010.04.012_bib2","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1056\/NEJMcp052967","article-title":"Clinical practice. Heparin-induced thrombocytopenia","volume":"355","author":"Arepally","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2010.04.012_bib3","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1160\/TH08-05-0312","article-title":"Heparin-induced thrombocytopenia (HIT): Clinical and economic outcomes","volume":"100","author":"Baroletti","year":"2008","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.clinthera.2010.04.012_bib4","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1056\/NEJM200104263441704","article-title":"Temporal aspects of heparin-induced thrombocytopenia","volume":"344","author":"Warkentin","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2010.04.012_bib5","doi-asserted-by":"crossref","first-page":"210","DOI":"10.7326\/0003-4819-136-3-200202050-00009","article-title":"Delayed-onset heparin-induced thrombocytopenia","volume":"136","author":"Rice","year":"2002","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.clinthera.2010.04.012_bib6","doi-asserted-by":"crossref","first-page":"502","DOI":"10.7326\/0003-4819-135-7-200110020-00009","article-title":"Delayed-onset heparin-induced thrombocytopenia and thrombosis","volume":"135","author":"Warkentin","year":"2001","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.clinthera.2010.04.012_bib7","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1056\/NEJMra044440","article-title":"Direct thrombin inhibitors [published correction appears in N Engl J Med. 2005;353:2827]","volume":"353","author":"Di Nisio","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2010.04.012_bib8","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1001\/archinte.164.18.1961","article-title":"Heparin-induced thrombocytopenia: Myths and misconceptions (that will cause trouble for you and your patient)","volume":"164","author":"Rice","year":"2004","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.clinthera.2010.04.012_bib9","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1182\/blood.V96.3.846","article-title":"Heparin-induced thrombocytopenia with thromboembolic complications: Meta-analysis of 2 prospective trials to assess the value of parenteral treatment with lepirudin and its therapeutic aPTT range","volume":"96","author":"Greinacher","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.clinthera.2010.04.012_bib10","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0002-9343(99)00124-2","article-title":"Failure of early heparin cessation as treatment for heparin-induced thrombocytopenia","volume":"106","author":"Wallis","year":"1999","journal-title":"Am J Med"},{"key":"10.1016\/j.clinthera.2010.04.012_bib11","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/S0002-9343(96)00258-6","article-title":"A 14-year study of heparin-induced thrombocytopenia","volume":"101","author":"Warkentin","year":"1996","journal-title":"Am J Med"},{"key":"10.1016\/j.clinthera.2010.04.012_bib12","series-title":"Argatroban [package insert]","year":"2008"},{"key":"10.1016\/j.clinthera.2010.04.012_bib13","series-title":"Angiomax [package insert]","year":"2005"},{"key":"10.1016\/j.clinthera.2010.04.012_bib14","series-title":"Refludan [package insert]","year":"2006"},{"key":"10.1016\/j.clinthera.2010.04.012_bib15","series-title":"Arixtra [package insert]","year":"2008"},{"key":"10.1016\/j.clinthera.2010.04.012_bib16","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1160\/TH07-09-0573","article-title":"Fondaparinux-related thrombocytopenia in a previous low-molecular-weight heparin (LMWH)-induced heparin-induced thrombocytopenia (HIT)","volume":"99","author":"Rota","year":"2008","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.clinthera.2010.04.012_bib17","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1056\/NEJMc070346","article-title":"Heparin-induced thrombocytopenia associated with fondaparinux","volume":"356","author":"Warkentin","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2010.04.012_bib18","series-title":"Iprivask [package insert]","year":"2010"},{"key":"10.1016\/j.clinthera.2010.04.012_bib19","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.ahj.2009.01.005","article-title":"Evaluation and management of thrombocytopenia and suspected heparin-induced thrombocytopenia in hospitalized patients: The Complications After Thrombocytopenia Caused by Heparin (CATCH) registry","volume":"157","author":"Crespo","year":"2009","journal-title":"Am Heart J"},{"key":"10.1016\/j.clinthera.2010.04.012_bib20","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1001\/archinternmed.2007.65","article-title":"Incidence and prognostic significance of thrombocytopenia in patients treated with prolonged heparin therapy","volume":"168","author":"Oliveira","year":"2008","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.clinthera.2010.04.012_bib21","doi-asserted-by":"crossref","first-page":"326","DOI":"10.2106\/00004623-199703000-00002","article-title":"Prevention of thromboembolism with use of recombinant hirudin. Results of a double-blind, multicenter trial comparing the efficacy of desirudin (Revasc) with that of unfractionated heparin in patients having a total hip replacement","volume":"79","author":"Eriksson","year":"1997","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.clinthera.2010.04.012_bib22","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1056\/NEJM199711063371901","article-title":"A comparison of recombinant hirudin with a low-molecular-weight heparin to prevent thromboembolic complications after total hip replacement","volume":"337","author":"Eriksson","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2010.04.012_bib23","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0140-6736(96)91200-3","article-title":"Prevention of deep-vein thrombosis after total hip replacement: Direct thrombin inhibition with recombinant hirudin, CGP 39393","volume":"347","author":"Eriksson","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.clinthera.2010.04.012_bib24","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1056\/NEJM199509213331203","article-title":"A comparison of hirudin with heparin in the prevention of restenosis after coronary angioplasty","volume":"333","author":"Serruys","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2010.04.012_bib25","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1161\/01.CIR.89.4.1557","article-title":"Recombinant hirudin for unstable angina pectoris. A multicenter, randomized angiographic trial","volume":"89","author":"Topol","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.clinthera.2010.04.012_bib26","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1161\/01.CIR.90.4.1631","article-title":"Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes","volume":"90","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.clinthera.2010.04.012_bib27","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1056\/NEJM199609123351103","article-title":"A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes","volume":"335","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2010.04.012_bib28","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/01.CIR.94.5.911","article-title":"Hirudin in acute myocardial infarction. Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9B trial","volume":"94","author":"Antman","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.clinthera.2010.04.012_bib29","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1161\/01.CIR.90.4.1624","article-title":"Hirudin in acute myocardial infarction. Safety report from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9A Trial","volume":"90","author":"Antman","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.clinthera.2010.04.012_bib30","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/0735-1097(94)90581-9","article-title":"A pilot trial of recombinant desulfatohirudin compared with heparin in conjunction with tissue-type plasminogen activator and aspirin for acute myocardial infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI) 5 trial","volume":"23","author":"Cannon","year":"1994","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.clinthera.2010.04.012_bib31","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0002-9149(99)80517-7","article-title":"Initial experience with hirudin and streptokinase in acute myocardial infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI) 6 trial","volume":"75","author":"Lee","year":"1995","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.clinthera.2010.04.012_bib32","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1161\/01.CIR.88.5.2058","article-title":"Safety and efficacy of recombinant hirudin (CGP 39 393) versus heparin in patients with stable angina undergoing coronary angioplasty","volume":"88","author":"van den Bos","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.clinthera.2010.04.012_bib33","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1161\/01.CIR.103.14.1838","article-title":"Argatroban anticoagulant therapy in patients with heparin-induced thrombocytopenia","volume":"103","author":"Lewis","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.clinthera.2010.04.012_bib34","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1001\/archinte.163.15.1849","article-title":"Argatroban anticoagulation in patients with heparin-induced thrombocytopenia","volume":"163","author":"Lewis","year":"2003","journal-title":"Arch Intern Med"},{"issue":"Suppl 6","key":"10.1016\/j.clinthera.2010.04.012_bib35","doi-asserted-by":"crossref","first-page":"141S","DOI":"10.1378\/chest.08-0689","article-title":"Parenteral anticoagulants: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) [published correction appears in Chest. 2008;134:473]","volume":"133","author":"Hirsh","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.clinthera.2010.04.012_bib36","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0140-6736(02)07495-0","article-title":"Direct thrombin inhibitors in acute coronary syndromes: Principal results of a meta-analysis based on individual patients' data","volume":"359","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.clinthera.2010.04.012_bib37","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.thromres.2005.02.010","article-title":"Direct thrombin inhibitors are not equally effective in vivo against arterial thrombosis: In vivo evaluation of DuP714 and argatroban in a porcine angioplasty model and comparison to r-hirudin","volume":"116","author":"McBane","year":"2005","journal-title":"Thromb Res"},{"key":"10.1016\/j.clinthera.2010.04.012_bib38","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1182\/blood-2002-04-1055","article-title":"Antihirudin antibodies following low-dose subcutaneous treatment with desirudin for thrombosis prophylaxis after hip-replacement surgery: Incidence and clinical relevance","volume":"101","author":"Greinacher","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.clinthera.2010.04.012_bib39","unstructured":"Levy J, Kurz M, Whelton A. Lack of clinically significant interactions between the subcutaneously administered direct thrombin inhibitor desirudin and orally administered warfarin upon the international normalized ratio. Presented at: 51st Annual Meeting of the American Society of Hematology; December 5\u20138, 2009; New Orleans, La. Abstract 22416."},{"key":"10.1016\/j.clinthera.2010.04.012_bib40","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.beha.2004.02.002","article-title":"Bivalent direct thrombin inhibitors: Hirudin and bivalirudin","volume":"17","author":"Warkentin","year":"2004","journal-title":"Best Pract Res Clin Haematol"},{"key":"10.1016\/j.clinthera.2010.04.012_bib41","doi-asserted-by":"crossref","first-page":"6517","DOI":"10.1021\/bi00417a048","article-title":"Use of site-directed mutagenesis to investigate the basis for the specificity of hirudin","volume":"27","author":"Braun","year":"1988","journal-title":"Biochemistry"},{"key":"10.1016\/j.clinthera.2010.04.012_bib42","first-page":"249","article-title":"Comparison of in vitro and in vivo properties of rhirudin (HBW 023) and a synthetic analogous peptide","volume":"23","author":"R\u00f6misch","year":"1993","journal-title":"Haemostasis"},{"key":"10.1016\/j.clinthera.2010.04.012_bib43","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1182\/blood.V96.7.2373","article-title":"Antihirudin antibodies in patients with heparin-induced thrombocytopenia treated with lepirudin: Incidence, effects on aPTT, and clinical relevance","volume":"96","author":"Eichler","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.clinthera.2010.04.012_bib44","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1309\/D79K4YG78NTNYY38","article-title":"Effect of direct thrombin inhibitors, bivalirudin, lepirudin, and argatroban, on prothrombin time and INR values","volume":"121","author":"Gosselin","year":"2004","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.clinthera.2010.04.012_bib45","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0049-3848(90)90120-2","article-title":"Effect of a synthetic thrombin-inhibitor MD805 on the reaction between thrombin and plasma antithrombin-III","volume":"59","author":"Hijikata-Okunomiya","year":"1990","journal-title":"Thromb Res"},{"key":"10.1016\/j.clinthera.2010.04.012_bib46","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/01.crd.0000164011.17381.6f","article-title":"The cost-effectiveness of argatroban treatment in heparin-induced thrombocytopenia: The effect of early versus delayed treatment","volume":"14","author":"Arnold","year":"2006","journal-title":"Cardiol Rev"},{"issue":"Suppl 3","key":"10.1016\/j.clinthera.2010.04.012_bib47","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1053\/j.seminhematol.2005.05.016","article-title":"The heparin-induced thrombocytopenia task force model: Implementing quality improvement and economic outcome initiatives","volume":"42","author":"Frame","year":"2005","journal-title":"Semin Hematol"},{"key":"10.1016\/j.clinthera.2010.04.012_bib48","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1378\/chest.08-0120","article-title":"The financial impact of heparin-induced thrombocytopenia","volume":"134","author":"Smythe","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.clinthera.2010.04.012_bib49","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0009-9236(97)90151-X","article-title":"Effect of renal impairment on the pharmacokinetics and pharmaco-dynamics of desirudin","volume":"62","author":"Lef\u00e8vre","year":"1997","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.clinthera.2010.04.012_bib50","unstructured":"Nafziger AN, Bertino JS Jr. Desirudin dosing and monitoring in moderate renal impairment [published online ahead of print November 13, 2009]. J Clin Pharmacol."},{"key":"10.1016\/j.clinthera.2010.04.012_bib51","series-title":"Heparin-Induced Thrombocytopenia","first-page":"345","article-title":"Lepirudin for the treatment of heparin-induced thrombocytopenia","author":"Greinacher","year":"2007"},{"key":"10.1016\/j.clinthera.2010.04.012_bib52","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s11239-006-9019-2","article-title":"Effect of renal function on argatroban therapy in heparin-induced thrombocytopenia","volume":"22","author":"Guzzi","year":"2006","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.clinthera.2010.04.012_bib53","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/FJC.0b013e3181926928","article-title":"Risk factors for major bleeding in patients with heparin-induced thrombocytopenia treated with argatroban: A retrospective study","volume":"52","author":"Hursting","year":"2008","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.clinthera.2010.04.012_bib54","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1345\/aph.1G033","article-title":"Argatroban anticoagulation in patients with heparin-induced thrombocytopenia requiring renal replacement therapy","volume":"39","author":"Reddy","year":"2005","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.clinthera.2010.04.012_bib55","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1345\/aph.1D163","article-title":"Effect of renal function on the pharmacodynamics of argatroban","volume":"38","author":"Arpino","year":"2004","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.clinthera.2010.04.012_bib56","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1055\/s-0038-1648844","article-title":"Direct thrombin inhibition with Rec-hirudin CGP 39393 as prophylaxis of thromboembolic complications after total hip replacement","volume":"72","author":"Eriksson","year":"1994","journal-title":"Thromb Haemost"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291810001360?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291810001360?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T05:35:55Z","timestamp":1591248955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291810001360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0149291810001360"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2010.04.012","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]}}}