{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T09:27:48Z","timestamp":1774171668580,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.clinthera.2010.09.017","type":"journal-article","created":{"date-parts":[[2010,11,22]],"date-time":"2010-11-22T09:11:28Z","timestamp":1290417088000},"page":"1935-1950","source":"Crossref","is-referenced-by-count":19,"title":["Adjunctive levetiracetam in patients aged 1 month to <4 years with partial-onset seizures: Subpopulation analysis of a prospective, open-label extension study of up to 48 weeks"],"prefix":"10.1016","volume":"32","clinical-trial-number":[{"clinical-trial-number":"nct00152516","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct00175890","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Jesus Eric","family":"Pi\u00f1a-Garza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimmy","family":"Schiemann-Delgado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haichen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Hadac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott J.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2010.09.017_bib1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0140-6736(06)68182-8","article-title":"Epilepsy in children","volume":"367","author":"Guerrini","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.clinthera.2010.09.017_bib2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2165\/00148581-200810040-00003","article-title":"Use of second-generation antiepileptic drugs in the pediatric population","volume":"10","author":"Chung","year":"2008","journal-title":"Paediatr Drugs"},{"key":"10.1016\/j.clinthera.2010.09.017_bib3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0920-1211(94)90086-8","article-title":"Cognitive side-effects of phenytoin compared with carbamazepine in patients with localization-related epilepsy","volume":"19","author":"Aldenkamp","year":"1994","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.clinthera.2010.09.017_bib4","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1056\/NEJM199002083220604","article-title":"Phenobarbital for febrile seizures\u2014effects on intelligence and on seizure recurrence [published correction appears in N Engl J Med. 1992;326:144]","volume":"322","author":"Farwell","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2010.09.017_bib5","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1212\/01.WNL.0000115653.82763.07","article-title":"Cognitive side effects of anti-epileptic drugs in children","volume":"62","author":"Loring","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.clinthera.2010.09.017_bib6","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1111\/j.1528-1157.2000.tb04605.x","article-title":"Efficacy and tolerability of levetiracetam 3000 mg\/d in patients with refractory partial seizures: A multicenter, double-blind, responder-selected study evaluating monotherapy","volume":"41","author":"Ben-Menachem","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.clinthera.2010.09.017_bib7","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1212\/WNL.55.2.236","article-title":"Levetiracetam for partial seizures: Results of a double-blind, randomized clinical trial","volume":"55","author":"Cereghino","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.clinthera.2010.09.017_bib8","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1111\/j.1528-1157.2000.tb00323.x","article-title":"Multicenter double-blind, randomized, placebo-controlled trial of levetiracetam as add-on therapy in patients with refractory partial seizures","volume":"41","author":"Shorvon","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.clinthera.2010.09.017_bib9","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1212\/01.wnl.0000297512.18364.40","article-title":"Levetiracetam for the treatment of idiopathic generalized epilepsy with myoclonic seizures","volume":"70","author":"Noachtar","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.clinthera.2010.09.017_bib10","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1212\/01.wnl.0000268699.34614.d3","article-title":"Placebo-controlled study of levetiracetam in idiopathic generalized epilepsy","volume":"69","author":"Berkovic","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.clinthera.2010.09.017_bib11","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1212\/01.wnl.0000217916.00225.3a","article-title":"Double-blind placebo-controlled trial of adjunctive levetiracetam in pediatric partial seizures","volume":"66","author":"Glauser","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.clinthera.2010.09.017_bib12","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1111\/j.1528-1167.2009.02197.x","article-title":"Neurocognitive effects of adjunctive levetiracetam in children with partial-onset seizures: A randomized, double-blind, placebo-controlled, noninferiority trial","volume":"50","author":"Levisohn","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.clinthera.2010.09.017_bib13","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1111\/j.1528-1167.2008.01981.x","article-title":"Adjunctive levetiracetam in infants and young children with refractory partial-onset seizures","volume":"50","author":"Pi\u00f1a-Garza","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.clinthera.2010.09.017_bib14","series-title":"Bayley Scales of Infant Development","author":"Bayley","year":"1993"},{"key":"10.1016\/j.clinthera.2010.09.017_bib15","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1528-1157.1981.tb06159.x","article-title":"Proposal for revised clinical and electroencephalographic classification of epileptic seizures. From the Commission on Classification and Terminology of the International League Against Epilepsy","volume":"22","year":"1981","journal-title":"Epilepsia"},{"issue":"Suppl 1","key":"10.1016\/j.clinthera.2010.09.017_bib16","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1097\/01.nrl.0000340789.15295.8f","article-title":"Cognitive disorders associated with epilepsy: Diagnosis and treatment","volume":"14","author":"Carre\u00f1o","year":"2008","journal-title":"Neurologist"},{"key":"10.1016\/j.clinthera.2010.09.017_bib17","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1542\/peds.2006-2530","article-title":"Developmental outcome after epilepsy surgery in infancy","volume":"119","author":"Loddenkemper","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2010.09.017_bib18","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.seizure.2005.08.007","article-title":"Vagus nerve stimulation in 15 children with therapy resistant epilepsy; its impact on cognition, quality of life, behaviour and mood","volume":"14","author":"Hallb\u00f6\u00f6k","year":"2005","journal-title":"Seizure"},{"key":"10.1016\/j.clinthera.2010.09.017_bib19","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0022-3476(79)80507-7","article-title":"Side effects of phenobarbital in toddlers; behavioral and cognitive aspects","volume":"95","author":"Camfield","year":"1979","journal-title":"J Pediatr"},{"key":"10.1016\/j.clinthera.2010.09.017_bib20","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.seizure.2007.02.004","article-title":"Efficacy and safety of levetiracetam in infants and young children with refractory epilepsy","volume":"16","author":"Grosso","year":"2007","journal-title":"Seizure"},{"key":"10.1016\/j.clinthera.2010.09.017_bib21","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/j.1528-1167.2007.01003.x","article-title":"Efficacy and tolerability of levetiracetam in children younger than 4 years: A retrospective review","volume":"48","author":"Perry","year":"2007","journal-title":"Epilepsia"},{"issue":"Suppl 2","key":"10.1016\/j.clinthera.2010.09.017_bib22","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1528-1167.2006.00683.x","article-title":"The effect of anti-epileptic drugs on cognition: Patient perceived cognitive problems of topiramate versus levetiracetam in clinical practice","volume":"47","author":"Bootsma","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.clinthera.2010.09.017_bib23","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.yebeh.2007.02.007","article-title":"The influence of antiepileptic drugs on cognition: A comparison of levetiracetam with topiramate","volume":"10","author":"Gomer","year":"2007","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.clinthera.2010.09.017_bib24","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1684\/epd.2008.0227","article-title":"Effect of levetiracetam on cognitive functions and quality of life: A one-year followup study","volume":"10","author":"L\u00f3pez-G\u00f3ngora","year":"2008","journal-title":"Epileptic Disord."},{"key":"10.1016\/j.clinthera.2010.09.017_bib25","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1212\/01.wnl.0000281104.55418.60","article-title":"Neuropsychological and neurophysiologic effects of carbamazepine and levetiracetam","volume":"69","author":"Meador","year":"2007","journal-title":"Neurology"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291810003267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291810003267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T11:49:04Z","timestamp":1711972144000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291810003267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0149291810003267"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2010.09.017","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}