{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:23:49Z","timestamp":1770963829215,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.clinthera.2011.09.013","type":"journal-article","created":{"date-parts":[[2011,10,17]],"date-time":"2011-10-17T18:47:47Z","timestamp":1318877267000},"page":"1537-1546","source":"Crossref","is-referenced-by-count":62,"title":["Design and Recruitment for the GAP Trial, Investigating the Preventive Effect on Asthma Development of an SQ-Standardized Grass Allergy Immunotherapy Tablet in Children with Grass Pollen\u2013Induced Allergic Rhinoconjunctivitis"],"prefix":"10.1016","volume":"33","clinical-trial-number":[{"clinical-trial-number":"2009-011235-12","registry":"10.18810\/euctr"}],"author":[{"given":"Erkka","family":"Valovirta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aud Katrine Herland","family":"Berstad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"de Blic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albrecht","family":"Bufe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Eng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Halken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Ojeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lene","family":"Tommerup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva-Maria","family":"Varga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inger","family":"Winnergard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2011.09.013_bib1","series-title":"Global Strategy for Asthma Management and Prevention","year":"2008"},{"key":"10.1016\/j.clinthera.2011.09.013_bib2","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1398-9995.2004.00526.x","article-title":"The global burden of asthma: executive summary of the GINA Dissemination Committee report","volume":"59","author":"Masoli","year":"2004","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2011.09.013_bib3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1398-9995.2007.01586.x","article-title":"Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report","volume":"63","author":"Bacharier","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2011.09.013_bib4","first-page":"7","article-title":"The nose-lung interaction in allergic rhinitis and asthma: united airways disease","volume":"1","author":"Passalacqua","year":"2001","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2011.09.013_bib5","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1111\/j.1398-9995.2005.00858.x","article-title":"The 'united airways' require an holistic approach to management","volume":"60","author":"Cruz","year":"2005","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2011.09.013_bib6","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1586\/eci.10.15","article-title":"The link between allergic rhinitis and asthma: the united airways disease","volume":"6","author":"Compalati","year":"2010","journal-title":"Expert Rev Clin Immunol"},{"issue":"Suppl 86","key":"10.1016\/j.clinthera.2011.09.013_bib7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1398-9995.2007.01620.x","article-title":"Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen)","volume":"63","author":"Bousquet","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2011.09.013_bib8","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1398-9995.2008.01628.x","article-title":"Links between allergic rhinitis and asthma still reinforced","volume":"63","author":"Demoly","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2011.09.013_bib9","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.jaci.2007.07.020","article-title":"Childhood allergic rhinitis predicts asthma incidence and persistence to middle age: a longitudinal study","volume":"120","author":"Burgess","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2011.09.013_bib10","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S0140-6736(08)61446-4","article-title":"Rhinitis and onset of asthma: a longitudinal population-based study","volume":"372","author":"Shaaban","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.clinthera.2011.09.013_bib11","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.jaci.2010.09.008","article-title":"Allergic rhinitis as a predictor for wheezing onset in school-aged children","volume":"126","author":"Rochat","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2011.09.013_bib12","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1136\/adc.2010.183095","article-title":"Preventing progression of allergic rhinitis: the role of specific immunotherapy","volume":"96","author":"Fiocchi","year":"2011","journal-title":"Arch Dis Child Educ Pract Ed"},{"key":"10.1016\/j.clinthera.2011.09.013_bib13","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/j.1398-9995.2007.01451.x","article-title":"Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10-year follow-up on the PAT study","volume":"62","author":"Jacobsen","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2011.09.013_bib14","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/j.1398-9995.2006.01068.x","article-title":"Five-year follow up on the PAT study: specific immunotherapy and long-term prevention of asthma in children","volume":"61","author":"Niggemann","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2011.09.013_bib15","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1067\/mai.2002.121317","article-title":"Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study)","volume":"109","author":"Moller","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2011.09.013_bib16","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S1081-1206(10)60211-6","article-title":"Preventive effects of sublingual immunotherapy in childhood: an open randomized controlled study","volume":"101","author":"Marogna","year":"2008","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.clinthera.2011.09.013_bib17","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jaci.2004.07.012","article-title":"Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis","volume":"114","author":"Novembre","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2011.09.013_bib18","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1398-9995.2006.01011.x","article-title":"Twelve-year follow-up after discontinuation of preseasonal grass pollen immunotherapy in childhood","volume":"61","author":"Eng","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2011.09.013_bib19","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1111\/j.1365-2222.2011.03740.x","article-title":"Specific immunotherapy in children","volume":"41","author":"Bufe","year":"2011","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.clinthera.2011.09.013_bib20","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jaci.2010.09.037","article-title":"Disease-modifying effect and economic implications of sublingual immunotherapy","volume":"127","author":"Canonica","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2011.09.013_bib21","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1398-9995.2006.01312.x","article-title":"Recommendations for standardization of clinical trials with Allergen Specific Immunotherapy for Respiratory allergy","volume":"62","author":"Canonica","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2011.09.013_bib22","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1111\/j.1398-9995.2011.02582.x","article-title":"Close collaboration between academia, industry and drug regulators is required in the development of allergen products for specific immunotherapy in children","volume":"66","author":"Eichler","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2011.09.013_bib23","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jaci.2006.05.003","article-title":"Efficacy and safety of sublingual immunotherapy with grass allergen tablet for seasonal allergic rhinoconjunctivitis","volume":"118","author":"Dahl","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2011.09.013_bib24","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jaci.2008.10.044","article-title":"Safety and efficacy in children of an SQ-standardized grass allergen tablet for sublingual immunotherapy","volume":"123","author":"Bufe","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2011.09.013_bib25","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jaci.2010.11.035","article-title":"Efficacy and safety of timothy grass allergy immunotherapy tablet treatment in North American adults","volume":"127","author":"Nelson","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2011.09.013_bib26","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jaci.2010.11.034","article-title":"Efficacy and safety of timothy grass allergy immunotherapy tablets in North American children and adolescents","volume":"127","author":"Blaiss","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2011.09.013_bib27","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.jaci.2007.07.046","article-title":"Optimal dose, efficacy, and safety of once-daily sublingual immunotherapy with a 5-grass pollen tablet for seasonal allergic rhinitis","volume":"120","author":"Didier","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2011.09.013_bib28","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jaci.2008.10.009","article-title":"Efficacy and safety of 5-grass-pollen sublingual immunotherapy tablets in pediatric allergic rhinoconjunctivitis","volume":"123","author":"Wahn","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2011.09.013_bib29","first-page":"689","article-title":"Disease-modifying effect of the SQ-standardised grass allergy immunotherapy tablet is sustained 2 years after treatment","volume":"65","author":"Durham","year":"2010","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2011.09.013_bib30","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.1398-9995.2009.02238.x","article-title":"Sustained effect of SQ-standardized grass allergy immunotherapy tablet on rhinoconjunctivitis quality of life","volume":"65","author":"Fr\u00f8lund","year":"2010","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2011.09.013_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD002893.pub2","article-title":"Sublingual immunotherapy for allergic rhinitis","volume":"12","author":"Radulovic","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.clinthera.2011.09.013_bib35","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1378\/chest.06-1425","article-title":"Metaanalysis of the efficacy of sublingual immunotherapy in the treatment of allergic asthma in pediatric patients, 3 to 18 years of age","volume":"133","author":"Penagos","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.clinthera.2011.09.013_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD001936.pub2","article-title":"Allergen injection immunotherapy for seasonal allergic rhinitis","volume":"1","author":"Calderon","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.clinthera.2011.09.013_bib37","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1111\/j.1398-9995.2010.02474.x","article-title":"GA2 LEN\/EAACI pocket guide for allergen-specific immunotherapy for allergic rhinitis and asthma","volume":"65","author":"Zuberbier","year":"2010","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2011.09.013_bib41","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jaci.2003.09.008","article-title":"Development of the asthma control test: a survey for assessing asthma control","volume":"113","author":"Nathan","year":"2004","journal-title":"J Allergy Clin Immunol"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291811006217?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291811006217?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T12:22:04Z","timestamp":1543494124000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291811006217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0149291811006217"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2011.09.013","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}