{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T09:58:48Z","timestamp":1760608728482},"reference-count":27,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T00:00:00Z","timestamp":1405555200000},"content-version":"vor","delay-in-days":442,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.clinthera.2013.03.014","type":"journal-article","created":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T06:48:03Z","timestamp":1365490083000},"page":"646-658","source":"Crossref","is-referenced-by-count":7,"title":["Effects of Injectable HP\u03b2CD-Diclofenac on the Human Delayed Rectifier Potassium Channel Current In Vitro and on Proarrhythmic QTc In Vivo"],"prefix":"10.1016","volume":"35","clinical-trial-number":[{"clinical-trial-number":"nct01812538","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Daniel B.","family":"Carr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"McDonnell Moorehead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"Bouchard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig R.","family":"Sprenger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas A.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna","family":"Madden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter G.","family":"Lacouture","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"IV","given":"Curtis","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2013.03.014_bib1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ahj.2006.05.024","article-title":"Clinical trial design and patient demographics of the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) study program: cardiovascular outcomes with etoricoxib versus diclofenac in patients with osteoarthritis and rheumatoid arthritis","volume":"152","author":"Cannon","year":"2006","journal-title":"Am Heart J"},{"key":"10.1016\/j.clinthera.2013.03.014_bib2","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1016\/S0140-6736(06)69666-9","article-title":"Cardiovascular outcomes with etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison","volume":"368","author":"Cannon","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.clinthera.2013.03.014_bib3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0002-9343(86)90085-9","article-title":"Worldwide safety experience with diclofenac","volume":"80","author":"Catalano","year":"1986","journal-title":"Am J Med"},{"issue":"Suppl 1","key":"10.1016\/j.clinthera.2013.03.014_bib4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0049-0172(85)80022-6","article-title":"Worldwide clinical safety experience with diclofenac","volume":"15","author":"Willkens","year":"1985","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2013.03.014_bib5","series-title":"Voltarol ampoules (injectable diclofenac) [product characteristics]","year":"2010"},{"key":"10.1016\/j.clinthera.2013.03.014_bib6","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2344\/0003-3006-58.2.73","article-title":"A double-blind placebo-controlled comparison of a novel formulation of intravenous diclofenac and ketorolac for postoperative third molar extraction pain","volume":"58","author":"Christensen","year":"2011","journal-title":"Anesth Prog"},{"key":"10.1016\/j.clinthera.2013.03.014_bib7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/00115550-200707000-00006","article-title":"Dyloject, a novel injectable diclofenac formulation, offers greater safety and efficacy than Voltarol for postoperative dental pain","volume":"32","author":"Leeson","year":"2007","journal-title":"Reg Anesth Pain Med"},{"key":"10.1016\/j.clinthera.2013.03.014_bib8","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1213\/ANE.0b013e3182691bf9","article-title":"A novel injectable formulation of diclofenac compared with intravenous ketorolac or placebo for acute moderate-to-severe pain after abdominal or pelvic surgery: a multicenter, double-blind, randomized, multiple-dose study","volume":"115","author":"Gan","year":"2012","journal-title":"Anesth Analg"},{"key":"10.1016\/j.clinthera.2013.03.014_bib9","doi-asserted-by":"crossref","unstructured":"Daniels SE, Melson T, Hamilton DA, et al. Analgesic efficacy and safety of a novel injectable formulation of diclofenac compared with intravenous ketorolac and placebo after orthopedic surgery: a multicenter, randomized, double-blinded, multiple-dose trial. Clin J Pain. In press: doi: 10.1097\/AJP.0b013e318270f957.","DOI":"10.1097\/AJP.0b013e318270f957"},{"key":"10.1016\/j.clinthera.2013.03.014_bib10","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.jclinane.2009.12.011","article-title":"Platelet function following administration of a novel formulation of intravenous diclofenac sodium versus active comparators: a randomized, single dose, crossover study in healthy male volunteers","volume":"22","author":"Bauer","year":"2010","journal-title":"J Clin Anesth"},{"key":"10.1016\/j.clinthera.2013.03.014_bib11","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1161\/01.CIR.83.6.1888","article-title":"QTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest","volume":"83","author":"Algra","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.clinthera.2013.03.014_bib12","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s12012-011-9133-z","article-title":"Supplemental studies for cardiovascular risk assessment in safety pharmacology: a critical overview","volume":"11","author":"Picard","year":"2011","journal-title":"Cardiovasc Toxicol"},{"key":"10.1016\/j.clinthera.2013.03.014_bib13","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0006-3495(98)77782-3","article-title":"Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature","volume":"74","author":"Zhou","year":"1998","journal-title":"Biophys J"},{"key":"10.1016\/j.clinthera.2013.03.014_bib14","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0092-8674(95)90340-2","article-title":"A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel","volume":"81","author":"Sanguinetti","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.clinthera.2013.03.014_bib15","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s004240050713","article-title":"Time course and voltage dependence of expressed HERG current compared with native \u201crapid\u201d delayed rectifier K current during the cardiac ventricular action potential","volume":"436","author":"Hancox","year":"1998","journal-title":"Pflugers Archiv: Eur J Physiol"},{"key":"10.1016\/j.clinthera.2013.03.014_bib16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0014-5793(02)03804-8","article-title":"Normal function of HERG K+ channels expressed in HEK293 cells requires basal protein kinase B activity","volume":"534","author":"Zhang","year":"2003","journal-title":"FEBS Lett"},{"key":"10.1016\/j.clinthera.2013.03.014_bib17","doi-asserted-by":"crossref","first-page":"387","DOI":"10.2174\/1389201043376715","article-title":"The patch clamp technique in ion channel research","volume":"5","author":"Jurkat-Rott","year":"2004","journal-title":"Curr Pharm Biotechnol"},{"key":"10.1016\/j.clinthera.2013.03.014_bib18","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1080\/10543400801995478","article-title":"Testing for positive control activity in a thorough QTc study","volume":"18","author":"Zhang","year":"2008","journal-title":"J Biopharm Stat"},{"key":"10.1016\/j.clinthera.2013.03.014_bib19","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.fct.2005.03.007","article-title":"2-Hydroxypropyl-beta-cyclodextrin (HP-beta-CD): a toxicology review","volume":"43","author":"Gould","year":"2005","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.clinthera.2013.03.014_bib20","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.addr.2007.05.012","article-title":"Cyclodextrins as pharmaceutical solubilizers","volume":"59","author":"Brewster","year":"2007","journal-title":"Adv Drug Del Rev"},{"key":"10.1016\/j.clinthera.2013.03.014_bib21","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1097\/00000542-200510000-00026","article-title":"Propofol: the challenges of formulation","volume":"103","author":"Baker","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1016\/j.clinthera.2013.03.014_bib22","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1592\/phco.19.8.603.31529","article-title":"Itraconazole in cyclodextrin solution","volume":"19","author":"Stevens","year":"1999","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.clinthera.2013.03.014_bib23","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/FJC.0b013e318036dd05","article-title":"Hydroxypropyl beta-cyclodextrins: a misleading vehicle for the in vitro hERG current assay","volume":"49","author":"Mikhail","year":"2007","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.clinthera.2013.03.014_bib24","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.vascn.2007.04.004","article-title":"Suitability of commonly used excipients for electrophysiological in-vitro safety pharmacology assessment of effects on hERG potassium current and on rabbit Purkinje fiber action potential","volume":"56","author":"Himmel","year":"2007","journal-title":"J Pharmacol Toxicol Methods"},{"key":"10.1016\/j.clinthera.2013.03.014_bib25","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1242\/jcs.02348","article-title":"Targeting of voltage-gated potassium channel isoforms to distinct cell surface microdomains","volume":"118","author":"O'Connell","year":"2005","journal-title":"J Cell Sci"},{"key":"10.1016\/j.clinthera.2013.03.014_bib26","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.pharmthera.2010.08.008","article-title":"An evaluation of hERG current assay performance: translating preclinical safety studies to clinical QT prolongation","volume":"129","author":"Gintant","year":"2011","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.clinthera.2013.03.014_bib27","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1001\/jama.1993.03510210076031","article-title":"Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs","volume":"270","author":"Makkar","year":"1993","journal-title":"JAMA"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291813001276?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291813001276?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T03:02:46Z","timestamp":1539745366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291813001276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0149291813001276"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2013.03.014","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}