{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:14:00Z","timestamp":1790270040316,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.clinthera.2014.11.004","type":"journal-article","created":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T19:31:35Z","timestamp":1417721495000},"page":"83-93","source":"Crossref","is-referenced-by-count":9,"title":["Pharmacokinetic Comparison Study of a Combination Containing 500 mg of Naproxen and 20 mg of Esomeprazole: A Randomized, Single-dose, 2-way Crossover, Open-label Study in Healthy Korean Men"],"prefix":"10.1016","volume":"37","clinical-trial-number":[{"clinical-trial-number":"kct0001117","registry":"10.18810\/cris"}],"author":[{"given":"Hyun-Gyu","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Young","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Shin","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunil","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyun","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Jin","family":"Im","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjeong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Gul","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2014.11.004_bib1","series-title":"Cancer pain relief: with a guide to opioid availability.","year":"1996"},{"issue":"6","key":"10.1016\/j.clinthera.2014.11.004_bib2","first-page":"514","article-title":"Is the WHO analgesic ladder still valid? Twenty-four years of experience","volume":"56","author":"Vargas-Schaffer","year":"2010","journal-title":"Can Fam Physician"},{"issue":"8","key":"10.1016\/j.clinthera.2014.11.004_bib3","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1002\/art.20424","article-title":"The discovery and development of antiinflammatory drugs","volume":"50","author":"Brune","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.clinthera.2014.11.004_bib4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/00045391-200007020-00008","article-title":"Gastrointestinal complications of prescription and over-the-counter nonsteroidal anti-inflammatory drugs: a view from the ARAMIS database. Arthritis, Rheumatism, and Aging Medical Information System","volume":"7","author":"Singh","year":"2000","journal-title":"Am J Ther"},{"issue":"2","key":"10.1016\/j.clinthera.2014.11.004_bib5","first-page":"285","article-title":"Dysmenorrhea","volume":"71","author":"French","year":"2005","journal-title":"Am Fam Physician"},{"issue":"1","key":"10.1016\/j.clinthera.2014.11.004_bib6","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4103\/2141-9248.126604","article-title":"An Overview of History, Pathogenesis and Treatment of Perforated Peptic Ulcer Disease with Evaluation of Prognostic Scoring in Adults","volume":"4","author":"Prabhu","year":"2014","journal-title":"Annals of medical and health sciences research"},{"issue":"11","key":"10.1016\/j.clinthera.2014.11.004_bib7","first-page":"1153","article-title":"Gastroduodenal mucosa and dyspeptic symptoms in arthritic patients during chronic nonsteroidal anti-inflammatory drug use","volume":"82","author":"Larkai","year":"1987","journal-title":"Am J Gastroenterol"},{"issue":"8","key":"10.1016\/j.clinthera.2014.11.004_bib8","doi-asserted-by":"crossref","first-page":"753","DOI":"10.3109\/00365529609010347","article-title":"Prevention of peptic ulcer and dyspeptic symptoms with omeprazole in patients receiving continuous non-steroidal anti-inflammatory drug therapy: a Nordic multicentre study","volume":"31","author":"Ekstrom","year":"1996","journal-title":"Scand J Gastroenterol"},{"issue":"11","key":"10.1016\/j.clinthera.2014.11.004_bib9","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJM199803123381105","article-title":"Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group","volume":"338","author":"Hawkey","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2014.11.004_bib10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.coph.2014.05.008","article-title":"NSAID-gastroenteropathy: new aspects of pathogenesis and prevention","volume":"19C","author":"Blackler","year":"2014","journal-title":"Curr Opin Pharmacol"},{"issue":"9\u201310","key":"10.1016\/j.clinthera.2014.11.004_bib11","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s002280000206","article-title":"Pharmacokinetics of esomeprazole after oral and intravenous administration of single and repeated doses to healthy subjects","volume":"56","author":"Hassan-Alin","year":"2000","journal-title":"Eur J Clin Pharmacol"},{"issue":"3","key":"10.1016\/j.clinthera.2014.11.004_bib12","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.clinthera.2006.03.010","article-title":"Pharmacokinetic properties of esomeprazole in adolescent patients aged 12 to 17 years with symptoms of gastroesophageal reflux disease: a randomized, open-label study","volume":"28","author":"Li","year":"2006","journal-title":"Clin Ther"},{"issue":"3","key":"10.1016\/j.clinthera.2014.11.004_bib13","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1365-2036.2010.04378.x","article-title":"Clinical trial: the incidence of NSAID-associated endoscopic gastric ulcers in patients treated with PN 400 (naproxen plus esomeprazole magnesium) vs. enteric-coated naproxen alone","volume":"32","author":"Goldstein","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"issue":"2","key":"10.1016\/j.clinthera.2014.11.004_bib14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/(SICI)1099-081X(199703)18:2<103::AID-BDD4>3.0.CO;2-S","article-title":"Partial-area method in bioequivalence assessment: naproxen","volume":"18","author":"Niazi","year":"1997","journal-title":"Biopharm Drug Dispos"},{"issue":"7","key":"10.1016\/j.clinthera.2014.11.004_bib15","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.clinthera.2010.07.007","article-title":"Relative bioavailability and pharmacokinetic properties of two different enteric formulations of esomeprazole in healthy Bangladeshi male volunteers: an open-label, single-dose, randomized-sequence, two-way crossover study","volume":"32","author":"Ullah","year":"2010","journal-title":"Clin Ther"},{"issue":"4","key":"10.1016\/j.clinthera.2014.11.004_bib16","article-title":"Bioequivalence between esomeprazole 40 mg MUPS and its encapsulated form","volume":"126","author":"Talpes","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clinthera.2014.11.004_bib17","unstructured":"Korea good clinical practice (KGCP) guidelines. Korea Ministry of Food and Drug Safety. 2013"},{"key":"10.1016\/j.clinthera.2014.11.004_bib18","unstructured":"The guidance for bioequivalence study of Korea. Korea Ministry of Food and Drug Safety. 2013"},{"key":"10.1016\/j.clinthera.2014.11.004_bib19","series-title":"ICH GCP guidelines: indexed pocketbook: ICH harmonised tripartite guideline: guideline for good clinical practice E6(R1) dated 10 June 1996 including post step 4 corrections","author":"Hutchinson","year":"2011"},{"key":"10.1016\/j.clinthera.2014.11.004_bib20","series-title":"Declaration of Helsinki: ethical principles for medical research involving human subjects, 2004","year":"2008"},{"issue":"5","key":"10.1016\/j.clinthera.2014.11.004_bib21","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1177\/0091270011405500","article-title":"Pharmacokinetics and relative bioavailability of a fixed-dose combination of enteric-coated naproxen and non-enteric-coated esomeprazole magnesium","volume":"52","author":"Wang-Smith","year":"2012","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.clinthera.2014.11.004_bib22","series-title":"Clinical pharmacokinetics and pharmacodynamics: concepts and applications.","author":"Rowland","year":"2009"},{"key":"10.1016\/j.clinthera.2014.11.004_bib23","series-title":"Design and analysis of bioavailability and bioequivalence studies.","author":"Chow","year":"2009"},{"key":"10.1016\/j.clinthera.2014.11.004_bib24","series-title":"Applied linear statistical models.","author":"Kutner","year":"2005"},{"issue":"2","key":"10.1016\/j.clinthera.2014.11.004_bib25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.canlet.2014.01.021","article-title":"Anti-tumor activity of non-steroidal anti-inflammatory drugs: cyclooxygenase-independent targets","volume":"346","author":"Liggett","year":"2014","journal-title":"Cancer Lett"},{"issue":"12","key":"10.1016\/j.clinthera.2014.11.004_bib26","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/BF03261999","article-title":"Individual NSAIDs and upper gastrointestinal complications: a systematic review and meta-analysis of observational studies (the SOS project)","volume":"35","author":"Castellsague","year":"2012","journal-title":"Drug safety: an international journal of medical toxicology and drug experience"},{"issue":"3","key":"10.1016\/j.clinthera.2014.11.004_bib27","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0304-3959(03)00318-X","article-title":"Initial pharmacokinetic, safety and efficacy evaluation of nasal morphine gluconate for breakthrough pain in cancer patients","volume":"106","author":"Fitzgibbon","year":"2003","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.clinthera.2014.11.004_bib28","doi-asserted-by":"crossref","first-page":"E58","DOI":"10.1016\/S1470-2045(12)70040-2","article-title":"Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC","volume":"13","author":"Caraceni","year":"2012","journal-title":"Lancet Oncol"},{"issue":"1","key":"10.1016\/j.clinthera.2014.11.004_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/SPC.0b013e3283260658","article-title":"Impact and management of breakthrough pain in cancer","volume":"3","author":"Zeppetella","year":"2009","journal-title":"Current opinion in supportive and palliative care"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291814007401?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291814007401?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T02:27:45Z","timestamp":1538015265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291814007401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S0149291814007401"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2014.11.004","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]}}}