{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:33:15Z","timestamp":1770510795367,"version":"3.49.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.clinthera.2015.03.028","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T18:27:47Z","timestamp":1432060067000},"page":"1402-1419.e5","source":"Crossref","is-referenced-by-count":31,"title":["Effect of Aspirin Pretreatment or Slow Dose Titration on Flushing and Gastrointestinal Events in Healthy Volunteers Receiving Delayed-release Dimethyl Fumarate"],"prefix":"10.1016","volume":"37","clinical-trial-number":[{"clinical-trial-number":"nct00420212","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct00451451","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct01281111","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct01568112","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"John","family":"O\u2019Gorman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidy K.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuwan C.","family":"Kurukulasuriya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vissia","family":"Viglietta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2015.03.028_bib1","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1056\/NEJMoa1114287","article-title":"Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis","volume":"367","author":"Gold","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2015.03.028_bib2","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1056\/NEJMoa1206328","article-title":"Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis","volume":"367","author":"Fox","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2015.03.028_bib3","doi-asserted-by":"crossref","unstructured":"Theodore Phillips J, Selmaj K, Gold R, et al. Clinical significance of gastrointestinal and flushing events in MS patients treated with delayed-release dimethyl fumarate. International Journal of MS Care, 2015, http:\/\/dx.doi.org\/10.7224\/1537-2073.2014-069 (in press).","DOI":"10.7224\/1537-2073.2014-069"},{"key":"10.1016\/j.clinthera.2015.03.028_bib4","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.clinthera.2013.08.009","article-title":"Tolerability and pharmacokinetics of delayed-release dimethyl fumarate administered with and without aspirin in healthy volunteers","volume":"35","author":"Sheikh","year":"2013","journal-title":"Clin Ther"},{"key":"10.1016\/j.clinthera.2015.03.028_bib5","doi-asserted-by":"crossref","first-page":"365","DOI":"10.4065\/mcp.2009.0535","article-title":"A \u201chot\u201d topic in dyslipidemia management\u2014\u201chow to beat a flush\u201d: optimizing niacin tolerability to promote long-term treatment adherence and coronary disease prevention","volume":"85","author":"Jacobson","year":"2010","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.clinthera.2015.03.028_bib6","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1111\/j.1742-1241.2008.01739.x","article-title":"Measuring flushing symptoms with extended-release niacin using the flushing symptom questionnaire: results from a randomised placebo-controlled clinical trial","volume":"62","author":"Paolini","year":"2008","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.clinthera.2015.03.028_bib7","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1185\/030079907X199637","article-title":"Validation of a questionnaire to assess niacin-induced cutaneous flushing","volume":"23","author":"Norquist","year":"2007","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.clinthera.2015.03.028_bib8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.bcp.2007.03.023","article-title":"PGD2 metabolism in plasma: kinetics and relationship with bioactivity on DP1 and CRTH2 receptors","volume":"74","author":"Schuligoi","year":"2007","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.clinthera.2015.03.028_bib9","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0378-4347(93)80430-C","article-title":"Simplification of the mass spectrometric assay for the major urinary metabolite of prostaglandin D2","volume":"617","author":"Awad","year":"1993","journal-title":"J Chromatogr"},{"key":"10.1016\/j.clinthera.2015.03.028_bib10","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nprot.2006.375","article-title":"Quantification of F2-isoprostanes as a biomarker of oxidative stress","volume":"2","author":"Milne","year":"2007","journal-title":"Nat Protoc"},{"key":"10.1016\/j.clinthera.2015.03.028_bib11","unstructured":"ICH harmonized tripartite guideline: guideline for Good Clinical Practice. J Postgrad Med. 2001;47:45-50."},{"key":"10.1016\/j.clinthera.2015.03.028_bib12","unstructured":"WMA. Declaration of Helsinki. June 1964."},{"key":"10.1016\/j.clinthera.2015.03.028_bib13","unstructured":"Zimmerman HJ. Hepatotoxicity: the adverse effects of drugs and other chemicals on the Liver. Appleton-Century-Crofts: New York 1978."},{"key":"10.1016\/j.clinthera.2015.03.028_bib14","unstructured":"Tecfidera\u2122 USPI [package insert]. Cambridge, MA: Biogen Idec; 2013."},{"key":"10.1016\/j.clinthera.2015.03.028_bib15","unstructured":"2014\/SmPC TPI. Tecfidera\u00ae Summary of Product Characteristics, 13 Feb 2014, Biogen Idec Inc. 2014."},{"key":"10.1016\/j.clinthera.2015.03.028_bib16","doi-asserted-by":"crossref","first-page":"257","DOI":"10.7326\/0003-4819-144-4-200602210-00007","article-title":"Brief communication: better ways to question patients about adverse medical events: a randomized, controlled trial","volume":"144","author":"Bent","year":"2006","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.clinthera.2015.03.028_bib17","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1111\/j.1526-4610.2004.04191.x","article-title":"Assessment of adverse events associated with triptans\u2014methods of assessment influence the results","volume":"44","author":"Sheftell","year":"2004","journal-title":"Headache"},{"key":"10.1016\/j.clinthera.2015.03.028_bib18","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1098\/rstb.2010.0394","article-title":"Lessons learned from placebo groups in antidepressant trials","volume":"366","author":"Mora","year":"2011","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.clinthera.2015.03.028_bib19","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.msard.2014.03.003","article-title":"Managing flushing and gastrointestinal events associated with delayed-release dimethyl fumarate: experiences of an international panel","volume":"3","author":"Phillips","year":"2014","journal-title":"Multiple Sclerosis and Related Disorders"},{"key":"10.1016\/j.clinthera.2015.03.028_bib20","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s11136-011-0031-4","article-title":"Reliability of adverse symptom event reporting by clinicians","volume":"21","author":"Atkinson","year":"2012","journal-title":"Qual Life Res"},{"key":"10.1016\/j.clinthera.2015.03.028_bib21","first-page":"530","article-title":"Agreement between patient-reported symptoms and their documentation in the medical record","volume":"14","author":"Pakhomov","year":"2008","journal-title":"Am J Manag Care"},{"key":"10.1016\/j.clinthera.2015.03.028_bib22","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/S0140-6736(08)61619-0","article-title":"Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study","volume":"372","author":"Kappos","year":"2008","journal-title":"Lancet"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291815001885?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291815001885?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T09:53:40Z","timestamp":1537610020000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291815001885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S0149291815001885"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2015.03.028","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]}}}