{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T01:51:09Z","timestamp":1768009869961,"version":"3.49.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.clinthera.2015.11.016","type":"journal-article","created":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T00:14:22Z","timestamp":1450397662000},"page":"192-201.e2","source":"Crossref","is-referenced-by-count":20,"title":["Dexmedetomidine-fentanyl Compared With Midazolam-fentanyl for Conscious Sedation in Patients Undergoing Lumbar Disc Surgery"],"prefix":"10.1016","volume":"38","clinical-trial-number":[{"clinical-trial-number":"chictr-trc-13003645","registry":"10.18810\/chictr"}],"author":[{"given":"Ke","family":"Peng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua-yue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-lan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu-hai","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2015.11.016_bib1","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1097\/BRS.0b013e318182e390","article-title":"The cost effectiveness of surgical versus nonoperative treatment for lumbar disc herniation over two years: evidence from the Spine Patient Outcomes Research Trial (SPORT)","volume":"33","author":"Tosteson","year":"2008","journal-title":"Spine"},{"key":"10.1016\/j.clinthera.2015.11.016_bib2","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jocn.2011.04.042","article-title":"Anesthetic and analgesic effects in patients undergoing a lumbar laminectomy of spinal, epidural or a combined spinal-epidural block with the addition of morphine","volume":"19","author":"D\u00fcger","year":"2012","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.clinthera.2015.11.016_bib3","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1213\/00000539-199609000-00021","article-title":"A prospective randomized study comparing short- and intermediate-term perioperative outcome variables after spinal or general anesthesia for lumbar disk and laminectomy surgery","volume":"83","author":"Jellish","year":"1996","journal-title":"Anesth Analg"},{"key":"10.1016\/j.clinthera.2015.11.016_bib4","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1111\/j.1572-0241.2006.00500.x","article-title":"Endoscopic sedation in the United States: results from a nationwide survey","volume":"101","author":"Cohen","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.clinthera.2015.11.016_bib5","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0016-5107(91)70773-6","article-title":"Results from the American Society for Gastrointestinal Endoscopy\/U.S. Food and Drug Administration collaborative study on complication rates and drug use during gastrointestinal endoscopy","volume":"37","author":"Arrowsmith","year":"1991","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.clinthera.2015.11.016_bib6","first-page":"128","article-title":"Paradoxical reactions to benzodiazepines in intravenous sedation: a report of 2 cases and review of the literature","volume":"49","author":"Robin","year":"2002","journal-title":"Anesth Prog"},{"key":"10.1016\/j.clinthera.2015.11.016_bib7","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1097\/00000542-200411000-00005","article-title":"Dexmedetomidine pharmacodynamics: part I: crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers","volume":"101","author":"Hsu","year":"2004","journal-title":"Anesthesiology"},{"key":"10.1016\/j.clinthera.2015.11.016_bib8","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1097\/00000542-200011000-00030","article-title":"Clinical uses of alpha2 -adrenergic agonists","volume":"93","author":"Kamibayashi","year":"2000","journal-title":"Anesthesiology"},{"key":"10.1016\/j.clinthera.2015.11.016_bib9","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1097\/00000539-200003000-00035","article-title":"Sedative, amnestic, and analgesic properties of small-dose dexmedetomidine infusions","volume":"90","author":"Hall","year":"2000","journal-title":"Anesth Analg"},{"key":"10.1016\/j.clinthera.2015.11.016_bib10","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1177\/0300060513515437","article-title":"Dexmedetomidine versus midazolam for sedation in upper gastrointestinal endoscopy","volume":"42","author":"Wu","year":"2014","journal-title":"J Int Med Res"},{"key":"10.1016\/j.clinthera.2015.11.016_bib11","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1097\/EJA.0b013e3283347bfe","article-title":"A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation","volume":"27","author":"Dere","year":"2010","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.clinthera.2015.11.016_bib12","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1001\/jama.2009.56","article-title":"Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial","volume":"301","author":"Riker","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.clinthera.2015.11.016_bib13","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/j.jocn.2014.02.023","article-title":"Dexmedetomidine as an anesthetic adjuvant for intracranial procedures: meta-analysis of randomized controlled trials","volume":"21","author":"Peng","year":"2014","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.clinthera.2015.11.016_bib14","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.pain.2013.03.029","article-title":"Is intraoperative dexmedetomidine a new option for postoperative pain treatment? A meta-analysis of randomized controlled trials","volume":"154","author":"Schnabel","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.clinthera.2015.11.016_bib15","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1097\/ALN.0b013e31825681cb","article-title":"Effect of perioperative systemic alpha2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials","volume":"116","author":"Blaudszun","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1016\/j.clinthera.2015.11.016_bib16","first-page":"354","article-title":"Awake laminotomy and discectomy using Dexmedetomidine as anesthetic","volume":"28","author":"Torres","year":"2009","journal-title":"P R Health Sci J"},{"key":"10.1016\/j.clinthera.2015.11.016_bib17","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1136\/bmj.2.5920.656","article-title":"Controlled sedation with alphaxalone-alphadolone","volume":"2","author":"Ramsay","year":"1974","journal-title":"Br Med J"},{"key":"10.1016\/j.clinthera.2015.11.016_bib18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0952-8180(94)00001-K","article-title":"The post-anesthesia recovery score revisited","volume":"7","author":"Aldrete","year":"1995","journal-title":"J Clin Anesth"},{"key":"10.1016\/j.clinthera.2015.11.016_bib19","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1177\/0163278709338554","article-title":"Analyzing longitudinal data with the linear mixed models procedure in SPSS","volume":"32","author":"West","year":"2009","journal-title":"Eval Health Prof"},{"key":"10.1016\/j.clinthera.2015.11.016_bib20","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/aas.12445","article-title":"Intranasal dexmedetomidine in combination with patient-controlled sedation during upper gastrointestinal endoscopy: a randomised trial","volume":"59","author":"Cheung","year":"2015","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.clinthera.2015.11.016_bib21","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1055\/s-2004-826149","article-title":"Preparation, premedication, and surveillance","volume":"37","author":"Lazzaroni","year":"2005","journal-title":"Endoscopy"},{"key":"10.1016\/j.clinthera.2015.11.016_bib22","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1097\/00000542-200302000-00024","article-title":"The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects","volume":"98","author":"Nelson","year":"2003","journal-title":"Anesthesiology"},{"key":"10.1016\/j.clinthera.2015.11.016_bib23","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.ijom.2014.03.019","article-title":"Comparison of dexmedetomidine\/fentanyl with midazolam\/fentanyl combination for sedation and analgesia during tooth extraction","volume":"43","author":"Yu","year":"2014","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.clinthera.2015.11.016_bib24","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/cc712","article-title":"Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care","volume":"4","author":"Venn","year":"2000","journal-title":"Crit Care"},{"key":"10.1016\/j.clinthera.2015.11.016_bib25","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1097\/00000542-200008000-00016","article-title":"The effects of increasing plasma concentrations of dexmedetomidine in humans","volume":"93","author":"Ebert","year":"2000","journal-title":"Anesthesiology"},{"key":"10.1016\/j.clinthera.2015.11.016_bib26","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1080\/110241501753171146","article-title":"Dextromethorphan and dexmedetomidine: new agents for the control of perioperative pain","volume":"167","author":"Weinbroum","year":"2001","journal-title":"Eur J Surg"},{"key":"10.1016\/j.clinthera.2015.11.016_bib27","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0197-0186(00)00096-6","article-title":"Effect of dexmedetomidine on the release of [3H]-noradrenaline from rat kidney cortex slices: characterization of alpha2-adrenoceptor","volume":"38","author":"Taoda","year":"2001","journal-title":"Neurochem Int"},{"key":"10.1016\/j.clinthera.2015.11.016_bib28","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1213\/00000539-198903000-00002","article-title":"Antinociceptive interactions between alpha 2-adrenergic and opiate agonists at the spinal level in rodents","volume":"68","author":"Ossipov","year":"1989","journal-title":"Anesth Analg"},{"key":"10.1016\/j.clinthera.2015.11.016_bib29","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jss.2014.10.008","article-title":"Effects of dexmedetomidine on patients undergoing radical gastrectomy","volume":"194","author":"Wang","year":"2015","journal-title":"J Surg Res"},{"key":"10.1016\/j.clinthera.2015.11.016_bib30","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1053\/j.jvca.2013.06.022","article-title":"Perioperative dexmedetomidine improves mortality in patients undergoing coronary artery bypass surgery","volume":"28","author":"Ji","year":"2014","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.clinthera.2015.11.016_bib31","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1161\/CIRCULATIONAHA.112.000936","article-title":"Perioperative dexmedetomidine improves outcomes of cardiac surgery","volume":"127","author":"Ji","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.clinthera.2015.11.016_bib32","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1365-2044.2007.05306.x","article-title":"Dexmedetomidine and cardiac protection for non-cardiac surgery: a meta-analysis of randomised controlled trials","volume":"63","author":"Biccard","year":"2008","journal-title":"Anaesthesia"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291815013004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291815013004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T17:27:49Z","timestamp":1537118869000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291815013004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0149291815013004"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2015.11.016","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}