{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T15:42:32Z","timestamp":1793374952120,"version":"4.5.0"},"reference-count":13,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","clinicaltherapeutics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.clinthera.2016.09.006","type":"journal-article","created":{"date-parts":[[2016,10,10]],"date-time":"2016-10-10T13:10:53Z","timestamp":1476105053000},"page":"2185-2194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Comparison of the Efficacy and Safety of Fixed-dose S-Amlodipine\/Telmisartan and Telmisartan in Hypertensive Patients Inadequately Controlled with Telmisartan: A Randomized, Double-blind, Multicenter Study"],"prefix":"10.1016","volume":"38","author":[{"given":"Chang Gyu","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Hun","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Ju","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Seob","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Yeong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Geun","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Soo","family":"Hyeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Je","family":"Tak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Jung","family":"Im","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Won","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wook Beom","family":"Pyeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je Geon","family":"Jae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyu Rok","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Hyung","family":"Doh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Wook","family":"Im","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myeong Muk","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2016.09.006_bib1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40885-014-0013-2","article-title":"2013 Korean Society of Hypertension guidelines for the management of hypertension. Part II: treatments of hypertension","volume":"21","year":"2015","journal-title":"Clin Hypertens"},{"key":"10.1016\/j.clinthera.2016.09.006_bib2","series-title":"The 3rd Korea National Health and Nutrition Examination Survey: Examinations","year":"2007"},{"key":"10.1016\/j.clinthera.2016.09.006_bib3","first-page":"2560","article-title":"National High Blood Pressure Education Program Coordination Committee","volume":"289","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.clinthera.2016.09.006_bib4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/08037050701461084","article-title":"2007 ESH-ESC Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)","volume":"16","year":"2007","journal-title":"Blood Press"},{"key":"10.1016\/j.clinthera.2016.09.006_bib5","first-page":"1983","article-title":"2003 World Health Organization (WHO)\/International Society of Hypertension (ISH) statement on management of hypertension: World Health Organization, International Society of Hypertension Writing Group","volume":"21","year":"2003"},{"key":"10.1016\/j.clinthera.2016.09.006_bib6","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1016\/S0140-6736(04)16451-9","article-title":"Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomized trial","volume":"363","author":"Julis","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.clinthera.2016.09.006_bib7","series-title":"Product Monograth NOVASC(amlodipine besylate) Tablets 2.5, 5 and 10 mg Antihypertensive-Antianginal Agent","year":"2005"},{"key":"10.1016\/j.clinthera.2016.09.006_bib10","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0149-2918(01)80072-2","article-title":"Telmisartan plus hydrochlorothiazide versus telmisartan or hydrochlorothiazide monotherapy in patients with mild to moderate hypertension: a multicenter, randomized, double-blind, placebo-controlled, parallel-group trial","volume":"23","author":"McGill","year":"2001","journal-title":"Clin ther"},{"key":"10.1016\/j.clinthera.2016.09.006_bib11","article-title":"Pharmaceutical Safety Bureau of the Korea Food and Drug Administration, Toxicity Study Division of the Institute of Food and Drug Safety Evaluation","year":"2009","journal-title":"Clinical Trial Guidelines on Antihypertensive Agents"},{"key":"10.1016\/j.clinthera.2016.09.006_bib12","doi-asserted-by":"crossref","first-page":"222","DOI":"10.4070\/kcj.2016.46.2.222","article-title":"Valsartan 160 mg\/amlodipine 5 mg combination therapy versus amlodipine 10 mg in hypertensive patients with inadequate response to amlodipine 5 mg monotherapy","volume":"46","author":"Sung","year":"2016","journal-title":"Korean Circ J"},{"key":"10.1016\/j.clinthera.2016.09.006_bib13","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1751-7176.2011.00468.x","article-title":"Telmiartan and amlodipine single-pill combinations vs amlodipine monotherapy for superior blood pressure lowering and improved tolerability in patients with uncontrolled hypertension: results of the TEAMSTA-5 study","volume":"13","author":"Steen","year":"2011","journal-title":"J Clin Hypertens"},{"key":"10.1016\/j.clinthera.2016.09.006_bib14","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3810\/pgm.2009.03.1972","article-title":"Telmisartan plus amlodipine in patients with moderate or severe hypertension: results from a subgroup analysis of a randomized, placebo-controlled, parallel-group, 4 x 4 factorial study","volume":"121","author":"Littlejohn","year":"2009","journal-title":"Postgrad Med"},{"key":"10.1016\/j.clinthera.2016.09.006_bib15","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1751-7176.2009.00098.x","article-title":"Result of treatment with telmisartan-amlodipine in hypertensive patients","volume":"11","author":"Littlejohn","year":"2009","journal-title":"J Clin Hypertens"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291816307287?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291816307287?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T19:56:44Z","timestamp":1536350204000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291816307287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S0149291816307287"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2016.09.006","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of the Efficacy and Safety of Fixed-dose S-Amlodipine\/Telmisartan and Telmisartan in Hypertensive Patients Inadequately Controlled with Telmisartan: A Randomized, Double-blind, Multicenter Study","name":"articletitle","label":"Article Title"},{"value":"Clinical Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinthera.2016.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}