{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:12:55Z","timestamp":1787314375546,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","clinicaltherapeutics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.clinthera.2017.05.343","type":"journal-article","created":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T14:00:22Z","timestamp":1496325622000},"page":"1233-1241","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Extended-interval Dosing of Gentamicin in Premature Neonates Born at &lt;32 Weeks\u2019 Gestation and &gt;7 Days of age"],"prefix":"10.1016","volume":"39","author":[{"given":"Arun","family":"Sundaram","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belal","family":"Alshaikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deonne","family":"Dersch-Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Dobry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert R.","family":"Akierman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Yusuf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2017.05.343_bib1","doi-asserted-by":"crossref","first-page":"e94","DOI":"10.1542\/neo.13-2-e94","article-title":"Antimicrobial therapy and late onset sepsis","volume":"12","author":"Chu","year":"2012","journal-title":"NeoReviews"},{"key":"10.1016\/j.clinthera.2017.05.343_bib2","doi-asserted-by":"crossref","first-page":"F257","DOI":"10.1136\/archdischild-2014-306213","article-title":"Late-onset neonatal sepsis: recent developments","volume":"100","author":"Dong","year":"2015","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.clinthera.2017.05.343_bib3","first-page":"CD005091","article-title":"One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in neonates","author":"Rao","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.clinthera.2017.05.343_bib4","doi-asserted-by":"crossref","first-page":"e243","DOI":"10.1542\/neo.3-12-e243","article-title":"Aminoglycoside therapy in neonates: with particular reference to gentamicin","volume":"3","author":"Young","year":"2002","journal-title":"NeoReviews"},{"key":"10.1016\/j.clinthera.2017.05.343_bib5","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1093\/ajhp\/62.8.823","article-title":"Prediction of gentamicin peak and trough concentrations from six extended-interval dosing protocols for neonates","volume":"62","author":"Murphy","year":"2005","journal-title":"Am J Health Syst Pharm"},{"key":"10.1016\/j.clinthera.2017.05.343_bib6","doi-asserted-by":"crossref","first-page":"c714","DOI":"10.1542\/neo.11-12-e714","article-title":"Core concepts: neonatal glomerular filtration rate","volume":"11","author":"Su","year":"2010","journal-title":"NeoReviews"},{"key":"10.1016\/j.clinthera.2017.05.343_bib7","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s004670000356","article-title":"Progression of renal function in preterm neonates with gestational age < or = 32 weeks","volume":"15","author":"Gallini","year":"2000","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.clinthera.2017.05.343_bib8","doi-asserted-by":"crossref","first-page":"e1186","DOI":"10.1542\/peds.2009-1426","article-title":"Glomerular filtration rate reference values in very preterm infants","volume":"125","author":"Vieux","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.clinthera.2017.05.343_bib9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/pan.12326","article-title":"Fluid homeostasis in the neonate","volume":"24","author":"O\u2019Brien","year":"2014","journal-title":"Paediatr Anaesth"},{"key":"10.1016\/j.clinthera.2017.05.343_bib10","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1111\/j.1651-2227.2012.02820.x","article-title":"Extended interval dosing of gentamicin in premature neonates <\/= 28-week gestation","volume":"101","author":"Alshaikh","year":"2012","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.clinthera.2017.05.343_bib11","series-title":"NeoFax: A Manual of Drugs Used in Neonatal Care","first-page":"50","author":"Young","year":"2010"},{"key":"10.1016\/j.clinthera.2017.05.343_bib12","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/jac\/dkl244","article-title":"Population pharmacokinetics of gentamicin in premature newborns","volume":"58","author":"Garcia","year":"2006","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.clinthera.2017.05.343_bib13","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/jac\/dkh261","article-title":"Pharmacokinetic basis for the use of extended interval dosage regimens of gentamicin in neonates","volume":"54","author":"Lanao","year":"2004","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.clinthera.2017.05.343_bib14","doi-asserted-by":"crossref","first-page":"F294","DOI":"10.1136\/adc.2004.056317","article-title":"Aminoglycoside extended interval dosing in neonates is safe and effective: a meta-analysis","volume":"90","author":"Nestaas","year":"2005","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.clinthera.2017.05.343_bib15","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.jpeds.2008.04.060","article-title":"Observational trial of a 48-hour gentamicin dosing regimen derived from Monte Carlo simulations in infants born at less than 28 weeks gestation","volume":"153","author":"Thingvoll","year":"2008","journal-title":"J Pediatr"},{"key":"10.1016\/j.clinthera.2017.05.343_bib16","first-page":"640","article-title":"Simplified dosing of gentamicin for treatment of sepsis in Bangladeshi neonates","volume":"27","author":"Hossain","year":"2009","journal-title":"J Health Popul Nutr"},{"key":"10.1016\/j.clinthera.2017.05.343_bib17","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1055\/s-2002-36836","article-title":"Gentamicin and tobramycin in neonates: comparison of a new extended dosing interval regimen with a traditional multiple daily dosing regimen","volume":"19","author":"Avent","year":"2002","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.clinthera.2017.05.343_bib18","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00431-013-2194-1","article-title":"High-dose gentamicin in newborn infants: is it safe?","volume":"173","author":"Fjalstad","year":"2014","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.clinthera.2017.05.343_bib19","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.3109\/14767058.2015.1051021","article-title":"Performance of a dosage individualization table for extended interval gentamicin in neonates beyond the first week of life","volume":"29","author":"Dersch-Mills","year":"2016","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.clinthera.2017.05.343_bib20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1471-2431-13-59","article-title":"A systematic review and meta-analysis to revise the Fenton growth chart for preterm infants","volume":"13","author":"Fenton","year":"2013","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.clinthera.2017.05.343_bib21","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2165\/11595640-000000000-00000","article-title":"Maturation of the glomerular filtration rate in neonates, as reflected by amikacin clearance","volume":"51","author":"De Cock","year":"2012","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.clinthera.2017.05.343_bib22","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/00006454-200203000-00014","article-title":"Comparison of two gentamicin dosing schedules in very low birth weight infants","volume":"21","author":"Rastogi","year":"2002","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.clinthera.2017.05.343_bib23","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/jp.2016.37","article-title":"Extended-interval gentamicin administration in neonates: a simplified approach","volume":"36","author":"El-Chaar","year":"2016","journal-title":"J Perinatol"},{"key":"10.1016\/j.clinthera.2017.05.343_bib24","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/jac\/48.6.887","article-title":"An extended interval dosing method for gentamicin in neonates","volume":"48","author":"Stickland","year":"2001","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.clinthera.2017.05.343_bib25","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1023\/B:PHAR.0000035880.56207.e0","article-title":"Gentamicin usage in newborns\u2014a simple and practical regime","volume":"26","author":"Bajaj","year":"2004","journal-title":"Pharm World Sci"},{"key":"10.1016\/j.clinthera.2017.05.343_bib26","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/infdis\/149.3.443","article-title":"The association of aminoglycoside plasma levels with mortality in patients with gram-negative bacteremia","volume":"149","author":"Moore","year":"1984","journal-title":"J Infect Dis"},{"key":"10.1016\/j.clinthera.2017.05.343_bib27","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/infdis\/155.1.93","article-title":"Clinical response to aminoglycoside therapy: importance of the ratio of peak concentration to minimal inhibitory concentration","volume":"155","author":"Moore","year":"1987","journal-title":"J Infect Dis"},{"key":"10.1016\/j.clinthera.2017.05.343_bib28","doi-asserted-by":"crossref","first-page":"713","DOI":"10.2165\/00003495-200161060-00001","article-title":"Aminoglycoside adaptive resistance: importance for effective dosage regimens","volume":"61","author":"Barclay","year":"2001","journal-title":"Drugs"},{"key":"10.1016\/j.clinthera.2017.05.343_bib29","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/jp.2016.141","article-title":"Extended-interval gentamicin administration in neonates: an over-simplified approach","volume":"36","author":"Dersch-Mills","year":"2016","journal-title":"J Perinatol"},{"key":"10.1016\/j.clinthera.2017.05.343_bib30","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00228-008-0599-y","article-title":"Clinical pharmacokinetics of aminoglycosides in the neonate: a review","volume":"65","author":"Pacifici","year":"2009","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.clinthera.2017.05.343_bib31","doi-asserted-by":"crossref","first-page":"F290","DOI":"10.1136\/adc.2009.197699","article-title":"Perinatal drug exposure and renal function in very preterm infants","volume":"96","author":"Vieux","year":"2011","journal-title":"Arch Dis Child Fetal Neonatal Ed"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291817306410?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291817306410?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T07:34:31Z","timestamp":1569396871000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291817306410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S0149291817306410"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2017.05.343","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extended-interval Dosing of Gentamicin in Premature Neonates Born at <32 Weeks\u2019 Gestation and >7 Days of age","name":"articletitle","label":"Article Title"},{"value":"Clinical Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinthera.2017.05.343","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}