{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T03:48:29Z","timestamp":1770781709646,"version":"3.50.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","clinicaltherapeutics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.clinthera.2017.08.003","type":"journal-article","created":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T21:15:19Z","timestamp":1503522919000},"page":"1858-1867","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Tolerability of the SQ Tree SLIT Tablet in Adults"],"prefix":"10.1016","volume":"39","author":[{"given":"Anne O.","family":"Birk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens S.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanne H.","family":"Villesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Steffensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moises A.","family":"Calderon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2017.08.003_bib1","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1111\/all.12696","article-title":"Tree pollen allergens-an update from a molecular perspective","volume":"70","author":"Asam","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2017.08.003_bib2","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1111\/j.1365-2222.2007.02706.x","article-title":"Cost-effectiveness of grass allergen tablet (GRAZAX) for the prevention of seasonal grass pollen induced rhinoconjunctivitis - a Northern European perspective","volume":"37","author":"Bachert","year":"2007","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.clinthera.2017.08.003_bib3","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/00130832-200106000-00011","article-title":"Atopic allergens of plant foods","volume":"1","author":"Breiteneder","year":"2001","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2017.08.003_bib4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1749-6632.2002.tb04132.x","article-title":"Current understanding of cross-reactivity of food allergens and pollen","volume":"964","author":"Vieths","year":"2002","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.clinthera.2017.08.003_bib5","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.drudis.2015.07.010","article-title":"Allergy immunotherapy: the future of allergy treatment","volume":"21","author":"Larsen","year":"2016","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.clinthera.2017.08.003_bib6","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1056\/NEJM199908123410702","article-title":"Long-term clinical efficacy of grass-pollen immunotherapy","volume":"341","author":"Durham","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2017.08.003_bib7","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1111\/j.1398-9995.1997.tb01251.x","article-title":"Immunotherapy with partially purified and standardized tree pollen extracts, IV: results from long-term (6 year) follow-up","volume":"52","author":"Jacobsen","year":"1997","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2017.08.003_bib8","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/j.1398-9995.2007.01451.x","article-title":"Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10-year follow-up on the PAT study","volume":"62","author":"Jacobsen","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2017.08.003_bib9","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1067\/mai.2002.121317","article-title":"Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study)","volume":"109","author":"Moller","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2017.08.003_bib10","doi-asserted-by":"crossref","first-page":"855v859","DOI":"10.1111\/j.1398-9995.2006.01068.x","article-title":"Five-year follow up on the PAT study: Specific immunotherapy and long-term prevention of asthma in children","volume":"61","author":"Niggemann","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2017.08.003_bib11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1136\/bmj.302.6771.265","article-title":"Usefulness of immunotherapy in patients with severe summer hay fever uncontrolled by antiallergic drugs","volume":"302","author":"Varney","year":"1991","journal-title":"BMJ"},{"key":"10.1016\/j.clinthera.2017.08.003_bib12","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/j.1365-2222.1997.tb01225.x","article-title":"Clinical efficacy of specific immunotherapy to cat dander: a double-blind placebo-controlled trial","volume":"27","author":"Varney","year":"1997","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.clinthera.2017.08.003_bib13","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1398-9995.1995.tb01170.x","article-title":"Grass pollen immunotherapy: efficacy and safety during a 4-year follow-up study","volume":"50","author":"Walker","year":"1995","journal-title":"Allergy"},{"issue":"Suppl 86","key":"10.1016\/j.clinthera.2017.08.003_bib14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1398-9995.2007.01620.x","article-title":"Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen)","volume":"63","author":"Bousquet","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2017.08.003_bib15","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s11882-014-0473-1","article-title":"Immune mechanisms of sublingual immunotherapy","volume":"14","author":"Jay","year":"2014","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.clinthera.2017.08.003_bib16","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/2045-7022-2-2","article-title":"Mechanisms of allergen-specific immunotherapy","volume":"2","author":"Fujita","year":"2012","journal-title":"Clin Transl Allergy"},{"key":"10.1016\/j.clinthera.2017.08.003_bib17","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1111\/j.1365-2222.2011.03866.x","article-title":"Bet v 1-like pollen allergens of multiple Fagales species can sensitize atopic individuals","volume":"41","author":"Hauser","year":"2011","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.clinthera.2017.08.003_bib18","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1365-2222.1992.tb03101.x","article-title":"Specificity mapping of patients IgE response towards the tree pollen major allergens Aln g I, Bet v I and Cor a I","volume":"22","author":"Ipsen","year":"1992","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.clinthera.2017.08.003_bib19","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/0091-6749(91)90388-5","article-title":"Homology of the major birch-pollen allergen, Bet v I, with the major pollen allergens of alder, hazel, and hornbeam at the nucleic acid level as determined by cross-hybridization","volume":"87","author":"Valenta","year":"1991","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2017.08.003_bib20","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jaci.2010.08.021","article-title":"Effect of birch pollen-specific immunotherapy on birch pollen-related hazelnut allergy","volume":"127","author":"van","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2017.08.003_bib22","article-title":"ICH Harmonised Tripartite Guideline Topic E2A","year":"1994","journal-title":"Clinical Safety Data Management: Definitions and Standards for Expedited Reporting"},{"key":"10.1016\/j.clinthera.2017.08.003_bib23","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.clinbiochem.2004.06.010","article-title":"Performance evaluation of a specific IgE assay developed for the ADVIA centaur immunoassay system","volume":"37","author":"Petersen","year":"2004","journal-title":"Clin Biochem"},{"key":"10.1016\/j.clinthera.2017.08.003_bib24","first-page":"154","article-title":"Tolerability during double-blinded randomised phase I trials with the house dust mite allergy immunotherapy tablet in adults and children","volume":"24","author":"Corzo","year":"2014","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.clinthera.2017.08.003_bib25","first-page":"162","article-title":"Safety and immunological changes during specific sublingual immunotherapy with SQ standardized grass allergen tablets","volume":"16","author":"Malling","year":"2006","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.clinthera.2017.08.003_bib26","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jaip.2013.11.018","article-title":"Subcutaneous immunotherapy versus sublingual immunotherapy: which is more effective?","volume":"2","author":"Nelson","year":"2014","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.clinthera.2017.08.003_bib27","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jaci.2013.09.043","article-title":"Grass tablet sublingual immunotherapy downregulates the TH2 cytokine response followed by regulatory T-cell generation","volume":"133","author":"Suarez-Fueyo","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2017.08.003_bib28","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.jaci.2007.10.039","article-title":"Sublingual grass allergen tablet immunotherapy provides sustained clinical benefit with progressive immunologic changes over 2 years","volume":"121","author":"Dahl","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2017.08.003_bib29","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jaci.2009.10.035","article-title":"Long-term clinical efficacy in grass pollen-induced rhinoconjunctivitis after treatment with SQ-standardized grass allergy immunotherapy tablet","volume":"125","author":"Durham","year":"2010","journal-title":"J Allergy Clin Immunol"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291817308743?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291817308743?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T06:51:12Z","timestamp":1535439072000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291817308743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S0149291817308743"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2017.08.003","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tolerability of the SQ Tree SLIT Tablet in Adults","name":"articletitle","label":"Article Title"},{"value":"Clinical Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinthera.2017.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}